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Aliases for SCARB1 Gene

Aliases for SCARB1 Gene

  • Scavenger Receptor Class B, Member 1 2 3
  • CD36L1 3 4 6
  • CLA1 3 4 6
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 1 2 3
  • CD36 And LIMPII Analogous 1 3 4
  • HDLQTL6 3 6
  • CLA-1 3 4
  • SR-BI 3 4
  • SRB1 3 4
  • Collagen Type I Receptor, Thrombospondin Receptor-Like 1 4
  • Scavenger Receptor Class B Member 1 3
  • Scavenger Receptor Class B Type III 3
  • CD36 Antigen-Like 1 4
  • CD36 Antigen 4

External Ids for SCARB1 Gene

Previous Symbols for SCARB1 Gene

  • CD36L1

Summaries for SCARB1 Gene

Entrez Gene Summary for SCARB1 Gene

  • The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for SCARB1 Gene

SCARB1 (Scavenger Receptor Class B, Member 1) is a Protein Coding gene. Diseases associated with SCARB1 include hepatitis c and specific granule deficiency. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include protein homodimerization activity and 1-phosphatidylinositol binding. An important paralog of this gene is CD36.

UniProtKB/Swiss-Prot for SCARB1 Gene

  • Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).

Gene Wiki entry for SCARB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARB1 Gene

Genomics for SCARB1 Gene

Genomic Location for SCARB1 Gene

Start:
124,776,856 bp from pter
End:
124,882,668 bp from pter
Size:
105,813 bases
Orientation:
Minus strand

Genomic View for SCARB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCARB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARB1 Gene

Regulatory Elements for SCARB1 Gene

Proteins for SCARB1 Gene

  • Protein details for SCARB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WTV0-SCRB1_HUMAN
    Recommended name:
    Scavenger receptor class B member 1
    Protein Accession:
    Q8WTV0
    Secondary Accessions:
    • F8W8N0
    • Q14016
    • Q52LZ5
    • Q6KFX4

    Protein attributes for SCARB1 Gene

    Size:
    552 amino acids
    Molecular mass:
    60878 Da
    Quaternary structure:
    • Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C-terminal region binds to PDZK1 (By similarity).

    Alternative splice isoforms for SCARB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCARB1 Gene

Proteomics data for SCARB1 Gene at MOPED

Post-translational modifications for SCARB1 Gene

  • N-glycosylated.
  • The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys484
  • Glycosylation at Asn102, Asn108, Asn173, Asn212, Asn227, Asn255, Asn310, Asn330, and Asn383

Other Protein References for SCARB1 Gene

No data available for DME Specific Peptides for SCARB1 Gene

Domains for SCARB1 Gene

Protein Domains for SCARB1 Gene

UniProtKB/Swiss-Prot:

SCRB1_HUMAN
Family:
  • Belongs to the CD36 family.:
    • Q8WTV0
genes like me logo Genes that share domains with SCARB1: view

No data available for Gene Families for SCARB1 Gene

Function for SCARB1 Gene

Molecular function for SCARB1 Gene

UniProtKB/Swiss-Prot Function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).

Gene Ontology (GO) - Molecular Function for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 12651854
GO:0001786 phosphatidylserine binding ISS --
GO:0001875 lipopolysaccharide receptor activity IDA 12651854
GO:0005215 transporter activity TAS 9211901
GO:0005515 protein binding IPI 12356718
genes like me logo Genes that share ontologies with SCARB1: view
genes like me logo Genes that share phenotypes with SCARB1: view

Animal Models for SCARB1 Gene

MGI Knock Outs for SCARB1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SCARB1 Gene

Localization for SCARB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARB1 Gene

Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCARB1 Gene COMPARTMENTS Subcellular localization image for SCARB1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
nucleus 2
peroxisome 2
cytosol 1
endosome 1
golgi apparatus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0005901 caveola TAS 12651854
genes like me logo Genes that share ontologies with SCARB1: view

