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Aliases for PMPCB Gene

Aliases for PMPCB Gene

  • Peptidase (Mitochondrial Processing) Beta 2 3
  • MPPB 3 4 6
  • EC 3.4.24.64 4 64
  • Beta-MPP 3 4
  • P-52 3 4
  • Mitochondrial Processing Peptidase Beta Subunit 3
  • Mitochondrial-Processing Peptidase Subunit Beta 3
  • MPPP52 3
  • MPP11 3

External Ids for PMPCB Gene

Summaries for PMPCB Gene

Entrez Gene Summary for PMPCB Gene

  • This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for PMPCB Gene

PMPCB (Peptidase (Mitochondrial Processing) Beta) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is UQCRC1.

UniProtKB/Swiss-Prot for PMPCB Gene

  • Cleaves presequences (transit peptides) from mitochondrial protein precursors.

Gene Wiki entry for PMPCB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PMPCB Gene

Genomics for PMPCB Gene

Genomic Location for PMPCB Gene

Start:
103,297,422 bp from pter
End:
103,329,902 bp from pter
Size:
32,481 bases
Orientation:
Plus strand

Genomic View for PMPCB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PMPCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PMPCB Gene

Regulatory Elements for PMPCB Gene

Proteins for PMPCB Gene

  • Protein details for PMPCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75439-MPPB_HUMAN
    Recommended name:
    Mitochondrial-processing peptidase subunit beta
    Protein Accession:
    O75439
    Secondary Accessions:
    • O60416
    • Q96FV4

    Protein attributes for PMPCB Gene

    Size:
    489 amino acids
    Molecular mass:
    54366 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Heterodimer of alpha and beta subunits.

neXtProt entry for PMPCB Gene

Proteomics data for PMPCB Gene at MOPED

Post-translational modifications for PMPCB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys95, Lys224, Lys235, and Lys472

Other Protein References for PMPCB Gene

Domains for PMPCB Gene

UniProtKB/Swiss-Prot:

MPPB_HUMAN
Family:
  • Belongs to the peptidase M16 family.:
    • O75439
genes like me logo Genes that share domains with PMPCB: view

No data available for Gene Families for PMPCB Gene

Function for PMPCB Gene

Molecular function for PMPCB Gene

GENATLAS Biochemistry: peptidase (mitochondrial processing) beta,M phase phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity: Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2
UniProtKB/Swiss-Prot Function: Cleaves presequences (transit peptides) from mitochondrial protein precursors.

Enzyme Numbers (IUBMB) for PMPCB Gene

Gene Ontology (GO) - Molecular Function for PMPCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004222 metalloendopeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PMPCB: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PMPCB Gene

Localization for PMPCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PMPCB Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PMPCB Gene COMPARTMENTS Subcellular localization image for PMPCB gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for PMPCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with PMPCB: view

Pathways for PMPCB Gene

genes like me logo Genes that share pathways with PMPCB: view

Pathways by source for PMPCB Gene

2 Reactome pathways for PMPCB Gene

Gene Ontology (GO) - Biological Process for PMPCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006626 protein targeting to mitochondrion TAS --
GO:0008152 metabolic process --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PMPCB: view

Transcripts for PMPCB Gene

Unigene Clusters for PMPCB Gene

Peptidase (mitochondrial processing) beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PMPCB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - - - - - -
SP6:
SP7:
SP8:

Relevant External Links for PMPCB Gene

GeneLoc Exon Structure for
PMPCB
ECgene alternative splicing isoforms for
PMPCB

Expression for PMPCB Gene

mRNA expression in normal human tissues for PMPCB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PMPCB Gene

