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Aliases for CD36 Gene

Aliases for CD36 Gene

  • CD36 Molecule (Thrombospondin Receptor) 2 3
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor) 2 3
  • Leukocyte Differentiation Antigen CD36 3 4
  • Platelet Glycoprotein IV 3 4
  • Fatty Acid Translocase 3 4
  • Glycoprotein IIIb 3 4
  • PAS IV 3 4
  • GPIIIB 3 4
  • GP3B 3 4
  • GPIV 3 4
  • FAT 3 4
  • GP4 3 4
  • Scavenger Receptor Class B, Member 3 3
  • Platelet Collagen Receptor 4
  • Thrombospondin Receptor 4
  • Cluster Determinant 36 3
  • PAS-4 Protein 3
  • CD36 Antigen 4
  • BDPLT10 3
  • SCARB3 3
  • CHDS7 3
  • PASIV 3
  • PAS-4 4

External Ids for CD36 Gene

Previous GeneCards Identifiers for CD36 Gene

  • GC07P078803
  • GC07P078534
  • GC07P079829
  • GC07P079880
  • GC07P079887
  • GC07P079876
  • GC07P080069
  • GC07P074834

Summaries for CD36 Gene

Entrez Gene Summary for CD36 Gene

  • The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CD36 Gene

CD36 (CD36 Molecule (Thrombospondin Receptor)) is a Protein Coding gene. Diseases associated with CD36 include malaria and platelet glycoprotein iv deficiency. Among its related pathways are Immune System and Developmental Biology. GO annotations related to this gene include lipid binding and low-density lipoprotein particle binding. An important paralog of this gene is SCARB1.

UniProtKB/Swiss-Prot for CD36 Gene

  • Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Gene Wiki entry for CD36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD36 Gene

Genomics for CD36 Gene

Regulatory Elements for CD36 Gene

Genomic Location for CD36 Gene

Chromosome:
7
Start:
80,369,575 bp from pter
End:
80,679,277 bp from pter
Size:
309,703 bases
Orientation:
Plus strand

Genomic View for CD36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD36 Gene

Proteins for CD36 Gene

  • Protein details for CD36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16671-CD36_HUMAN
    Recommended name:
    Platelet glycoprotein 4
    Protein Accession:
    P16671
    Secondary Accessions:
    • D9IX66
    • D9IX67
    • D9IX68
    • D9IX69
    • Q13966
    • Q16093
    • Q8TCV7
    • Q9BPZ8
    • Q9BQC2
    • Q9BZM8
    • Q9BZN3
    • Q9BZN4
    • Q9BZN5

    Protein attributes for CD36 Gene

    Size:
    472 amino acids
    Molecular mass:
    53053 Da
    Quaternary structure:
    • Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4-TLR6 heterodimerization and signal initiation.
    SequenceCaution:
    • Sequence=AAM14636.2; Type=Frameshift; Positions=53; Evidence={ECO:0000305};

    Alternative splice isoforms for CD36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD36 Gene

Proteomics data for CD36 Gene at MOPED

Post-translational modifications for CD36 Gene

  • N-glycosylated and O-glycosylated with a ratio of 2:1.
  • Glycosylation at Asn 79, Asn 102, Asn 134, Asn 163, Asn 205, Asn 220, Asn 235, Asn 247, Asn 321, and Asn 417
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD36 (CD36)

No data available for DME Specific Peptides for CD36 Gene

Domains & Families for CD36 Gene

Gene Families for CD36 Gene

Protein Domains for CD36 Gene

Graphical View of Domain Structure for InterPro Entry

P16671

UniProtKB/Swiss-Prot:

CD36_HUMAN :
  • Belongs to the CD36 family.
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with CD36: view

Function for CD36 Gene

Molecular function for CD36 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD36 (platelet GPIV),85kDa,adhesive cell surface,single glycoprotein,identified by monoclonal antibodies TP85,SMO,ESIVC7,5F1,CD38,expressed in various epithelial and endothelial cells and in erythrocytes
UniProtKB/Swiss-Prot Function:
Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Gene Ontology (GO) - Molecular Function for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity TAS 9568716
GO:0005515 protein binding --
GO:0008035 high-density lipoprotein particle binding IEA --
GO:0008289 lipid binding IDA 10772654
GO:0030169 low-density lipoprotein particle binding IDA 10772654
genes like me logo Genes that share ontologies with CD36: view
genes like me logo Genes that share phenotypes with CD36: view

Animal Models for CD36 Gene

MGI Knock Outs for CD36:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD36

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD36 Gene

Localization for CD36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD36 Gene

Cell membrane; Multi-pass membrane protein. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD36 Gene COMPARTMENTS Subcellular localization image for CD36 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 2
peroxisome 2
cytoskeleton 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9568716
genes like me logo Genes that share ontologies with CD36: view

Pathways & Interactions for CD36 Gene

genes like me logo Genes that share pathways with CD36: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 17416590
GO:0002221 pattern recognition receptor signaling pathway --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with CD36: view

No data available for SIGNOR curated interactions for CD36 Gene

Drugs & Compounds for CD36 Gene

(60) Drugs for CD36 Gene - From: NovoSeek, ClinicalTrials, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Alendronate Approved Pharma Inhibition, Inhibitor Bone resorption inhibitor, Osteoclast function modifiers (important in bone metastasis) 153
Budesonide Approved Pharma Anti-inflammatory corticosteroid 368
Calcium carbonate Approved Pharma 185
Captopril Approved Pharma Inhibition, Inhibitor ACE inhibitor, ACE inhibitor; also inhibits LTA4 hydrolase 28

(63) Additional Compounds for CD36 Gene - From: NovoSeek and HMDB