Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAMTS1 Gene

Aliases for ADAMTS1 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 1 2 3
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 1 2 3
  • ADAM-TS 1 3 4
  • ADAM-TS1 3 4
  • ADAMTS-1 3 4
  • METH-1 3 4
  • METH1 3 4
  • Human Metalloproteinase With Thrombospondin Type 1 Motifs 3
  • EC 3.4.24.82 63
  • EC 3.4.24.14 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • KIAA1346 4
  • C3-C5 3

External Ids for ADAMTS1 Gene

Previous GeneCards Identifiers for ADAMTS1 Gene

  • GC21M024787
  • GC21M027130
  • GC21M028208
  • GC21M013613

Summaries for ADAMTS1 Gene

Entrez Gene Summary for ADAMTS1 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS1 Gene

ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 1) is a Protein Coding gene. Diseases associated with ADAMTS1 include type 2a von willebrand disease and brown-sequard syndrome. Among its related pathways are Endochondral Ossification and Angiogenesis (CST). GO annotations related to this gene include heparin binding and metallopeptidase activity. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS1 Gene

  • Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Gene Wiki entry for ADAMTS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS1 Gene

Genomics for ADAMTS1 Gene

Regulatory Elements for ADAMTS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAMTS1 Gene

Chromosome:
21
Start:
26,835,747 bp from pter
End:
26,845,409 bp from pter
Size:
9,663 bases
Orientation:
Minus strand

Genomic View for ADAMTS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS1 Gene

Proteins for ADAMTS1 Gene

  • Protein details for ADAMTS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHI8-ATS1_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 1
    Protein Accession:
    Q9UHI8
    Secondary Accessions:
    • D3DSD5
    • Q9NSJ8
    • Q9P2K0
    • Q9UH83
    • Q9UP80

    Protein attributes for ADAMTS1 Gene

    Size:
    967 amino acids
    Molecular mass:
    105358 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD48080.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92584.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADAMTS1 Gene

neXtProt entry for ADAMTS1 Gene

Proteomics data for ADAMTS1 Gene at MOPED

Post-translational modifications for ADAMTS1 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Ubiquitination at Lys 735
  • Glycosylation at Thr 170, Thr 197, Thr 208, Asn 547, Asn 720, and Asn 764
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTS1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADAMTS1 (ADAMTS1)

Domains & Families for ADAMTS1 Gene

Gene Families for ADAMTS1 Gene

Suggested Antigen Peptide Sequences for ADAMTS1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHI8

UniProtKB/Swiss-Prot:

ATS1_HUMAN :
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Contains 1 disintegrin domain.
  • Contains 1 peptidase M12B domain.
  • Contains 3 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTS1: view

Function for ADAMTS1 Gene

Molecular function for ADAMTS1 Gene

GENATLAS Biochemistry:
a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 1,extracellular matrix protein,inflammation-induced gene inhibiting endothelial cell proliferation,vascular endothelial growth factor induced angiogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
Cleaves aggrecan at the 1938-Glu- -Leu-1939 site, within the chondroitin sulfate attachment domain
UniProtKB/Swiss-Prot Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Enzyme Numbers (IUBMB) for ADAMTS1 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008201 heparin binding IEA --
GO:0008237 metallopeptidase activity TAS 10438512
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS1: view
genes like me logo Genes that share phenotypes with ADAMTS1: view

Animal Models for ADAMTS1 Gene

MGI Knock Outs for ADAMTS1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ADAMTS1 Gene

Localization for ADAMTS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS1 Gene COMPARTMENTS Subcellular localization image for ADAMTS1 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ADAMTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix --
GO:0005604 basement membrane IEA --
GO:0005737 cytoplasm IDA --
GO:0031012 extracellular matrix --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ADAMTS1: view

Pathways & Interactions for ADAMTS1 Gene

genes like me logo Genes that share pathways with ADAMTS1: view

Pathways by source for ADAMTS1 Gene

1 Sino Biological pathway for ADAMTS1 Gene
2 Cell Signaling Technology pathways for ADAMTS1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADAMTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001542 ovulation from ovarian follicle IEA --
GO:0001822 kidney development IEA --
GO:0006508 proteolysis IEA --
GO:0007229 integrin-mediated signaling pathway TAS 8995297
GO:0008285 negative regulation of cell proliferation TAS 10438512
genes like me logo Genes that share ontologies with ADAMTS1: view

No data available for SIGNOR curated interactions for ADAMTS1 Gene

Drugs & Compounds for ADAMTS1 Gene

(8) Drugs for ADAMTS1 Gene - From: NovoSeek, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pravastatin Approved Pharma 142
Heparin Approved, Investigational Pharma Antagonist 672,226
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Forskolin Experimental Pharma 0
thymidine Experimental Pharma 0

