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Aliases for CROCC Gene

Aliases for CROCC Gene

  • Ciliary Rootlet Coiled-Coil, Rootletin 2 3 5
  • Ciliary Rootlet Coiled-Coil Protein 3 4
  • Rootletin, Ciliary Rootlet Protein 2 3
  • Tax1-Binding Protein 2 3
  • Rootletin 3
  • KIAA0445 4
  • TAX1BP2 3
  • ROLT 3

External Ids for CROCC Gene

Previous GeneCards Identifiers for CROCC Gene

  • GC01P016201
  • GC01P016631
  • GC01P016993
  • GC01P017121
  • GC01P017049
  • GC01P017223
  • GC01P015492
  • GC01P017093
  • GC01P017099
  • GC01P016741
  • GC01P016745
  • GC01P016748
  • GC01P016754
  • GC01P016757
  • GC01P016759
  • GC01P016761

Summaries for CROCC Gene

GeneCards Summary for CROCC Gene

CROCC (Ciliary Rootlet Coiled-Coil, Rootletin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity and kinesin binding. An important paralog of this gene is CROCC2.

UniProtKB/Swiss-Prot for CROCC Gene

  • Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).

Gene Wiki entry for CROCC Gene

Additional gene information for CROCC Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CROCC Gene

Genomics for CROCC Gene

GeneHancer (GH) Regulatory Elements for CROCC Gene

Promoters and enhancers for CROCC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I016921 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 550.1 +181.6 181640 1.8 HDAC1 HDGF KLF17 SIN3A ETS1 ZNF335 GLIS2 ZNF366 SCRT2 ZNF143 CROCC EIF1AXP1 RPL22P3 MFAP2 SDHB FBXO42 LOC105376805 RCC2 MST1P2 GC01M016886
GH01I016739 Promoter/Enhancer 0.7 Ensembl dbSUPER 550.8 +0.1 128 1.2 CROCCP4 PIR38064 RNU1-4 CROCC ENSG00000282740
GH01I016741 Enhancer 0.2 dbSUPER 550.8 +0.9 852 0.2 CROCC CROCCP4 RNU1-4 PIR38064 ENSG00000282740 PIR43378
GH01I016902 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 48 +164.8 164777 4.9 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000272426 CROCC ZBTB17 CROCCP3 LINC01772 RPL22P3 ARHGEF19 MFAP2 NBPF1 NECAP2
GH01I016142 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.2 -588.6 -588612 17.5 CLOCK MLX FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC MEF2D EPHA2 SPEN CROCC ENSG00000237938 ZBTB17 TMEM51-AS1 FBXO42 RPL22P3 ARHGEF19 FBLIM1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CROCC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CROCC gene promoter:

Genomic Locations for CROCC Gene

Genomic Locations for CROCC Gene
232,707 bases
Plus strand

Genomic View for CROCC Gene

Genes around CROCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CROCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CROCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CROCC Gene

Proteins for CROCC Gene

  • Protein details for CROCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q2VHY3
    • Q66GT7
    • Q7Z2L4
    • Q7Z5D7

    Protein attributes for CROCC Gene

    2017 amino acids
    Molecular mass:
    228523 Da
    Quaternary structure:
    • Homopolymer. Interacts with KLC3, NEK2 and the N-terminus of CEP250.

    Alternative splice isoforms for CROCC Gene


neXtProt entry for CROCC Gene

Post-translational modifications for CROCC Gene

  • Phosphorylated by NEK2 which may regulate its association with centrosomes.

No data available for DME Specific Peptides for CROCC Gene

Domains & Families for CROCC Gene

Gene Families for CROCC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CROCC Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the rootletin family.
  • Belongs to the rootletin family.
genes like me logo Genes that share domains with CROCC: view

Function for CROCC Gene

Molecular function for CROCC Gene

UniProtKB/Swiss-Prot Function:
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (PubMed:27623382). Contributes to centrosome cohesion before mitosis (PubMed:16203858).

