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Aliases for BCAR1 Gene

Aliases for BCAR1 Gene

  • Breast Cancer Anti-Estrogen Resistance 1 2 3
  • Cas Scaffolding Protein Family Member 1 2 3 4
  • P130Cas 3 4
  • CASS1 3 4
  • CRKAS 3 4
  • CAS 3 4
  • Crk-Associated Substrate P130Cas 3
  • Crk-Associated Substrate 2
  • CRK-Associated Substrate 4
  • CAS1 3

External Ids for BCAR1 Gene

Previous GeneCards Identifiers for BCAR1 Gene

  • GC16M066192
  • GC16M076223
  • GC16M075001
  • GC16M075042
  • GC16M073820
  • GC16M075262
  • GC16M061013

Summaries for BCAR1 Gene

Entrez Gene Summary for BCAR1 Gene

  • BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]

GeneCards Summary for BCAR1 Gene

BCAR1 (Breast Cancer Anti-Estrogen Resistance 1) is a Protein Coding gene. Diseases associated with BCAR1 include estrogen resistance and nephronophthisis 1, juvenile. Among its related pathways are Signaling by GPCR and Ras signaling pathway. GO annotations related to this gene include protein kinase binding and SH3 domain binding. An important paralog of this gene is NEDD9.

UniProtKB/Swiss-Prot for BCAR1 Gene

  • Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Gene Wiki entry for BCAR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAR1 Gene

Genomics for BCAR1 Gene

Regulatory Elements for BCAR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BCAR1 Gene

Chromosome:
16
Start:
75,228,187 bp from pter
End:
75,268,053 bp from pter
Size:
39,867 bases
Orientation:
Minus strand

Genomic View for BCAR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BCAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAR1 Gene

Proteins for BCAR1 Gene

  • Protein details for BCAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56945-BCAR1_HUMAN
    Recommended name:
    Breast cancer anti-estrogen resistance protein 1
    Protein Accession:
    P56945
    Secondary Accessions:
    • B3KWD7
    • B4DEV4
    • B4DGB5
    • B4DIW5
    • B7Z7X7
    • E9PCL5
    • E9PCV2
    • F5GXA2
    • F5GXV6
    • F5H7Z0
    • F8WA69
    • Q6QEF7

    Protein attributes for BCAR1 Gene

    Size:
    870 amino acids
    Molecular mass:
    93372 Da
    Quaternary structure:
    • Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Interacts with BCAR3, the interaction regulates adhesion-dependent serine phosphorylation. Interacts with NPHP1 and SH2D3C. Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1. Part of a collagen-stimulated complex involved in cell migration made of CDC42, CRK, TNK2 and BCAR1/p130cas. Interacts with TNK2 via SH3 domains. Interacts with PTK2B/PYK2.

    Three dimensional structures from OCA and Proteopedia for BCAR1 Gene

    Alternative splice isoforms for BCAR1 Gene

neXtProt entry for BCAR1 Gene

Proteomics data for BCAR1 Gene at MOPED

Post-translational modifications for BCAR1 Gene

  • Dephosphorylated by PTPN14 at Tyr-128
  • PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin-mediated adhesion of cells to the extracellular matrix.
  • Ubiquitination at Lys 702
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BCAR1 (P130Cas)

No data available for DME Specific Peptides for BCAR1 Gene

Domains & Families for BCAR1 Gene

Gene Families for BCAR1 Gene

Protein Domains for BCAR1 Gene

Graphical View of Domain Structure for InterPro Entry

P56945

UniProtKB/Swiss-Prot:

BCAR1_HUMAN :
  • Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).
  • Belongs to the CAS family.
Domain:
  • Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL1 SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9 (By similarity).
  • A serine-rich region promotes activation of the serum response element (SRE)
  • The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK11
  • Contains 1 SH3 domain.
Family:
  • Belongs to the CAS family.
genes like me logo Genes that share domains with BCAR1: view

Function for BCAR1 Gene

Molecular function for BCAR1 Gene

UniProtKB/Swiss-Prot Function:
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

Gene Ontology (GO) - Molecular Function for BCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS 8070403
GO:0005515 protein binding IPI 9285683
GO:0017124 SH3 domain binding IEA --
GO:0019901 protein kinase binding IPI 8070403
genes like me logo Genes that share ontologies with BCAR1: view
genes like me logo Genes that share phenotypes with BCAR1: view

Animal Models for BCAR1 Gene

MGI Knock Outs for BCAR1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCAR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BCAR1 Gene

Localization for BCAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAR1 Gene

Cell junction, focal adhesion. Cytoplasm. Note=Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCAR1 Gene COMPARTMENTS Subcellular localization image for BCAR1 gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
cytoskeleton 2
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for BCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 9472046
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 8070403
GO:0005829 cytosol TAS --
GO:0005886 colocalizes_with plasma membrane IDA 21245381
genes like me logo Genes that share ontologies with BCAR1: view

Pathways & Interactions for BCAR1 Gene

genes like me logo Genes that share pathways with BCAR1: view

PCR Array Products

SIGNOR curated interactions for BCAR1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BCAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 11607844
GO:0007015 actin filament organization IDA 16105984
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction --
GO:0007173 epidermal growth factor receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with BCAR1: view

Drugs & Compounds for BCAR1 Gene

(14) Drugs for BCAR1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist ER antagonist, Anti-Estrogens 341
calyculin a Experimental Pharma 0
okadaic acid Experimental Pharma 0
Sucrose Experimental Pharma 0
Genistein Investigational Pharma Activator AR agonist 51

