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Aliases for GSTO1 Gene

Aliases for GSTO1 Gene

  • Glutathione S-Transferase Omega 1 2 3 5
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 1-1 3 4
  • S-(Phenacyl)Glutathione Reductase 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • EC 4 58
  • GSTO 1-1 3 4
  • GSTTLp28 3 4
  • SPG-R 3 4
  • Epididymis Secretory Protein Li 21 3
  • Glutathione S-Transferase Omega-1 3
  • Glutathione-S-Transferase Like 3
  • EC 4
  • EC 4
  • HEL-S-21 3
  • GSTO-1 4
  • P28 3

External Ids for GSTO1 Gene

Previous GeneCards Identifiers for GSTO1 Gene

  • GC10P106145
  • GC10P105679
  • GC10P106004
  • GC10P099645

Summaries for GSTO1 Gene

Entrez Gene Summary for GSTO1 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO1 Gene

GSTO1 (Glutathione S-Transferase Omega 1) is a Protein Coding gene. Diseases associated with GSTO1 include Proliferative Type Fibrocystic Change Of Breast and Intracystic Papillary Adenoma. Among its related pathways are Glutathione metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.

UniProtKB/Swiss-Prot for GSTO1 Gene

  • Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Gene Wiki entry for GSTO1 Gene

Additional gene information for GSTO1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTO1 Gene

Genomics for GSTO1 Gene

Regulatory Elements for GSTO1 Gene

Enhancers for GSTO1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H104258 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23.9 +25.1 25056 3 TAL1 JUN FOSL1 TCF12 POLR2A NCOR1 TRIM24 FOS SMARCE1 ZNF362 GSTO2 GSTO1 MIR609 SFR1 SLK CFAP58 ITPRIP MIR4482 GC10M104249
GH10H104249 1.4 ENCODE dbSUPER 16.7 +18.4 18362 7.6 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 GSTO2 ENSG00000260461 GSTO1 PDCD11 CFAP58 CFAP58-AS1 GC10M104249 MIR4482
GH10H104267 1.2 ENCODE dbSUPER 16.6 +33.2 33173 2.8 HDGF PKNOX1 SIN3A ZNF2 BRCA1 ETS1 ZNF143 ZNF207 FOS RUNX3 GSTO2 PDCD11 TAF5 GSTO1 PCGF6 CFAP58 CFAP58-AS1 GC10P104302
GH10H104257 1 Ensembl ENCODE 16.6 +23.0 22961 1 ELF3 FOXA2 SAP130 ARID4B MAX THRB RARA NR2F6 CREM THAP11 GSTO2 GSTO1 GC10M104249 MIR4482
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GSTO1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GSTO1 Gene

Genomic Locations for GSTO1 Gene
32,109 bases
Plus strand

Genomic View for GSTO1 Gene

Genes around GSTO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO1 Gene

Proteins for GSTO1 Gene

  • Protein details for GSTO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutathione S-transferase omega-1
    Protein Accession:
    Secondary Accessions:
    • D3DRA3
    • F5H7H0
    • Q5TA03
    • Q7Z3T2

    Protein attributes for GSTO1 Gene

    241 amino acids
    Molecular mass:
    27566 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSTO1 Gene

    Alternative splice isoforms for GSTO1 Gene


neXtProt entry for GSTO1 Gene

Selected DME Specific Peptides for GSTO1 Gene


Post-translational modifications for GSTO1 Gene

  • Ubiquitination at posLast=1111
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTO1 Gene

Domains & Families for GSTO1 Gene

Gene Families for GSTO1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for GSTO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GST superfamily. Omega family.
  • Belongs to the GST superfamily. Omega family.
genes like me logo Genes that share domains with GSTO1: view

Function for GSTO1 Gene

Molecular function for GSTO1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:11511179, ECO:0000269 PubMed:17226937};
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot CatalyticActivity:
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
UniProtKB/Swiss-Prot CatalyticActivity:
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
UniProtKB/Swiss-Prot Function:
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Enzyme Numbers (IUBMB) for GSTO1 Gene

Phenotypes From GWAS Catalog for GSTO1 Gene

Gene Ontology (GO) - Molecular Function for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0005515 protein binding IPI 25277244
GO:0016491 oxidoreductase activity IEA,IDA 11511179
GO:0016740 transferase activity IEA --
GO:0045174 glutathione dehydrogenase (ascorbate) activity IDA,IEA 11511179
genes like me logo Genes that share ontologies with GSTO1: view
genes like me logo Genes that share phenotypes with GSTO1: view

Animal Model Products

CRISPR Products

miRNA for GSTO1 Gene

miRTarBase miRNAs that target GSTO1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTO1 Gene

Localization for GSTO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTO1 Gene

Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTO1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11511179
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GSTO1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GSTO1 Gene

Pathways & Interactions for GSTO1 Gene

genes like me logo Genes that share pathways with GSTO1: view

Gene Ontology (GO) - Biological Process for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IBA --
GO:0008152 metabolic process IEA --
GO:0009407 toxin catabolic process IBA --
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA 11035031
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC 11035031
genes like me logo Genes that share ontologies with GSTO1: view

