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Aliases for CD40LG Gene

Aliases for CD40LG Gene

  • CD40 Ligand 2 3
  • TNF-Related Activation Protein 2 3 4
  • TNFSF5 3 4 6
  • Tumor Necrosis Factor (Ligand) Superfamily Member 5 2 3
  • T-B Cell-Activating Molecule 2 3
  • CD40 Antigen Ligand 2 3
  • T-Cell Antigen Gp39 3 4
  • CD40-L 3 4
  • HIGM1 3 6
  • CD40L 3 4
  • TRAP 3 4
  • IGM 3 6
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 5 (Hyper-IgM Syndrome) 2
  • Tumor Necrosis Factor Ligand Superfamily Member 5 4
  • Hyper-IgM Syndrome 2
  • CD154 Antigen 4
  • HCD40L 3
  • CD154 3
  • T-BAM 3
  • Gp39 3
  • IMD3 3

External Ids for CD40LG Gene

Previous HGNC Symbols for CD40LG Gene

  • HIGM1
  • IMD3
  • TNFSF5

Previous GeneCards Identifiers for CD40LG Gene

  • GC0XP135456
  • GC0XP135558
  • GC0XP135730
  • GC0XP125001

Summaries for CD40LG Gene

Entrez Gene Summary for CD40LG Gene

  • The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD40LG Gene

CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include immunodeficiency, x-linked, with hyper-igm and x-linked hyper igm syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and NF-KappaB Family Pathway. GO annotations related to this gene include cytokine activity and CD40 receptor binding.

UniProtKB/Swiss-Prot for CD40LG Gene

  • Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.

  • Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Gene Wiki entry for CD40LG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD40LG Gene

Genomics for CD40LG Gene

Regulatory Elements for CD40LG Gene

Genomic Location for CD40LG Gene

136,648,177 bp from pter
136,660,390 bp from pter
12,214 bases
Plus strand

Genomic View for CD40LG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD40LG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD40LG Gene

Proteins for CD40LG Gene

  • Protein details for CD40LG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD40 ligand
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CD40LG Gene

    261 amino acids
    Molecular mass:
    29274 Da
    Quaternary structure:
    • Homotrimer

    Three dimensional structures from OCA and Proteopedia for CD40LG Gene

neXtProt entry for CD40LG Gene

Proteomics data for CD40LG Gene at MOPED

Post-translational modifications for CD40LG Gene

  • N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40
  • Not O-glycosylated
  • The soluble form derives from the membrane form by proteolytic processing.
  • Glycosylation at Asn240
  • Modification sites at PhosphoSitePlus

Other Protein References for CD40LG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CD40LG (CD40 Ligand/TNFSF5)
  • Cell Signaling Technology (CST) Antibodies for CD40LG (CD40LG)

Protein Products

  • Enzo Life Sciences proteins for CD40LG

Assay Products

  • Enzo Life Sciences assays for CD40LG
  • antibodies-online kits for CD40LG

No data available for DME Specific Peptides for CD40LG Gene

Domains for CD40LG Gene

Gene Families for CD40LG Gene

  • CD :CD molecules
  • ENDOLIG :Endogenous ligands
  • TNFSF :Tumor necrosis factor (ligand) superfamily

Graphical View of Domain Structure for InterPro Entry



  • P29965
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with CD40LG: view

Function for CD40LG Gene

Molecular function for CD40LG Gene

UniProtKB/Swiss-Prot Function: Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
UniProtKB/Swiss-Prot Function: Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Gene Ontology (GO) - Molecular Function for CD40LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005174 CD40 receptor binding IPI 9468137
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CD40LG: view
genes like me logo Genes that share phenotypes with CD40LG: view

Animal Models for CD40LG Gene

MGI Knock Outs for CD40LG:

Animal Model Products

CRISPR Products

miRNA for CD40LG Gene

miRTarBase miRNAs that target CD40LG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD40LG Gene

Localization for CD40LG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD40LG Gene

Cell membrane; Single-pass type II membrane protein.
CD40 ligand, soluble form: Secreted.

Subcellular locations from

Jensen Localization Image for CD40LG Gene COMPARTMENTS Subcellular localization image for CD40LG gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD40LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7678552
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CD40LG: view

Pathways for CD40LG Gene

genes like me logo Genes that share pathways with CD40LG: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CD40LG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IDA 9468137
GO:0006955 immune response --
GO:0007159 leukocyte cell-cell adhesion NAS 9468137
GO:0030168 platelet activation IDA 9468137
GO:0030183 B cell differentiation IEA --
genes like me logo Genes that share ontologies with CD40LG: view

Compounds for CD40LG Gene

(1) HMDB Compounds for CD40LG Gene

Compound Synonyms Cas Number PubMed IDs
  • Atorvastatin acid

(127) Novoseek inferred chemical compound relationships for CD40LG Gene

Compound -log(P) Hits PubMed IDs
cardiolipin 65.7 38
stresson 55.8 1
fibrinogen 54.7 100
ivig 54.6 41
hu5c8 54.6 1
genes like me logo Genes that share compounds with CD40LG: view

