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Aliases for NFE2L3 Gene

Aliases for NFE2L3 Gene

  • Nuclear Factor, Erythroid 2-Like 3 2 3
  • NRF3 3 4 6
  • Nuclear Factor (Erythroid-Derived 2)-Like 3 2 3
  • Nuclear Factor, Erythroid Derived 2, Like 3 3 4
  • NF-E2-Related Factor 3 3 4
  • NFE2-Related Factor 3 3 4
  • Nuclear Factor-Erythroid 2 P45-Related Factor 3 3
  • Nuclear Factor Erythroid 2-Related Factor 3 3
  • Nuclear Factor-Erythroid 2-Related Factor 3 3

External Ids for NFE2L3 Gene

Previous GeneCards Identifiers for NFE2L3 Gene

  • GC07P025834
  • GC07P025934
  • GC07P025965
  • GC07P026158
  • GC07P026191

Summaries for NFE2L3 Gene

Entrez Gene Summary for NFE2L3 Gene

  • This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]

GeneCards Summary for NFE2L3 Gene

NFE2L3 (Nuclear Factor, Erythroid 2-Like 3) is a Protein Coding gene. Diseases associated with NFE2L3 include fibrosarcoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is NFE2.

UniProtKB/Swiss-Prot for NFE2L3 Gene

  • Activates erythroid-specific, globin gene expression

Gene Wiki entry for NFE2L3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NFE2L3 Gene

Genomics for NFE2L3 Gene

Regulatory Elements for NFE2L3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NFE2L3 Gene

26,152,227 bp from pter
26,187,137 bp from pter
34,911 bases
Plus strand

Genomic View for NFE2L3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NFE2L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NFE2L3 Gene

Proteins for NFE2L3 Gene

  • Protein details for NFE2L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear factor erythroid 2-related factor 3
    Protein Accession:
    Secondary Accessions:
    • Q6NUS0
    • Q7Z498
    • Q86UJ4
    • Q86VR5
    • Q9UQA4

    Protein attributes for NFE2L3 Gene

    694 amino acids
    Molecular mass:
    76154 Da
    Quaternary structure:
    • Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).
    • Sequence=AAP22344.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA76288.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NFE2L3 Gene

Proteomics data for NFE2L3 Gene at MOPED

Post-translational modifications for NFE2L3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NFE2L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NFE2L3 Gene

Domains for NFE2L3 Gene

Gene Families for NFE2L3 Gene

  • bZIP :basic leucine zipper proteins

Protein Domains for NFE2L3 Gene

Suggested Antigen Peptide Sequences for NFE2L3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y4A8
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. CNC subfamily.
genes like me logo Genes that share domains with NFE2L3: view

Function for NFE2L3 Gene

Molecular function for NFE2L3 Gene

GENATLAS Biochemistry: nuclear factor (erythroid-derived 2)-like 3,Capncollar (CNC) family of transcription factor,highly expressed in placenta,B cell and monocyte lineage
UniProtKB/Swiss-Prot Function: Activates erythroid-specific, globin gene expression

Gene Ontology (GO) - Molecular Function for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10037736
GO:0003713 transcription coactivator activity TAS 10037736
genes like me logo Genes that share ontologies with NFE2L3: view

Phenotypes for NFE2L3 Gene

MGI mutant phenotypes for NFE2L3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NFE2L3: view

Animal Models for NFE2L3 Gene

MGI Knock Outs for NFE2L3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NFE2L3 Gene

Localization for NFE2L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NFE2L3 Gene

Subcellular locations from

Jensen Localization Image for NFE2L3 Gene COMPARTMENTS Subcellular localization image for NFE2L3 gene
Compartment Confidence
nucleus 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NFE2L3: view

Pathways for NFE2L3 Gene

SuperPathways for NFE2L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NFE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 10037736
genes like me logo Genes that share ontologies with NFE2L3: view

