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Aliases for MRPL33 Gene

Aliases for MRPL33 Gene

  • Mitochondrial Ribosomal Protein L33 2 3 5
  • MRP-L33 3 4
  • C2orf1 3 4
  • L33mt 3 4
  • RPL33L 3

External Ids for MRPL33 Gene

Previous HGNC Symbols for MRPL33 Gene

  • C2orf1

Previous GeneCards Identifiers for MRPL33 Gene

  • GC02P027915
  • GC02P028087
  • GC02P027969
  • GC02P027906
  • GC02P027994

Summaries for MRPL33 Gene

Entrez Gene Summary for MRPL33 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL33 Gene

MRPL33 (Mitochondrial Ribosomal Protein L33) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Mitochondrial translation. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL33 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL33 Gene

Genomics for MRPL33 Gene

Regulatory Elements for MRPL33 Gene

Enhancers for MRPL33 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL33 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL33 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL33 Gene

Chromosome:
2
Start:
27,771,717 bp from pter
End:
27,988,087 bp from pter
Size:
216,371 bases
Orientation:
Plus strand

Genomic View for MRPL33 Gene

Genes around MRPL33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL33 Gene

Proteins for MRPL33 Gene

  • Protein details for MRPL33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75394-RM33_HUMAN
    Recommended name:
    39S ribosomal protein L33, mitochondrial
    Protein Accession:
    O75394
    Secondary Accessions:
    • Q53RZ6
    • Q5FVE3
    • Q96Q50

    Protein attributes for MRPL33 Gene

    Size:
    65 amino acids
    Molecular mass:
    7619 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL33 Gene

    Alternative splice isoforms for MRPL33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL33 Gene

Proteomics data for MRPL33 Gene at MOPED

Post-translational modifications for MRPL33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL33 Gene

No data available for DME Specific Peptides for MRPL33 Gene

Domains & Families for MRPL33 Gene

Gene Families for MRPL33 Gene

Protein Domains for MRPL33 Gene

Suggested Antigen Peptide Sequences for MRPL33 Gene

Graphical View of Domain Structure for InterPro Entry

O75394

UniProtKB/Swiss-Prot:

RM33_HUMAN :
  • Belongs to the ribosomal protein L33P family.
Family:
  • Belongs to the ribosomal protein L33P family.
genes like me logo Genes that share domains with MRPL33: view

Function for MRPL33 Gene

Phenotypes for MRPL33 Gene

GenomeRNAi human phenotypes for MRPL33:
genes like me logo Genes that share phenotypes with MRPL33: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPL33 Gene

Localization for MRPL33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL33 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL33 Gene COMPARTMENTS Subcellular localization image for MRPL33 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL33: view

Pathways & Interactions for MRPL33 Gene

genes like me logo Genes that share pathways with MRPL33: view

Interacting Proteins for MRPL33 Gene

Gene Ontology (GO) - Biological Process for MRPL33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL33: view

No data available for SIGNOR curated interactions for MRPL33 Gene

Drugs & Compounds for MRPL33 Gene

No Compound Related Data Available

Transcripts for MRPL33 Gene

Unigene Clusters for MRPL33 Gene

Mitochondrial ribosomal protein L33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL33 Gene

No ASD Table

Relevant External Links for MRPL33 Gene

GeneLoc Exon Structure for
MRPL33
ECgene alternative splicing isoforms for
MRPL33

Expression for MRPL33 Gene

mRNA expression in normal human tissues for MRPL33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRPL33 Gene

This gene is overexpressed in Adrenal Gland (x4.6).

Protein differential expression in normal tissues from HIPED for MRPL33 Gene

This gene is overexpressed in Breast (31.1) and Lung (24.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL33 Gene



SOURCE GeneReport for Unigene cluster for MRPL33 Gene Hs.515879

genes like me logo Genes that share expression patterns with MRPL33: view

Protein tissue co-expression partners for MRPL33 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MRPL33 Gene

Orthologs for MRPL33 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MRPL33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL33 35
  • 86.15 (n)
  • 84.62 (a)
MRPL33 36
  • 85 (a)
OneToMany
MRPL33 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrpl33 35
  • 82.05 (n)
  • 76.92 (a)
Mrpl33 16
Mrpl33 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL33 35
  • 99.49 (n)
  • 100 (a)
MRPL33 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl33 35
  • 82.56 (n)
  • 78.46 (a)
dog
(Canis familiaris)
Mammalia MRPL33 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL33 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL33 36
  • 75 (a)
OneToOne
Species with no ortholog for MRPL33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRPL33 Gene

ENSEMBL:
Gene Tree for MRPL33 (if available)
TreeFam:
Gene Tree for MRPL33 (if available)

Paralogs for MRPL33 Gene

No data available for Paralogs for MRPL33 Gene

Variants for MRPL33 Gene

Sequence variations from dbSNP and Humsavar for MRPL33 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1802248 -- 27,779,677(+) TGCAT(A/C)ACATT utr-variant-3-prime
rs953954 -- 27,774,338(-) AACTC(C/T)GTAGG intron-variant
rs3736594 -- 27,772,914(-) TTCCT(G/T)CAAGT intron-variant
rs3792252 -- 27,773,064(+) ACTAC(A/G)GGAAT intron-variant
rs3792253 -- 27,779,135(+) AACAT(C/T)GTTTT intron-variant

Variation tolerance for MRPL33 Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL33 Gene

HapMap Linkage Disequilibrium report
MRPL33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL33 Gene

Disorders for MRPL33 Gene

Relevant External Links for MRPL33

Genetic Association Database (GAD)
MRPL33
Human Genome Epidemiology (HuGE) Navigator
MRPL33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL33

No disorders were found for MRPL33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL33 Gene

Publications for MRPL33 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. (PMID: 22581228) Manning A.K. … Langenberg C. (Nat. Genet. 2012) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for MRPL33 Gene

Sources for MRPL33 Gene

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