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Aliases for CD36 Gene

Aliases for CD36 Gene

  • CD36 Molecule (Thrombospondin Receptor) 2 3
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor) 2 3
  • Leukocyte Differentiation Antigen CD36 3 4
  • Platelet Glycoprotein IV 3 4
  • Fatty Acid Translocase 3 4
  • Glycoprotein IIIb 3 4
  • BDPLT10 3 6
  • PAS IV 3 4
  • GPIIIB 3 4
  • CHDS7 3 6
  • GP3B 3 4
  • GPIV 3 4
  • FAT 3 4
  • GP4 3 4
  • Scavenger Receptor Class B, Member 3 3
  • Platelet Collagen Receptor 4
  • Platelet Glycoprotein 4 3
  • Thrombospondin Receptor 4
  • Cluster Determinant 36 3
  • PAS-4 Protein 3
  • CD36 Antigen 4
  • SCARB3 3
  • PASIV 3
  • PAS-4 4

External Ids for CD36 Gene

Previous GeneCards Identifiers for CD36 Gene

  • GC07P078803
  • GC07P078534
  • GC07P079829
  • GC07P079880
  • GC07P079887
  • GC07P079876
  • GC07P080069
  • GC07P074834

Summaries for CD36 Gene

Entrez Gene Summary for CD36 Gene

  • The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]

GeneCards Summary for CD36 Gene

CD36 (CD36 Molecule (Thrombospondin Receptor)) is a Protein Coding gene. Diseases associated with CD36 include platelet glycoprotein iv deficiency and coronary heart disease 7. Among its related pathways are Class I MHC mediated antigen processing and presentation and L1CAM interactions. GO annotations related to this gene include lipid binding and transforming growth factor beta binding. An important paralog of this gene is SCARB1.

UniProtKB/Swiss-Prot for CD36 Gene

  • Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Gene Wiki entry for CD36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD36 Gene

Genomics for CD36 Gene

Regulatory Elements for CD36 Gene

Genomic Location for CD36 Gene

Start:
80,369,575 bp from pter
End:
80,679,277 bp from pter
Size:
309,703 bases
Orientation:
Plus strand

Genomic View for CD36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD36 Gene

Proteins for CD36 Gene

  • Protein details for CD36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16671-CD36_HUMAN
    Recommended name:
    Platelet glycoprotein 4
    Protein Accession:
    P16671
    Secondary Accessions:
    • D9IX66
    • D9IX67
    • D9IX68
    • D9IX69
    • Q13966
    • Q16093
    • Q8TCV7
    • Q9BPZ8
    • Q9BQC2
    • Q9BZM8
    • Q9BZN3
    • Q9BZN4
    • Q9BZN5

    Protein attributes for CD36 Gene

    Size:
    472 amino acids
    Molecular mass:
    53053 Da
    Quaternary structure:
    • Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4-TLR6 heterodimerization and signal initiation.
    SequenceCaution:
    • Sequence=AAM14636.2; Type=Frameshift; Positions=53; Evidence={ECO:0000305};

    Alternative splice isoforms for CD36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD36 Gene

Proteomics data for CD36 Gene at MOPED

Post-translational modifications for CD36 Gene

  • N-glycosylated and O-glycosylated with a ratio of 2:1.
  • Glycosylation at Asn79, Asn102, Asn134, Asn163, Asn205, Asn220, Asn235, Asn247, Asn321, and Asn417
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD36 Gene

Domains for CD36 Gene

Gene Families for CD36 Gene

HGNC:
  • CD :CD molecules

Protein Domains for CD36 Gene

Graphical View of Domain Structure for InterPro Entry

P16671

UniProtKB/Swiss-Prot:

CD36_HUMAN :
  • P16671
Family:
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with CD36: view

