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Aliases for MED7 Gene

Aliases for MED7 Gene

  • Mediator Complex Subunit 7 2 3 4 5
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 9, 33kDa 2 3
  • RNA Polymerase Transcriptional Regulation Mediator Subunit 7 Homolog 3 4
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 9 3 4
  • Activator-Recruited Cofactor 34 KDa Component 3 4
  • Transcriptional Coactivator CRSP33 3 4
  • CRSP Complex Subunit 9 3 4
  • ARC34 3 4
  • CRSP9 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 9 (33kD) 3
  • Mediator Of RNA Polymerase II Transcription Subunit 7 3
  • CRSP33 3
  • HMED7 4

External Ids for MED7 Gene

Previous HGNC Symbols for MED7 Gene

  • CRSP9

Previous GeneCards Identifiers for MED7 Gene

  • GC05M156495
  • GC05M156564
  • GC05M151653

Summaries for MED7 Gene

Entrez Gene Summary for MED7 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MED7 Gene

MED7 (Mediator Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and RNA polymerase II transcription cofactor activity.

UniProtKB/Swiss-Prot for MED7 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED7 Gene

Additional gene information for MED7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED7 Gene

Genomics for MED7 Gene

GeneHancer (GH) Regulatory Elements for MED7 Gene

Promoters and enhancers for MED7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I157141 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 560.4 +16.0 16038 2.5 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 POLR2B E2F8 MED7 ITK HAVCR2 THG1L PPP1R2P3 HAVCR1
GH05I157158 Enhancer 0.8 FANTOM5 ENCODE dbSUPER 550.8 -0.5 -482 1.6 RFX1 NFE2 MED7 HAVCR2 CYFIP2 ITK FAM71B
GH05I157178 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.2 -22.8 -22750 6.5 ZNF664 ZNF112 ITK MED7 HAVCR2 HAVCR1 CYFIP2 FNDC9 FAM71B ENSG00000253980
GH05I157265 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -111.2 -111216 9.9 HDGF ATF1 PKNOX1 SIN3A FEZF1 IRF4 YY1 ETS1 ZNF766 GLIS2 CYFIP2 LOC102724404 HAVCR2 THG1L ITK MED7 NIPAL4 ADAM19 ENSG00000248544 ENSG00000253653
GH05I157105 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.2 +50.8 50786 5.1 HDGF KLF1 SMAD1 RB1 EBF1 IRF4 POLR2A ATF7 IKZF2 RUNX3 HAVCR2 ITK MED7 TIMD4 HAVCR1 ENSG00000254246 PIR42544
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MED7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED7 gene promoter:

Genomic Locations for MED7 Gene

Genomic Locations for MED7 Gene
chr5:157,137,412-157,159,019
(GRCh38/hg38)
Size:
21,608 bases
Orientation:
Minus strand
chr5:156,564,423-156,586,030
(GRCh37/hg19)

Genomic View for MED7 Gene

Genes around MED7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED7 Gene

Proteins for MED7 Gene

  • Protein details for MED7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43513-MED7_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 7
    Protein Accession:
    O43513

    Protein attributes for MED7 Gene

    Size:
    233 amino acids
    Molecular mass:
    27245 Da
    Quaternary structure:
    • Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

neXtProt entry for MED7 Gene

Post-translational modifications for MED7 Gene

Other Protein References for MED7 Gene

No data available for DME Specific Peptides for MED7 Gene

Domains & Families for MED7 Gene

Gene Families for MED7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED7 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43513

UniProtKB/Swiss-Prot:

MED7_HUMAN :
  • Belongs to the Mediator complex subunit 7 family.
Family:
  • Belongs to the Mediator complex subunit 7 family.
genes like me logo Genes that share domains with MED7: view

Function for MED7 Gene

Molecular function for MED7 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Phenotypes From GWAS Catalog for MED7 Gene

