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Aliases for SLC4A8 Gene

Aliases for SLC4A8 Gene

  • Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 8 2 3
  • NBC3 3 4 6
  • Electroneutral Na(+)-Driven Cl-HCO3 Exchanger 3 4
  • K-NBC3 3 4
  • Electroneutral Sodium Bicarbonate Exchanger 1 3
  • Solute Carrier Family 4 Member 8 4
  • KIAA0739 4
  • NDCBE1 4
  • NDCBE 3
  • NBC 4

External Ids for SLC4A8 Gene

Summaries for SLC4A8 Gene

Entrez Gene Summary for SLC4A8 Gene

  • The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for SLC4A8 Gene

SLC4A8 (Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 8) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include inorganic anion exchanger activity. An important paralog of this gene is SLC4A5.

UniProtKB/Swiss-Prot for SLC4A8 Gene

  • Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.

Gene Wiki entry for SLC4A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC4A8 Gene

Genomics for SLC4A8 Gene

Genomic Location for SLC4A8 Gene

Start:
51,391,317 bp from pter
End:
51,515,763 bp from pter
Size:
124,447 bases
Orientation:
Plus strand

Genomic View for SLC4A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC4A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC4A8 Gene

Regulatory Elements for SLC4A8 Gene

Proteins for SLC4A8 Gene

  • Protein details for SLC4A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2Y0W8-S4A8_HUMAN
    Recommended name:
    Electroneutral sodium bicarbonate exchanger 1
    Protein Accession:
    Q2Y0W8
    Secondary Accessions:
    • A0MMZ1
    • B4DHY0
    • E7EML0
    • F5GZ31
    • F5H7F5
    • O94843
    • O95233
    • Q004B4
    • Q8N3U2
    • Q8TC60
    • Q9UKX8

    Protein attributes for SLC4A8 Gene

    Size:
    1093 amino acids
    Molecular mass:
    122938 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34459.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38576.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC4A8 Gene

neXtProt entry for SLC4A8 Gene

Proteomics data for SLC4A8 Gene at MOPED

Post-translational modifications for SLC4A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC4A8 Gene

No data available for DME Specific Peptides for SLC4A8 Gene

Domains for SLC4A8 Gene

Gene Families for SLC4A8 Gene

Suggested Antigen Peptide Sequences for SLC4A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2Y0W8

UniProtKB/Swiss-Prot:

S4A8_HUMAN
Family:
  • Belongs to the anion exchanger (TC 2.A.31) family.:
    • Q2Y0W8
genes like me logo Genes that share domains with SLC4A8: view

Function for SLC4A8 Gene

Molecular function for SLC4A8 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Activity is inhibited by 4,4-Di-isothiocyanatostilbene-2,2-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters)
UniProtKB/Swiss-Prot Function: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.

Gene Ontology (GO) - Molecular Function for SLC4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005452 inorganic anion exchanger activity IEA --
GO:0008509 anion transmembrane transporter activity --
GO:0008510 sodium:bicarbonate symporter activity IBA --
genes like me logo Genes that share ontologies with SLC4A8: view

Phenotypes for SLC4A8 Gene

genes like me logo Genes that share phenotypes with SLC4A8: view

Animal Models for SLC4A8 Gene

MGI Knock Outs for SLC4A8:

miRNA for SLC4A8 Gene

miRTarBase miRNAs that target SLC4A8

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC4A8 Gene

Localization for SLC4A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC4A8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC4A8 Gene COMPARTMENTS Subcellular localization image for SLC4A8 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0032809 neuronal cell body membrane IEA --
genes like me logo Genes that share ontologies with SLC4A8: view

Pathways for SLC4A8 Gene

genes like me logo Genes that share pathways with SLC4A8: view

Gene Ontology (GO) - Biological Process for SLC4A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006814 sodium ion transport --
GO:0006820 anion transport --
GO:0015701 bicarbonate transport TAS --
genes like me logo Genes that share ontologies with SLC4A8: view

Compounds for SLC4A8 Gene

(1) HMDB Compounds for SLC4A8 Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SLC4A8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Sodium bicarbonate
  • Bicarbonate of soda
144-55-8 transporter substrate
genes like me logo Genes that share compounds with SLC4A8: view

