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Aliases for PIGB Gene

Aliases for PIGB Gene

  • Phosphatidylinositol Glycan Anchor Biosynthesis, Class B 2 3
  • Phosphatidylinositol-Glycan Biosynthesis Class B Protein 3 4
  • Dol-P-Man Dependent GPI Mannosyltransferase 2 3
  • Phosphatidylinositol Glycan, Class B 2 3
  • GPI Mannosyltransferase III 3 4
  • GPI Mannosyltransferase 3 2 3
  • GPI-MT-III 3 4
  • PIG-B 3 4
  • EC 2.4.1.- 4
  • EC 2.4.1 63

External Ids for PIGB Gene

Previous GeneCards Identifiers for PIGB Gene

  • GC15P051169
  • GC15P048658
  • GC15P053190
  • GC15P053327
  • GC15P053398
  • GC15P055611
  • GC15P032437

Summaries for PIGB Gene

Entrez Gene Summary for PIGB Gene

  • This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIGB Gene

PIGB (Phosphatidylinositol Glycan Anchor Biosynthesis, Class B) is a Protein Coding gene. Diseases associated with PIGB include griscelli syndrome. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include mannosyltransferase activity.

UniProtKB/Swiss-Prot for PIGB Gene

  • Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.

Gene Wiki entry for PIGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIGB Gene

Genomics for PIGB Gene

Regulatory Elements for PIGB Gene

Genomic Location for PIGB Gene

55,318,935 bp from pter
55,355,708 bp from pter
36,774 bases
Plus strand

Genomic View for PIGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIGB Gene

Proteins for PIGB Gene

  • Protein details for PIGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GPI mannosyltransferase 3
    Protein Accession:
    Secondary Accessions:
    • Q53FF9
    • Q8WVN7

    Protein attributes for PIGB Gene

    554 amino acids
    Molecular mass:
    65056 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIGB Gene

Proteomics data for PIGB Gene at MOPED

Selected DME Specific Peptides for PIGB Gene

Post-translational modifications for PIGB Gene

  • Glycosylation at Asn26 and Asn427
  • Modification sites at PhosphoSitePlus

Other Protein References for PIGB Gene

Domains for PIGB Gene

Gene Families for PIGB Gene

  • DOLPM :Dolichyl D-mannosyl phosphate dependent mannosyltransferases
  • PIG :Phosphatidylinositol glycan anchor biosynthesis

Protein Domains for PIGB Gene

Suggested Antigen Peptide Sequences for PIGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92521
  • Belongs to the glycosyltransferase 22 family. PIGB subfamily.
genes like me logo Genes that share domains with PIGB: view

Function for PIGB Gene

Molecular function for PIGB Gene

GENATLAS Biochemistry: glycosyl-phosphatidylinositol (GPI) anchor synthesis,class B
UniProtKB/Swiss-Prot Function: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.

Enzyme Numbers (IUBMB) for PIGB Gene

Gene Ontology (GO) - Molecular Function for PIGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IDA 8861954
GO:0016757 transferase activity, transferring glycosyl groups --
genes like me logo Genes that share ontologies with PIGB: view

miRNA for PIGB Gene

miRTarBase miRNAs that target PIGB

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PIGB Gene

Localization for PIGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIGB Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PIGB Gene COMPARTMENTS Subcellular localization image for PIGB gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 3
plasma membrane 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PIGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane NAS 8861954
genes like me logo Genes that share ontologies with PIGB: view

Pathways for PIGB Gene

genes like me logo Genes that share pathways with PIGB: view

UniProtKB/Swiss-Prot Q92521-PIGB_HUMAN

  • Pathway: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis

Gene Ontology (GO) - Biological Process for PIGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process IDA 8861954
GO:0008152 metabolic process --
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with PIGB: view