No data available for SIGNOR curated interactions for GSTO1 Gene

Drugs & Compounds for GSTO1 Gene

(11) Drugs for GSTO1 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Vitamin E Approved, Vet_approved Nutra Enzyme, inhibitor 428,431
Water Approved Pharma 0
Vitamin C Approved Nutra 560,560
dehydroascorbic acid Experimental Pharma 0

(47) Additional Compounds for GSTO1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(2) ApexBio Compounds for GSTO1 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with GSTO1: view

Drug Products

Transcripts for GSTO1 Gene

Unigene Clusters for GSTO1 Gene

Glutathione S-transferase omega 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - -
SP7: - -

Relevant External Links for GSTO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GSTO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTO1 Gene

Protein differential expression in normal tissues from HIPED for GSTO1 Gene

This gene is overexpressed in Liver, secretome (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTO1 Gene

Protein tissue co-expression partners for GSTO1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTO1 Gene:


SOURCE GeneReport for Unigene cluster for GSTO1 Gene:


mRNA Expression by UniProt/SwissProt for GSTO1 Gene:

Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.

Evidence on tissue expression from TISSUES for GSTO1 Gene

  • Liver(4.6)
  • Eye(4.2)
  • Skin(3.9)
  • Nervous system(3.8)
  • Lung(3.6)
  • Heart(2.7)
  • Muscle(2.7)
  • Kidney(2.4)
  • Blood(2.3)
  • Bone marrow(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with GSTO1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTO1 Gene

Orthologs for GSTO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GSTO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GSTO1 33 34
  • 99.45 (n)
(Canis familiaris)
Mammalia GSTO1 33 34
  • 86.17 (n)
(Bos Taurus)
Mammalia GSTO1 33
  • 85.48 (n)
-- 34
  • 83 (a)
-- 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Gsto1 33
  • 80.08 (n)
(Mus musculus)
Mammalia Gsto1 33 16 34
  • 76.94 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
(Monodelphis domestica)
Mammalia GSTO1 34
  • 68 (a)
(Gallus gallus)
Aves GSTO1 33 34
  • 66.95 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1986 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24164 33
(Danio rerio)
Actinopterygii gsto1 33 34
  • 62.71 (n)
gsto2 34
  • 56 (a)
Dr.16014 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11014 33
fruit fly
(Drosophila melanogaster)
Insecta se 33 34
  • 52.61 (n)
CG6776 34
  • 35 (a)
CG6662 34
  • 31 (a)
CG6673 34
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GSTO1 33
  • 48.27 (n)
(Caenorhabditis elegans)
Secernentea gst-44 33 34
  • 48.38 (n)
C02D5.4 34
  • 33 (a)
gsto-2 34
  • 33 (a)
gsto-1 34
  • 32 (a)
gsto-3 34
  • 24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00549 33
  • 48.43 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3044 34
  • 35 (a)
-- 34
  • 32 (a)
Species where no ortholog for GSTO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTO1 Gene

Gene Tree for GSTO1 (if available)
Gene Tree for GSTO1 (if available)

Paralogs for GSTO1 Gene

Paralogs for GSTO1 Gene

(1) SIMAP similar genes for GSTO1 Gene using alignment to 3 proteins: Pseudogenes for GSTO1 Gene

genes like me logo Genes that share paralogs with GSTO1: view

Variants for GSTO1 Gene

Sequence variations from dbSNP and Humsavar for GSTO1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000117213 -- 104,256,127(+) TTTTC(A/C)CTAAA intron-variant
rs1000490830 -- 104,255,806(+) AGAGG(G/T)AAGTG intron-variant
rs1000711862 -- 104,258,798(+) AGCTG(C/T)GATCA intron-variant
rs1000825968 -- 104,265,893(+) GTTGA(G/T)TGTTT intron-variant, upstream-variant-2KB
rs1000997548 -- 104,264,667(+) GTTAC(A/G)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTO1 Gene

Variant ID Type Subtype PubMed ID
nsv831971 CNV gain 17160897
nsv552062 CNV loss 21841781
nsv1039166 CNV loss 25217958

Variation tolerance for GSTO1 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.70; 86.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GSTO1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTO1 Gene

Disorders for GSTO1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for GSTO1 Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
proliferative type fibrocystic change of breast
  • fibrocystic change, proliferative type with atypia
intracystic papillary adenoma
  • intracystic papilloma
cavernous sinus meningioma
  • meningioma of the cavernous sinus
patella, chondromalacia of
  • chondromalacia patellae
facial neuralgia
- elite association - COSMIC cancer census association via MalaCards
Search GSTO1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for GSTO1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GSTO1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTO1 Gene

Publications for GSTO1 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread AK … Board PG (Pharmacogenetics 2003) 2 3 4 22 60
  2. No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (PMID: 19859803) Andonova IE … Brauch H (Breast cancer research and treatment 2010) 3 22 45 60
  3. Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study. (PMID: 20367187) Piacentini S … Fuciarelli M (Annals of human biology 2010) 3 22 45 60
  4. Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia. (PMID: 18941778) Pongstaporn W … Petmitr S (Journal of cancer research and clinical oncology 2009) 3 22 45 60
  5. Diversity of glutathione s-transferase omega 1 (a140d) and 2 (n142d) gene polymorphisms in worldwide populations. (PMID: 18986335) Takeshita H … Kunito T (Clinical and experimental pharmacology & physiology 2009) 3 22 45 60

Products for GSTO1 Gene

Sources for GSTO1 Gene

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