SOURCE GeneReport for Unigene cluster for PMPCB Gene Hs.184211

genes like me logo Genes that share expressions with PMPCB: view

Orthologs for PMPCB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PMPCB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PMPCB 36
  • 99.52 (n)
  • 99.18 (a)
PMPCB 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PMPCB 36
  • 92.64 (n)
  • 94.37 (a)
PMPCB 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PMPCB 36
  • 90.42 (n)
  • 92.71 (a)
PMPCB 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pmpcb 36
  • 85.48 (n)
  • 90.18 (a)
Pmpcb 16
Pmpcb 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PMPCB 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pmpcb 36
  • 83.71 (n)
  • 89.37 (a)
chicken
(Gallus gallus)
Aves PMPCB 36
  • 76.36 (n)
  • 82.27 (a)
PMPCB 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PMPCB 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pmpcb 36
  • 75.65 (n)
  • 85.26 (a)
Str.15357 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10147 36
zebrafish
(Danio rerio)
Actinopterygii pmpcb 36
  • 70.54 (n)
  • 83.33 (a)
pmpcb 37
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000935 36
  • 58.66 (n)
  • 69.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3731 36
  • 60.67 (n)
  • 71.01 (a)
CG3731 37
  • 68 (a)
OneToMany
CG3731 38
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea mppb-1 36
  • 55.56 (n)
  • 49.77 (a)
mppb-1 37
  • 48 (a)
ManyToMany
ucr-1 37
  • 38 (a)
ManyToMany
F56D2.1 38
  • 38 (a)
ZC410.2 38
  • 50 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL138C 36
  • 51.69 (n)
  • 47.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAS1 36
  • 52.94 (n)
  • 47.06 (a)
MAS1 37
  • 43 (a)
OneToMany
MAS1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18095g 36
  • 54.21 (n)
  • 46.92 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6917 36
soybean
(Glycine max)
eudicotyledons Gma.1751 36
thale cress
(Arabidopsis thaliana)
eudicotyledons MPPBETA 36
  • 56.04 (n)
  • 52.98 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5304 36
corn
(Zea mays)
Liliopsida Zm.5860 36
rice
(Oryza sativa)
Liliopsida Os.4124 36
Os03g0212700 36
  • 55 (n)
  • 53.78 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.27578 36
bread mold
(Neurospora crassa)
Ascomycetes NCU02549 36
  • 53.68 (n)
  • 53.44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes qcr1 36
  • 54.36 (n)
  • 51.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4874 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3431 37
  • 63 (a)
OneToMany
Species with no ortholog for PMPCB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PMPCB Gene

ENSEMBL:
Gene Tree for PMPCB (if available)
TreeFam:
Gene Tree for PMPCB (if available)

Paralogs for PMPCB Gene

Paralogs for PMPCB Gene

Selected SIMAP similar genes for PMPCB Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with PMPCB: view

Variants for PMPCB Gene

Sequence variations from dbSNP and Humsavar for PMPCB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1057797 -- 103,309,037(-) TGAGA(A/C/T)AGATT missense, reference, nc-transcript-variant
rs1060201 -- 103,297,505(+) GCGCG(A/C)GGCGG synonymous-codon, reference, nc-transcript-variant
rs2023926 -- 103,304,495(-) ATTGA(A/C)TAACC intron-variant
rs2301861 -- 103,297,437(-) TAGAG(A/G)ATGAA utr-variant-5-prime, nc-transcript-variant
rs3087615 - 103,311,676(-) GCAAC(A/C)TCACT reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PMPCB Gene

Variant ID Type Subtype PubMed ID
nsv831084 CNV Gain 17160897

Relevant External Links for PMPCB Gene

HapMap Linkage Disequilibrium report
PMPCB

Disorders for PMPCB Gene

Relevant External Links for PMPCB

Genetic Association Database (GAD)
PMPCB
Human Genome Epidemiology (HuGE) Navigator
PMPCB
genes like me logo Genes that share disorders with PMPCB: view

No data available for UniProtKB/Swiss-Prot for PMPCB Gene

Publications for PMPCB Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. Maturation of wild-type and mutated frataxin by the mitochondrial processing peptidase. (PMID: 9700204) Koutnikova H. … Koenig M. (Hum. Mol. Genet. 1998) 3 23
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for PMPCB Gene

Sources for PMPCB Gene

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