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Aliases for SYTL4 Gene

Aliases for SYTL4 Gene

  • Synaptotagmin Like 4 2 3 5
  • Exophilin-2 2 3 4
  • Granuphilin-A 2 3
  • Synaptotagmin-Like Protein 4 3
  • Granuphilin 4
  • SLP4 3

External Ids for SYTL4 Gene

Previous GeneCards Identifiers for SYTL4 Gene

  • GC0XM095211
  • GC0XM096890
  • GC0XM097965
  • GC0XM098701
  • GC0XM099735
  • GC0XM099929
  • GC0XM089729

Summaries for SYTL4 Gene

Entrez Gene Summary for SYTL4 Gene

  • This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

GeneCards Summary for SYTL4 Gene

SYTL4 (Synaptotagmin Like 4) is a Protein Coding gene. Diseases associated with SYTL4 include Epileptic Encephalopathy, Early Infantile, 9. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Deregulation of Rab and Rab Effector Genes in Bladder Cancer. GO annotations related to this gene include calcium ion binding and phospholipid binding. An important paralog of this gene is SYTL5.

UniProtKB/Swiss-Prot for SYTL4 Gene

  • Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).

Gene Wiki entry for SYTL4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYTL4 Gene

Genomics for SYTL4 Gene

Regulatory Elements for SYTL4 Gene

Enhancers for SYTL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG100819 1 ENCODE 42.9 -88.1 -88126 1.7 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 ZNF121 ELK1 SYTL4 CSTF2 ENSG00000275320
GH0XG100745 0.8 ENCODE 43.2 -15.0 -14964 3.6 SIX4 JUN FOSL1 CTBP1 GATA3 GATA2 FOSL2 FOS SMARCE1 CEBPB SYTL4 LOC442460
GH0XG100642 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.7 +85.1 85136 8.9 TBP FOXA2 NFIB ARID4B DMAP1 RAD21 RARA YY1 SCRT2 FOS SYTL4 SRPX2 TSPAN6 CSTF2 PCDH19 GC0XP100679
GH0XG100742 0.7 ENCODE 41.1 -11.0 -10969 1.8 MTA2 TAL1 FOXM1 TCF12 ARID1B FOSL1 ZNF766 NCOR1 KLF16 GATA2 SYTL4 LOC442460
GH0XG100812 0.5 ENCODE 42.6 -80.5 -80519 1.2 ZNF316 MAFG NFE2 EMSY SYTL4 ENSG00000275320 LOC392508
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SYTL4 on UCSC Golden Path with GeneCards custom track

Promoters for SYTL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247589 348 1200 CTCF SUZ12 SIN3A MAX GLIS2 ZBTB48 SCRT2 EZH2 SCRT1 SP3

Transcription factor binding sites by QIAGEN in the SYTL4 gene promoter:

Genomic Location for SYTL4 Gene

Chromosome:
X
Start:
100,674,491 bp from pter
End:
100,732,148 bp from pter
Size:
57,658 bases
Orientation:
Minus strand

Genomic View for SYTL4 Gene

Genes around SYTL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYTL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYTL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYTL4 Gene

Proteins for SYTL4 Gene

  • Protein details for SYTL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C24-SYTL4_HUMAN
    Recommended name:
    Synaptotagmin-like protein 4
    Protein Accession:
    Q96C24
    Secondary Accessions:
    • Q5H9J3
    • Q5JPG8
    • Q8N9P4
    • Q9H4R0
    • Q9H4R1

    Protein attributes for SYTL4 Gene

    Size:
    671 amino acids
    Molecular mass:
    76024 Da
    Quaternary structure:
    • Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity).

    Three dimensional structures from OCA and Proteopedia for SYTL4 Gene

    Alternative splice isoforms for SYTL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SYTL4 Gene

Post-translational modifications for SYTL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SYTL4 Gene

Domains & Families for SYTL4 Gene

Gene Families for SYTL4 Gene

Suggested Antigen Peptide Sequences for SYTL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SYTL4: view

No data available for UniProtKB/Swiss-Prot for SYTL4 Gene

Function for SYTL4 Gene

Molecular function for SYTL4 Gene

UniProtKB/Swiss-Prot Function:
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).

