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Aliases for ADAMTS1 Gene

Aliases for ADAMTS1 Gene

  • ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 1 2 3
  • METH1 3 4 6
  • A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 1 2 3
  • ADAM-TS 1 3 4
  • ADAM-TS1 3 4
  • ADAMTS-1 3 4
  • METH-1 3 4
  • A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1 3
  • Human Metalloproteinase With Thrombospondin Type 1 Motifs 3
  • EC 3.4.24.82 64
  • EC 3.4.24.14 64
  • EC 3.4.24.- 4
  • EC 3.4.24 64
  • KIAA1346 4
  • C3-C5 3

External Ids for ADAMTS1 Gene

Summaries for ADAMTS1 Gene

Entrez Gene Summary for ADAMTS1 Gene

  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAMTS1 Gene

ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif, 1) is a Protein Coding gene. Diseases associated with ADAMTS1 include type 2a von willebrand disease. Among its related pathways are Endochondral Ossification and Angiogenesis (CST). GO annotations related to this gene include heparin binding and metallopeptidase activity. An important paralog of this gene is ADAMTS16.

UniProtKB/Swiss-Prot for ADAMTS1 Gene

  • Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Gene Wiki entry for ADAMTS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTS1 Gene

Genomics for ADAMTS1 Gene

Genomic Location for ADAMTS1 Gene

Start:
26,835,747 bp from pter
End:
26,845,409 bp from pter
Size:
9,663 bases
Orientation:
Minus strand

Genomic View for ADAMTS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTS1 Gene

Regulatory Elements for ADAMTS1 Gene

Proteins for ADAMTS1 Gene

  • Protein details for ADAMTS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHI8-ATS1_HUMAN
    Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 1
    Protein Accession:
    Q9UHI8
    Secondary Accessions:
    • D3DSD5
    • Q9NSJ8
    • Q9P2K0
    • Q9UH83
    • Q9UP80

    Protein attributes for ADAMTS1 Gene

    Size:
    967 amino acids
    Molecular mass:
    105358 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD48080.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92584.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADAMTS1 Gene

neXtProt entry for ADAMTS1 Gene

Proteomics data for ADAMTS1 Gene at MOPED

Post-translational modifications for ADAMTS1 Gene

  • Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • The precursor is cleaved by a furin endopeptidase.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys735
  • Glycosylation at Thr170, Thr197, Thr208, Asn547, Asn720, and Asn764

Other Protein References for ADAMTS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADAMTS1 Gene

Gene Families for ADAMTS1 Gene

HGNC:
  • ADAMTS :ADAM metallopeptidases with thrombospondin type 1 motif
IUPHAR :

UniProtKB/Swiss-Prot:

ATS1_HUMAN
Domain:
  • The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix:
    • Q9UHI8
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q9UHI8
  • Contains 1 disintegrin domain.:
    • Q9UHI8
  • Contains 1 peptidase M12B domain.:
    • Q9UHI8
  • Contains 3 TSP type-1 domains.:
    • Q9UHI8
genes like me logo Genes that share domains with ADAMTS1: view

Function for ADAMTS1 Gene

Molecular function for ADAMTS1 Gene

GENATLAS Biochemistry: a disintegrin-like and metalloprotease domain (reprolysin type) with thrombospondin type 1 motif 1,extracellular matrix protein,inflammation-induced gene inhibiting endothelial cell proliferation,vascular endothelial growth factor induced angiogenesis
UniProtKB/Swiss-Prot CatalyticActivity: Cleaves aggrecan at the 1938-Glu- -Leu-1939 site, within the chondroitin sulfate attachment domain
UniProtKB/Swiss-Prot Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Enzyme Numbers (IUBMB) for ADAMTS1 Gene

Gene Ontology (GO) - Molecular Function for ADAMTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding --
GO:0008201 heparin binding IEA --
GO:0008237 metallopeptidase activity TAS 10438512
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTS1: view
genes like me logo Genes that share phenotypes with ADAMTS1: view

Animal Models for ADAMTS1 Gene

MGI Knock Outs for ADAMTS1:

miRNA for ADAMTS1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for ADAMTS1 Gene

Localization for ADAMTS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTS1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTS1 Gene COMPARTMENTS Subcellular localization image for ADAMTS1 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAMTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005737 cytoplasm IDA --
GO:0031012 extracellular matrix --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ADAMTS1: view

Pathways for ADAMTS1 Gene

genes like me logo Genes that share pathways with ADAMTS1: view

Pathways by source for ADAMTS1 Gene

1 Sino Biological pathway for ADAMTS1 Gene
2 Cell Signaling Technology pathways for ADAMTS1 Gene
1 BioSystems pathway for ADAMTS1 Gene

Gene Ontology (GO) - Biological Process for ADAMTS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001542 ovulation from ovarian follicle IEA --
GO:0001822 kidney development IEA --
GO:0006508 proteolysis IEA --
GO:0007229 integrin-mediated signaling pathway TAS 8995297
GO:0008285 negative regulation of cell proliferation TAS 10438512
genes like me logo Genes that share ontologies with ADAMTS1: view

Compounds for ADAMTS1 Gene

(2) HMDB Compounds for ADAMTS1 Gene

Compound Synonyms Cas Number PubMed IDs
Chondroitin
  • Chondroitin-D-glucuronate
9007-27-6
Chondroitin sulfate
  • Chondritinsulfate
9007-28-7

