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Aliases for PCYT1B Gene

Aliases for PCYT1B Gene

  • Phosphate Cytidylyltransferase 1, Choline, Beta 2 3
  • CTP:Phosphocholine Cytidylyltransferase B 3 4
  • Phosphorylcholine Transferase B 3 4
  • EC 2.7.7.15 4 64
  • CCT-Beta 3 4
  • CCT B 3 4
  • CT B 3 4
  • CCTB 3 4
  • Phosphate Cytidylyltransferase 1, Choline, Beta Isoform 2
  • Choline-Phosphate Cytidylyltransferase B 3
  • EC 2.7.7 64
  • CTB 3

External Ids for PCYT1B Gene

Summaries for PCYT1B Gene

Entrez Gene Summary for PCYT1B Gene

  • The protein encoded by this gene belongs to the cytidylyltransferase family. It is involved in the regulation of phosphatidylcholine biosynthesis. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for PCYT1B Gene

PCYT1B (Phosphate Cytidylyltransferase 1, Choline, Beta) is a Protein Coding gene. Diseases associated with PCYT1B include periventricular nodular heterotopia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include choline-phosphate cytidylyltransferase activity. An important paralog of this gene is PCYT1A.

UniProtKB/Swiss-Prot for PCYT1B Gene

  • Controls phosphatidylcholine synthesis

Gene Wiki entry for PCYT1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCYT1B Gene

Genomics for PCYT1B Gene

Genomic Location for PCYT1B Gene

Start:
24,558,087 bp from pter
End:
24,672,862 bp from pter
Size:
114,776 bases
Orientation:
Minus strand

Genomic View for PCYT1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCYT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCYT1B Gene

Regulatory Elements for PCYT1B Gene

Proteins for PCYT1B Gene

  • Protein details for PCYT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5K3-PCY1B_HUMAN
    Recommended name:
    Choline-phosphate cytidylyltransferase B
    Protein Accession:
    Q9Y5K3
    Secondary Accessions:
    • A8IX00
    • B2RCX8
    • B4DK10
    • E9PD84
    • O60621
    • Q86XC9

    Protein attributes for PCYT1B Gene

    Size:
    369 amino acids
    Molecular mass:
    41940 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCYT1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PCYT1B Gene

Proteomics data for PCYT1B Gene at MOPED

Selected DME Specific Peptides for PCYT1B Gene

Post-translational modifications for PCYT1B Gene

  • Extensively phosphorylated. The beta-1 isoform seems to be much less phosphorylated
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PCYT1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PCYT1B Gene

Protein Domains for PCYT1B Gene

UniProtKB/Swiss-Prot:

PCY1B_HUMAN
Family:
  • Belongs to the cytidylyltransferase family.:
    • Q9Y5K3
genes like me logo Genes that share domains with PCYT1B: view

No data available for Gene Families for PCYT1B Gene

Function for PCYT1B Gene

Molecular function for PCYT1B Gene

UniProtKB/Swiss-Prot CatalyticActivity: CTP + phosphocholine = diphosphate + CDP-choline
UniProtKB/Swiss-Prot Function: Controls phosphatidylcholine synthesis

Enzyme Numbers (IUBMB) for PCYT1B Gene

Gene Ontology (GO) - Molecular Function for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004105 choline-phosphate cytidylyltransferase activity IEA --
genes like me logo Genes that share ontologies with PCYT1B: view
genes like me logo Genes that share phenotypes with PCYT1B: view

Animal Models for PCYT1B Gene

MGI Knock Outs for PCYT1B:

miRNA for PCYT1B Gene

miRTarBase miRNAs that target PCYT1B

No data available for Transcription Factor Targeting and HOMER Transcription for PCYT1B Gene

Localization for PCYT1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCYT1B Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PCYT1B Gene COMPARTMENTS Subcellular localization image for PCYT1B gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9593753
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with PCYT1B: view

Pathways for PCYT1B Gene

genes like me logo Genes that share pathways with PCYT1B: view

Pathways by source for PCYT1B Gene

UniProtKB/Swiss-Prot Q9Y5K3-PCY1B_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2

Gene Ontology (GO) - Biological Process for PCYT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway TAS 9593753
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with PCYT1B: view

Compounds for PCYT1B Gene

(1081) HMDB Compounds for PCYT1B Gene

Compound Synonyms Cas Number PubMed IDs
Choline
  • (2-Hydroxyethyl)trimethyl ammonium
62-49-7
Citicoline
  • Audes
987-78-0
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
PC(14:0/14:0)
  • Phosphatidylcholine(14:0/14:0)
Not Available
PC(14:0/14:1(9Z))
  • Phosphatidylcholine(14:0/14:1)
Not Available