No data available for Pathways by source for NFE2L3 Gene

Transcripts for NFE2L3 Gene

mRNA/cDNA for NFE2L3 Gene

Unigene Clusters for NFE2L3 Gene

Nuclear factor (erythroid-derived 2)-like 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NFE2L3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NFE2L3 Gene

No ASD Table

Relevant External Links for NFE2L3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NFE2L3 Gene

mRNA expression in normal human tissues for NFE2L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NFE2L3 Gene

SOURCE GeneReport for Unigene cluster for NFE2L3 Gene Hs.404741

mRNA Expression by UniProt/SwissProt for NFE2L3 Gene

Tissue specificity: Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with NFE2L3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NFE2L3 Gene

Orthologs for NFE2L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NFE2L3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NFE2L3 35
  • 98.99 (n)
  • 98.27 (a)
NFE2L3 36
  • 98 (a)
(Bos Taurus)
Mammalia NFE2L3 35
  • 83.5 (n)
  • 78.41 (a)
NFE2L3 36
  • 76 (a)
(Canis familiaris)
Mammalia NFE2L3 35
  • 83.52 (n)
  • 78.15 (a)
NFE2L3 36
  • 79 (a)
(Mus musculus)
Mammalia Nfe2l3 35
  • 77.49 (n)
  • 69.82 (a)
Nfe2l3 16
Nfe2l3 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia NFE2L3 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Nfe2l3 35
  • 76.32 (n)
  • 68.01 (a)
(Anolis carolinensis)
Reptilia NFE2L3 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nfe2l3 35
  • 56.25 (n)
  • 47.92 (a)
Str.17162 35
(Danio rerio)
Actinopterygii nfe2l3 36
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta cnc 36
  • 14 (a)
cnc 37
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
Species with no ortholog for NFE2L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NFE2L3 Gene

Gene Tree for NFE2L3 (if available)
Gene Tree for NFE2L3 (if available)

Paralogs for NFE2L3 Gene

Paralogs for NFE2L3 Gene

Selected SIMAP similar genes for NFE2L3 Gene using alignment to 3 proteins: Pseudogenes for NFE2L3 Gene

genes like me logo Genes that share paralogs with NFE2L3: view

Variants for NFE2L3 Gene

Sequence variations from dbSNP and Humsavar for NFE2L3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4367 -- 26,185,241(-) CCACG(A/G)AAAAG reference, missense
rs932270 -- 26,180,812(+) ACATA(A/G)GACAA intron-variant
rs2040784 -- 26,169,441(-) TCAGG(C/T)GAGGG intron-variant
rs2040785 -- 26,169,185(-) AGAGA(A/G)GGAGA intron-variant
rs2040786 -- 26,169,116(-) GCCTA(C/T)GGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NFE2L3 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887849 CNV Gain 21882294
esv1600800 CNV Insertion 17803354
esv1335165 CNV Deletion 17803354
esv2671129 CNV Deletion 23128226
esv22494 CNV Loss 19812545
esv2659850 CNV Deletion 23128226
esv2734156 CNV Deletion 23290073

Relevant External Links for NFE2L3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NFE2L3 Gene

Disorders for NFE2L3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NFE2L3 Gene including...

Search for NFE2L3 Gene in MalaCards »

Relevant External Links for NFE2L3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NFE2L3: view

No data available for UniProtKB/Swiss-Prot for NFE2L3 Gene

Publications for NFE2L3 Gene

  1. Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. (PMID: 10037736) Kobayashi A. … Yamamoto M. (J. Biol. Chem. 1999) 2 3 4 23
  2. Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin. (PMID: 11286316) Terui K. … Ito E. (Tohoku J. Exp. Med. 2000) 3 23
  3. Functional and placental expression analysis of the human NRF3 transcription factor. (PMID: 15388789) ChAcnais B. … Blank V. (Mol. Endocrinol. 2005) 3 23
  4. Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor. (PMID: 17976382) Nouhi Z. … Blank V. (FEBS Lett. 2007) 3 23
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for NFE2L3 Gene

Sources for NFE2L3 Gene

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