Aliases for BRE Gene
- Brain And Reproductive Organ-Expressed (TNFRSF1A Modulator) 2 3
- BRCC45 3 4 6
- Brain And Reproductive Organ-Expressed Protein 3 4
- BRCA1/BRCA2-Containing Complex Subunit 45 3 4
- BRCC4 3 6
- BRCA1/BRCA2-Containing Complex, Subunit 4 3
- BRCA1/BRCA2-Containing Complex 2
- BRCA1-A Complex Subunit BRE 3
- Subunit 4 2
External Ids for BRE Gene
GeneCards Summary for BRE Gene
BRE (Brain And Reproductive Organ-Expressed (TNFRSF1A Modulator)) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Cell Cycle / Checkpoint Control. GO annotations related to this gene include tumor necrosis factor receptor binding and peroxisome targeting sequence binding.
UniProtKB/Swiss-Prot for BRE Gene
Component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.