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Aliases for SCARB1 Gene

Aliases for SCARB1 Gene

  • Scavenger Receptor Class B, Member 1 2 3
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 1 2 3
  • CD36 And LIMPII Analogous 1 3 4
  • CD36L1 3 4
  • CLA-1 3 4
  • SR-BI 3 4
  • CLA1 3 4
  • SRB1 3 4
  • Collagen Type I Receptor, Thrombospondin Receptor-Like 1 4
  • Scavenger Receptor Class B Type III 3
  • CD36 Antigen-Like 1 4
  • CD36 Antigen 4
  • HDLQTL6 3

External Ids for SCARB1 Gene

Previous HGNC Symbols for SCARB1 Gene

  • CD36L1

Previous GeneCards Identifiers for SCARB1 Gene

  • GC12M123982
  • GC12M125008
  • GC12M123615
  • GC12M123787
  • GC12M125262
  • GC12M122224

Summaries for SCARB1 Gene

Entrez Gene Summary for SCARB1 Gene

  • The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for SCARB1 Gene

SCARB1 (Scavenger Receptor Class B, Member 1) is a Protein Coding gene. Diseases associated with SCARB1 include hepatitis c and hepatitis. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include protein homodimerization activity and phosphatidylserine binding. An important paralog of this gene is CD36.

UniProtKB/Swiss-Prot for SCARB1 Gene

  • Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).

  • (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes.

Gene Wiki entry for SCARB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARB1 Gene

Genomics for SCARB1 Gene

Regulatory Elements for SCARB1 Gene

Genomic Location for SCARB1 Gene

Chromosome:
12
Start:
124,776,856 bp from pter
End:
124,882,668 bp from pter
Size:
105,813 bases
Orientation:
Minus strand

Genomic View for SCARB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCARB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARB1 Gene

Proteins for SCARB1 Gene

  • Protein details for SCARB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTV0-SCRB1_HUMAN
    Recommended name:
    Scavenger receptor class B member 1
    Protein Accession:
    Q8WTV0
    Secondary Accessions:
    • F8W8N0
    • Q14016
    • Q52LZ5
    • Q6KFX4

    Protein attributes for SCARB1 Gene

    Size:
    552 amino acids
    Molecular mass:
    60878 Da
    Quaternary structure:
    • The C-terminal region binds to PDZK1 (By similarity). (Microbial infection) Interacts with hepatitis C virus E1:E2 glycoproteins (PubMed:18000990).

    Alternative splice isoforms for SCARB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARB1 Gene

Proteomics data for SCARB1 Gene at MOPED

Post-translational modifications for SCARB1 Gene

  • N-glycosylated.
  • The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
  • Ubiquitination at Lys 484
  • Glycosylation at Asn 102, Asn 108, Asn 173, Asn 212, Asn 227, Asn 255, Asn 310, Asn 330, and Asn 383
  • Modification sites at PhosphoSitePlus

Other Protein References for SCARB1 Gene

Antibody Products

No data available for DME Specific Peptides for SCARB1 Gene

Domains & Families for SCARB1 Gene

Protein Domains for SCARB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WTV0

UniProtKB/Swiss-Prot:

SCRB1_HUMAN :
  • Belongs to the CD36 family.
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with SCARB1: view

No data available for Gene Families for SCARB1 Gene

Function for SCARB1 Gene

Molecular function for SCARB1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes.

Gene Ontology (GO) - Molecular Function for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 12651854
GO:0001618 virus receptor activity IEA --
GO:0001786 phosphatidylserine binding ISS --
GO:0001875 lipopolysaccharide receptor activity IDA 12651854
GO:0005215 transporter activity TAS 9211901
genes like me logo Genes that share ontologies with SCARB1: view
genes like me logo Genes that share phenotypes with SCARB1: view

Animal Models for SCARB1 Gene

MGI Knock Outs for SCARB1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SCARB1 Gene

Localization for SCARB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARB1 Gene

Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCARB1 Gene COMPARTMENTS Subcellular localization image for SCARB1 gene
Compartment Confidence
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 2
mitochondrion 2
nucleus 2
peroxisome 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane --
GO:0005901 caveola TAS 12651854
genes like me logo Genes that share ontologies with SCARB1: view

