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Aliases for IPO13 Gene

Aliases for IPO13 Gene

  • Importin 13 2 3
  • RANBP13 3 4 6
  • IMP13 3 4 6
  • Ran-Binding Protein 13 3 4
  • Karyopherin-13 3 4
  • KIAA0724 4 6
  • KAP13 3 4
  • Ran Binding Protein 13 3
  • Late Gestation Lung 2 3
  • Karyopherin 13 3
  • Importin-13 3
  • LGL2 3

External Ids for IPO13 Gene

Previous GeneCards Identifiers for IPO13 Gene

  • GC01P043413
  • GC01P043842
  • GC01P043825
  • GC01P044081
  • GC01P044185
  • GC01P044412
  • GC01P042531

Summaries for IPO13 Gene

Entrez Gene Summary for IPO13 Gene

  • This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]

GeneCards Summary for IPO13 Gene

IPO13 (Importin 13) is a Protein Coding gene. GO annotations related to this gene include Ran GTPase binding. An important paralog of this gene is TNPO3.

UniProtKB/Swiss-Prot for IPO13 Gene

  • Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Gene Wiki entry for IPO13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IPO13 Gene

Genomics for IPO13 Gene

Regulatory Elements for IPO13 Gene

Genomic Location for IPO13 Gene

Start:
43,946,806 bp from pter
End:
43,968,022 bp from pter
Size:
21,217 bases
Orientation:
Plus strand

Genomic View for IPO13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IPO13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IPO13 Gene

Proteins for IPO13 Gene

  • Protein details for IPO13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94829-IPO13_HUMAN
    Recommended name:
    Importin-13
    Protein Accession:
    O94829
    Secondary Accessions:
    • D3DPY4
    • Q5T4X3
    • Q7LC04
    • Q96HS3
    • Q9H8N3
    • Q9UFR1

    Protein attributes for IPO13 Gene

    Size:
    963 amino acids
    Molecular mass:
    108195 Da
    Quaternary structure:
    • Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.
    SequenceCaution:
    • Sequence=BAA34444.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14575.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IPO13 Gene

neXtProt entry for IPO13 Gene

Proteomics data for IPO13 Gene at MOPED

Post-translational modifications for IPO13 Gene

  • Ubiquitination at Lys923
  • Modification sites at PhosphoSitePlus

Other Protein References for IPO13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IPO13 Gene

Domains for IPO13 Gene

Gene Families for IPO13 Gene

HGNC:
  • IPO :Importins

Suggested Antigen Peptide Sequences for IPO13 Gene

Graphical View of Domain Structure for InterPro Entry

O94829

UniProtKB/Swiss-Prot:

IPO13_HUMAN :
  • O94829
Domain:
  • Contains 1 importin N-terminal domain.
Family:
  • Belongs to the importin beta family.
Similarity:
  • Contains 20 HEAT repeats.
genes like me logo Genes that share domains with IPO13: view

Function for IPO13 Gene

Molecular function for IPO13 Gene

UniProtKB/Swiss-Prot Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

Gene Ontology (GO) - Molecular Function for IPO13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 16189514
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with IPO13: view

Phenotypes for IPO13 Gene

GenomeRNAi human phenotypes for IPO13:
genes like me logo Genes that share phenotypes with IPO13: view

miRNA for IPO13 Gene

miRTarBase miRNAs that target IPO13

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IPO13 Gene

Localization for IPO13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IPO13 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IPO13 Gene COMPARTMENTS Subcellular localization image for IPO13 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IPO13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with IPO13: view

Pathways for IPO13 Gene

SuperPathways for IPO13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IPO13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IDA 15964792
GO:0006886 intracellular protein transport --
genes like me logo Genes that share ontologies with IPO13: view

No data available for Pathways by source for IPO13 Gene

Compounds for IPO13 Gene

(1) HMDB Compounds for IPO13 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with IPO13: view

Transcripts for IPO13 Gene

Unigene Clusters for IPO13 Gene

Importin 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IPO13 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: -
SP3:
SP4: -
SP5:
SP6:

ExUns: 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for IPO13 Gene

GeneLoc Exon Structure for
IPO13
ECgene alternative splicing isoforms for
IPO13

Expression for IPO13 Gene

mRNA expression in normal human tissues for IPO13 Gene

mRNA differential expression in normal tissues according to GTEx for IPO13 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IPO13 Gene

SOURCE GeneReport for Unigene cluster for IPO13 Gene Hs.158497

mRNA Expression by UniProt/SwissProt for IPO13 Gene

O94829-IPO13_HUMAN
Tissue specificity: Expressed in fetal brain, heart, intestine and kidney.
genes like me logo Genes that share expressions with IPO13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IPO13 Gene

Orthologs for IPO13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IPO13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IPO13 35
  • 99.92 (n)
  • 100 (a)
IPO13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IPO13 35
  • 94.57 (n)
  • 98.86 (a)
IPO13 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IPO13 35
  • 95.08 (n)
  • 99.17 (a)
IPO13 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ipo13 35
  • 93.18 (n)
  • 99.17 (a)
Ipo13 16
Ipo13 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IPO13 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IPO13 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ipo13 35
  • 92.87 (n)
  • 98.44 (a)
chicken
(Gallus gallus)
Aves IPO13 35
  • 81.87 (n)
  • 88.2 (a)
IPO13 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IPO13 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ipo13 35
  • 74.46 (n)
  • 83.54 (a)
zebrafish
(Danio rerio)
Actinopterygii ipo13 35
  • 75.53 (n)
  • 82.94 (a)
ipo13 36
  • 82 (a)
OneToMany
IPO13 (2 of 2) 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009571 35
  • 45.43 (n)
  • 28.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta cdm 35
  • 45.74 (n)
  • 29.85 (a)
cdm 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T16G12.6 36
  • 17 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTR10 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for IPO13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IPO13 Gene

ENSEMBL:
Gene Tree for IPO13 (if available)
TreeFam:
Gene Tree for IPO13 (if available)

Paralogs for IPO13 Gene

Paralogs for IPO13 Gene

genes like me logo Genes that share paralogs with IPO13: view

Variants for IPO13 Gene

Sequence variations from dbSNP and Humsavar for IPO13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1008137 -- 43,955,082(+) TCCTT(C/T)CTCAT intron-variant
rs1636879 -- 43,963,008(+) AGCAG(C/G)GTGGC intron-variant
rs2240447 -- 43,949,743(-) CAAGC(A/G)TCAGG reference, synonymous-codon
rs2301992 -- 43,961,151(-) AGCAG(A/G)GAATG intron-variant
rs2301993 -- 43,960,353(-) GGGAG(C/T)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IPO13 Gene

Variant ID Type Subtype PubMed ID
nsv870942 CNV Loss 21882294
nsv870606 CNV Loss 21882294

Relevant External Links for IPO13 Gene

HapMap Linkage Disequilibrium report
IPO13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IPO13 Gene

Disorders for IPO13 Gene

Relevant External Links for IPO13

Genetic Association Database (GAD)
IPO13
Human Genome Epidemiology (HuGE) Navigator
IPO13
genes like me logo Genes that share disorders with IPO13: view

No data available for UniProtKB/Swiss-Prot for IPO13 Gene

Publications for IPO13 Gene

  1. Importin 13: a novel mediator of nuclear import and export. (PMID: 11447110) Mingot J.-M. … Goerlich D. (EMBO J. 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma. (PMID: 19619331) Raby B.A. … Weiss S.T. (Respir. Res. 2009) 3 23 48
  4. Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13. (PMID: 20122403) Bono F. … Conti E. (Mol. Cell 2010) 4 23
  5. Importin 13 serves as a potential marker for corneal epithelial progenitor cells. (PMID: 19593795) Wang H. … Liu Z.G. (Stem Cells 2009) 3 23

Products for IPO13 Gene

Sources for IPO13 Gene

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