(6) Novoseek inferred chemical compound relationships for ADAMTS1 Gene

Compound -log(P) Hits PubMed IDs
tgf beta1 41.3 3
forskolin 11.6 1
thymidine 0 1
progesterone 0 2
serine 0 1

(1) PharmGKB related drug/compound annotations for ADAMTS1 Gene

Drug/compound Annotation
pravastatin CA
genes like me logo Genes that share compounds with ADAMTS1: view

Transcripts for ADAMTS1 Gene

Unigene Clusters for ADAMTS1 Gene

ADAM metallopeptidase with thrombospondin type 1 motif, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:

Relevant External Links for ADAMTS1 Gene

GeneLoc Exon Structure for
ADAMTS1
ECgene alternative splicing isoforms for
ADAMTS1

Expression for ADAMTS1 Gene

mRNA expression in normal human tissues for ADAMTS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTS1 Gene

This gene is overexpressed in Ovary (5.5) and Artery - Tibial (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAMTS1 Gene

SOURCE GeneReport for Unigene cluster for ADAMTS1 Gene Hs.643357

genes like me logo Genes that share expressions with ADAMTS1: view

Orthologs for ADAMTS1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAMTS1 36
  • 99.69 (n)
  • 99.9 (a)
ADAMTS1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADAMTS1 36
  • 83.65 (n)
  • 84.03 (a)
ADAMTS1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTS1 36
  • 84.53 (n)
  • 86.96 (a)
ADAMTS1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamts1 36
  • 81.04 (n)
  • 82.71 (a)
Adamts1 16
Adamts1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAMTS1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamts1 36
  • 81.6 (n)
  • 82.81 (a)
chicken
(Gallus gallus)
Aves ADAMTS1 36
  • 74.53 (n)
  • 78.09 (a)
ADAMTS1 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTS1 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adamts1 36
  • 71.35 (n)
  • 75.84 (a)
zebrafish
(Danio rerio)
Actinopterygii adamts1 36
  • 62.3 (n)
  • 62.1 (a)
adamts1 37
  • 52 (a)
OneToOne
Species with no ortholog for ADAMTS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTS1 Gene

ENSEMBL:
Gene Tree for ADAMTS1 (if available)
TreeFam:
Gene Tree for ADAMTS1 (if available)

Paralogs for ADAMTS1 Gene

genes like me logo Genes that share paralogs with ADAMTS1: view

Variants for ADAMTS1 Gene

Sequence variations from dbSNP and Humsavar for ADAMTS1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs2738 -- 26,836,585(+) TGGAC(A/C)AGCTG utr-variant-3-prime
rs8992 -- 26,836,635(+) ACAAG(A/G)CAAGT utr-variant-3-prime
rs12140 -- 26,837,076(-) CTGCT(A/G)TGGTT utr-variant-3-prime
rs13615 -- 26,837,348(+) ATGCT(A/G)TATCA utr-variant-3-prime
rs229041 -- 26,836,149(+) CAGCC(A/C/G)TCTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ADAMTS1 Gene

Variant ID Type Subtype PubMed ID
nsv834068 CNV Loss 17160897
nsv3482 CNV Loss 18451855
nsv470897 CNV Loss 18288195
nsv528278 CNV Gain 19592680

Relevant External Links for ADAMTS1 Gene

HapMap Linkage Disequilibrium report
ADAMTS1
Human Gene Mutation Database (HGMD)
ADAMTS1

Disorders for ADAMTS1 Gene

(11) Novoseek inferred disease relationships for ADAMTS1 Gene

Disease -log(P) Hits PubMed IDs
chondrosarcoma 32 7
arthritis 32 1
osteosarcoma 13.8 1
neurodegeneration 9.92 1
prostate cancer 9.68 1

Relevant External Links for ADAMTS1

Genetic Association Database (GAD)
ADAMTS1
Human Genome Epidemiology (HuGE) Navigator
ADAMTS1
genes like me logo Genes that share disorders with ADAMTS1: view

No data available for UniProtKB/Swiss-Prot for ADAMTS1 Gene

Publications for ADAMTS1 Gene

  1. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. (PMID: 10438512) Vazquez F. … Iruela-Arispe M.L. (J. Biol. Chem. 1999) 2 3 4 23
  2. Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains. (PMID: 17897672) Gerhardt S. … Abbott W.M. (J. Mol. Biol. 2007) 3 4 23
  3. Altered expression of genes regulating angiogenesis in experimental androgen-independent prostate cancer. (PMID: 18076023) Gustavsson H. … Damber J.E. (Prostate 2008) 3 23
  4. Increased expression of a disintegrin and metalloproteinase thrombospondin 1 in thrombosed hemodialysis grafts. (PMID: 18192475) Misra S. … Mukhopadhyay D. (J Vasc Interv Radiol 2008) 3 23
  5. ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. (PMID: 19349275) Hatipoglu O.F. … Ninomiya Y. (J. Biol. Chem. 2009) 3 23

Products for ADAMTS1 Gene

  • antibodies-online proteins for ADAMTS1
  • antibodies-online antibodies for ADAMTS1
  • antibodies-online kits for ADAMTS1

Sources for ADAMTS1 Gene

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