Pathways & Interactions for SCARB1 Gene

genes like me logo Genes that share pathways with SCARB1: view

Gene Ontology (GO) - Biological Process for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001935 endothelial cell proliferation --
GO:0006702 androgen biosynthetic process --
GO:0006707 cholesterol catabolic process --
GO:0006869 lipid transport --
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with SCARB1: view

No data available for SIGNOR curated interactions for SCARB1 Gene

Drugs & Compounds for SCARB1 Gene

(34) Drugs for SCARB1 Gene - From: NovoSeek, PharmGKB, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphatidylserine Approved Nutra Target 0
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Fenofibrate Approved Pharma PPARalpha agonist 158
Aspirin Approved Pharma Channel blocker 971
cholic acid Approved Pharma Full agonist, Agonist 0

(179) Additional Compounds for SCARB1 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CE(10:0)
  • 3b-(Decanoyloxy)-5-cholestene
  • 5-Cholesten-3b-ol caprate
  • Cholest-5-en-3b-ol caprate
  • Cholesterol 3-decanoate
  • Cholesterol 3-decanoic acid
1183-04-6
CE(12:0)
  • (3beta)-Cholest-5-en-3-ol dodecanoate
  • (3beta)-Cholest-5-en-3-ol dodecanoic acid
  • 12:0 Cholesterol ester
  • Cholest-5-en-3-beta-yl laurate
  • Cholest-5-en-3-yl laurate
1908-11-8
CE(14:0)
  • 1-Myristoyl-cholesterol
  • 14:0 Cholesterol ester
  • CE(14:0)
  • CE(14:0/0:0)
  • Cholest-5-en-3-ol (3beta)-tetradecanoate
1989-52-2
CE(14:1(9Z))
  • 1-Myristoleoyl-cholesterol
  • 14:1(9Z) Cholesterol ester
  • CE(14:1)
  • CE(14:1/0:0)
  • CE(14:1n5/0:0)
CE(16:0)
  • 1-Palmitoyl-cholesterol
  • 16:0 Cholesterol ester
  • Cholest-5-en-3-yl palmitate
  • Cholest-5-ene-3-beta-yl palmitate
  • Cholesterol 1-hexadecanoate
601-34-3
genes like me logo Genes that share compounds with SCARB1: view

Transcripts for SCARB1 Gene

Unigene Clusters for SCARB1 Gene

Scavenger receptor class B, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCARB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCARB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16
SP1: - - - - - - -
SP2:
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8:

Relevant External Links for SCARB1 Gene

GeneLoc Exon Structure for
SCARB1
ECgene alternative splicing isoforms for
SCARB1

Expression for SCARB1 Gene

mRNA expression in normal human tissues for SCARB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCARB1 Gene

This gene is overexpressed in Adrenal Gland (x20.9) and Liver (x6.3).

Protein differential expression in normal tissues from HIPED for SCARB1 Gene

This gene is overexpressed in Adrenal (49.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCARB1 Gene



SOURCE GeneReport for Unigene cluster for SCARB1 Gene Hs.731377

mRNA Expression by UniProt/SwissProt for SCARB1 Gene

Q8WTV0-SCRB1_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expression patterns with SCARB1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SCARB1 Gene

