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Aliases for GSTO1 Gene

Aliases for GSTO1 Gene

  • Glutathione S-Transferase Omega 1 2 3
  • Glutathione-Dependent Dehydroascorbate Reductase 3 4
  • Glutathione S-Transferase Omega 1-1 3 4
  • S-(Phenacyl)Glutathione Reductase 3 4
  • Monomethylarsonic Acid Reductase 3 4
  • MMA(V) Reductase 3 4
  • EC 2.5.1.18 4 64
  • GSTO 1-1 3 4
  • GSTTLp28 3 4
  • SPG-R 3 4
  • Epididymis Secretory Protein Li 21 3
  • Glutathione S-Transferase Omega-1 3
  • Glutathione-S-Transferase Like 3
  • EC 1.20.4.2 4
  • EC 1.8.5.1 4
  • HEL-S-21 3
  • GSTO-1 4
  • P28 3

External Ids for GSTO1 Gene

Summaries for GSTO1 Gene

Entrez Gene Summary for GSTO1 Gene

  • The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for GSTO1 Gene

GSTO1 (Glutathione S-Transferase Omega 1) is a Protein Coding gene. Diseases associated with GSTO1 include cisplatin toxicity and barretts adenocarcinoma. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include oxidoreductase activity and glutathione dehydrogenase (ascorbate) activity. An important paralog of this gene is GSTO2.

UniProtKB/Swiss-Prot for GSTO1 Gene

  • Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Gene Wiki entry for GSTO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GSTO1 Gene

Genomics for GSTO1 Gene

Genomic Location for GSTO1 Gene

Start:
104,235,356 bp from pter
End:
104,267,464 bp from pter
Size:
32,109 bases
Orientation:
Plus strand

Genomic View for GSTO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GSTO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTO1 Gene

Regulatory Elements for GSTO1 Gene

Proteins for GSTO1 Gene

  • Protein details for GSTO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78417-GSTO1_HUMAN
    Recommended name:
    Glutathione S-transferase omega-1
    Protein Accession:
    P78417
    Secondary Accessions:
    • D3DRA3
    • F5H7H0
    • Q5TA03
    • Q7Z3T2

    Protein attributes for GSTO1 Gene

    Size:
    241 amino acids
    Molecular mass:
    27566 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAD97673.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GSTO1 Gene

    Alternative splice isoforms for GSTO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GSTO1 Gene

Proteomics data for GSTO1 Gene at MOPED

Selected DME Specific Peptides for GSTO1 Gene

Post-translational modifications for GSTO1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11

Other Protein References for GSTO1 Gene

Domains for GSTO1 Gene

Gene Families for GSTO1 Gene

HGNC:
  • SGST :Glutathione S-transferases / Soluble

UniProtKB/Swiss-Prot:

GSTO1_HUMAN
Domain:
  • Contains 1 GST C-terminal domain.:
    • P78417
  • Contains 1 GST N-terminal domain.:
    • P78417
Family:
  • Belongs to the GST superfamily. Omega family.:
    • P78417
genes like me logo Genes that share domains with GSTO1: view

Function for GSTO1 Gene

Molecular function for GSTO1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 8. {ECO:0000269 PubMed:11511179, ECO:0000269 PubMed:17226937};
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione
UniProtKB/Swiss-Prot CatalyticActivity: 2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate
UniProtKB/Swiss-Prot CatalyticActivity: Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation: Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate
UniProtKB/Swiss-Prot Function: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Enzyme Numbers (IUBMB) for GSTO1 Gene

Gene Ontology (GO) - Molecular Function for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 11511179
GO:0005515 protein binding IPI 25277244
GO:0016491 oxidoreductase activity IDA 11511179
GO:0045174 glutathione dehydrogenase (ascorbate) activity IDA 11511179
GO:0050610 methylarsonate reductase activity IEA --
genes like me logo Genes that share ontologies with GSTO1: view
genes like me logo Genes that share phenotypes with GSTO1: view

miRNA for GSTO1 Gene

miRTarBase miRNAs that target GSTO1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for GSTO1 Gene

Localization for GSTO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTO1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GSTO1 Gene COMPARTMENTS Subcellular localization image for GSTO1 gene
Compartment Confidence
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11511179
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GSTO1: view

Pathways for GSTO1 Gene

SuperPathways for GSTO1 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Chemical carcinogenesis
3 Glutathione metabolism
4 Biological oxidations
5 Disease
genes like me logo Genes that share pathways with GSTO1: view

Gene Ontology (GO) - Biological Process for GSTO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process --
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA 11035031
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC 11035031
GO:0014810 positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion IC 11035031
genes like me logo Genes that share ontologies with GSTO1: view

Compounds for GSTO1 Gene

(12) HMDB Compounds for GSTO1 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(2) Drugbank Compounds for GSTO1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target
Vitamin E
  • alpha-Tocopherol
59-02-9 enzyme inhibitor

(9) Novoseek inferred chemical compound relationships for GSTO1 Gene

Compound -log(P) Hits PubMed IDs
monomethylarsonic acid 79.9 2
gsts 76.1 4
arsenate 72.1 4
dehydroascorbic acid 65.7 1
1-chloro-24-dinitrobenzene 54.4 1
genes like me logo Genes that share compounds with GSTO1: view