Phenotypes From GWAS Catalog for CROCC Gene

Gene Ontology (GO) - Molecular Function for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005198 structural molecule activity IEA,ISS --
GO:0005515 protein binding IPI 18086858
GO:0019894 kinesin binding ISS,IEA --
genes like me logo Genes that share ontologies with CROCC: view
genes like me logo Genes that share phenotypes with CROCC: view

Animal Models for CROCC Gene

MGI Knock Outs for CROCC:

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CROCC Gene

Localization for CROCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CROCC Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase. {ECO:0000269 PubMed:14654843}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CROCC gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001917 photoreceptor inner segment IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole ISS,IDA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with CROCC: view

Pathways & Interactions for CROCC Gene

SuperPathways for CROCC Gene

No Data Available

SIGNOR curated interactions for CROCC Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CROCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007098 centrosome cycle IEA,IDA 16203858
GO:0008104 protein localization IMP 18086858
GO:0010457 centriole-centriole cohesion IMP 24554434
GO:0010669 epithelial structure maintenance IEA --
genes like me logo Genes that share ontologies with CROCC: view

No data available for Pathways by source for CROCC Gene

Drugs & Compounds for CROCC Gene

No Compound Related Data Available

Transcripts for CROCC Gene

Unigene Clusters for CROCC Gene

Ciliary rootlet coiled-coil, rootletin:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CROCC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a ·

ExUns: 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c ^ 27a · 27b · 27c · 27d
SP1: - - -
SP2: -
SP5: - - - - - - -
SP6: -

Relevant External Links for CROCC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CROCC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CROCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CROCC Gene

This gene is overexpressed in Neutrophil (11.9), Retina (9.2), and Lymph node (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CROCC Gene

Protein tissue co-expression partners for CROCC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CROCC Gene:


SOURCE GeneReport for Unigene cluster for CROCC Gene:


Evidence on tissue expression from TISSUES for CROCC Gene

  • Eye(5)
  • Nervous system(4.5)
  • Liver(4.4)
  • Blood(4.1)
  • Lung(3.6)
  • Skin(3.1)
  • Intestine(2.2)
  • Kidney(2.2)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with CROCC: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CROCC Gene

Orthologs for CROCC Gene

This gene was present in the common ancestor of animals.

Orthologs for CROCC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CROCC 33 34
  • 98.91 (n)
(Canis familiaris)
Mammalia CROCC 33 34
  • 88.06 (n)
(Bos Taurus)
Mammalia CROCC 33 34
  • 86.29 (n)
(Mus musculus)
Mammalia Crocc 33 16 34
  • 83.45 (n)
(Rattus norvegicus)
Mammalia Crocc 33
  • 83.35 (n)
(Ornithorhynchus anatinus)
Mammalia CROCC 34
  • 70 (a)
(Monodelphis domestica)
Mammalia CROCC 34
  • 58 (a)
(Gallus gallus)
Aves CROCC 33 34
  • 63.2 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
-- 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498193 33
  • 52.91 (n)
(Danio rerio)
Actinopterygii LOC101885282 33
  • 50.49 (n)
CABZ01072698.1 34
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rootletin 33 34
  • 60.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003449 33
  • 45.26 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5391 33
Species where no ortholog for CROCC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CROCC Gene

Gene Tree for CROCC (if available)
Gene Tree for CROCC (if available)

Paralogs for CROCC Gene

Paralogs for CROCC Gene

(4) SIMAP similar genes for CROCC Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CROCC: view

Variants for CROCC Gene

Sequence variations from dbSNP and Humsavar for CROCC Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000179201 -- 16,926,884(+) C/A intron_variant
rs1000422112 -- 16,943,142(+) T/G intron_variant
rs1000437740 -- 16,953,205(+) G/A intron_variant
rs1000717614 -- 16,926,284(+) C/T intron_variant
rs1000726527 -- 16,964,090(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CROCC Gene

