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Aliases for MRPL33 Gene

Aliases for MRPL33 Gene

  • Mitochondrial Ribosomal Protein L33 2 3
  • MRP-L33 3 4
  • C2orf1 3 4
  • L33mt 3 4
  • 39S Ribosomal Protein L33, Mitochondrial 3
  • RPL33L 3

External Ids for MRPL33 Gene

Previous HGNC Symbols for MRPL33 Gene

  • C2orf1

Previous GeneCards Identifiers for MRPL33 Gene

  • GC02P027915
  • GC02P028087
  • GC02P027969
  • GC02P027906
  • GC02P027994

Summaries for MRPL33 Gene

Entrez Gene Summary for MRPL33 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL33 Gene

MRPL33 (Mitochondrial Ribosomal Protein L33) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL33 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL33 Gene

Genomics for MRPL33 Gene

Regulatory Elements for MRPL33 Gene

Genomic Location for MRPL33 Gene

27,771,717 bp from pter
27,988,087 bp from pter
216,371 bases
Plus strand

Genomic View for MRPL33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL33 Gene

Proteins for MRPL33 Gene

  • Protein details for MRPL33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L33, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53RZ6
    • Q5FVE3
    • Q96Q50

    Protein attributes for MRPL33 Gene

    65 amino acids
    Molecular mass:
    7619 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL33 Gene

    Alternative splice isoforms for MRPL33 Gene


neXtProt entry for MRPL33 Gene

Proteomics data for MRPL33 Gene at MOPED

Post-translational modifications for MRPL33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL33 Gene

No data available for DME Specific Peptides for MRPL33 Gene

Domains for MRPL33 Gene

Gene Families for MRPL33 Gene

  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL33 Gene

Suggested Antigen Peptide Sequences for MRPL33 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75394
  • Belongs to the ribosomal protein L33P family.
genes like me logo Genes that share domains with MRPL33: view

Function for MRPL33 Gene

Gene Ontology (GO) - Molecular Function for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with MRPL33: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRPL33 Gene

Localization for MRPL33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL33 Gene


Subcellular locations from

Jensen Localization Image for MRPL33 Gene COMPARTMENTS Subcellular localization image for MRPL33 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL33: view

Pathways for MRPL33 Gene

SuperPathways for MRPL33 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPL33: view

Pathways by source for MRPL33 Gene

1 KEGG pathway for MRPL33 Gene

Interacting Proteins for MRPL33 Gene

Gene Ontology (GO) - Biological Process for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL33: view

Transcripts for MRPL33 Gene

Unigene Clusters for MRPL33 Gene

Mitochondrial ribosomal protein L33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL33 Gene

No ASD Table

Relevant External Links for MRPL33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL33 Gene

mRNA expression in normal human tissues for MRPL33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRPL33 Gene

This gene is overexpressed in Adrenal Gland (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL33 Gene

SOURCE GeneReport for Unigene cluster for MRPL33 Gene Hs.515879

genes like me logo Genes that share expressions with MRPL33: view

No data available for mRNA Expression by UniProt/SwissProt for MRPL33 Gene

Orthologs for MRPL33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MRPL33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL33 35
  • 99.49 (n)
  • 100 (a)
MRPL33 36
  • 98 (a)
(Bos Taurus)
Mammalia MRPL33 35
  • 86.15 (n)
  • 84.62 (a)
MRPL33 36
  • 85 (a)
MRPL33 36
  • 85 (a)
(Canis familiaris)
Mammalia MRPL33 36
  • 80 (a)
(Mus musculus)
Mammalia Mrpl33 35
  • 82.05 (n)
  • 76.92 (a)
Mrpl33 16
Mrpl33 36
  • 77 (a)
(Monodelphis domestica)
Mammalia MRPL33 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL33 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Mrpl33 35
  • 82.56 (n)
  • 78.46 (a)
Species with no ortholog for MRPL33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRPL33 Gene

Gene Tree for MRPL33 (if available)
Gene Tree for MRPL33 (if available)

Paralogs for MRPL33 Gene

No data available for Paralogs for MRPL33 Gene

Variants for MRPL33 Gene

Sequence variations from dbSNP and Humsavar for MRPL33 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs953954 -- 27,774,338(-) AACTC(C/T)GTAGG intron-variant
rs1802248 -- 27,779,677(+) TGCAT(A/C)ACATT utr-variant-3-prime
rs3736594 -- 27,772,914(-) TTCCT(G/T)CAAGT intron-variant
rs3792252 -- 27,773,064(+) ACTAC(A/G)GGAAT intron-variant
rs3792253 -- 27,779,135(+) AACAT(C/T)GTTTT intron-variant

Relevant External Links for MRPL33 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL33 Gene

Disorders for MRPL33 Gene

Relevant External Links for MRPL33

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MRPL33: view

No data available for UniProtKB/Swiss-Prot for MRPL33 Gene

Publications for MRPL33 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPL33 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MRPL33
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL33
  • Block miRNA regulation of MRPL33 using miScript Target Protectors
  • antibodies-online proteins for MRPL33
  • antibodies-online antibodies for MRPL33
  • antibodies-online kits for MRPL33

Sources for MRPL33 Gene

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