Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NCOR2 Gene

Aliases for NCOR2 Gene

  • Nuclear Receptor Corepressor 2 2 3 5
  • Thyroid-, Retinoic-Acid-Receptor-Associated Corepressor 3 4
  • T3 Receptor-Associating Factor 3 4
  • CTG Repeat Protein 26 3 4
  • SMAP270 3 4
  • N-CoR2 3 4
  • CTG26 3 4
  • SMRT 3 4
  • TRAC 3 4
  • Silencing Mediator Of Retinoic Acid And Thyroid Hormone Receptor 4
  • Silencing Mediator For Retinoid And Thyroid Hormone Receptors 3
  • Nuclear Receptor Co-Repressor 2 2
  • SMRTE-Tau 3
  • TNRC14 3
  • TRAC-1 3
  • TRAC1 3
  • SMRTE 3

External Ids for NCOR2 Gene

Previous GeneCards Identifiers for NCOR2 Gene

  • GC12M123498
  • GC12M124551
  • GC12M123162
  • GC12M123333
  • GC12M124808
  • GC12M121771

Summaries for NCOR2 Gene

Entrez Gene Summary for NCOR2 Gene

  • This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

GeneCards Summary for NCOR2 Gene

NCOR2 (Nuclear Receptor Corepressor 2) is a Protein Coding gene. Diseases associated with NCOR2 include Leukemia, Acute Promyelocytic, Somatic and Lymphoma, Non-Hodgkin. Among its related pathways are Notch signaling pathway (KEGG) and Signaling by NOTCH1. GO annotations related to this gene include sequence-specific DNA binding and protein complex binding. An important paralog of this gene is NCOR1.

UniProtKB/Swiss-Prot for NCOR2 Gene

  • Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.

Gene Wiki entry for NCOR2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOR2 Gene

Genomics for NCOR2 Gene

Regulatory Elements for NCOR2 Gene

Enhancers for NCOR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G124913 2.2 FANTOM5 Ensembl ENCODE dbSUPER 63 -351.6 -351594 12.7 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 NCOR2 DHX37 DNAH10OS ENSG00000275389 ENSG00000270130 ENSG00000269938 ENSG00000270061 ENSG00000269997 SCARB1 BRI3BP
GH12G124504 2 FANTOM5 Ensembl ENCODE dbSUPER 38.9 +51.0 50986 24.5 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 EIF2B1 NCOR2 TCTN2 LOC101927415 ATP6V0A2 DHX37 ENSG00000275389 ENSG00000270130 UBC LOC105370047
GH12G124427 1.7 Ensembl ENCODE dbSUPER 45.7 +138.8 138842 3.1 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 EIF2B1 NCOR2 ATP6V0A2 LOC101927415 DHX37 GTF2H3 TCTN2 ENSG00000270130 ENSG00000269938 ENSG00000270061
GH12G124679 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.4 -116.6 -116594 10.1 PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF766 ZNF207 ZNF548 FOS NFYC ATP6V0A2 NCOR2 TMEM132B DNAH10 UBC PIR31698 GC12M124443
GH12G124719 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.9 -153.5 -153511 2.6 PKNOX1 FEZF1 ZNF2 ZBTB7B GLIS2 GATA2 ZNF548 FOS ZNF263 YY2 NCOR2 LOC105370047 UBC ENSG00000279931 PIR31698
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCOR2 on UCSC Golden Path with GeneCards custom track

Promoters for NCOR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058911 589 2001 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 ZNF143 KLF7 KDM4B

Genomic Location for NCOR2 Gene

Chromosome:
12
Start:
124,324,411 bp from pter
End:
124,567,589 bp from pter
Size:
243,179 bases
Orientation:
Minus strand

Genomic View for NCOR2 Gene

Genes around NCOR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOR2 Gene

Proteins for NCOR2 Gene

  • Protein details for NCOR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y618-NCOR2_HUMAN
    Recommended name:
    Nuclear receptor corepressor 2
    Protein Accession:
    Q9Y618
    Secondary Accessions:
    • O00613
    • O15416
    • O15421
    • Q13354
    • Q56D06
    • Q59GM0
    • Q9Y5U0