Pathways for SCARB1 Gene

genes like me logo Genes that share pathways with SCARB1: view

Gene Ontology (GO) - Biological Process for SCARB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001935 endothelial cell proliferation IEA --
GO:0006702 androgen biosynthetic process IEA --
GO:0006707 cholesterol catabolic process IEA --
GO:0006869 lipid transport --
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with SCARB1: view

Compounds for SCARB1 Gene

(155) HMDB Compounds for SCARB1 Gene

Compound Synonyms Cas Number PubMed IDs
CE(10:0)
  • Decanoic acid cholesteryl ester
1183-04-6
CE(12:0)
  • cholest-5-en-3beta-yl dodecanoate
1908-11-8
CE(14:0)
  • 14:0 Cholesterol ester
1989-52-2
CE(14:1(9Z))
  • CE(14:1/0:0)
Not Available
CE(16:0)
  • Cholest-5-ene-3-beta-yl palmitate
601-34-3

(1) Drugbank Compounds for SCARB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphatidylserine
  • 3-O-sn-Phosphatidyl-L-serine
8002-43-5 target

(58) Novoseek inferred chemical compound relationships for SCARB1 Gene

Compound -log(P) Hits PubMed IDs
cholesterol 83.5 252
cholesterol ester 70.2 15
lipid 64.8 93
sterol 58.3 22
phospholipid 55.6 25

(2) PharmGKB related drug/compound annotations for SCARB1 Gene

Drug/compound Annotation
atorvastatin CA
fenofibrate CA
genes like me logo Genes that share compounds with SCARB1: view

Transcripts for SCARB1 Gene

Unigene Clusters for SCARB1 Gene

Scavenger receptor class B, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCARB1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^ 16
SP1: - - - - - - -
SP2:
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8:

Relevant External Links for SCARB1 Gene

GeneLoc Exon Structure for
SCARB1
ECgene alternative splicing isoforms for
SCARB1

Expression for SCARB1 Gene

mRNA expression in normal human tissues for SCARB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCARB1 Gene

This gene is overexpressed in Adrenal Gland (20.9) and Liver (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SCARB1 Gene

SOURCE GeneReport for Unigene cluster for SCARB1 Gene Hs.731377

mRNA Expression by UniProt/SwissProt for SCARB1 Gene

Q8WTV0-SCRB1_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with SCARB1: view

Orthologs for SCARB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCARB1 36
  • 99.54 (n)
  • 100 (a)
SCARB1 37
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCARB1 36
  • 85 (n)
  • 83.1 (a)
SCARB1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCARB1 36
  • 85.14 (n)
  • 85.42 (a)
SCARB1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scarb1 36
  • 80.29 (n)
  • 79.57 (a)
Scarb1 16
Scarb1 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCARB1 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCARB1 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scarb1 36
  • 79.57 (n)
  • 78.59 (a)
chicken
(Gallus gallus)
Aves SCARB1 36
  • 68.4 (n)
  • 62 (a)
SCARB1 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCARB1 37
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scarb1 36
  • 62.42 (n)
  • 56.88 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3433 36
zebrafish
(Danio rerio)
Actinopterygii scarb1 36
  • 63.5 (n)
  • 59.23 (a)
scarb1 37
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10345 37
  • 23 (a)
OneToMany
CG1887 37
  • 21 (a)
OneToMany
CG2736 37
  • 20 (a)
OneToMany
CG31741 37
  • 24 (a)
OneToMany
CG3829 37
  • 21 (a)
OneToMany
CG40006 37
  • 18 (a)
OneToMany
CG7227 37
  • 21 (a)
OneToMany
crq 36
  • 46.81 (n)
  • 31.58 (a)
crq 37
  • 26 (a)
OneToMany
emp 37
  • 27 (a)
OneToMany
ninaD 37
  • 24 (a)
OneToMany
pes 37
  • 23 (a)
OneToMany
santa-maria 37
  • 23 (a)
OneToMany
Snmp1 37
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scav-3 37
  • 23 (a)
OneToMany
scav-4 37
  • 19 (a)
OneToMany
scav-5 37
  • 20 (a)
OneToMany
scav-6 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToOne
Species with no ortholog for SCARB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCARB1 Gene