Gene Ontology (GO) - Molecular Function for MED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IEA --
GO:0003713 transcription coactivator activity TAS 9989412
GO:0005515 protein binding IPI 14576168
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with MED7: view
genes like me logo Genes that share phenotypes with MED7: view

Animal Model Products

CRISPR Products

miRNA for MED7 Gene

miRTarBase miRNAs that target MED7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MED7 Gene

Localization for MED7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED7 gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IDA 9989412
GO:0016592 mediator complex IBA --
genes like me logo Genes that share ontologies with MED7: view

Pathways & Interactions for MED7 Gene

genes like me logo Genes that share pathways with MED7: view

Gene Ontology (GO) - Biological Process for MED7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IDA 9989412
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED7: view

No data available for SIGNOR curated interactions for MED7 Gene

Drugs & Compounds for MED7 Gene

No Compound Related Data Available

Transcripts for MED7 Gene

Unigene Clusters for MED7 Gene

Mediator complex subunit 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MED7 Gene

No ASD Table

Relevant External Links for MED7 Gene

GeneLoc Exon Structure for
MED7
ECgene alternative splicing isoforms for
MED7

Expression for MED7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED7 Gene

Protein differential expression in normal tissues from HIPED for MED7 Gene

This gene is overexpressed in Fetal ovary (42.8) and Blymphocyte (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED7 Gene



Protein tissue co-expression partners for MED7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MED7 Gene:

MED7

SOURCE GeneReport for Unigene cluster for MED7 Gene:

Hs.279902
genes like me logo Genes that share expression patterns with MED7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED7 Gene

Orthologs for MED7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MED7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED7 33 34
  • 99.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MED7 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED7 33 34
  • 93.56 (n)
cow
(Bos Taurus)
Mammalia MED7 33
  • 92.56 (n)
HAVCR2 34
  • 45 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med7 33 16 34
  • 91.27 (n)
rat
(Rattus norvegicus)
Mammalia Med7 33
  • 91.27 (n)
oppossum
(Monodelphis domestica)
Mammalia MED7 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED7 33 34
  • 80.72 (n)
lizard
(Anolis carolinensis)
Reptilia MED7 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med7 33
  • 71.35 (n)
Str.15008 33
zebrafish
(Danio rerio)
Actinopterygii med7 33 34
  • 70.43 (n)
wufd99d12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1621 33
African malaria mosquito
(Anopheles gambiae)
Insecta MED7_ANOGA 33
  • 57.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta MED7 33 34
  • 55.13 (n)
worm
(Caenorhabditis elegans)
Secernentea let-49 33 34
  • 48.24 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MED7 34 36
  • 30 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G03500 33
  • 49.38 (n)
rice
(Oryza sativa)
Liliopsida Os04g0661800 33
  • 49.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
OneToOne
Species where no ortholog for MED7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED7 Gene

ENSEMBL:
Gene Tree for MED7 (if available)
TreeFam:
Gene Tree for MED7 (if available)

Paralogs for MED7 Gene

(1) SIMAP similar genes for MED7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MED7: view

No data available for Paralogs for MED7 Gene

Variants for MED7 Gene

Sequence variations from dbSNP and Humsavar for MED7 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000281814 -- 157,142,865(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000547977 -- 157,142,900(-) C/G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001196804 -- 157,138,301(-) T/C downstream_transcript_variant
rs1001669367 -- 157,137,999(-) A/C downstream_transcript_variant
rs1002225971 -- 157,139,805(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MED7 Gene

Variant ID Type Subtype PubMed ID
esv3575892 CNV gain 25503493

Variation tolerance for MED7 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED7 Gene

Disorders for MED7 Gene

Additional Disease Information for MED7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MED7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED7 Gene

Publications for MED7 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S … Tjian R (Nature 1999) 2 3 4 58
  2. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PMID: 17709345) Jakobs A … Niedenthal R (Nucleic acids research 2007) 3 4 58
  3. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4 58
  4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MED7 Gene

Sources for MED7 Gene

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