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Aliases for MED23 Gene

Aliases for MED23 Gene

  • Mediator Complex Subunit 23 2 3 4 5
  • Cofactor Required For Sp1 Transcriptional Activation Subunit 3 3 4
  • Activator-Recruited Cofactor 130 KDa Component 3 4
  • DRIP130 3 4
  • ARC130 3 4
  • CRSP3 3 4
  • SUR2 3 4
  • Cofactor Required For Sp1 Transcriptional Activation, Subunit 3, 130kDa 2
  • Vitamin D3 Receptor-Interacting Protein Complex 130 KDa Component 4
  • Mediator Complex Subunit MED23 Variant MED23_i6 3
  • Mediator Complex Subunit MED23 Variant MED23_i7 3
  • Vitamin D3 Receptor Interacting Protein 3
  • 130 KDa Transcriptional Co-Activator 3
  • 133 KDa Transcriptional Co-Activator 3
  • Transcriptional Coactivator CRSP130 4
  • CRSP Complex Subunit 3 4
  • Protein Sur-2 Homolog 4
  • KIAA1216 4
  • CRSP130 3
  • CRSP133 3
  • HSur-2 4
  • MRT18 3
  • SUR-2 3

External Ids for MED23 Gene

Previous HGNC Symbols for MED23 Gene

  • CRSP3

Previous GeneCards Identifiers for MED23 Gene

  • GC06M131937
  • GC06M129476
  • GC06M131895

Summaries for MED23 Gene

Entrez Gene Summary for MED23 Gene

  • The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MED23 Gene

MED23 (Mediator Complex Subunit 23) is a Protein Coding gene. Diseases associated with MED23 include Mental Retardation, Autosomal Recessive 18 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Gene Expression. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for MED23 Gene

  • Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.

Gene Wiki entry for MED23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED23 Gene

Genomics for MED23 Gene

Regulatory Elements for MED23 Gene

Enhancers for MED23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MED23 on UCSC Golden Path with GeneCards custom track

Promoters for MED23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MED23 on UCSC Golden Path with GeneCards custom track

Genomic Location for MED23 Gene

Chromosome:
6
Start:
131,573,966 bp from pter
End:
131,628,239 bp from pter
Size:
54,274 bases
Orientation:
Minus strand

Genomic View for MED23 Gene

Genes around MED23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED23 Gene

Proteins for MED23 Gene

  • Protein details for MED23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULK4-MED23_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 23
    Protein Accession:
    Q9ULK4
    Secondary Accessions:
    • B9TX55
    • O95403
    • Q5JWT3
    • Q5JWT4
    • Q6P9H6
    • Q9H0J2
    • Q9NTT9
    • Q9NTU0
    • Q9Y5P7
    • Q9Y667

    Protein attributes for MED23 Gene

    Size:
    1368 amino acids
    Molecular mass:
    156474 Da
    Quaternary structure:
    • Interacts with ELK1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated), CTNNB1, and GLI3. Interacts with the adenovirus E1A protein.
    SequenceCaution:
    • Sequence=AAD12724.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAD31729.1; Type=Frameshift; Positions=945, 950; Evidence={ECO:0000305}; Sequence=BAA86530.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MED23 Gene

neXtProt entry for MED23 Gene

Proteomics data for MED23 Gene at MOPED

Post-translational modifications for MED23 Gene

  • Ubiquitination at Lys 242, Lys 253, Lys 260, Lys 673, and Lys 1082
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MED23 Gene

Domains & Families for MED23 Gene

Gene Families for MED23 Gene

Protein Domains for MED23 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9ULK4

UniProtKB/Swiss-Prot:

MED23_HUMAN :
  • Belongs to the Mediator complex subunit 23 family.
Family:
  • Belongs to the Mediator complex subunit 23 family.
genes like me logo Genes that share domains with MED23: view

Function for MED23 Gene

Molecular function for MED23 Gene

UniProtKB/Swiss-Prot Function:
Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.
genes like me logo Genes that share phenotypes with MED23: view

Human Phenotype Ontology for MED23 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MED23 Gene

MGI Knock Outs for MED23:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for MED23 Gene

Localization for MED23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED23 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MED23 Gene COMPARTMENTS Subcellular localization image for MED23 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MED23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with MED23: view

