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Aliases for TBPL1 Gene

Aliases for TBPL1 Gene

  • TBP-Like 1 2 3
  • TATA Box-Binding Protein-Related Factor 2 3 4
  • Second TBP Of Unique DNA Protein 3 4
  • TBP-Related Factor 2 3 4
  • TBP-Related Protein 3 4
  • STUD 3 4
  • TRF2 3 4
  • TLF 3 4
  • TLP 3 4
  • TATA Box-Binding Protein-Like Protein 1 3
  • 21-KDA TBP-Like Protein 3
  • 21 KDa TBP-Like Protein 4
  • TBP-Like Protein 1 4
  • TBP-Like Factor 4
  • MGC:8389 3
  • MGC:9620 3
  • TLP21 4
  • TRP 4

External Ids for TBPL1 Gene

Summaries for TBPL1 Gene

Entrez Gene Summary for TBPL1 Gene

  • This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]

GeneCards Summary for TBPL1 Gene

TBPL1 (TBP-Like 1) is a Protein Coding gene. Diseases associated with TBPL1 include degenerative disc disease and sleeping sickness. Among its related pathways are Epstein-Barr virus infection and Influenza A. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is TBP.

UniProtKB/Swiss-Prot for TBPL1 Gene

  • Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5-TCT-3 motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.

Gene Wiki entry for TBPL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBPL1 Gene

Genomics for TBPL1 Gene

Genomic Location for TBPL1 Gene

Start:
133,952,170 bp from pter
End:
133,990,432 bp from pter
Size:
38,263 bases
Orientation:
Plus strand

Genomic View for TBPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TBPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBPL1 Gene

Regulatory Elements for TBPL1 Gene

Proteins for TBPL1 Gene

  • Protein details for TBPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62380-TBPL1_HUMAN
    Recommended name:
    TATA box-binding protein-like protein 1
    Protein Accession:
    P62380
    Secondary Accessions:
    • A8K8F5
    • O95753
    • Q9BWD5
    • Q9Z2Z0

    Protein attributes for TBPL1 Gene

    Size:
    186 amino acids
    Molecular mass:
    20887 Da
    Quaternary structure:
    • Binds TFIIA and TFIIB

neXtProt entry for TBPL1 Gene

Proteomics data for TBPL1 Gene at MOPED

Post-translational modifications for TBPL1 Gene

No Post-translational modifications

Other Protein References for TBPL1 Gene

No data available for DME Specific Peptides for TBPL1 Gene

Domains for TBPL1 Gene

Protein Domains for TBPL1 Gene

UniProtKB/Swiss-Prot:

TBPL1_HUMAN
Family:
  • Belongs to the TBP family.:
    • P62380
genes like me logo Genes that share domains with TBPL1: view

No data available for Gene Families for TBPL1 Gene

Function for TBPL1 Gene

Molecular function for TBPL1 Gene

GENATLAS Biochemistry: TATA box protein (TBP)-like 1,component of the RNA polymerase II (POLR*),transcription apparatus,binding GTF2A,GTF2B,not binding directly canonical TATA boxes
UniProtKB/Swiss-Prot Function: Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5-TCT-3 motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.

Gene Ontology (GO) - Molecular Function for TBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity TAS 10220372
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TBPL1: view
genes like me logo Genes that share phenotypes with TBPL1: view

Animal Models for TBPL1 Gene

MGI Knock Outs for TBPL1:

miRNA for TBPL1 Gene

miRTarBase miRNAs that target TBPL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TBPL1 Gene

Localization for TBPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBPL1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TBPL1 Gene COMPARTMENTS Subcellular localization image for TBPL1 gene
Compartment Confidence
nucleus 5
cytosol 2
lysosome 2
extracellular 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005672 transcription factor TFIIA complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TBPL1: view

Pathways for TBPL1 Gene

genes like me logo Genes that share pathways with TBPL1: view

Gene Ontology (GO) - Biological Process for TBPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly IEA --
GO:0006235 dTTP biosynthetic process IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 10220372
genes like me logo Genes that share ontologies with TBPL1: view

Transcripts for TBPL1 Gene

Unigene Clusters for TBPL1 Gene

TBP-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TBPL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for TBPL1 Gene

