Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PCYT1B Gene

Aliases for PCYT1B Gene

  • Phosphate Cytidylyltransferase 1, Choline, Beta 2 3
  • CTP:Phosphocholine Cytidylyltransferase B 3 4
  • Phosphorylcholine Transferase B 3 4
  • EC 2.7.7.15 4 63
  • CCT-Beta 3 4
  • CCT B 3 4
  • CT B 3 4
  • CCTB 3 4
  • Phosphate Cytidylyltransferase 1, Choline, Beta Isoform 2
  • EC 2.7.7 63
  • CTB 3

External Ids for PCYT1B Gene

Previous GeneCards Identifiers for PCYT1B Gene

  • GC0XM023407
  • GC0XM023238
  • GC0XM023778
  • GC0XM023941
  • GC0XM024339
  • GC0XM024486
  • GC0XM022318

Summaries for PCYT1B Gene

Entrez Gene Summary for PCYT1B Gene

  • The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for PCYT1B Gene

PCYT1B (Phosphate Cytidylyltransferase 1, Choline, Beta) is a Protein Coding gene. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include choline-phosphate cytidylyltransferase activity. An important paralog of this gene is PCYT1A.

UniProtKB/Swiss-Prot for PCYT1B Gene

  • Controls phosphatidylcholine synthesis

Gene Wiki entry for PCYT1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCYT1B Gene

Genomics for PCYT1B Gene

Regulatory Elements for PCYT1B Gene

Genomic Location for PCYT1B Gene

Chromosome:
X
Start:
24,558,087 bp from pter
End:
24,672,862 bp from pter
Size:
114,776 bases
Orientation:
Minus strand

Genomic View for PCYT1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCYT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCYT1B Gene

Proteins for PCYT1B Gene

  • Protein details for PCYT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5K3-PCY1B_HUMAN
    Recommended name:
    Choline-phosphate cytidylyltransferase B
    Protein Accession:
    Q9Y5K3
    Secondary Accessions:
    • A8IX00
    • B2RCX8
    • B4DK10
    • E9PD84
    • O60621
    • Q86XC9

    Protein attributes for PCYT1B Gene

    Size:
    369 amino acids
    Molecular mass:
    41940 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCYT1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCYT1B Gene

Proteomics data for PCYT1B Gene at MOPED

Selected DME Specific Peptides for PCYT1B Gene

Post-translational modifications for PCYT1B Gene

  • Extensively phosphorylated. The beta-1 isoform seems to be much less phosphorylated
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCYT1B Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PCYT1B

Domains & Families for PCYT1B Gene

Protein Domains for PCYT1B Gene

Suggested Antigen Peptide Sequences for PCYT1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5K3

UniProtKB/Swiss-Prot:

PCY1B_HUMAN :
  • Belongs to the cytidylyltransferase family.
Family:
  • Belongs to the cytidylyltransferase family.
genes like me logo Genes that share domains with PCYT1B: view

No data available for Gene Families for PCYT1B Gene

Function for PCYT1B Gene

Molecular function for PCYT1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CTP + phosphocholine = diphosphate + CDP-choline
UniProtKB/Swiss-Prot Function:
Controls phosphatidylcholine synthesis

Enzyme Numbers (IUBMB) for PCYT1B Gene

Gene Ontology (GO) - Molecular Function for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004105 choline-phosphate cytidylyltransferase activity IEA --
genes like me logo Genes that share ontologies with PCYT1B: view
genes like me logo Genes that share phenotypes with PCYT1B: view

Animal Models for PCYT1B Gene

MGI Knock Outs for PCYT1B:

Animal Model Products

CRISPR Products

miRNA for PCYT1B Gene

miRTarBase miRNAs that target PCYT1B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCYT1B

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PCYT1B Gene

Localization for PCYT1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCYT1B Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCYT1B Gene COMPARTMENTS Subcellular localization image for PCYT1B gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9593753
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PCYT1B: view

Pathways & Interactions for PCYT1B Gene

genes like me logo Genes that share pathways with PCYT1B: view

Pathways by source for PCYT1B Gene

UniProtKB/Swiss-Prot Q9Y5K3-PCY1B_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2

Gene Ontology (GO) - Biological Process for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway TAS 9593753
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with PCYT1B: view

No data available for SIGNOR curated interactions for PCYT1B Gene

Drugs & Compounds for PCYT1B Gene

(4) Drugs for PCYT1B Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Target, product of 122
Cytidine triphosphate Experimental Pharma 0
Diphosphate Experimental Pharma 0
Phosphocholine Experimental Pharma 0

(6) Additional Compounds for PCYT1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Citicoline
  • Audes
  • CDP-Choline
  • Cereb
  • Choline 5'-cytidine diphosphate
  • Choline cytidine diphosphate
987-78-0
CMP-N-trimethyl-2-aminoethylphosphonate
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7, 63-89-8
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
genes like me logo Genes that share compounds with PCYT1B: view

