Aliases for CD40LG Gene
- CD40 Ligand 2 3 5
- TNF-Related Activation Protein 2 3 4
- Tumor Necrosis Factor (Ligand) Superfamily Member 5 2 3
- T-B Cell-Activating Molecule 2 3
- CD40 Antigen Ligand 2 3
- T-Cell Antigen Gp39 3 4
- TNFSF5 3 4
- CD40-L 3 4
- CD40L 3 4
- TRAP 3 4
- Tumor Necrosis Factor (Ligand) Superfamily, Member 5 (Hyper-IgM Syndrome) 2
External Ids for CD40LG Gene
Previous HGNC Symbols for CD40LG Gene
Previous GeneCards Identifiers for CD40LG Gene
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD40LG Gene
CD40LG (CD40 Ligand) is a Protein Coding gene. Diseases associated with CD40LG include Immunodeficiency, X-Linked, With Hyper-Igm and Cd40 Ligand Deficiency. Among its related pathways are TNF Signaling (sino) and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include cytokine activity and CD40 receptor binding.
UniProtKB/Swiss-Prot for CD40LG Gene
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.
Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.