(1) Drugbank Compounds for PCYT1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Choline
  • Bilineurine
62-49-7 target product of
genes like me logo Genes that share compounds with PCYT1B: view

Transcripts for PCYT1B Gene

Unigene Clusters for PCYT1B Gene

Phosphate cytidylyltransferase 1, choline, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PCYT1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1:
SP2:

Relevant External Links for PCYT1B Gene

GeneLoc Exon Structure for
PCYT1B
ECgene alternative splicing isoforms for
PCYT1B

Expression for PCYT1B Gene

mRNA expression in normal human tissues for PCYT1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PCYT1B Gene

This gene is overexpressed in Brain - Amygdala (4.3) and Brain - Nucleus accumbens (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCYT1B Gene

SOURCE GeneReport for Unigene cluster for PCYT1B Gene Hs.660708

mRNA Expression by UniProt/SwissProt for PCYT1B Gene

Q9Y5K3-PCY1B_HUMAN
Tissue specificity: Highly expressed in testis, placenta, brain, ovary and fetus
genes like me logo Genes that share expressions with PCYT1B: view

Orthologs for PCYT1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PCYT1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCYT1B 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PCYT1B 36
  • 91.78 (n)
  • 96.48 (a)
PCYT1B 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PCYT1B 36
  • 92.77 (n)
  • 98.37 (a)
PCYT1B 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pcyt1b 36
  • 91.24 (n)
  • 98.1 (a)
Pcyt1b 16
Pcyt1b 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PCYT1B 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 75 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pcyt1b 36
  • 91.78 (n)
  • 98.64 (a)
chicken
(Gallus gallus)
Aves PCYT1B 36
  • 81.76 (n)
  • 93.92 (a)
PCYT1B 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PCYT1B 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pcyt1b 36
  • 78.14 (n)
  • 86.61 (a)
zebrafish
(Danio rerio)
Actinopterygii pcyt1ba 36
  • 74.15 (n)
  • 83.67 (a)
pcyt1ba 37
  • 82 (a)
OneToMany
pcyt1bb 37
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cct1 37
  • 32 (a)
ManyToMany
Cct2 37
  • 45 (a)
ManyToMany
Cct2 38
  • 55 (a)
Cct1 38
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea F28A10.10 37
  • 49 (a)
ManyToMany
pcyt-1 37
  • 38 (a)
ManyToMany
Y18H1A.11 37
  • 46 (a)
ManyToMany
F28A10.10 38
  • 46 (a)
F08C6.2 38
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PCT1 37
  • 31 (a)
OneToMany
PCT1 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2898 36
barley
(Hordeum vulgare)
Liliopsida Hv.5080 36
rice
(Oryza sativa)
Liliopsida Os08g0161800 36
  • 57.73 (n)
  • 55.91 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.9635 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7625 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9202 37
  • 55 (a)
OneToMany
Species with no ortholog for PCYT1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PCYT1B Gene

ENSEMBL:
Gene Tree for PCYT1B (if available)
TreeFam:
Gene Tree for PCYT1B (if available)

Paralogs for PCYT1B Gene

Paralogs for PCYT1B Gene

Selected SIMAP similar genes for PCYT1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PCYT1B: view

Variants for PCYT1B Gene

Sequence variations from dbSNP and Humsavar for PCYT1B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs714522 -- 24,668,422(-) TCAAA(A/T)GGAAA intron-variant
rs718676 -- 24,641,775(+) ttaac(C/T)tttaa intron-variant
rs984059 -- 24,605,236(+) AGATA(C/T)ACAAA intron-variant
rs1133910 -- 24,562,466(-) TGCAG(G/T)CCTTA reference, missense
rs1207649 -- 24,673,851(+) GGTTA(C/T)TTTGC upstream-variant-2KB

Relevant External Links for PCYT1B Gene

HapMap Linkage Disequilibrium report
PCYT1B
Locus Specific Mutation Databases (LSDB)
PCYT1B

No data available for Structural Variations from Database of Genomic Variants (DGV) for PCYT1B Gene

Disorders for PCYT1B Gene

(1) University of Copenhagen DISEASES for PCYT1B Gene

Relevant External Links for PCYT1B

Genetic Association Database (GAD)
PCYT1B
Human Genome Epidemiology (HuGE) Navigator
PCYT1B
genes like me logo Genes that share disorders with PCYT1B: view

No data available for UniProtKB/Swiss-Prot for PCYT1B Gene

Publications for PCYT1B Gene

  1. Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. (PMID: 9593753) Lykidis A. … Jackowski S. (J. Biol. Chem. 1998) 2 3 4 23
  2. Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. (PMID: 10480912) Lykidis A. … Jackowski S. (J. Biol. Chem. 1999) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PCYT1B Gene

Sources for PCYT1B Gene

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