Transcripts for GSTO1 Gene

Unigene Clusters for GSTO1 Gene

Glutathione S-transferase omega 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GSTO1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3: - - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - -
SP7: - -

Relevant External Links for GSTO1 Gene

GeneLoc Exon Structure for
GSTO1
ECgene alternative splicing isoforms for
GSTO1

Expression for GSTO1 Gene

mRNA expression in normal human tissues for GSTO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GSTO1 Gene

SOURCE GeneReport for Unigene cluster for GSTO1 Gene Hs.190028

mRNA Expression by UniProt/SwissProt for GSTO1 Gene

P78417-GSTO1_HUMAN
Tissue specificity: Ubiquitous. Highest expression in liver, pancreas, skeletal muscle, spleen, thymus, colon, blood leukocyte and heart. Lowest expression in brain, placenta and lung.
genes like me logo Genes that share expressions with GSTO1: view

Orthologs for GSTO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GSTO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTO1 36
  • 99.45 (n)
  • 99.17 (a)
GSTO1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
GSTO1 36
  • 85.48 (n)
  • 83.4 (a)
dog
(Canis familiaris)
Mammalia GSTO1 36
  • 86.17 (n)
  • 86.31 (a)
GSTO1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gsto1 36
  • 76.94 (n)
  • 72.5 (a)
Gsto1 16
Gsto1 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GSTO1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Gsto1 36
  • 80.08 (n)
  • 77.59 (a)
chicken
(Gallus gallus)
Aves GSTO1 36
  • 66.95 (n)
  • 63.18 (a)
GSTO1 37
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 66 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.24164 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1986 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11014 36
zebrafish
(Danio rerio)
Actinopterygii Dr.16014 36
gsto1 36
  • 62.71 (n)
  • 58.47 (a)
gsto1 37
  • 58 (a)
ManyToMany
gsto2 37
  • 56 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GSTO1 36
  • 48.27 (n)
  • 40.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6662 37
  • 31 (a)
ManyToMany
CG6673 37
  • 31 (a)
ManyToMany
CG6776 37
  • 35 (a)
ManyToMany
se 36
  • 52.61 (n)
  • 46.08 (a)
se 37
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea C02D5.4 37
  • 33 (a)
ManyToMany
gst-44 36
  • 48.38 (n)
  • 41.77 (a)
gst-44 37
  • 38 (a)
ManyToMany
gsto-1 37
  • 32 (a)
ManyToMany
gsto-2 37
  • 33 (a)
ManyToMany
gsto-3 37
  • 24 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00549 36
  • 48.43 (n)
  • 41.51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
ManyToMany
CSA.3044 37
  • 35 (a)
ManyToMany
Species with no ortholog for GSTO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTO1 Gene

ENSEMBL:
Gene Tree for GSTO1 (if available)
TreeFam:
Gene Tree for GSTO1 (if available)

Paralogs for GSTO1 Gene

Paralogs for GSTO1 Gene

Selected SIMAP similar genes for GSTO1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for GSTO1 Gene

genes like me logo Genes that share paralogs with GSTO1: view

Variants for GSTO1 Gene

Sequence variations from dbSNP and Humsavar for GSTO1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4925 - 104,263,031(+) CTATG(A/C)TGGCC intron-variant, missense, reference
rs594471 -- 104,256,390(+) CACAG(C/G)TGGAT intron-variant
rs597366 -- 104,257,043(+) CTGTT(C/T)TAGCT intron-variant
rs610917 -- 104,253,070(+) AGGGG(A/G)AGCAA upstream-variant-2KB
rs628480 -- 104,254,709(+) GTGCA(A/G)CCCTT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GSTO1 Gene

Variant ID Type Subtype PubMed ID
nsv831971 CNV Gain 17160897

Relevant External Links for GSTO1 Gene

HapMap Linkage Disequilibrium report
GSTO1
Human Gene Mutation Database (HGMD)
GSTO1

Disorders for GSTO1 Gene

(4) Novoseek inferred disease relationships for GSTO1 Gene

Disease -log(P) Hits PubMed IDs
parkinson disease 37.8 5
alzheimers disease 27.7 6
neurodegenerative diseases 24.7 2
cancer 0 5

Relevant External Links for GSTO1

Genetic Association Database (GAD)
GSTO1
Human Genome Epidemiology (HuGE) Navigator
GSTO1
genes like me logo Genes that share disorders with GSTO1: view

No data available for UniProtKB/Swiss-Prot for GSTO1 Gene

Publications for GSTO1 Gene

  1. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. (PMID: 12618591) Whitbread A.K. … Board P.G. (Pharmacogenetics 2003) 2 3 4 23
  2. Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke. (PMID: 15623683) KAPlsch H. … Heun R. (Neurology 2004) 3 23 49
  3. Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina. (PMID: 17450230) SchlAowicke EngstrAPm K. … Vahter M. (Environ. Health Perspect. 2007) 3 23 49
  4. Frequency of two human glutathione-S-transferase omega-1 polymorphisms (E155 deletion and E208K) in Ovambo and Japanese populations using the PCR-based genotyping method. (PMID: 17484623) Fujihara J. … Takeshita H. (Clin. Chem. Lab. Med. 2007) 3 23 49
  5. Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression. (PMID: 17717316) KAPlsch H. … Thal D.R. (Stroke 2007) 3 23 49

Products for GSTO1 Gene

Sources for GSTO1 Gene

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