Transcripts for SLC4A8 Gene

Unigene Clusters for SLC4A8 Gene

Solute carrier family 4, sodium bicarbonate cotransporter, member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC4A8 Gene

No ASD Table

Relevant External Links for SLC4A8 Gene

GeneLoc Exon Structure for
SLC4A8
ECgene alternative splicing isoforms for
SLC4A8

Expression for SLC4A8 Gene

mRNA expression in normal human tissues for SLC4A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC4A8 Gene

This gene is overexpressed in Pituitary (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC4A8 Gene

SOURCE GeneReport for Unigene cluster for SLC4A8 Gene Hs.4749

mRNA Expression by UniProt/SwissProt for SLC4A8 Gene

Q2Y0W8-S4A8_HUMAN
Tissue specificity: Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.
genes like me logo Genes that share expressions with SLC4A8: view

Orthologs for SLC4A8 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC4A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC4A8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC4A8 35
  • 92.4 (n)
  • 98.08 (a)
SLC4A8 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KNBC3 36
  • 98 (a)
OneToOne
SLC4A8 35
  • 93.69 (n)
  • 97.98 (a)
mouse
(Mus musculus)
Mammalia Slc4a8 35
  • 87.53 (n)
  • 95.77 (a)
Slc4a8 16
Slc4a8 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC4A8 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc4a8 35
  • 86.78 (n)
  • 94.79 (a)
chicken
(Gallus gallus)
Aves LOC425441 35
  • 75.26 (n)
  • 80.2 (a)
SLC4A8 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc4a8 35
  • 76.12 (n)
  • 86.61 (a)
zebrafish
(Danio rerio)
Actinopterygii slc4a8 35
  • 70.63 (n)
  • 77.72 (a)
SLC4A8 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ndae1 36
  • 45 (a)
OneToMany
Ndae1 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea abts-1 36
  • 41 (a)
OneToMany
F52B5.1 37
  • 49 (a)
R03E9.3 37
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for SLC4A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC4A8 Gene

ENSEMBL:
Gene Tree for SLC4A8 (if available)
TreeFam:
Gene Tree for SLC4A8 (if available)

Paralogs for SLC4A8 Gene

Paralogs for SLC4A8 Gene

genes like me logo Genes that share paralogs with SLC4A8: view

Variants for SLC4A8 Gene

Sequence variations from dbSNP and Humsavar for SLC4A8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs9409 -- 51,515,348(+) TGGCT(C/G)CCCTT utr-variant-3-prime
rs868884 -- 51,475,314(-) ACATC(C/T)GGAGT intron-variant
rs870814 -- 51,441,476(+) TCCTT(C/T)TTCCC intron-variant
rs873674 -- 51,495,827(-) aacat(A/G)gatga intron-variant
rs907348 -- 51,394,556(+) GCTCA(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC4A8 Gene

Variant ID Type Subtype PubMed ID
nsv832408 CNV Gain 17160897
nsv519438 CNV Gain 19592680
nsv513361 CNV Insertion 21212237
esv1700899 CNV Insertion 17803354
nsv705 CNV Insertion 18451855

Relevant External Links for SLC4A8 Gene

HapMap Linkage Disequilibrium report
SLC4A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC4A8 Gene

Disorders for SLC4A8 Gene

No disorders were found for SLC4A8 Gene.

No data available for UniProtKB/Swiss-Prot for SLC4A8 Gene

Publications for SLC4A8 Gene

  1. Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger. (PMID: 11133997) Grichtchenko I.I. … Boron W.F. (J. Biol. Chem. 2001) 2 3 4 23
  2. Molecular expression of SLC4-derived Na+-dependent anion transporters in selected human tissues. (PMID: 17715183) Damkier H.H. … Praetorius J. (Am. J. Physiol. 2007) 4 23
  3. Cloning and characterization of novel human SLC4A8 gene products encoding Na+-driven Cl-/HCO3(-) exchanger variants NDCBE-A, -C, and -D. (PMID: 18577713) Parker M.D. … Boron W.F. (Physiol. Genomics 2008) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. Characterization of Na+/HCO-3 cotransporter isoform NBC-3. (PMID: 10362779) Amlal H. … Soleimani M. (Am. J. Physiol. 1999) 3 4

Products for SLC4A8 Gene

Sources for SLC4A8 Gene

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