Transcripts for PCYT1B Gene

Unigene Clusters for PCYT1B Gene

Phosphate cytidylyltransferase 1, choline, beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCYT1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCYT1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2:

Relevant External Links for PCYT1B Gene

GeneLoc Exon Structure for
PCYT1B
ECgene alternative splicing isoforms for
PCYT1B

Expression for PCYT1B Gene

mRNA expression in normal human tissues for PCYT1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCYT1B Gene

This gene is overexpressed in Brain - Amygdala (x4.3) and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for PCYT1B Gene

This gene is overexpressed in Synovial fluid (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCYT1B Gene



SOURCE GeneReport for Unigene cluster for PCYT1B Gene Hs.660708

mRNA Expression by UniProt/SwissProt for PCYT1B Gene

Q9Y5K3-PCY1B_HUMAN
Tissue specificity: Highly expressed in testis, placenta, brain, ovary and fetus
genes like me logo Genes that share expression patterns with PCYT1B: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PCYT1B Gene

Orthologs for PCYT1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCYT1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PCYT1B 35
  • 91.78 (n)
  • 96.48 (a)
PCYT1B 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCYT1B 35
  • 92.77 (n)
  • 98.37 (a)
PCYT1B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcyt1b 35
  • 91.24 (n)
  • 98.1 (a)
Pcyt1b 16
Pcyt1b 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pcyt1b 35
  • 91.78 (n)
  • 98.64 (a)
oppossum
(Monodelphis domestica)
Mammalia PCYT1B 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia PCYT1B 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves PCYT1B 35
  • 81.76 (n)
  • 93.92 (a)
PCYT1B 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCYT1B 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcyt1b 35
  • 78.14 (n)
  • 86.61 (a)
zebrafish
(Danio rerio)
Actinopterygii pcyt1ba 35
  • 74.15 (n)
  • 83.67 (a)
pcyt1ba 36
  • 82 (a)
OneToMany
pcyt1bb 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cct1 37
  • 55 (a)
Cct2 37
  • 55 (a)
Cct1 36
  • 32 (a)
ManyToMany
Cct2 36
  • 45 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F08C6.2 37
  • 50 (a)
F28A10.10 37
  • 46 (a)
F28A10.10 36
  • 49 (a)
ManyToMany
pcyt-1 36
  • 38 (a)
ManyToMany
Y18H1A.11 36
  • 46 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PCT1 36
  • 31 (a)
OneToMany
PCT1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2898 35
barley
(Hordeum vulgare)
Liliopsida Hv.5080 35
rice
(Oryza sativa)
Liliopsida Os08g0161800 35
  • 57.73 (n)
  • 55.91 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9635 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7625 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9202 36
  • 55 (a)
OneToMany
Species with no ortholog for PCYT1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PCYT1B Gene

ENSEMBL:
Gene Tree for PCYT1B (if available)
TreeFam:
Gene Tree for PCYT1B (if available)

Paralogs for PCYT1B Gene

Paralogs for PCYT1B Gene

(1) SIMAP similar genes for PCYT1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PCYT1B: view

Variants for PCYT1B Gene

Sequence variations from dbSNP and Humsavar for PCYT1B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs714522 -- 24,668,422(-) TCAAA(A/C/T)GGAAA intron-variant
rs718676 -- 24,641,775(+) ttaac(C/T)tttaa intron-variant
rs984059 -- 24,605,236(+) AGATA(C/T)ACAAA intron-variant
rs1133910 -- 24,562,466(-) TGCAG(G/T)CCTTA reference, missense
rs1207649 -- 24,673,851(+) GGTTA(C/T)TTTGC upstream-variant-2KB

Variation tolerance for PCYT1B Gene

Residual Variation Intolerance Score: 49.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PCYT1B Gene

HapMap Linkage Disequilibrium report
PCYT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PCYT1B Gene

Disorders for PCYT1B Gene

Relevant External Links for PCYT1B

Genetic Association Database (GAD)
PCYT1B
Human Genome Epidemiology (HuGE) Navigator
PCYT1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PCYT1B
genes like me logo Genes that share disorders with PCYT1B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCYT1B Gene

Publications for PCYT1B Gene

  1. Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. (PMID: 9593753) Lykidis A. … Jackowski S. (J. Biol. Chem. 1998) 2 23 67
  2. Sp1 is a co-activator with Ets-1, and Net is an important repressor of the transcription of CTP:phosphocholine cytidylyltransferase alpha. (PMID: 16157598) Sugimoto H. … Izumi T. (J. Biol. Chem. 2005) 23 67
  3. Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. (PMID: 10480912) Lykidis A. … Jackowski S. (J. Biol. Chem. 1999) 23 67
  4. Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia. (PMID: 25452470) Parchim N.F. … Xia Y. (Hypertension 2015) 67
  5. Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. (PMID: 21163940) Soler-LA^pez M. … Aloy P. (Genome Res. 2011) 67

Products for PCYT1B Gene

Sources for PCYT1B Gene

Back to Top

Content