Aliases for CHST2 Gene
- Carbohydrate Sulfotransferase 2 2 3
- Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 2 2 3 5
- Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 2 3 4
- N-Acetylglucosamine 6-O-Sulfotransferase 1 3 4
- GlcNAc6ST-1 3 4
- Gn6ST-1 3 4
- GST-2 3 4
- Carbohydrate (Chondroitin 6/Keratan) Sulfotransferase 2 3
External Ids for CHST2 Gene
Previous GeneCards Identifiers for CHST2 Gene
This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011]
GeneCards Summary for CHST2 Gene
CHST2 (Carbohydrate Sulfotransferase 2) is a Protein Coding gene. Diseases associated with CHST2 include spondyloepiphyseal dysplasia with congenital joint dislocations. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sulfotransferase activity and N-acetylglucosamine 6-O-sulfotransferase activity. An important paralog of this gene is CHST4.
UniProtKB/Swiss-Prot for CHST2 Gene
Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.