Variant ID Type Subtype PubMed ID
dgv101n100 CNV gain 25217958
dgv104n100 CNV loss 25217958
dgv105n100 CNV gain+loss 25217958
dgv106n100 CNV gain 25217958
dgv107n100 CNV gain 25217958
dgv108n100 CNV gain 25217958
dgv111n100 CNV gain 25217958
dgv113n100 CNV gain 25217958
dgv114n100 CNV gain+loss 25217958
dgv115n100 CNV loss 25217958
dgv116n100 CNV gain+loss 25217958
dgv117n100 CNV gain+loss 25217958
dgv118n100 CNV gain 25217958
dgv119n100 CNV gain 25217958
dgv120n100 CNV gain 25217958
dgv121n100 CNV loss 25217958
dgv122n100 CNV gain 25217958
dgv123n100 CNV loss 25217958
dgv124n100 CNV gain+loss 25217958
dgv125n100 CNV loss 25217958
dgv126n100 CNV loss 25217958
dgv127n100 CNV loss 25217958
dgv13e214 CNV gain 21293372
dgv14e214 CNV gain 21293372
dgv166n54 CNV gain+loss 21841781
dgv167n54 CNV loss 21841781
dgv168n54 CNV loss 21841781
dgv169n54 CNV loss 21841781
dgv170n54 CNV loss 21841781
dgv171n54 CNV loss 21841781
dgv1e203 CNV gain+loss 21179565
dgv23n67 CNV gain 20364138
dgv24n67 CNV gain 20364138
dgv25n67 CNV gain 20364138
dgv39n100 CNV gain 25217958
dgv54e59 CNV duplication 20981092
dgv55n100 CNV gain+loss 25217958
dgv57e59 CNV duplication 20981092
dgv63n100 CNV gain 25217958
dgv78n100 CNV loss 25217958
dgv86n100 CNV gain 25217958
dgv91n100 CNV gain+loss 25217958
dgv92n100 CNV gain 25217958
esv2421455 CNV duplication 20811451
esv26111 CNV gain+loss 19812545
esv2758925 CNV gain+loss 17122850
esv29948 CNV loss 18421352
esv29988 CNV loss 17803354
esv3343101 CNV duplication 20981092
esv33965 CNV gain+loss 17666407
esv3577752 CNV loss 25503493
esv3584587 CNV gain 24956385
esv3892303 CNV gain+loss 25118596
esv3892414 CNV gain 25118596
esv3892525 CNV loss 25118596
esv990069 CNV loss 20482838
nsv1002599 CNV gain 25217958
nsv1002613 CNV loss 25217958
nsv1004093 CNV gain+loss 25217958
nsv1004224 CNV gain+loss 25217958
nsv1006384 CNV loss 25217958
nsv1006828 CNV gain+loss 25217958
nsv1076186 CNV deletion 25765185
nsv1119667 CNV deletion 24896259
nsv1128591 CNV duplication 24896259
nsv1139475 CNV duplication 24896259
nsv1151399 CNV duplication 26484159
nsv1160181 CNV duplication 26073780
nsv428421 CNV gain+loss 18775914
nsv433184 CNV loss 18776910
nsv437207 CNV loss 16327808
nsv437208 CNV loss 16327808
nsv438355 CNV loss 16468122
nsv442727 CNV gain 18776908
nsv471438 CNV gain 19718026
nsv482201 CNV gain 20164927
nsv508947 CNV insertion 20534489
nsv545672 CNV loss 21841781
nsv7173 OTHER inversion 18451855
nsv821037 CNV duplication 20802225
nsv829625 CNV gain 20364138
nsv834258 CNV loss 17160897
nsv834269 CNV loss 17160897
nsv834280 CNV loss 17160897
nsv9324 CNV gain+loss 18304495
nsv945800 CNV duplication 23825009
nsv954854 CNV deletion 24416366
nsv957534 CNV deletion 24416366

Variation tolerance for CROCC Gene

Residual Variation Intolerance Score: 99.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.05; 93.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CROCC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CROCC Gene

Disorders for CROCC Gene

Additional Disease Information for CROCC

No disorders were found for CROCC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CROCC Gene

Publications for CROCC Gene

  1. Rootletin forms centriole-associated filaments and functions in centrosome cohesion. (PMID: 16203858) Bahe S … Nigg EA (The Journal of cell biology 2005) 3 4 22 58
  2. Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. (PMID: 12427867) Yang J … Li T (The Journal of cell biology 2002) 2 3 22 58
  3. A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. (PMID: 27623382) Nechipurenko IV … Sengupta P (Developmental cell 2016) 3 4 58
  4. Tissue expression patterns identify mouse cilia genes. (PMID: 17971504) McClintock TS … Bergman DA (Physiological genomics 2008) 2 3 58
  5. beta-Catenin is a Nek2 substrate involved in centrosome separation. (PMID: 18086858) Bahmanyar S … Barth AI (Genes & development 2008) 3 22 58

Products for CROCC Gene

  • Addgene plasmids for CROCC

Sources for CROCC Gene

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