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Aliases for TRAM2 Gene

Aliases for TRAM2 Gene

  • Translocation Associated Membrane Protein 2 2 3 5
  • KIAA0057 4

External Ids for TRAM2 Gene

Previous GeneCards Identifiers for TRAM2 Gene

  • GC06M052358
  • GC06M052409
  • GC06M052414
  • GC06U900790
  • GC06M052193
  • GC06M052363

Summaries for TRAM2 Gene

Entrez Gene Summary for TRAM2 Gene

  • TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]

GeneCards Summary for TRAM2 Gene

TRAM2 (Translocation Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with TRAM2 include polycystic kidney and hepatic disease and epilepsy, generalized, with febrile seizures plus, type 5. An important paralog of this gene is TRAM1.

UniProtKB/Swiss-Prot for TRAM2 Gene

  • Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.

Gene Wiki entry for TRAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAM2 Gene

Genomics for TRAM2 Gene

Regulatory Elements for TRAM2 Gene

Promoters for TRAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRAM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRAM2 Gene

Chromosome:
6
Start:
52,497,402 bp from pter
End:
52,577,064 bp from pter
Size:
79,663 bases
Orientation:
Minus strand

Genomic View for TRAM2 Gene

Genes around TRAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM2 Gene

Proteins for TRAM2 Gene

  • Protein details for TRAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15035-TRAM2_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 2
    Protein Accession:
    Q15035
    Secondary Accessions:
    • A8K6T6

    Protein attributes for TRAM2 Gene

    Size:
    370 amino acids
    Molecular mass:
    43328 Da
    Quaternary structure:
    • Interacts with SERCA2B and COL1A1.
    SequenceCaution:
    • Sequence=BAA06540.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TRAM2 Gene

Proteomics data for TRAM2 Gene at MOPED

Post-translational modifications for TRAM2 Gene

  • Glycosylation at Asn 55
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRAM2 Gene

Domains & Families for TRAM2 Gene

Suggested Antigen Peptide Sequences for TRAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15035

UniProtKB/Swiss-Prot:

TRAM2_HUMAN :
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Belongs to the TRAM family.
Domain:
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM2: view

No data available for Gene Families for TRAM2 Gene

Function for TRAM2 Gene

Molecular function for TRAM2 Gene

UniProtKB/Swiss-Prot Function:
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.
genes like me logo Genes that share phenotypes with TRAM2: view

Animal Models for TRAM2 Gene

MGI Knock Outs for TRAM2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAM2 Gene

Localization for TRAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRAM2 Gene COMPARTMENTS Subcellular localization image for TRAM2 gene
Compartment Confidence
plasma membrane 3
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for TRAM2 Gene

Pathways & Interactions for TRAM2 Gene

SuperPathways for TRAM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRAM2 Gene

Drugs & Compounds for TRAM2 Gene

No Compound Related Data Available

Transcripts for TRAM2 Gene

mRNA/cDNA for TRAM2 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRAM2 Gene

Translocation associated membrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM2 Gene

No ASD Table

Relevant External Links for TRAM2 Gene

GeneLoc Exon Structure for
TRAM2
ECgene alternative splicing isoforms for
TRAM2

Expression for TRAM2 Gene

mRNA expression in normal human tissues for TRAM2 Gene

Protein differential expression in normal tissues from HIPED for TRAM2 Gene

This gene is overexpressed in Placenta (42.9) and Pancreas (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRAM2 Gene



SOURCE GeneReport for Unigene cluster for TRAM2 Gene Hs.520182

genes like me logo Genes that share expression patterns with TRAM2: view

Protein tissue co-expression partners for TRAM2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRAM2 Gene

Orthologs for TRAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAM2 35
  • 99.73 (n)
  • 99.73 (a)
TRAM2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRAM2 36
  • 95 (a)
OneToOne
TRAM2 35
  • 89.82 (n)
  • 95.14 (a)
dog
(Canis familiaris)
Mammalia TRAM2 35
  • 93 (n)
  • 95.8 (a)
TRAM2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tram2 16
Tram2 35
  • 88.65 (n)
  • 90 (a)
Tram2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRAM2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAM2 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100361830 35
  • 88.56 (n)
  • 89.73 (a)
chicken
(Gallus gallus)
Aves TRAM2 35
  • 77.95 (n)
  • 79.15 (a)
TRAM2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRAM2 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tram2 35
  • 73.08 (n)
  • 74.8 (a)
zebrafish
(Danio rerio)
Actinopterygii tram2 36
  • 65 (a)
OneToOne
Dr.4811 35
tram2 35
  • 64.68 (n)
  • 66.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta TRAM 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tram-1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TRAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAM2 Gene

ENSEMBL:
Gene Tree for TRAM2 (if available)
TreeFam:
Gene Tree for TRAM2 (if available)

Paralogs for TRAM2 Gene

Paralogs for TRAM2 Gene

(2) SIMAP similar genes for TRAM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRAM2: view

Variants for TRAM2 Gene

Sequence variations from dbSNP and Humsavar for TRAM2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1064217 -- 52,502,437(-) GGACA(C/T)GTCTT utr-variant-3-prime
rs1064229 -- 52,499,035(-) TGAAA(A/G)CTGCC utr-variant-3-prime
rs998100 -- 52,500,047(-) GTGGC(A/C/G)CTGGT utr-variant-3-prime
rs1983641 -- 52,554,533(+) aaaaa(A/G)aaaaa intron-variant
rs2268708 -- 52,566,605(-) CTTAG(A/G)TCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRAM2 Gene

Variant ID Type Subtype PubMed ID
nsv522674 CNV Loss 19592680
nsv518713 CNV Loss 19592680
nsv527895 CNV Loss 19592680
nsv830663 CNV Loss 17160897
esv2732081 CNV Deletion 23290073
esv2732082 CNV Deletion 23290073

Variation tolerance for TRAM2 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRAM2 Gene

HapMap Linkage Disequilibrium report
TRAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAM2 Gene

Disorders for TRAM2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAM2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
polycystic kidney and hepatic disease
  • polycystic kidney and hepatic disease 1
epilepsy, generalized, with febrile seizures plus, type 5
  • epilepsy, idiopathic generalized, 10
- elite association - COSMIC cancer census association via MalaCards
Search TRAM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRAM2

Genetic Association Database (GAD)
TRAM2
Human Genome Epidemiology (HuGE) Navigator
TRAM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRAM2
genes like me logo Genes that share disorders with TRAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAM2 Gene

Publications for TRAM2 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 67
  2. Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene. (PMID: 10594243) Onuchic L.F. … Guay-Woodford L.M. (Mamm. Genome 1999) 2 3 23
  3. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. (PMID: 14749390) Stefanovic B. … Brenner D.A. (Mol. Cell. Biol. 2004) 3 23
  4. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. (PMID: 25957402) Zhong L. … Bu G. (J. Biol. Chem. 2015) 3
  5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3

Products for TRAM2 Gene

Sources for TRAM2 Gene

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