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Aliases for MRPL33 Gene

Aliases for MRPL33 Gene

  • Mitochondrial Ribosomal Protein L33 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL33m 3 4
  • MRP-L33 3 4
  • C2orf1 3 4
  • L33mt 3 4
  • 39S Ribosomal Protein L33, Mitochondrial 3
  • RPL33L 3

External Ids for MRPL33 Gene

Previous HGNC Symbols for MRPL33 Gene

  • C2orf1

Previous GeneCards Identifiers for MRPL33 Gene

  • GC02P027915
  • GC02P028087
  • GC02P027969
  • GC02P027906
  • GC02P027994

Summaries for MRPL33 Gene

Entrez Gene Summary for MRPL33 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL33 Gene

MRPL33 (Mitochondrial Ribosomal Protein L33) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL33 Gene

Additional gene information for MRPL33 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL33 Gene

Genomics for MRPL33 Gene

Regulatory Elements for MRPL33 Gene

Enhancers for MRPL33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H027794 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +26.5 26537 6.6 ATF1 SIN3A DMAP1 BRCA1 ZNF2 ATF7 FOS SP3 SP5 MXD4 MRPL33 FNDC4 LOC102723530 PLB1 SNRPGP7 SNX17 RBKS ATRAID GC02P027841
GH02H027734 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -34.6 -34614 4.3 FOXA2 ATF1 MLX ARID4B SIN3A YY1 ZNF766 ELK1 ZNF143 ATF7 MRPL33 LINC01460 LOC102723530 PLB1 SNRPGP7 FLJ31356 FOSL2 FNDC4 RBKS
GH02H027722 1.4 Ensembl ENCODE dbSUPER 11.9 -47.4 -47353 2.9 FOXA2 ATF1 MLX ARID4B SIN3A SLC30A9 ZNF143 ATF7 SP5 REST MRPL33 LINC01460
GH02H027792 0.6 Ensembl dbSUPER 11.8 +21.1 21085 0.4 JUND MRPL33 SLC4A1AP GC02P027841
GH02H027801 0.6 FANTOM5 dbSUPER 5.9 +30.3 30268 0.1 LOC102723530 PLB1 SNRPGP7 FNDC4 MRPL33 CCDC121 IFT172 ZNF512 SLC4A1AP SUPT7L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL33 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for MRPL33 Gene

Genomic Locations for MRPL33 Gene
216,371 bases
Plus strand

Genomic View for MRPL33 Gene

Genes around MRPL33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL33 Gene

Proteins for MRPL33 Gene

  • Protein details for MRPL33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L33, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53RZ6
    • Q5FVE3
    • Q96Q50

    Protein attributes for MRPL33 Gene

    65 amino acids
    Molecular mass:
    7619 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL33 Gene

    Alternative splice isoforms for MRPL33 Gene


neXtProt entry for MRPL33 Gene

Post-translational modifications for MRPL33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL33 Gene

No data available for DME Specific Peptides for MRPL33 Gene

Domains & Families for MRPL33 Gene

Gene Families for MRPL33 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL33 Gene

Suggested Antigen Peptide Sequences for MRPL33 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bacterial ribosomal protein bL33 family.
  • Belongs to the bacterial ribosomal protein bL33 family.
genes like me logo Genes that share domains with MRPL33: view

Function for MRPL33 Gene

Phenotypes From GWAS Catalog for MRPL33 Gene

Gene Ontology (GO) - Molecular Function for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL33: view

Phenotypes for MRPL33 Gene

GenomeRNAi human phenotypes for MRPL33:
genes like me logo Genes that share phenotypes with MRPL33: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPL33 Gene

Localization for MRPL33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL33 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL33 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL33: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL33 Gene

Pathways & Interactions for MRPL33 Gene

genes like me logo Genes that share pathways with MRPL33: view

Gene Ontology (GO) - Biological Process for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL33: view

No data available for SIGNOR curated interactions for MRPL33 Gene

Drugs & Compounds for MRPL33 Gene

No Compound Related Data Available

Transcripts for MRPL33 Gene

Unigene Clusters for MRPL33 Gene

Mitochondrial ribosomal protein L33:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL33 Gene

No ASD Table

Relevant External Links for MRPL33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRPL33 Gene

This gene is overexpressed in Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for MRPL33 Gene

This gene is overexpressed in Breast (31.1) and Lung (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL33 Gene

Protein tissue co-expression partners for MRPL33 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPL33 Gene:


SOURCE GeneReport for Unigene cluster for MRPL33 Gene:


Evidence on tissue expression from TISSUES for MRPL33 Gene

  • Nervous system(4.3)
  • Blood(4.2)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with MRPL33: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL33 Gene

Orthologs for MRPL33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MRPL33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL33 34 33
  • 99.49 (n)
(Bos Taurus)
Mammalia MRPL33 33 34 34
  • 86.15 (n)
(Rattus norvegicus)
Mammalia Mrpl33 33
  • 82.56 (n)
(Mus musculus)
Mammalia Mrpl33 33 16 34
  • 82.05 (n)
(Canis familiaris)
Mammalia MRPL33 34
  • 80 (a)
(Monodelphis domestica)
Mammalia MRPL33 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL33 34
  • 75 (a)
Species where no ortholog for MRPL33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRPL33 Gene

Gene Tree for MRPL33 (if available)
Gene Tree for MRPL33 (if available)

Paralogs for MRPL33 Gene

No data available for Paralogs for MRPL33 Gene

Variants for MRPL33 Gene

Sequence variations from dbSNP and Humsavar for MRPL33 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000489197 -- 27,776,693(+) TTCCT(G/T)GGATG intron-variant
rs1000779349 -- 27,770,710(+) GCTAT(C/T)TCGGC upstream-variant-2KB
rs1000803604 -- 27,778,579(+) GACGG(A/G)GTTTC intron-variant
rs1000898253 -- 27,778,227(+) CTTAG(A/G)TAAGC intron-variant
rs1000931364 -- 27,775,891(+) GTGGA(A/G)AAATG intron-variant

Variation tolerance for MRPL33 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL33 Gene

Disorders for MRPL33 Gene

Relevant External Links for MRPL33

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL33 Gene

Publications for MRPL33 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 3 4 60

Products for MRPL33 Gene

Sources for MRPL33 Gene

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