(13) Additional Compounds for BCAR1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
Agar
Cytochalasin D
Ganglioside
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
genes like me logo Genes that share compounds with BCAR1: view

Transcripts for BCAR1 Gene

Unigene Clusters for BCAR1 Gene

Breast cancer anti-estrogen resistance 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BCAR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BCAR1 Gene

No ASD Table

Relevant External Links for BCAR1 Gene

GeneLoc Exon Structure for
BCAR1
ECgene alternative splicing isoforms for
BCAR1

Expression for BCAR1 Gene

mRNA expression in normal human tissues for BCAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BCAR1 Gene

This gene is overexpressed in Testis (9.6), Plasma (9.5), Islet of Langerhans (9.1), Fetal Brain (7.3), Placenta (7.2), and Pancreas (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BCAR1 Gene



SOURCE GeneReport for Unigene cluster for BCAR1 Gene Hs.479747

mRNA Expression by UniProt/SwissProt for BCAR1 Gene

P56945-BCAR1_HUMAN
Tissue specificity: Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line
genes like me logo Genes that share expression patterns with BCAR1: view

Protein tissue co-expression partners for BCAR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BCAR1 Gene

Orthologs for BCAR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BCAR1 35
  • 86.7 (n)
  • 89.43 (a)
BCAR1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCAR1 35
  • 88.34 (n)
  • 92.82 (a)
BCAR1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcar1 35
  • 85.22 (n)
  • 90.18 (a)
Bcar1 16
Bcar1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCAR1 35
  • 99.55 (n)
  • 99.66 (a)
BCAR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcar1 35
  • 85.31 (n)
  • 90.54 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia BCAR1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves BCAR1 35
  • 72.39 (n)
  • 68.22 (a)
BCAR1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bcar1 35
  • 59.58 (n)
  • 61.69 (a)
Str.15275 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68466 35
zebrafish
(Danio rerio)
Actinopterygii bcar1 35
  • 65.18 (n)
  • 61.66 (a)
Dr.4707 35
bcar1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta p130CAS 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6681 36
  • 30 (a)
OneToMany
Species with no ortholog for BCAR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BCAR1 Gene

ENSEMBL:
Gene Tree for BCAR1 (if available)
TreeFam:
Gene Tree for BCAR1 (if available)

Paralogs for BCAR1 Gene

Paralogs for BCAR1 Gene

Pseudogenes.org Pseudogenes for BCAR1 Gene

genes like me logo Genes that share paralogs with BCAR1: view

Variants for BCAR1 Gene

Sequence variations from dbSNP and Humsavar for BCAR1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs5842 -- 75,229,126(+) CCTGG(A/T)AAGGC utr-variant-3-prime
rs730367 -- 75,238,131(+) AGTGG(A/G)TGAAG intron-variant, utr-variant-5-prime
rs889514 -- 75,238,614(+) GCAGA(A/G)CTGGG intron-variant, utr-variant-5-prime
rs1035539 - 75,242,877(+) GCCGG(A/C/G)GCCAG reference, missense, intron-variant
rs1035540 -- 75,244,897(+) AGACA(A/G)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BCAR1 Gene

Variant ID Type Subtype PubMed ID
nsv833282 CNV Gain+Loss 17160897
nsv7286 OTHER Inversion 18451855
nsv516504 CNV Gain+Loss 19592680
nsv523405 CNV Loss 19592680
dgv2912n71 CNV Loss 21882294
nsv149 OTHER Inversion 15895083
nsv906911 CNV Loss 21882294
nsv906913 CNV Loss 21882294
nsv471095 CNV Loss 18288195
nsv9459 CNV Gain 18304495

Variation tolerance for BCAR1 Gene

Residual Variation Intolerance Score: 75.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.52; 71.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCAR1 Gene

HapMap Linkage Disequilibrium report
BCAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAR1 Gene

Disorders for BCAR1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for BCAR1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
estrogen resistance
  • estrogen insensitivity
nephronophthisis 1, juvenile
  • nephronophthisis 1
cerebral hypoxia
  • brain hypoxia
nephronophthisis
  • medullary cystic kidney disease 1
breast cancer
  • breast cancer, invasive ductal
- elite association
Search BCAR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BCAR1

Genetic Association Database (GAD)
BCAR1
Human Genome Epidemiology (HuGE) Navigator
BCAR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCAR1
genes like me logo Genes that share disorders with BCAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BCAR1 Gene

Publications for BCAR1 Gene

  1. BCAR1, a human homologue of the adapter protein p130Cas, induces anti-estrogen resistance in breast cancer cells. (PMID: 10639512) Brinkman A. … Dorssers L.C.J. (J. Natl. Cancer Inst. 2000) 2 23 67
  2. CAS proteins in normal and pathological cell growth control. (PMID: 19937461) Tikhmyanova N. … Golemis E.A. (Cell. Mol. Life Sci. 2010) 23 67
  3. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. (PMID: 20038795) Huang J. … Han Z.G. (J. Clin. Invest. 2010) 23 67
  4. BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling. (PMID: 19940159) Schuh N.R. … Bouton A.H. (J. Biol. Chem. 2010) 23 67
  5. Calcium mobilization triggered by the chemokine CXCL12 regulates migration in wounded intestinal epithelial monolayers. (PMID: 20348095) Agle K.A. … Dwinell M.B. (J. Biol. Chem. 2010) 23 67

Products for BCAR1 Gene

Sources for BCAR1 Gene

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