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Aliases for BAG3 Gene

Aliases for BAG3 Gene

  • BCL2-Associated Athanogene 3 2 3
  • Bcl-2-Binding Protein Bis 3 4
  • Docking Protein CAIR-1 3 4
  • BAG-3 3 4
  • BIS 3 4
  • Bcl-2-Associated Athanogene 3 4
  • BCL2-Binding Athanogene 3 3
  • CAIR-1 3
  • MFM6 3

External Ids for BAG3 Gene

Previous GeneCards Identifiers for BAG3 Gene

  • GC10P120329
  • GC10P120654
  • GC10P121542
  • GC10P121075
  • GC10P121400
  • GC10P115040

Summaries for BAG3 Gene

Entrez Gene Summary for BAG3 Gene

  • BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG3 Gene

BAG3 (BCL2-Associated Athanogene 3) is a Protein Coding gene. Diseases associated with BAG3 include muscular dystrophy, selcen type and bag3-related dilated cardiomyopathy. Among its related pathways are Cellular Senescence and Apoptosis (WikiPathways). GO annotations related to this gene include protein complex binding and chaperone binding. An important paralog of this gene is BAG4.

UniProtKB/Swiss-Prot for BAG3 Gene

  • Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity

Gene Wiki entry for BAG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG3 Gene

Genomics for BAG3 Gene

Regulatory Elements for BAG3 Gene

Genomic Location for BAG3 Gene

Chromosome:
10
Start:
119,651,347 bp from pter
End:
119,677,819 bp from pter
Size:
26,473 bases
Orientation:
Plus strand

Genomic View for BAG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG3 Gene

Proteins for BAG3 Gene

  • Protein details for BAG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95817-BAG3_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 3
    Protein Accession:
    O95817
    Secondary Accessions:
    • A8K5L8
    • Q3B763
    • Q9NT20
    • Q9P120

    Protein attributes for BAG3 Gene

    Size:
    575 amino acids
    Molecular mass:
    61595 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to Bcl-2 and PLC-gamma. Interacts with DNAJB6.

neXtProt entry for BAG3 Gene

Proteomics data for BAG3 Gene at MOPED

Post-translational modifications for BAG3 Gene

  • Ubiquitination at Lys 450
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BAG3 Gene

Domains & Families for BAG3 Gene

Gene Families for BAG3 Gene

Protein Domains for BAG3 Gene

Suggested Antigen Peptide Sequences for BAG3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95817

UniProtKB/Swiss-Prot:

BAG3_HUMAN :
  • Contains 1 BAG domain.
Domain:
  • Contains 1 BAG domain.
  • Contains 2 WW domains.
genes like me logo Genes that share domains with BAG3: view

Function for BAG3 Gene

Molecular function for BAG3 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity

Gene Ontology (GO) - Molecular Function for BAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0032403 protein complex binding IEA --
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with BAG3: view
genes like me logo Genes that share phenotypes with BAG3: view

Animal Models for BAG3 Gene

MGI Knock Outs for BAG3:

Animal Model Products

miRNA for BAG3 Gene

miRTarBase miRNAs that target BAG3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAG3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BAG3 Gene

Localization for BAG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAG3 Gene COMPARTMENTS Subcellular localization image for BAG3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 2
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for BAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0030018 Z disc IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with BAG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG3 Gene

Pathways & Interactions for BAG3 Gene

genes like me logo Genes that share pathways with BAG3: view

Pathways by source for BAG3 Gene

PCR Array Products

SIGNOR curated interactions for BAG3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for BAG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 9873016
GO:0007420 brain development IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA 10597216
GO:0010664 negative regulation of striated muscle cell apoptotic process IEA --
GO:0021510 spinal cord development IEA --
genes like me logo Genes that share ontologies with BAG3: view

Drugs & Compounds for BAG3 Gene

No Compound Related Data Available

Transcripts for BAG3 Gene

mRNA/cDNA for BAG3 Gene

Unigene Clusters for BAG3 Gene

BCL2-associated athanogene 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BAG3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BAG3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - -
SP3:

Relevant External Links for BAG3 Gene

GeneLoc Exon Structure for
BAG3
ECgene alternative splicing isoforms for
BAG3

Expression for BAG3 Gene

mRNA expression in normal human tissues for BAG3 Gene

mRNA differential expression in normal tissues according to GTEx for BAG3 Gene

This gene is overexpressed in Muscle - Skeletal (x8.1).

