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Aliases for EEF1E1 Gene

Aliases for EEF1E1 Gene

  • Eukaryotic Translation Elongation Factor 1 Epsilon 1 2 3
  • Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 3 2 3 4
  • Multisynthase Complex Auxiliary Component P18 3 4
  • AIMP3 3 4
  • P18 3 4
  • P18 Component Of Aminoacyl-TRNA Synthetase Complex 3
  • ARS-Interacting Multifunctional Protein 3 3
  • Elongation Factor P18 4

External Ids for EEF1E1 Gene

Previous HGNC Symbols for EEF1E1 Gene

  • P18

Previous GeneCards Identifiers for EEF1E1 Gene

  • GC06M008064

Summaries for EEF1E1 Gene

Entrez Gene Summary for EEF1E1 Gene

  • This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

GeneCards Summary for EEF1E1 Gene

EEF1E1 (Eukaryotic Translation Elongation Factor 1 Epsilon 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA Aminoacylation. An important paralog of this gene is EEF1E1-BLOC1S5.

UniProtKB/Swiss-Prot for EEF1E1 Gene

  • Positive modulator of ATM response to DNA damage

Gene Wiki entry for EEF1E1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EEF1E1 Gene

Genomics for EEF1E1 Gene

Regulatory Elements for EEF1E1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EEF1E1 Gene

Chromosome:
6
Start:
8,073,360 bp from pter
End:
8,102,595 bp from pter
Size:
29,236 bases
Orientation:
Minus strand

Genomic View for EEF1E1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EEF1E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EEF1E1 Gene

Proteins for EEF1E1 Gene

  • Protein details for EEF1E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43324-MCA3_HUMAN
    Recommended name:
    Eukaryotic translation elongation factor 1 epsilon-1
    Protein Accession:
    O43324
    Secondary Accessions:
    • C9JLK5
    • Q5THS2

    Protein attributes for EEF1E1 Gene

    Size:
    174 amino acids
    Molecular mass:
    19811 Da
    Quaternary structure:
    • Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation.

    Three dimensional structures from OCA and Proteopedia for EEF1E1 Gene

    Alternative splice isoforms for EEF1E1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EEF1E1 Gene

Proteomics data for EEF1E1 Gene at MOPED

Post-translational modifications for EEF1E1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for EEF1E1 Gene

Antibody Products

No data available for DME Specific Peptides for EEF1E1 Gene

Domains & Families for EEF1E1 Gene

Protein Domains for EEF1E1 Gene

Suggested Antigen Peptide Sequences for EEF1E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43324

UniProtKB/Swiss-Prot:

MCA3_HUMAN :
  • Contains 1 GST C-terminal domain.
Domain:
  • Contains 1 GST C-terminal domain.
genes like me logo Genes that share domains with EEF1E1: view

No data available for Gene Families for EEF1E1 Gene

Function for EEF1E1 Gene

Molecular function for EEF1E1 Gene

GENATLAS Biochemistry:
eukaryotic translation elongation factor 1,epsilon 1
UniProtKB/Swiss-Prot Function:
Positive modulator of ATM response to DNA damage
UniProtKB/Swiss-Prot Induction:
By DNA damaging agents such as UV, adriamycin, actinomycin-D and cisplatin

Gene Ontology (GO) - Molecular Function for EEF1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003746 translation elongation factor activity IBA --
GO:0004364 glutathione transferase activity IBA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with EEF1E1: view
genes like me logo Genes that share phenotypes with EEF1E1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF1E1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EEF1E1 Gene

Localization for EEF1E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EEF1E1 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EEF1E1 Gene COMPARTMENTS Subcellular localization image for EEF1E1 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for EEF1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with EEF1E1: view

Pathways & Interactions for EEF1E1 Gene

genes like me logo Genes that share pathways with EEF1E1: view

Pathways by source for EEF1E1 Gene

Gene Ontology (GO) - Biological Process for EEF1E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006414 translational elongation IBA --
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006749 glutathione metabolic process IBA --
GO:0008285 negative regulation of cell proliferation ISS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with EEF1E1: view

No data available for SIGNOR curated interactions for EEF1E1 Gene

Drugs & Compounds for EEF1E1 Gene

(2) Additional Compounds for EEF1E1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aminoacyl-tRNA
tRNA
genes like me logo Genes that share compounds with EEF1E1: view