(2) Additional Compounds for ADAMTS1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chondroitin sulfate
  • Chondritinsulfate
  • Chondritinsulphate
  • Chondroitin 6-sulfate
  • Chondroitin 6-sulphate
  • Chondroitin polysulfate
9007-28-7
TGF beta1
genes like me logo Genes that share compounds with ADAMTS1: view

Transcripts for ADAMTS1 Gene

mRNA/cDNA for ADAMTS1 Gene

Unigene Clusters for ADAMTS1 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:

Relevant External Links for ADAMTS1 Gene

GeneLoc Exon Structure for
ADAMTS1
ECgene alternative splicing isoforms for
ADAMTS1

Expression for ADAMTS1 Gene

mRNA expression in normal human tissues for ADAMTS1 Gene

mRNA differential expression in normal tissues according to GTEx for ADAMTS1 Gene

This gene is overexpressed in Ovary (x5.5) and Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for ADAMTS1 Gene

This gene is overexpressed in Cerebrospinal fluid (41.3), Vitreous humor (8.4), Bone marrow mesenchymal stem cell (6.3), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAMTS1 Gene



SOURCE GeneReport for Unigene cluster for ADAMTS1 Gene Hs.643357

genes like me logo Genes that share expression patterns with ADAMTS1: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADAMTS1 Gene

Orthologs for ADAMTS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTS1 35
  • 83.65 (n)
  • 84.03 (a)
ADAMTS1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS1 35
  • 84.53 (n)
  • 86.96 (a)
ADAMTS1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts1 35
  • 81.04 (n)
  • 82.71 (a)
Adamts1 16
Adamts1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS1 35
  • 99.69 (n)
  • 99.9 (a)
ADAMTS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts1 35
  • 81.6 (n)
  • 82.81 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAMTS1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAMTS1 35
  • 74.53 (n)
  • 78.09 (a)
ADAMTS1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts1 35
  • 71.35 (n)
  • 75.84 (a)
zebrafish
(Danio rerio)
Actinopterygii adamts1 35
  • 62.3 (n)
  • 62.1 (a)
adamts1 36
  • 52 (a)
OneToOne
Species with no ortholog for ADAMTS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS1 Gene

ENSEMBL:
Gene Tree for ADAMTS1 (if available)
TreeFam:
Gene Tree for ADAMTS1 (if available)

Paralogs for ADAMTS1 Gene

genes like me logo Genes that share paralogs with ADAMTS1: view

Variants for ADAMTS1 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
VAR_030001 -

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS1 Gene

Variant ID Type Subtype PubMed ID
nsv834068 CNV Loss 17160897
nsv3482 CNV Loss 18451855
nsv470897 CNV Loss 18288195
nsv528278 CNV Gain 19592680

Variation tolerance for ADAMTS1 Gene

Residual Variation Intolerance Score: 30.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTS1 Gene

HapMap Linkage Disequilibrium report
ADAMTS1
Human Gene Mutation Database (HGMD)
ADAMTS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTS1 Gene

Disorders for ADAMTS1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ADAMTS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
type 2a von willebrand disease
  • von willebrand disease type 2a
brown-sequard syndrome
  • brown-squard syndrome
cerebral artery occlusion
mongolian spot
  • pseudoxanthoma elasticum
anterior spinal artery syndrome
  • anterior spinal artery occlusion syndrome
- elite association

Relevant External Links for ADAMTS1

Genetic Association Database (GAD)
ADAMTS1
Human Genome Epidemiology (HuGE) Navigator
ADAMTS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTS1
genes like me logo Genes that share disorders with ADAMTS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAMTS1 Gene

Publications for ADAMTS1 Gene

  1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PMID: 10438512) Vazquez F. … Iruela-Arispe M.L. (J. Biol. Chem. 1999) 2 23 67
  2. Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma. (PMID: 20305301) Stokes A. … KAohAori V.M. (Clin. Cancer Res. 2010) 23 67
  3. The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep. (PMID: 20107206) Dunlap K.A. … Bayless K.J. (Biol. Reprod. 2010) 23 67
  4. ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. (PMID: 19349275) Hatipoglu O.F. … Ninomiya Y. (J. Biol. Chem. 2009) 23 67
  5. Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. (PMID: 19180493) Pockert A.J. … Hoyland J.A. (Arthritis Rheum. 2009) 23 67

Products for ADAMTS1 Gene

Sources for ADAMTS1 Gene

Back to Top

Content