Protein differential expression in normal tissues from HIPED for BAG3 Gene

This gene is overexpressed in Bone (21.6) and Bone marrow stromal cell (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG3 Gene



SOURCE GeneReport for Unigene cluster for BAG3 Gene Hs.523309

genes like me logo Genes that share expression patterns with BAG3: view

Protein tissue co-expression partners for BAG3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BAG3 Gene

Orthologs for BAG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BAG3 35
  • 85.15 (n)
  • 85.96 (a)
BAG3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG3 35
  • 85.16 (n)
  • 83.3 (a)
BAG3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag3 35
  • 85.29 (n)
  • 84.76 (a)
Bag3 16
Bag3 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BAG3 35
  • 99.42 (n)
  • 98.96 (a)
BAG3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bag3 35
  • 86.34 (n)
  • 86.51 (a)
oppossum
(Monodelphis domestica)
Mammalia BAG3 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAG3 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAG3 35
  • 65.31 (n)
  • 60.59 (a)
BAG3 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAG3 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia bag3-A 35
zebrafish
(Danio rerio)
Actinopterygii bag3 35
  • 52.38 (n)
  • 46.87 (a)
bag3 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stv 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 36
  • 28 (a)
OneToMany
Species with no ortholog for BAG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG3 Gene

ENSEMBL:
Gene Tree for BAG3 (if available)
TreeFam:
Gene Tree for BAG3 (if available)

Paralogs for BAG3 Gene

Paralogs for BAG3 Gene

Pseudogenes.org Pseudogenes for BAG3 Gene

genes like me logo Genes that share paralogs with BAG3: view

Variants for BAG3 Gene

Sequence variations from dbSNP and Humsavar for BAG3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8946 -- 119,677,500(+) TGTTT(C/G)AGAAG utr-variant-3-prime
rs125585 -- 119,661,042(+) gagcc(A/G)agatc intron-variant
rs171909 -- 119,662,927(+) GGAGA(A/G)TGGCG intron-variant
rs171910 -- 119,665,824(+) ACCCC(A/G)CCAGA intron-variant
rs185504 -- 119,662,937(+) GTGAA(C/T)GCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BAG3 Gene

Variant ID Type Subtype PubMed ID
nsv825585 CNV Gain 20364138
nsv522347 CNV Loss 19592680

Variation tolerance for BAG3 Gene

Residual Variation Intolerance Score: 52.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.63; 89.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BAG3 Gene

HapMap Linkage Disequilibrium report
BAG3
Human Gene Mutation Database (HGMD)
BAG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG3 Gene

Disorders for BAG3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for BAG3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
muscular dystrophy, selcen type
bag3-related dilated cardiomyopathy
  • cardiomyopathy, dilated, 1hh
myopathy, myofibrillar, 6
  • myopathy, myofibrillar, bag3-related
cardiomyopathy, dilated, 1hh
  • cmd1hh
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
- elite association
Search BAG3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BAG3_HUMAN
  • Cardiomyopathy, dilated 1HH (CMD1HH) [MIM:613881]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269 PubMed:21353195, ECO:0000269 PubMed:21459883, ECO:0000269 PubMed:21898660}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Myopathy, myofibrillar, 6 (MFM6) [MIM:612954]: A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material. {ECO:0000269 PubMed:19085932, ECO:0000269 PubMed:21361913}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for BAG3

Genetic Association Database (GAD)
BAG3
Human Genome Epidemiology (HuGE) Navigator
BAG3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BAG3
genes like me logo Genes that share disorders with BAG3: view

No data available for Genatlas for BAG3 Gene

Publications for BAG3 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 23 67
  2. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. (PMID: 19845507) Fuchs M. … Landry J. (Biochem. J. 2010) 23 67
  3. The co-chaperone BAG3 interacts with the cytosolic chaperonin CCT: new hints for actin folding. (PMID: 20018251) Fontanella B. … Tosco A. (Int. J. Biochem. Cell Biol. 2010) 23 67
  4. {zeta}-Crystallin is a bcl-2 mRNA binding protein involved in bcl-2 overexpression in T-cell acute lymphocytic leukemia. (PMID: 20103721) Lapucci A. … Capaccioli S. (FASEB J. 2010) 23 67
  5. Quantitative proteomics analysis reveals BAG3 as a potential target to suppress severe acute respiratory syndrome coronavirus replication. (PMID: 20392858) Zhang L. … Ge F. (J. Virol. 2010) 23 67

Products for BAG3 Gene

Sources for BAG3 Gene

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