Orthologs for SCARB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCARB1 35
  • 85 (n)
  • 83.1 (a)
SCARB1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCARB1 35
  • 85.14 (n)
  • 85.42 (a)
SCARB1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scarb1 35
  • 80.29 (n)
  • 79.57 (a)
Scarb1 16
Scarb1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCARB1 35
  • 99.54 (n)
  • 100 (a)
SCARB1 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scarb1 35
  • 79.57 (n)
  • 78.59 (a)
oppossum
(Monodelphis domestica)
Mammalia SCARB1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCARB1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCARB1 35
  • 68.4 (n)
  • 62 (a)
SCARB1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCARB1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scarb1 35
  • 62.42 (n)
  • 56.88 (a)
zebrafish
(Danio rerio)
Actinopterygii scarb1 35
  • 63.5 (n)
  • 59.23 (a)
scarb1 36
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3433 35
fruit fly
(Drosophila melanogaster)
Insecta crq 35
  • 46.81 (n)
  • 31.58 (a)
CG10345 36
  • 23 (a)
OneToMany
CG1887 36
  • 21 (a)
OneToMany
CG2736 36
  • 20 (a)
OneToMany
CG31741 36
  • 24 (a)
OneToMany
CG3829 36
  • 21 (a)
OneToMany
CG40006 36
  • 18 (a)
OneToMany
CG7227 36
  • 21 (a)
OneToMany
crq 36
  • 26 (a)
OneToMany
emp 36
  • 27 (a)
OneToMany
ninaD 36
  • 24 (a)
OneToMany
pes 36
  • 23 (a)
OneToMany
santa-maria 36
  • 23 (a)
OneToMany
Snmp1 36
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scav-3 36
  • 23 (a)
OneToMany
scav-4 36
  • 19 (a)
OneToMany
scav-5 36
  • 20 (a)
OneToMany
scav-6 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for SCARB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCARB1 Gene

ENSEMBL:
Gene Tree for SCARB1 (if available)
TreeFam:
Gene Tree for SCARB1 (if available)

Paralogs for SCARB1 Gene

Paralogs for SCARB1 Gene

(2) SIMAP similar genes for SCARB1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SCARB1 Gene

genes like me logo Genes that share paralogs with SCARB1: view

Variants for SCARB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SCARB1 Gene

Q8WTV0-SCRB1_HUMAN
Genetic variations in SCARB1 define the high density lipoprotein cholesterol level quantitative trait locus 6 (HDLCQ16) [MIM:610762]

Sequence variations from dbSNP and Humsavar for SCARB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs5888 -- 124,800,202(-) AACGC(C/T)GACCC synonymous-codon, reference
rs5889 -- 124,814,331(-) CTCGG(C/T)GAACG reference, synonymous-codon
rs5890 -- 124,815,068(-) ACACC(A/G)TGTCC missense, reference
rs5891 - 124,814,996(-) ACATC(A/G)TCATG missense, reference
rs5892 -- 124,807,867(-) CGCTT(C/T)GTGGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SCARB1 Gene

Variant ID Type Subtype PubMed ID
nsv899595 CNV Loss 21882294
nsv52719 CNV Loss 16902084
esv1953401 CNV Deletion 18987734
esv2746550 CNV Deletion 23290073
esv2665124 CNV Deletion 23128226

Variation tolerance for SCARB1 Gene

Residual Variation Intolerance Score: 24.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.33; 76.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCARB1 Gene

HapMap Linkage Disequilibrium report
SCARB1
Human Gene Mutation Database (HGMD)
SCARB1

Disorders for SCARB1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for SCARB1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis c
  • hepatitis c infection
hepatitis
  • hepatitis a
neutrophil-specific granule deficiency
  • lactoferrin-deficient neutrophils
specific granule deficiency
phencyclidine abuse
  • pcp abuse
- elite association

Relevant External Links for SCARB1

Genetic Association Database (GAD)
SCARB1
Human Genome Epidemiology (HuGE) Navigator
SCARB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCARB1
genes like me logo Genes that share disorders with SCARB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCARB1 Gene

Publications for SCARB1 Gene

  1. In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux. (PMID: 14594995) Yancey P.G. … Rothblat G.H. (J. Lipid Res. 2004) 23 25 26 67
  2. Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. (PMID: 7689561) Calvo D. … Vega M. (J. Biol. Chem. 1993) 2 23 67
  3. Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids. (PMID: 19443194) Alvaro A. … VallvAc J.C. (J. Nutr. Biochem. 2010) 23 67
  4. Disodium ascorbyl phytostanol phosphate (FM-VP4), a modified phytostanol, is a highly active hypocholesterolaemic agent that affects the enterohepatic circulation of both cholesterol and bile acids in mice. (PMID: 19822032) MAcndez-GonzA!lez J. … Blanco-Vaca F. (Br. J. Nutr. 2010) 23 67
  5. TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells. (PMID: 20057170) Hu Y.W. … Tang C.K. (J. Atheroscler. Thromb. 2010) 23 67

Products for SCARB1 Gene

Sources for SCARB1 Gene

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