Function for CD36 Gene

Molecular function for CD36 Gene

GENATLAS Biochemistry: cell differentiation antigen CD36 (platelet GPIV),85kDa,adhesive cell surface,single glycoprotein,identified by monoclonal antibodies TP85,SMO,ESIVC7,5F1,CD38,expressed in various epithelial and endothelial cells and in erythrocytes
UniProtKB/Swiss-Prot Function: Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Gene Ontology (GO) - Molecular Function for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity TAS 9568716
GO:0005515 protein binding --
GO:0008035 high-density lipoprotein particle binding IEA --
GO:0008289 lipid binding IDA 10772654
GO:0030169 low-density lipoprotein particle binding IDA 10772654
genes like me logo Genes that share ontologies with CD36: view
genes like me logo Genes that share phenotypes with CD36: view

Animal Models for CD36 Gene

MGI Knock Outs for CD36:

miRNA for CD36 Gene

miRTarBase miRNAs that target CD36

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD36 Gene

Localization for CD36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD36 Gene

Cell membrane; Multi-pass membrane protein. Note=Upon ligand-binding, internalized through dynamin-dependent endocytosis. {ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD36 Gene COMPARTMENTS Subcellular localization image for CD36 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytoskeleton 2
golgi apparatus 2
mitochondrion 2
nucleus 2
peroxisome 2
cytosol 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9568716
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CD36: view

Pathways for CD36 Gene

genes like me logo Genes that share pathways with CD36: view

Gene Ontology (GO) - Biological Process for CD36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001954 positive regulation of cell-matrix adhesion IDA 17416590
GO:0002221 pattern recognition receptor signaling pathway --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
genes like me logo Genes that share ontologies with CD36: view

Compounds for CD36 Gene

(119) Novoseek inferred chemical compound relationships for CD36 Gene

Compound -log(P) Hits PubMed IDs
pyridinoline 89.2 127
procollagen 88.8 122
deoxypyridinoline 87.5 109
hydroxyproline 78 86
matrigel 75.1 135
genes like me logo Genes that share compounds with CD36: view

Transcripts for CD36 Gene

Unigene Clusters for CD36 Gene

CD36 molecule (thrombospondin receptor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD36 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c · 14d ·
SP1: - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - -
SP13: -
SP14:
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - - - - - -
SP18: - - - - - - - -
SP19: -
SP20:

ExUns: 14e · 14f ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c ^ 25
SP1: - - -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: - - - -
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:

Relevant External Links for CD36 Gene

GeneLoc Exon Structure for
CD36
ECgene alternative splicing isoforms for
CD36

Expression for CD36 Gene

mRNA expression in normal human tissues for CD36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD36 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (11.0), Adipose - Subcutaneous (9.6), Heart - Left Ventricle (8.8), and Breast - Mammary Tissue (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD36 Gene

SOURCE GeneReport for Unigene cluster for CD36 Gene Hs.120949

genes like me logo Genes that share expressions with CD36: view

No data available for mRNA Expression by UniProt/SwissProt for CD36 Gene

Orthologs for CD36 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD36 35
  • 99.65 (n)
  • 99.36 (a)
CD36 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
CD36 35
  • 86.98 (n)
  • 83.01 (a)
CD36 36
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CD36 35
  • 86.35 (n)
  • 83.01 (a)
CD36 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd36 35
  • 83.83 (n)
  • 84.11 (a)
Cd36 16
Cd36 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD36 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD36 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd36 35
  • 83.33 (n)
  • 86.44 (a)
chicken
(Gallus gallus)
Aves CD36 35
  • 65.53 (n)
  • 61.36 (a)
CD36 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD36 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd36 35
  • 63.08 (n)
  • 55.91 (a)
zebrafish
(Danio rerio)
Actinopterygii cd36 35
  • 60.07 (n)
  • 53.85 (a)
cd36 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Snmp2 36
  • 24 (a)
OneToMany
CG7227 37
  • 26 (a)
CG3829 37
  • 27 (a)
BEST:CK01577 37
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea scav-1 36
  • 24 (a)
ManyToMany
scav-2 35
  • 45.03 (n)
  • 34.4 (a)
scav-2 36
  • 24 (a)
ManyToMany
Y76A2B.6 37
  • 28 (a)
C03F11.3 37
  • 24 (a)
Species with no ortholog for CD36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD36 Gene

