Aliases for ABCG1 Gene
External Ids for ABCG1 Gene
Previous GeneCards Identifiers for ABCG1 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCG1 Gene
ABCG1 (ATP Binding Cassette Subfamily G Member 1) is a Protein Coding gene. Diseases associated with ABCG1 include tangier disease and autosomal recessive nonsyndromic deafness. Among its related pathways are Lipoprotein metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and GTP binding. An important paralog of this gene is ABCG8.
UniProtKB/Swiss-Prot for ABCG1 Gene
Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.