ENSEMBL:
Gene Tree for SCARB1 (if available)
TreeFam:
Gene Tree for SCARB1 (if available)

Paralogs for SCARB1 Gene

Paralogs for SCARB1 Gene

Selected SIMAP similar genes for SCARB1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SCARB1 Gene

genes like me logo Genes that share paralogs with SCARB1: view

Variants for SCARB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SCARB1 Gene

Q8WTV0-SCRB1_HUMAN
Genetic variations in SCARB1 define the high density lipoprotein cholesterol level quantitative trait locus 6 (HDLCQ16) [MIM:610762]

Sequence variations from dbSNP and Humsavar for SCARB1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs5888 -- 124,800,202(-) AACGC(C/T)GACCC synonymous-codon, reference
rs5889 -- 124,814,331(-) CTCGG(C/T)GAACG reference, synonymous-codon
rs5890 -- 124,815,068(-) ACACC(A/G)TGTCC missense, reference
rs5891 - 124,814,996(-) ACATC(A/G)TCATG missense, reference
rs5892 -- 124,807,867(-) CGCTT(C/T)GTGGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SCARB1 Gene

Variant ID Type Subtype PubMed ID
nsv899595 CNV Loss 21882294
nsv52719 CNV Loss 16902084
esv1953401 CNV Deletion 18987734
esv2746550 CNV Deletion 23290073
esv2665124 CNV Deletion 23128226

Relevant External Links for SCARB1 Gene

HapMap Linkage Disequilibrium report
SCARB1
Human Gene Mutation Database (HGMD)
SCARB1

Disorders for SCARB1 Gene

(1) OMIM Diseases for SCARB1 Gene (601040)

(3) University of Copenhagen DISEASES for SCARB1 Gene

(30) Novoseek inferred disease relationships for SCARB1 Gene

Disease -log(P) Hits PubMed IDs
cetp deficiency 70.5 1
atherosclerosis 70.4 44
hyperalphalipoproteinemia 69.1 1
hepatitis c 45.3 8
atherosclerotic plaque 44.2 8

Relevant External Links for SCARB1

Genetic Association Database (GAD)
SCARB1
Human Genome Epidemiology (HuGE) Navigator
SCARB1
genes like me logo Genes that share disorders with SCARB1: view

No data available for UniProtKB/Swiss-Prot for SCARB1 Gene

Publications for SCARB1 Gene

  1. Identification, primary structure and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. (PMID: 7689561) Calvo D. … Vega M. (J. Biol. Chem. 1993) 2 3 4 23
  2. Relationship of genetic variation in genes encoding apolipoprotein A-IV, scavenger receptor BI, HMG-CoA reductase, CETP and apolipoprotein E with cholesterol metabolism and the response to plant stanol ester consumption. (PMID: 11952809) Plat J. … Mensink R.P. (Eur. J. Clin. Invest. 2002) 3 23 49
  3. Molecular genetic analysis of familial hypercholesterolemia: spectrum and regional difference of LDL receptor gene mutations in Japanese population. (PMID: 12417285) Yu W. … Mabuchi H. (Atherosclerosis 2002) 3 23 49
  4. Association between HaeIII polymorphism of scavenger receptor class B type I gene and plasma HDL-cholesterol concentration. (PMID: 12227853) Hong S.H. … Kim J.Q. (Ann. Clin. Biochem. 2002) 3 23 49
  5. Genetic variation at the scavenger receptor class B type I gene locus determines plasma lipoprotein concentrations and particle size and interacts with type 2 diabetes: the framingham study. (PMID: 12788901) Osgood D. … Ordovas J.M. (J. Clin. Endocrinol. Metab. 2003) 3 23 49

Products for SCARB1 Gene

Sources for SCARB1 Gene

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