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Aliases for EIF5B Gene

Aliases for EIF5B Gene

  • Eukaryotic Translation Initiation Factor 5B 2 3 5
  • Translation Initiation Factor IF-2 3 4
  • Translation Initiation Factor IF2 2 3
  • EIF-5B 3 4
  • IF2 3 4
  • EC 3.6.5.3 4
  • KIAA0741 4

External Ids for EIF5B Gene

Previous GeneCards Identifiers for EIF5B Gene

  • GC02P099575
  • GC02P099412
  • GC02P099953
  • GC02P093719

Summaries for EIF5B Gene

Entrez Gene Summary for EIF5B Gene

  • Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

GeneCards Summary for EIF5B Gene

EIF5B (Eukaryotic Translation Initiation Factor 5B) is a Protein Coding gene. Diseases associated with EIF5B include Inflammatory Liposarcoma and Skeletal Tuberculosis. Among its related pathways are Viral mRNA Translation and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and GTPase activity.

UniProtKB/Swiss-Prot for EIF5B Gene

  • Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.

Gene Wiki entry for EIF5B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF5B Gene

Genomics for EIF5B Gene

Regulatory Elements for EIF5B Gene

Enhancers for EIF5B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G099388 0.8 ENCODE 11.4 +52.4 52354 1.5 PKNOX1 LEF1 ZSCAN4 FEZF1 HIC1 GLIS2 ZNF350 FOS KLF8 SCRT1 TSGA10 LYG1 TXNDC9 EIF5B MITD1 REV1 LOC550644 ENSG00000273306
GH02G099430 0.7 ENCODE 11.2 +93.9 93891 1.4 ZFP37 MAFG EP300 OSR2 ZSCAN21 PRDM6 ZNF316 BCL11A SMARCA4 EMSY TSGA10 TXNDC9 EIF5B REV1 MRPL30 LIPT1 LYG1 ENSG00000273306
GH02G099856 0.5 dbSUPER 5 +520.3 520259 1.5 ZNF316 MAFG EMSY MAFK EIF5B GC02P099881 LOC105373504
GH02G099334 1.2 ENCODE 0.7 -0.4 -389 3.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TSGA10 LYG1 REV1 EIF5B PIR33754
GH02G099323 0.6 ENCODE 0.4 -13.0 -12964 1.4 MAX FOS HNF4A RAD21 ZIC2 MAFK TSGA10 REV1 ENSG00000241962 MITD1 MRPL30 LIPT1 LYG1 PIR33754 EIF5B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around EIF5B on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF5B Gene

Chromosome:
2
Start:
99,337,353 bp from pter
End:
99,401,326 bp from pter
Size:
63,974 bases
Orientation:
Plus strand

Genomic View for EIF5B Gene

Genes around EIF5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF5B Gene

Proteins for EIF5B Gene

  • Protein details for EIF5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60841-IF2P_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 5B
    Protein Accession:
    O60841
    Secondary Accessions:
    • O95805
    • Q53RV7
    • Q53SI8
    • Q9UF81
    • Q9UMN7

    Protein attributes for EIF5B Gene

    Size:
    1220 amino acids
    Molecular mass:
    138827 Da
    Cofactor:
    Name=a monovalent cation; Xref=ChEBI:CHEBI:60242;
    Quaternary structure:
    • Interacts with ANXA5 in a calcium and phospholipid-dependent manner.
    SequenceCaution:
    • Sequence=BAA34461.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for EIF5B Gene

Post-translational modifications for EIF5B Gene

  • Ubiquitination at Lys932 and Lys1185
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for EIF5B Gene

Domains & Families for EIF5B Gene

Graphical View of Domain Structure for InterPro Entry

O60841

UniProtKB/Swiss-Prot:

IF2P_HUMAN :
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
Family:
  • Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
genes like me logo Genes that share domains with EIF5B: view

No data available for Gene Families for EIF5B Gene

Function for EIF5B Gene

Molecular function for EIF5B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.
UniProtKB/Swiss-Prot Function:
Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.