    Protein attributes for NCOR2 Gene

    Size:
    2525 amino acids
    Molecular mass:
    274804 Da
    Quaternary structure:
    • Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SMRT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity. Interacts with HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3. Interacts with BCL6 (via the BTB domain), required for BCL6 transcriptional repressor activity on a subset of target genes. Forms ternary complexes with BCOR and BCL6 on target gene promoters but, on enhancer elements, interacts with BCL6 and HDAC3 to repress proximal gene expression. May interact with DEAF1. Interacts with RXRA. Interacts with MECP2 (By similarity).
    SequenceCaution:
    • Sequence=AAB91452.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAC50236.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAD20946.1; Type=Frameshift; Positions=787, 794; Evidence={ECO:0000305}; Sequence=BAD92326.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCOR2 Gene

    Alternative splice isoforms for NCOR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCOR2 Gene

Post-translational modifications for NCOR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NCOR2 Gene

Domains & Families for NCOR2 Gene

Protein Domains for NCOR2 Gene

Suggested Antigen Peptide Sequences for NCOR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y618

UniProtKB/Swiss-Prot:

NCOR2_HUMAN :
  • The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
  • Belongs to the N-CoR nuclear receptor corepressors family.
Domain:
  • The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor-interacting domains that are divided in two separate interaction domains (ID1 and ID2).
  • The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.
Family:
  • Belongs to the N-CoR nuclear receptor corepressors family.
genes like me logo Genes that share domains with NCOR2: view

Function for NCOR2 Gene

Molecular function for NCOR2 Gene

GENATLAS Biochemistry:
nuclear hormone receptor co-repressor 2,silencing mediator of retinoic acid and thyroid hormone receptors,ubiquitously expressed,recruiting the histone deacytylation complex Sin3A/HDAC1/HDAC2,resulting in chromatin remodeling and repression of transcription
UniProtKB/Swiss-Prot Function:
Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.
UniProtKB/Swiss-Prot Induction:
Regulated during cell cycle progression.

Gene Ontology (GO) - Molecular Function for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001012 RNA polymerase II regulatory region DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity IDA,IMP 12628926
GO:0005112 Notch binding IPI 10713164
genes like me logo Genes that share ontologies with NCOR2: view
genes like me logo Genes that share phenotypes with NCOR2: view

Animal Models for NCOR2 Gene

MGI Knock Outs for NCOR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NCOR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCOR2 Gene

Localization for NCOR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOR2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOR2 gene
Compartment Confidence
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IBA --
GO:0000785 chromatin IEA --
GO:0000790 nuclear chromatin IDA 20388878
GO:0005634 nucleus IC,IDA 12628926
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with NCOR2: view

Pathways & Interactions for NCOR2 Gene

genes like me logo Genes that share pathways with NCOR2: view

SIGNOR curated interactions for NCOR2 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NCOR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007595 lactation IEA --
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with NCOR2: view

Drugs & Compounds for NCOR2 Gene

(12) Drugs for NCOR2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for NCOR2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
all-trans-retinoic acid
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
  • Acide retinoique (French)
Full agonist, Agonist 302-79-4
genes like me logo Genes that share compounds with NCOR2: view

Transcripts for NCOR2 Gene

mRNA/cDNA for NCOR2 Gene

(3) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(24) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NCOR2 Gene

Nuclear receptor corepressor 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NCOR2

Alternative Splicing Database (ASD) splice patterns (SP) for NCOR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

ExUns: 24c ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b · 28c ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c · 33d ^ 34a · 34b · 34c ^ 35 ^ 36a · 36b ^ 37 ^ 38a ·
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: - -
SP21: -
SP22:
SP23:
SP24:
SP25: -
SP26:

ExUns: 38b ^ 39 ^ 40a · 40b · 40c · 40d ^ 41a · 41b · 41c · 41d ^ 42a · 42b · 42c · 42d
SP1: - - -
SP2:
SP3: - - - - - - -
SP4: - - - -
SP5: -
SP6: - - - - -
SP7: - - - - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: -
SP23:
SP24:
SP25:
SP26:

Relevant External Links for NCOR2 Gene

GeneLoc Exon Structure for
NCOR2
ECgene alternative splicing isoforms for
NCOR2

Expression for NCOR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCOR2 Gene

Protein differential expression in normal tissues from HIPED for NCOR2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.8) and Cerebrospinal fluid (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCOR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of NCOR2 Gene:

NCOR2

SOURCE GeneReport for Unigene cluster for NCOR2 Gene:

Hs.137510

mRNA Expression by UniProt/SwissProt for NCOR2 Gene:

Q9Y618-NCOR2_HUMAN
Tissue specificity: Ubiquitous. High levels of expression are detected in lung, spleen and brain.

Evidence on tissue expression from TISSUES for NCOR2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(2.9)
  • Skin(2.9)
  • Thyroid gland(2.8)
  • Intestine(2.6)
  • Muscle(2.4)
  • Blood(2.3)
  • Pancreas(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with NCOR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOR2 Gene

Orthologs for NCOR2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCOR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOR2 35 34
  • 96.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCOR2 35 34
  • 89.11 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCOR2 35 34
  • 88.66 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncor2 34
  • 84.21 (n)
mouse
(Mus musculus)
Mammalia Ncor2 34 16 35
  • 83.97 (n)
oppossum
(Monodelphis domestica)
Mammalia NCOR2 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOR2 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOR2 35 34
  • 75.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOR2 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncor2 34
  • 65.34 (n)
zebrafish
(Danio rerio)
Actinopterygii ncor2 35 34
  • 61.06 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Smr 35
  • 12 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea gei-8 35
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNT1 35
  • 14 (a)
OneToMany
Species where no ortholog for NCOR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCOR2 Gene

ENSEMBL:
Gene Tree for NCOR2 (if available)
TreeFam:
Gene Tree for NCOR2 (if available)

Paralogs for NCOR2 Gene

Paralogs for NCOR2 Gene

genes like me logo Genes that share paralogs with NCOR2: view

Variants for NCOR2 Gene

Sequence variations from dbSNP and Humsavar for NCOR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000004914 -- 124,367,112(+) CATGC(A/C)GTCTG intron-variant
rs1000007316 -- 124,396,787(+) CACCC(C/T)CCACA intron-variant
rs1000014917 -- 124,504,715(+) GTAAG(C/T)GCTGA intron-variant
rs1000023697 -- 124,473,080(+) AGTGT(G/T)CGGGG reference, missense
rs1000028280 -- 124,462,921(+) GCTGA(C/T)TTCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOR2 Gene