GeneLoc Exon Structure for
TBPL1
ECgene alternative splicing isoforms for
TBPL1

Expression for TBPL1 Gene

mRNA expression in normal human tissues for TBPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBPL1 Gene

This gene is overexpressed in Testis (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TBPL1 Gene

SOURCE GeneReport for Unigene cluster for TBPL1 Gene Hs.486507

mRNA Expression by UniProt/SwissProt for TBPL1 Gene

P62380-TBPL1_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in the testis and ovary.
genes like me logo Genes that share expressions with TBPL1: view

Orthologs for TBPL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBPL1 36
  • 99.82 (n)
  • 100 (a)
TBPL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TBPL1 36
  • 96.77 (n)
  • 100 (a)
TBPL1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 85 (a)
OneToMany
-- 37
  • 81 (a)
OneToMany
TBPL1 36
  • 97.13 (n)
  • 100 (a)
TBPL1 37
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tbpl1 36
  • 94.27 (n)
  • 100 (a)
Tbpl1 16
Tbpl1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TBPL1 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBPL1 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbpl1 36
  • 94.27 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves TBPL1 36
  • 88.89 (n)
  • 97.81 (a)
TBPL1 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBPL1 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia TLF 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4573 36
tbpl1 36
  • 79.03 (n)
  • 92.47 (a)
zebrafish
(Danio rerio)
Actinopterygii rps9 36
tbpl1 36
  • 71.35 (n)
  • 78.38 (a)
tbpl1 37
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007517 36
  • 55.87 (n)
  • 59.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trf2 37
  • 6 (a)
OneToOne
Trf2 38
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea tlf-1 36
  • 49.26 (n)
  • 40.56 (a)
tlf-1 37
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPT15 37
  • 28 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3079 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2563 37
  • 34 (a)
OneToOne
Species with no ortholog for TBPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBPL1 Gene

ENSEMBL:
Gene Tree for TBPL1 (if available)
TreeFam:
Gene Tree for TBPL1 (if available)

Paralogs for TBPL1 Gene

Paralogs for TBPL1 Gene

Selected SIMAP similar genes for TBPL1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TBPL1 Gene

genes like me logo Genes that share paralogs with TBPL1: view

Variants for TBPL1 Gene

Sequence variations from dbSNP and Humsavar for TBPL1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs170703 -- 133,963,191(-) TGTTT(A/T)TCAGA intron-variant
rs189095 -- 133,960,550(-) GCATT(C/T)TAAAT intron-variant
rs229909 -- 133,953,086(-) GCTCC(A/C)GTCAC intron-variant, upstream-variant-2KB
rs229910 -- 133,952,898(-) TATCC(C/T)TTGTA intron-variant, upstream-variant-2KB
rs229918 -- 133,978,770(-) CCTTT(A/C)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TBPL1 Gene

Variant ID Type Subtype PubMed ID
esv34122 CNV Loss 18971310
nsv507364 CNV Insertion 20534489
esv2441837 CNV Deletion 19546169

Relevant External Links for TBPL1 Gene

HapMap Linkage Disequilibrium report
TBPL1

Disorders for TBPL1 Gene

(2) University of Copenhagen DISEASES for TBPL1 Gene

Relevant External Links for TBPL1

Genetic Association Database (GAD)
TBPL1
Human Genome Epidemiology (HuGE) Navigator
TBPL1
genes like me logo Genes that share disorders with TBPL1: view

No data available for UniProtKB/Swiss-Prot for TBPL1 Gene

Publications for TBPL1 Gene

  1. Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein. (PMID: 10082669) Ohbayashi T. … Tamura T.-A. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. (PMID: 15767669) Chong J.A. … Clapham D.E. (Mol. Cell. Biol. 2005) 2 3 4 23
  3. TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. (PMID: 10220372) Rabenstein M.D. … Tjian R. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  4. TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene. (PMID: 19858204) Suenaga Y. … Tamura T.A. (J. Biol. Chem. 2009) 3 23
  5. Genomics, evolution, and expression of TBPL2, a member of the TBP family. (PMID: 17570761) Di Pietro C. … Purrello M. (DNA Cell Biol. 2007) 4 23

Products for TBPL1 Gene

  • Addgene plasmids for TBPL1

Sources for TBPL1 Gene

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