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Aliases for BAG5 Gene

Aliases for BAG5 Gene

  • BCL2-Associated Athanogene 5 2 3
  • Bcl-2-Associated Athanogene 5 3 4
  • BAG-5 3 4
  • BAG Family Molecular Chaperone Regulator 5 3
  • BAG-Family Molecular Chaperone Regulator-5 3
  • KIAA0873 4

External Ids for BAG5 Gene

Summaries for BAG5 Gene

Entrez Gene Summary for BAG5 Gene

  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG5 Gene

BAG5 (BCL2-Associated Athanogene 5) is a Protein Coding gene. Diseases associated with BAG5 include brain cancer. GO annotations related to this gene include ubiquitin protein ligase binding and chaperone binding. An important paralog of this gene is BAG4.

UniProtKB/Swiss-Prot for BAG5 Gene

  • Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.

Gene Wiki entry for BAG5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG5 Gene

Genomics for BAG5 Gene

Genomic Location for BAG5 Gene

Start:
103,556,544 bp from pter
End:
103,562,831 bp from pter
Size:
6,288 bases
Orientation:
Minus strand

Genomic View for BAG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BAG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG5 Gene

Regulatory Elements for BAG5 Gene

Proteins for BAG5 Gene

  • Protein details for BAG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL15-BAG5_HUMAN
    Recommended name:
    BAG family molecular chaperone regulator 5
    Protein Accession:
    Q9UL15
    Secondary Accessions:
    • O94950
    • Q86W59

    Protein attributes for BAG5 Gene

    Size:
    447 amino acids
    Molecular mass:
    51200 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2.
    SequenceCaution:
    • Sequence=BAA74896.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAG5 Gene

    Alternative splice isoforms for BAG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BAG5 Gene

Proteomics data for BAG5 Gene at MOPED

Post-translational modifications for BAG5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys48

Other Protein References for BAG5 Gene

No data available for DME Specific Peptides for BAG5 Gene

Domains for BAG5 Gene

Protein Domains for BAG5 Gene

UniProtKB/Swiss-Prot:

BAG5_HUMAN
Domain:
  • The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.:
    • Q9UL15
  • Contains 5 BAG domains.:
    • Q9UL15
genes like me logo Genes that share domains with BAG5: view

No data available for Gene Families for BAG5 Gene

Function for BAG5 Gene

Molecular function for BAG5 Gene

GENATLAS Biochemistry: BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity
UniProtKB/Swiss-Prot Function: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.

Gene Ontology (GO) - Molecular Function for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24510904
GO:0019901 protein kinase binding IPI 24475098
GO:0031625 ubiquitin protein ligase binding ISS 15603737
GO:0051087 chaperone binding IPI 15603737
genes like me logo Genes that share ontologies with BAG5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BAG5 Gene

Localization for BAG5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BAG5 Gene COMPARTMENTS Subcellular localization image for BAG5 gene
Compartment Confidence
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 24475098
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0016234 inclusion body IDA 15603737
genes like me logo Genes that share ontologies with BAG5: view

Pathways for BAG5 Gene

SuperPathways for BAG5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0031397 negative regulation of protein ubiquitination ISS 15603737
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 24475098
GO:0034605 cellular response to heat TAS --
GO:0051444 negative regulation of ubiquitin-protein transferase activity ISS 15603737
genes like me logo Genes that share ontologies with BAG5: view

No data available for Pathways by source for BAG5 Gene

Transcripts for BAG5 Gene

Unigene Clusters for BAG5 Gene

BCL2-associated athanogene 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BAG5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -
SP3:

Relevant External Links for BAG5 Gene

GeneLoc Exon Structure for
BAG5
ECgene alternative splicing isoforms for
BAG5

Expression for BAG5 Gene

mRNA expression in normal human tissues for BAG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BAG5 Gene

SOURCE GeneReport for Unigene cluster for BAG5 Gene Hs.5443

genes like me logo Genes that share expressions with BAG5: view

Orthologs for BAG5 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAG5 36
  • 99.33 (n)
  • 99.55 (a)
BAG5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAG5 36
  • 87.47 (n)
  • 93.74 (a)
BAG5 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAG5 36
  • 90.08 (n)
  • 96.42 (a)
BAG5 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bag5 36
  • 83.82 (n)
  • 91.28 (a)
Bag5 16
Bag5 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAG5 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAG5 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bag5 36
  • 84.94 (n)
  • 90.83 (a)
chicken
(Gallus gallus)
Aves BAG5 36
  • 73.75 (n)
  • 79.87 (a)
BAG5 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAG5 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33765 36
tropical clawed frog
(Silurana tropicalis)
Amphibia bag5 36
  • 64.94 (n)
  • 66.74 (a)
Str.13078 36
zebrafish
(Danio rerio)
Actinopterygii bag5 36
  • 56.9 (n)
  • 54 (a)
bag5 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta stv 37
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 37
  • 17 (a)
OneToMany
Species with no ortholog for BAG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG5 Gene

ENSEMBL:
Gene Tree for BAG5 (if available)
TreeFam:
Gene Tree for BAG5 (if available)

Paralogs for BAG5 Gene

Paralogs for BAG5 Gene

genes like me logo Genes that share paralogs with BAG5: view

Variants for BAG5 Gene

Sequence variations from dbSNP and Humsavar for BAG5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7693 -- 103,557,367(+) GAAAC(C/T)AGAAA utr-variant-3-prime
rs14906 -- 103,556,754(-) TTTCT(C/T)TTAAT utr-variant-3-prime
rs7154587 -- 103,556,413(+) gatcg(C/T)gctat downstream-variant-500B
rs7154948 -- 103,556,607(+) ATTAA(C/T)ACATG utr-variant-3-prime
rs11376839 -- 103,556,457(+) GTCTC(-/AA)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for BAG5 Gene

Variant ID Type Subtype PubMed ID
nsv832883 CNV Loss 17160897
dgv1992n71 CNV Loss 21882294
nsv902300 CNV Loss 21882294
dgv1994n71 CNV Loss 21882294
dgv389n67 CNV Gain 20364138

Relevant External Links for BAG5 Gene

HapMap Linkage Disequilibrium report
BAG5

Disorders for BAG5 Gene

(1) MalaCards Diseases for BAG5 Gene

Search for BAG5 Gene in MalaCards »

Relevant External Links for BAG5

Genetic Association Database (GAD)
BAG5
Human Genome Epidemiology (HuGE) Navigator
BAG5
genes like me logo Genes that share disorders with BAG5: view

No data available for UniProtKB/Swiss-Prot for BAG5 Gene

Publications for BAG5 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S. … Reed J.C. (J. Biol. Chem. 1999) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. (PMID: 15603737) Kalia S.K. … Lozano A.M. (Neuron 2004) 2 3
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for BAG5 Gene

  • Addgene plasmids for BAG5

Sources for BAG5 Gene

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