Gene Ontology (GO) - Molecular Function for SYTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0005543 phospholipid binding ISS --
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0017137 Rab GTPase binding IEA --
genes like me logo Genes that share ontologies with SYTL4: view
genes like me logo Genes that share phenotypes with SYTL4: view

Animal Models for SYTL4 Gene

MGI Knock Outs for SYTL4:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SYTL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SYTL4 Gene

Localization for SYTL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYTL4 Gene

Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein. Note=Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYTL4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
endosome 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SYTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IDA 19966785
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SYTL4: view

Pathways & Interactions for SYTL4 Gene

genes like me logo Genes that share pathways with SYTL4: view

Gene Ontology (GO) - Biological Process for SYTL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006886 intracellular protein transport IEA --
GO:0006887 exocytosis IEA --
GO:0006906 vesicle fusion IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
genes like me logo Genes that share ontologies with SYTL4: view

No data available for SIGNOR curated interactions for SYTL4 Gene

Drugs & Compounds for SYTL4 Gene

(3) Drugs for SYTL4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Human Approved, Investigational Pharma Target 0
Insulin Pork Approved Pharma Target 0
genes like me logo Genes that share compounds with SYTL4: view

Transcripts for SYTL4 Gene

Unigene Clusters for SYTL4 Gene

Synaptotagmin-like 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SYTL4

Alternative Splicing Database (ASD) splice patterns (SP) for SYTL4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - -
SP7:

ExUns: 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SYTL4 Gene

GeneLoc Exon Structure for
SYTL4
ECgene alternative splicing isoforms for
SYTL4

Expression for SYTL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYTL4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SYTL4 Gene

This gene is overexpressed in Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for SYTL4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (55.1) and Platelet (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYTL4 Gene



Protein tissue co-expression partners for SYTL4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SYTL4 Gene:

SYTL4

SOURCE GeneReport for Unigene cluster for SYTL4 Gene:

Hs.592224

Evidence on tissue expression from TISSUES for SYTL4 Gene

  • Blood(4.4)
  • Adrenal gland(4.3)
  • Nervous system(4.3)
  • Liver(4.2)
  • Pancreas(2.8)
genes like me logo Genes that share expression patterns with SYTL4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYTL4 Gene

Orthologs for SYTL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYTL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYTL4 34 35
  • 95.18 (n)
dog
(Canis familiaris)
Mammalia SYTL4 34 35
  • 93.39 (n)
cow
(Bos Taurus)
Mammalia SYTL4 34 35
  • 91.95 (n)
rat
(Rattus norvegicus)
Mammalia Sytl4 34
  • 89.62 (n)
mouse
(Mus musculus)
Mammalia Sytl4 34 16 35
  • 89.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SYTL4 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYTL4 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SYTL4 34 35
  • 71.74 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sytl4 34
  • 65.11 (n)
Str.18750 34
zebrafish
(Danio rerio)
Actinopterygii sytl4 34 35
  • 56.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta btsz 34
  • 49.74 (n)
CG7343 36
  • 43 (a)
Species where no ortholog for SYTL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SYTL4 Gene

ENSEMBL:
Gene Tree for SYTL4 (if available)
TreeFam:
Gene Tree for SYTL4 (if available)

Paralogs for SYTL4 Gene

Paralogs for SYTL4 Gene

(14) SIMAP similar genes for SYTL4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYTL4: view

Variants for SYTL4 Gene

Sequence variations from dbSNP and Humsavar for SYTL4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000015883 -- 100,700,780(+) GTACT(C/T)TTCAA intron-variant
rs1000161420 -- 100,690,370(+) CAAGT(G/T)AATTT intron-variant
rs1000294431 -- 100,689,985(+) GCCAA(A/G)TCAAA intron-variant
rs1000339126 -- 100,680,752(+) TCCTA(G/T)ATCTG intron-variant
rs1000387615 -- 100,688,566(+) TTCTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYTL4 Gene

Variant ID Type Subtype PubMed ID
nsv510850 CNV deletion 20534489

Variation tolerance for SYTL4 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYTL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SYTL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYTL4 Gene

Disorders for SYTL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SYTL4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epileptic encephalopathy, early infantile, 9
  • early infantile epileptic encephalopathy 9
- elite association - COSMIC cancer census association via MalaCards
Search SYTL4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SYTL4

Genetic Association Database (GAD)
SYTL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYTL4
genes like me logo Genes that share disorders with SYTL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SYTL4 Gene

Publications for SYTL4 Gene

  1. Rab27a and Rab27b control different steps of the exosome secretion pathway. (PMID: 19966785) Ostrowski M. … Thery C. (Nat. Cell Biol. 2010) 3 22 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. (PMID: 16831872) Plaisance V. … Regazzi R. (J. Biol. Chem. 2006) 3 22 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SYTL4 Gene

  • Addgene plasmids for SYTL4

Sources for SYTL4 Gene

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