ENSEMBL:
Gene Tree for CD36 (if available)
TreeFam:
Gene Tree for CD36 (if available)

Paralogs for CD36 Gene

Paralogs for CD36 Gene

genes like me logo Genes that share paralogs with CD36: view

Variants for CD36 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CD36 Gene

P16671-CD36_HUMAN
Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIM:611162]

Sequence variations from dbSNP and Humsavar for CD36 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1924 -- 80,662,082(-) TGTTT(C/T)CGTTT intron-variant
rs5956 -- 80,663,133(+) GTTCC(A/G)TACCC synonymous-codon, reference, intron-variant, nc-transcript-variant
rs5957 - 80,663,020(+) AATTT(G/T)TTCAA reference, missense, intron-variant, nc-transcript-variant
rs7755 -- 80,676,955(+) TTGCT(A/G)TCATA utr-variant-3-prime
rs8956 -- 80,674,373(+) TGACC(A/G)TTGTA utr-variant-3-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CD36 Gene

Variant ID Type Subtype PubMed ID
nsv888512 CNV Loss 21882294
nsv888524 CNV Gain 21882294
nsv831043 CNV Loss 17160897
nsv888525 CNV Loss 21882294
nsv464606 CNV Gain 19166990
nsv525704 CNV Loss 19592680
nsv888526 CNV Loss 21882294
dgv7350n71 CNV Loss 21882294
nsv888529 CNV Loss 21882294
dgv7351n71 CNV Loss 21882294
nsv464607 CNV Loss 19166990
nsv888533 CNV Loss 21882294
nsv888534 CNV Loss 21882294
nsv888535 CNV Loss 21882294
nsv888536 CNV Gain 21882294
nsv888537 CNV Loss 21882294
nsv888538 CNV Gain+Loss 21882294
dgv7352n71 CNV Loss 21882294
dgv7353n71 CNV Gain+Loss 21882294
nsv888542 CNV Loss 21882294
nsv888547 CNV Gain 21882294

Relevant External Links for CD36 Gene

HapMap Linkage Disequilibrium report
CD36
Human Gene Mutation Database (HGMD)
CD36

Disorders for CD36 Gene

(3) OMIM Diseases for CD36 Gene (173510)

UniProtKB/Swiss-Prot

CD36_HUMAN
  • Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. {ECO:0000269 PubMed:11950861, ECO:0000269 PubMed:7533783}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269 PubMed:15282206}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for CD36 Gene

(95) Novoseek inferred disease relationships for CD36 Gene

Disease -log(P) Hits PubMed IDs
osteogenesis imperfecta 89.4 114
collagen fibril 87.1 127
oi, type i 81.9 19
osteogenesis imperfecta, type ii 80.3 6
oi, type iii 78.9 14

Genatlas disease for CD36 Gene

platelet CD36 deficiency,type I,with no expression at cell surface

Relevant External Links for CD36

Genetic Association Database (GAD)
CD36
Human Genome Epidemiology (HuGE) Navigator
CD36
genes like me logo Genes that share disorders with CD36: view

Publications for CD36 Gene

  1. CD36 polymorphism is associated with protection from cerebral malaria. (PMID: 12506336) Omi K. … Tokunaga K. (Am. J. Hum. Genet. 2003) 3 4 23 48
  2. Increased risk of colorectal cancer due to interactions between meat consumption and the CD36 gene A52C polymorphism among Japanese. (PMID: 15860439) Kuriki K. … Tajima K. (Nutr Cancer 2005) 3 23 48
  3. Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India. (PMID: 19055786) Sinha S. … Habib S. (Malar. J. 2008) 3 23 48
  4. Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. (PMID: 7503937) Fernandez-Ruiz E. … Vega M.A. (Genomics 1993) 2 3 4
  5. A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. (PMID: 15282206) Ma X. … Doria A. (Hum. Mol. Genet. 2004) 3 4 48

Products for CD36 Gene

Sources for CD36 Gene

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