Aliases for LITAF Gene
External Ids for LITAF Gene
Previous GeneCards Identifiers for LITAF Gene
Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for LITAF Gene
LITAF (Lipopolysaccharide Induced TNF Factor) is a Protein Coding gene. Diseases associated with LITAF include Charcot-Marie-Tooth Disease, Type 1C and Charcot-Marie-Tooth Hereditary Neuropathy. Among its related pathways are NF-kappaB Signaling and Lysosome. GO annotations related to this gene include signal transducer activity and WW domain binding. An important paralog of this gene is CDIP1.
UniProtKB/Swiss-Prot for LITAF Gene
Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.