External Ids for TRAM2 Gene
Previous GeneCards Identifiers for TRAM2 Gene
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
GeneCards Summary for TRAM2 Gene
TRAM2 (Translocation Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with TRAM2 include Polycystic Kidney Disease 4, With Or Without Hepatic Disease and Epilepsy, Generalized, With Febrile Seizures Plus, Type 5. An important paralog of this gene is TRAM1.
UniProtKB/Swiss-Prot for TRAM2 Gene
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).