Variant ID Type Subtype PubMed ID
dgv201e201 CNV deletion 23290073
dgv2935n54 CNV loss 21841781
dgv2936n54 CNV loss 21841781
dgv2937n54 CNV gain+loss 21841781
dgv2938n54 CNV gain 21841781
dgv2939n54 CNV gain+loss 21841781
dgv2940n54 CNV gain+loss 21841781
dgv2941n54 CNV loss 21841781
dgv2942n54 CNV gain+loss 21841781
dgv2943n54 CNV loss 21841781
dgv2944n54 CNV loss 21841781
dgv2945n54 CNV loss 21841781
dgv2946n54 CNV loss 21841781
dgv928e59 CNV duplication 20981092
esv1008328 CNV insertion 20482838
esv1118928 CNV insertion 17803354
esv1449756 CNV insertion 17803354
esv1465850 CNV insertion 17803354
esv1526249 CNV deletion 17803354
esv1669172 CNV insertion 17803354
esv1772285 CNV insertion 17803354
esv2130547 CNV deletion 18987734
esv24001 CNV gain 19812545
esv2428288 CNV deletion 19546169
esv2658789 CNV deletion 23128226
esv2662504 CNV deletion 23128226
esv2664620 CNV deletion 23128226
esv2666569 CNV deletion 23128226
esv2670996 CNV deletion 23128226
esv2746527 CNV deletion 23290073
esv2746528 CNV deletion 23290073
esv2746529 CNV deletion 23290073
esv2746531 CNV deletion 23290073
esv2746532 CNV deletion 23290073
esv2746534 CNV deletion 23290073
esv2746536 CNV deletion 23290073
esv2746537 CNV deletion 23290073
esv2746538 CNV deletion 23290073
esv2746539 CNV deletion 23290073
esv2746540 CNV deletion 23290073
esv2746542 CNV deletion 23290073
esv3401431 CNV insertion 20981092
esv3549934 CNV deletion 23714750
esv3631010 CNV gain 21293372
esv3631011 CNV gain 21293372
esv3631012 CNV gain 21293372
esv3631014 CNV loss 21293372
esv3631016 CNV loss 21293372
nsv1069709 CNV deletion 25765185
nsv1069710 CNV deletion 25765185
nsv1070560 CNV deletion 25765185
nsv1112624 CNV deletion 24896259
nsv1116714 CNV tandem duplication 24896259
nsv1120270 CNV tandem duplication 24896259
nsv1125186 CNV insertion 24896259
nsv1130668 CNV deletion 24896259
nsv1134274 CNV deletion 24896259
nsv1135797 CNV deletion 24896259
nsv1136160 CNV deletion 24896259
nsv1139576 CNV duplication 24896259
nsv1141340 CNV deletion 24896259
nsv1141343 CNV deletion 24896259
nsv1146892 CNV duplication 26484159
nsv1148270 CNV duplication 26484159
nsv1149521 CNV deletion 26484159
nsv455737 CNV loss 19166990
nsv455738 CNV loss 19166990
nsv455739 CNV loss 19166990
nsv470322 CNV loss 18288195
nsv470323 CNV loss 18288195
nsv474040 CNV novel sequence insertion 20440878
nsv560540 CNV loss 21841781
nsv560541 CNV loss 21841781
nsv560542 CNV loss 21841781
nsv560543 CNV gain 21841781
nsv560544 CNV loss 21841781
nsv560545 CNV loss 21841781
nsv560566 CNV loss 21841781
nsv560573 CNV gain 21841781
nsv560574 CNV gain 21841781
nsv560575 CNV loss 21841781
nsv560581 CNV loss 21841781
nsv560584 CNV loss 21841781
nsv818930 CNV gain 17921354
nsv821299 CNV deletion 20802225
nsv826536 CNV gain 20364138
nsv826537 CNV gain 20364138
nsv832535 CNV gain 17160897
nsv832538 CNV loss 17160897
nsv832539 CNV loss 17160897
nsv916 CNV insertion 18451855
nsv952500 CNV deletion 24416366
nsv957930 CNV deletion 24416366

Variation tolerance for NCOR2 Gene

Residual Variation Intolerance Score: 3.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.65; 97.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOR2 Gene

Human Gene Mutation Database (HGMD)
NCOR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOR2 Gene

Disorders for NCOR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NCOR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute promyelocytic, somatic
  • leukemia, acute promyelocytic
lymphoma, non-hodgkin
  • lymphoma, non-hodgkin, somatic
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search NCOR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCOR2

Genetic Association Database (GAD)
NCOR2
Human Genome Epidemiology (HuGE) Navigator
NCOR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOR2
genes like me logo Genes that share disorders with NCOR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOR2 Gene

Publications for NCOR2 Gene

  1. A transcriptional co-repressor that interacts with nuclear hormone receptors. (PMID: 7566127) Chen J.D. … Evans R.M. (Nature 1995) 2 3 4 22 64
  2. Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort. (PMID: 19183483) Haiman C.A. … Press M.F. (BMC Cancer 2009) 3 22 46 64
  3. Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. (PMID: 15632172) Goodson M.L. … Privalsky M.L. (J. Biol. Chem. 2005) 3 4 22 64
  4. Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand. (PMID: 12554770) Hauksdottir H. … Privalsky M.L. (Mol. Endocrinol. 2003) 3 4 22 64
  5. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. (PMID: 10944117) Li J. … Wong J. (EMBO J. 2000) 3 4 22 64

Products for NCOR2 Gene