Enzyme Numbers (IUBMB) for EIF5B Gene

Gene Ontology (GO) - Molecular Function for EIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003743 translation initiation factor activity NAS 10200264
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 12569173
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with EIF5B: view
genes like me logo Genes that share phenotypes with EIF5B: view

Animal Model Products

CRISPR Products

miRNA for EIF5B Gene

miRTarBase miRNAs that target EIF5B

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF5B Gene

Localization for EIF5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF5B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for EIF5B gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for EIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 12426392
GO:0005737 cytoplasm IDA,IEA 12426392
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with EIF5B: view

Pathways & Interactions for EIF5B Gene

genes like me logo Genes that share pathways with EIF5B: view

Pathways by source for EIF5B Gene

Gene Ontology (GO) - Biological Process for EIF5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006413 translational initiation IEA --
GO:0006446 regulation of translational initiation NAS 10200264
genes like me logo Genes that share ontologies with EIF5B: view

No data available for SIGNOR curated interactions for EIF5B Gene

Drugs & Compounds for EIF5B Gene

(2) Drugs for EIF5B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for EIF5B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF5B: view

Transcripts for EIF5B Gene

Unigene Clusters for EIF5B Gene

Eukaryotic translation initiation factor 5B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF5B Gene

No ASD Table

Relevant External Links for EIF5B Gene

GeneLoc Exon Structure for
EIF5B
ECgene alternative splicing isoforms for
EIF5B

Expression for EIF5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for EIF5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for EIF5B Gene

This gene is overexpressed in Lymph node (10.9) and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EIF5B Gene



Protein tissue co-expression partners for EIF5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of EIF5B Gene:

EIF5B

SOURCE GeneReport for Unigene cluster for EIF5B Gene:

Hs.158688

Evidence on tissue expression from TISSUES for EIF5B Gene

  • Nervous system(4.8)
  • Blood(4.7)
  • Liver(4.5)
  • Lung(3.7)
  • Intestine(3.3)
  • Heart(2.9)
  • Kidney(2.7)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with EIF5B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EIF5B Gene

Orthologs for EIF5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for EIF5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF5B 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia EIF5B 34 35
  • 92.85 (n)
cow
(Bos Taurus)
Mammalia EIF5B 34 35
  • 90.64 (n)
mouse
(Mus musculus)
Mammalia Eif5b 34 16 35
  • 87.15 (n)
rat
(Rattus norvegicus)
Mammalia Eif5b 34
  • 86.13 (n)
oppossum
(Monodelphis domestica)
Mammalia EIF5B 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF5B 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF5B 35 34
  • 78.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF5B 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif5b 34
  • 74.25 (n)
Str.1394 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6800 34
zebrafish
(Danio rerio)
Actinopterygii eif5b 34 35
  • 65.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta eIF5B 35
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea iffb-1 35
  • 45 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FUN12 35 37
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5675 35
  • 56 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2784 34
Species where no ortholog for EIF5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EIF5B Gene

ENSEMBL:
Gene Tree for EIF5B (if available)
TreeFam:
Gene Tree for EIF5B (if available)

Paralogs for EIF5B Gene

No data available for Paralogs for EIF5B Gene

Variants for EIF5B Gene

Sequence variations from dbSNP and Humsavar for EIF5B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000005861 -- 99,389,042(+) AATAT(C/T)CTAAG intron-variant
rs1000036984 -- 99,388,610(+) AACAA(C/T)ATAAT intron-variant
rs1000099786 -- 99,350,792(+) ACAAC(A/G)TTATG intron-variant
rs1000172480 -- 99,350,414(+) TATAA(C/T)AGTTC intron-variant
rs1000315112 -- 99,367,804(+) ACTTT(C/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF5B Gene

Variant ID Type Subtype PubMed ID
dgv4032n100 CNV gain 25217958
nsv524466 CNV loss 19592680

Variation tolerance for EIF5B Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
EIF5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF5B Gene

Disorders for EIF5B Gene

MalaCards: The human disease database

(3) MalaCards diseases for EIF5B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inflammatory liposarcoma
skeletal tuberculosis
  • osteoarticular tuberculosis
adult medulloblastoma
  • adult brain medulloblastoma
- elite association - COSMIC cancer census association via MalaCards
Search EIF5B in MalaCards View complete list of genes associated with diseases

Relevant External Links for EIF5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF5B
genes like me logo Genes that share disorders with EIF5B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EIF5B Gene

Publications for EIF5B Gene

  1. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. (PMID: 10200264) Lee J.H. … Dever T.E. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 64
  2. Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2 and its interaction with HIV-1 matrix. (PMID: 10432305) Wilson S.A. … Martin-Rendon E. (Biochem. J. 1999) 2 3 4 64
  3. Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases. (PMID: 18572216) de Breyne S. … Hellen C.U. (Virology 2008) 3 22 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. (PMID: 12569173) Marintchev A. … Wagner G. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 22 64

Products for EIF5B Gene

Sources for EIF5B Gene

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