Transcripts for EEF1E1 Gene

Unigene Clusters for EEF1E1 Gene

Eukaryotic translation elongation factor 1 epsilon 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EEF1E1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EEF1E1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for EEF1E1 Gene

GeneLoc Exon Structure for
EEF1E1
ECgene alternative splicing isoforms for
EEF1E1

Expression for EEF1E1 Gene

mRNA expression in normal human tissues for EEF1E1 Gene

Protein differential expression in normal tissues from HIPED for EEF1E1 Gene

This gene is overexpressed in Bone (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EEF1E1 Gene



SOURCE GeneReport for Unigene cluster for EEF1E1 Gene Hs.745033

mRNA Expression by UniProt/SwissProt for EEF1E1 Gene

O43324-MCA3_HUMAN
Tissue specificity: Down-regulated in various cancer tissues.
genes like me logo Genes that share expression patterns with EEF1E1: view

Protein tissue co-expression partners for EEF1E1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for EEF1E1 Gene

Orthologs for EEF1E1 Gene

This gene was present in the common ancestor of animals.

Orthologs for EEF1E1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EEF1E1 35
  • 89.79 (n)
  • 96.53 (a)
EEF1E1 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia EEF1E1 35
  • 92.49 (n)
  • 95.95 (a)
-- 36
  • 95 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eef1e1 35
  • 86.59 (n)
  • 88.51 (a)
Eef1e1 16
Eef1e1 36
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia EEF1E1 35
  • 99.23 (n)
  • 100 (a)
EEF1E1 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Eef1e1 35
  • 83.72 (n)
  • 87.93 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves EEF1E1 35
  • 75.86 (n)
  • 77.59 (a)
-- 36
  • 75 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 79 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia eef1e1 35
  • 67.64 (n)
  • 69.59 (a)
Str.6247 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7661 35
zebrafish
(Danio rerio)
Actinopterygii eef1e1 35
  • 62.96 (n)
  • 63.74 (a)
eef1e1 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30185 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2900 36
  • 34 (a)
OneToMany
Species with no ortholog for EEF1E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EEF1E1 Gene

ENSEMBL:
Gene Tree for EEF1E1 (if available)
TreeFam:
Gene Tree for EEF1E1 (if available)

Paralogs for EEF1E1 Gene

Paralogs for EEF1E1 Gene

Pseudogenes.org Pseudogenes for EEF1E1 Gene

genes like me logo Genes that share paralogs with EEF1E1: view

Variants for EEF1E1 Gene

Structural Variations from Database of Genomic Variants (DGV) for EEF1E1 Gene

Variant ID Type Subtype PubMed ID
esv2731544 CNV Deletion 23290073
esv2672674 CNV Deletion 23128226

Variation tolerance for EEF1E1 Gene

Residual Variation Intolerance Score: 49.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EEF1E1 Gene

HapMap Linkage Disequilibrium report
EEF1E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for EEF1E1 Gene

Disorders for EEF1E1 Gene

Relevant External Links for EEF1E1

Genetic Association Database (GAD)
EEF1E1
Human Genome Epidemiology (HuGE) Navigator
EEF1E1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EEF1E1
genes like me logo Genes that share disorders with EEF1E1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EEF1E1 Gene

Publications for EEF1E1 Gene

  1. Dissection of the structural organization of the aminoacyl-tRNA synthetase complex. (PMID: 19131329) Kaminska M. … Mirande M. (J. Biol. Chem. 2009) 23 67
  2. Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers. (PMID: 19024604) Kim M.S. … Lee S.H. (APMIS 2008) 23 67
  3. Characterization of p43(ARF), a derivative of the p43 component of multiaminoacyl-tRNA synthetase complex released during apoptosis. (PMID: 17303557) Shalak V. … Mirande M. (J. Biol. Chem. 2007) 23 67
  4. A three-dimensional working model of the multienzyme complex of aminoacyl-tRNA synthetases based on electron microscopic placements of tRNA and proteins. (PMID: 16169847) Wolfe C.L. … Norcum M.T. (J. Biol. Chem. 2005) 23 67
  5. The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. (PMID: 15680327) Park B.-J. … Kim S. (Cell 2005) 23 67

Products for EEF1E1 Gene

Sources for EEF1E1 Gene

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