Transcripts for CD40LG Gene

mRNA/cDNA for CD40LG Gene

(11) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD40LG Gene

CD40 ligand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD40LG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD40LG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for CD40LG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD40LG Gene

mRNA expression in normal human tissues for CD40LG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD40LG Gene

This gene is overexpressed in Whole Blood (19.7), Small Intestine - Terminal Ileum (6.4), and Spleen (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD40LG Gene

SOURCE GeneReport for Unigene cluster for CD40LG Gene Hs.592244

mRNA Expression by UniProt/SwissProt for CD40LG Gene

Tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes
genes like me logo Genes that share expressions with CD40LG: view

In Situ Assay Products

Orthologs for CD40LG Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD40LG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD40LG 35
  • 99.37 (n)
  • 99.05 (a)
CD40LG 36
  • 98 (a)
(Bos Taurus)
Mammalia CD40LG 35
  • 88.76 (n)
  • 88.51 (a)
CD40LG 36
  • 83 (a)
(Canis familiaris)
Mammalia CD40LG 35
  • 85.77 (n)
  • 83.08 (a)
CD40LG 36
  • 83 (a)
(Mus musculus)
Mammalia Cd40lg 35
  • 83.33 (n)
  • 77.69 (a)
Cd40lg 16
Cd40lg 36
  • 78 (a)
(Monodelphis domestica)
Mammalia CD40LG 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia CD40LG 36
  • 49 (a)
(Rattus norvegicus)
Mammalia Cd40lg 35
  • 83.85 (n)
  • 77.31 (a)
(Gallus gallus)
Aves CD40LG 35
  • 57.97 (n)
  • 43.08 (a)
CD40LG 36
  • 38 (a)
(Anolis carolinensis)
Reptilia CD40LG 36
  • 33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd40lg 35
  • 54.48 (n)
  • 40.34 (a)
Species with no ortholog for CD40LG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD40LG Gene

Gene Tree for CD40LG (if available)
Gene Tree for CD40LG (if available)

Paralogs for CD40LG Gene

Selected SIMAP similar genes for CD40LG Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CD40LG: view

No data available for Paralogs for CD40LG Gene

Variants for CD40LG Gene

Sequence variations from dbSNP and Humsavar for CD40LG Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs715762 -- 136,651,254(-) GCCGA(A/G)GCCCA intron-variant
rs1126535 -- 136,648,396(+) GAAGG(C/T)TGGAC synonymous-codon, reference
rs3092921 -- 136,660,841(+) TCCAA(C/T)AGAGG downstream-variant-500B
rs3092922 -- 136,659,397(+) TCCTT(C/T)GGCTT synonymous-codon, reference
rs3092923 -- 136,659,026(+) TCCCT(C/T)TCTTT intron-variant

Relevant External Links for CD40LG Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD40LG Gene

Disorders for CD40LG Gene

(1) OMIM Diseases for CD40LG Gene (300386)


  • X-linked immunodeficiency with hyper-IgM 1 (HIGM1) [MIM:308230]: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. {ECO:0000269 PubMed:7532185, ECO:0000269 PubMed:7678782, ECO:0000269 PubMed:7679206, ECO:0000269 PubMed:7679801, ECO:0000269 PubMed:7717401, ECO:0000269 PubMed:8094231, ECO:0000269 PubMed:8550833, ECO:0000269 PubMed:8889581, ECO:0000269 PubMed:9150729, ECO:0000269 PubMed:9746782}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(95) Novoseek inferred disease relationships for CD40LG Gene

Disease -log(P) Hits PubMed IDs
hyper-igm syndrome 86 52
waldenstrom macroglobulinemia 73.4 39
m syndrome 70.8 3
lupus erythematosus systemic 70.4 50
rheumatoid arthritis 65.6 68

Relevant External Links for CD40LG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD40LG: view

Publications for CD40LG Gene

  1. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. (PMID: 7678782) Aruffo A. … Ochs H.D. (Cell 1993) 2 3 4 23
  2. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. (PMID: 7679206) Korthaeuer U. … Kroczek R.A. (Nature 1993) 3 4 23
  3. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. (PMID: 7679801) Allen R.C. … Spriggs M.K. (Science 1993) 3 4 23
  4. Signaling through CD40 rescues IgE but not IgG or IgA secretion in X- linked immunodeficiency with hyper-IgM. (PMID: 7532185) Saiki O. … Matsuda I. (J. Clin. Invest. 1995) 3 4 23
  5. Cloning of TRAP, a ligand for CD40 on human T cells. (PMID: 1280226) Graf D. … Kroczek R.A. (Eur. J. Immunol. 1992) 3 4 23

Products for CD40LG Gene

Sources for CD40LG Gene

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