Pathways & Interactions for MED23 Gene

genes like me logo Genes that share pathways with MED23: view

Gene Ontology (GO) - Biological Process for MED23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IDA 9989412
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with MED23: view

No data available for SIGNOR curated interactions for MED23 Gene

Drugs & Compounds for MED23 Gene

(1) Drugs for MED23 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
selective beta-2-adrenoreceptor agonists Pharma 0
genes like me logo Genes that share compounds with MED23: view

Transcripts for MED23 Gene

Unigene Clusters for MED23 Gene

Mediator complex subunit 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED23 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: -
SP2: -
SP3:

ExUns: 25b ^ 26a · 26b ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:

Relevant External Links for MED23 Gene

GeneLoc Exon Structure for
MED23
ECgene alternative splicing isoforms for
MED23

Expression for MED23 Gene

mRNA expression in normal human tissues for MED23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MED23 Gene

This gene is overexpressed in Breast (12.3), Kidney (11.2), Skin (8.5), and Cervix (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MED23 Gene



SOURCE GeneReport for Unigene cluster for MED23 Gene Hs.29679

genes like me logo Genes that share expression patterns with MED23: view

Protein tissue co-expression partners for MED23 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MED23 Gene

Orthologs for MED23 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MED23 35
  • 92.3 (n)
  • 98.1 (a)
MED23 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED23 35
  • 93.1 (n)
  • 98.46 (a)
MED23 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Med23 35
  • 87.95 (n)
  • 96.34 (a)
Med23 16
Med23 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MED23 35
  • 99.63 (n)
  • 100 (a)
MED23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Med23 35
  • 87.69 (n)
  • 96.71 (a)
oppossum
(Monodelphis domestica)
Mammalia MED23 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MED23 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves MED23 35
  • 82.72 (n)
  • 95.47 (a)
MED23 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MED23 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med23 35
  • 79.28 (n)
  • 93.34 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68685 35
zebrafish
(Danio rerio)
Actinopterygii med23 35
  • 75.52 (n)
  • 91.22 (a)
med23 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006046 35
  • 54.23 (n)
  • 53.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta MED23 35
  • 55.73 (n)
  • 50.38 (a)
MED23 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sur-2 35
  • 40.23 (n)
  • 24.17 (a)
sur-2 36
  • 16 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13682 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for MED23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED23 Gene

ENSEMBL:
Gene Tree for MED23 (if available)
TreeFam:
Gene Tree for MED23 (if available)

Paralogs for MED23 Gene

No data available for Paralogs for MED23 Gene

Variants for MED23 Gene

Sequence variations from dbSNP and Humsavar for MED23 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_066596 Mental retardation, autosomal recessive 18 (MRT18)
rs5880072 -- 131,615,067(+) TTACC(-/A)AAAAA intron-variant
rs6901614 -- 131,603,780(+) TCTTC(C/T)GCAAG intron-variant
rs9493031 -- 131,596,590(+) ACAAA(A/G)TCACT reference, synonymous-codon
rs10081029 -- 131,595,075(+) GAGGG(A/G)AGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MED23 Gene

Variant ID Type Subtype PubMed ID
nsv886668 CNV Gain 21882294
nsv7968 CNV Loss 18304495

Variation tolerance for MED23 Gene

Residual Variation Intolerance Score: 2.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MED23 Gene

Human Gene Mutation Database (HGMD)
MED23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED23 Gene

Disorders for MED23 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MED23 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 18
  • mental retardation non-syndromic autosomal recessive 18
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
med23
  • autosomal recessive nonsyndromic mental retardation-18
- elite association - COSMIC cancer census association via MalaCards
Search MED23 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MED23_HUMAN
  • Mental retardation, autosomal recessive 18 (MRT18) [MIM:614249]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:21868677}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MED23

Genetic Association Database (GAD)
MED23
Human Genome Epidemiology (HuGE) Navigator
MED23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MED23
genes like me logo Genes that share disorders with MED23: view

No data available for Genatlas for MED23 Gene

Publications for MED23 Gene

  1. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. (PMID: 9989412) Ryu S. … Tjian R. (Nature 1999) 2 3 4 67
  2. Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP. (PMID: 12543799) Goldberg S.F. … Welch D.R. (Cancer Res. 2003) 3 23
  3. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. (PMID: 12242338) Asada S. … Uesugi M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for MED23 Gene

Sources for MED23 Gene

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