Aliases for CD40LG Gene
External Ids for CD40LG Gene
Previous Symbols for CD40LG Gene
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD40LG Gene
CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include epstein-barr virus hepatitis and immunoglobulin g deficiency. Among its related pathways are Class I MHC mediated antigen processing and presentation and NF-KappaB Family Pathway. GO annotations related to this gene include cytokine activity and CD40 receptor binding.
UniProtKB/Swiss-Prot for CD40LG Gene
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.