Compounds for PIGB Gene

(898) HMDB Compounds for PIGB Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Hydroxy-2-amino-3-oxo-octadecane
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • Sulfatide (d18:1/12:0)
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • Sulfatide (d18:1/14:0)
Not Available
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • Sulfatide (d18:1/16:0)
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • Sulfatide (d18:1/18:0)
genes like me logo Genes that share compounds with PIGB: view

Transcripts for PIGB Gene

Unigene Clusters for PIGB Gene

Phosphatidylinositol glycan anchor biosynthesis, class B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIGB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: -
SP2: -
SP3: -
SP4: - - - -

Relevant External Links for PIGB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIGB Gene

mRNA expression in normal human tissues for PIGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIGB Gene

SOURCE GeneReport for Unigene cluster for PIGB Gene Hs.612814

genes like me logo Genes that share expressions with PIGB: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIGB Gene

Orthologs for PIGB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIGB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIGB 35
  • 99.58 (n)
  • 99.46 (a)
  • 99 (a)
(Bos Taurus)
Mammalia PIGB 35
  • 89.78 (n)
  • 86.67 (a)
  • 75 (a)
(Canis familiaris)
Mammalia PIGB 35
  • 89.4 (n)
  • 86.88 (a)
  • 88 (a)
(Mus musculus)
Mammalia Pigb 35
  • 78.82 (n)
  • 80.75 (a)
Pigb 16
Pigb 36
  • 79 (a)
(Monodelphis domestica)
Mammalia PIGB 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia PIGB 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Pigb 35
  • 80.48 (n)
  • 81.04 (a)
(Gallus gallus)
Aves PIGB 35
  • 69.83 (n)
  • 70.52 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia PIGB 36
  • 53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10358 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pigb 35
  • 67.51 (n)
  • 67.57 (a)
(Danio rerio)
Actinopterygii pigb 35
  • 58.54 (n)
  • 56.05 (a)
pigb 36
  • 54 (a)
zgc63658 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003792 35
  • 49.86 (n)
  • 47.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12006 35
  • 48.95 (n)
  • 43.25 (a)
CG12006 36
  • 37 (a)
CG12006 37
  • 40 (a)
(Caenorhabditis elegans)
Secernentea T27F7.4 36
  • 33 (a)
T27F7.3a 37
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPI10 36
  • 25 (a)
GPI10 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14850 35
  • 51.39 (n)
  • 42.5 (a)
(Oryza sativa)
Liliopsida Os01g0580100 35
  • 49.56 (n)
  • 42.57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for PIGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIGB Gene

Gene Tree for PIGB (if available)
Gene Tree for PIGB (if available)

Paralogs for PIGB Gene

No data available for Paralogs for PIGB Gene

Variants for PIGB Gene

Sequence variations from dbSNP and Humsavar for PIGB Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs565647 -- 55,334,112(+) TGTCA(A/G)TGAGA intron-variant
rs569333 -- 55,333,735(-) GTTTT(G/T)TTTGA intron-variant
rs574923 -- 55,339,671(-) TTTTT(C/T)GGACT intron-variant
rs582350 -- 55,344,245(+) TGGGT(A/G)GATAG intron-variant
rs585345 -- 55,341,563(+) ATATC(A/G)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIGB Gene

Variant ID Type Subtype PubMed ID
esv267383 CNV Insertion 20981092
nsv904243 CNV Loss 21882294
nsv520799 CNV Loss 19592680

Relevant External Links for PIGB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIGB Gene

Disorders for PIGB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PIGB Gene including...

Search for PIGB Gene in MalaCards »

Relevant External Links for PIGB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PIGB: view

No data available for UniProtKB/Swiss-Prot for PIGB Gene

Publications for PIGB Gene

  1. PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor. (PMID: 8861954) Takahashi M. … Kinoshita T. (EMBO J. 1996) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1- murine lymphoma mutants. (PMID: 7907094) Mohney R.P. … Medof M.E. (J. Biol. Chem. 1994) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for PIGB Gene

Sources for PIGB Gene

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