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Aliases for MED21 Gene

Aliases for MED21 Gene

  • Mediator Complex Subunit 21 2 3 4 5
  • RNA Polymerase II Holoenzyme Component SRB7 3 4
  • RNAPII Complex Component SRB7 3 4
  • SURB7 3 4
  • HSrb7 3 4
  • SRB7 3 4
  • Mediator Of RNA Polymerase II Transcription Subunit 21 3
  • SRB7 (Suppressor Of RNA Polymerase B, Yeast) Homolog 2
  • SRB7 Suppressor Of RNA Polymerase B Homolog (Yeast) 2
  • SRB7 Suppressor Of RNA Polymerase B Homolog 3

External Ids for MED21 Gene

Previous HGNC Symbols for MED21 Gene

  • SURB7

Previous GeneCards Identifiers for MED21 Gene

  • GC12P027067
  • GC12P027175
  • GC12P026945

Summaries for MED21 Gene

Entrez Gene Summary for MED21 Gene

  • This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for MED21 Gene

MED21 (Mediator Complex Subunit 21) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and DNA-directed 5-3 RNA polymerase activity.

UniProtKB/Swiss-Prot for MED21 Gene

  • Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Wiki entry for MED21 Gene

Additional gene information for MED21 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MED21 Gene

Genomics for MED21 Gene

GeneHancer (GH) Regulatory Elements for MED21 Gene

Promoters and enhancers for MED21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I027021 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 574.6 +0.2 207 2.2 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 MED21 LOC729222 ENSG00000247903 C12orf71 ENSG00000275764
GH12I027022 Enhancer 0.4 FANTOM5 561.5 -1.1 -1063 0.2 MZF1 EBF1 ZNF18 MED21 C12orf71 TM7SF3
GH12I027079 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 28.6 +58.7 58687 2.8 CTCF ZFP64 EBF1 BATF RAD21 ZNF697 ZNF316 MAFK SRF RFX1 C12orf71 MED21 ENSG00000247903 LOC101928625
GH12I027242 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 14 +222.2 222247 4.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B PIR41524 STK38L MED21 ENSG00000247903 TM7SF3 C12orf71 GC12P027317
GH12I027011 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.1 -8.4 -8352 4.4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF213 TM7SF3 ENSG00000247903 MED21 C12orf71
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MED21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MED21 gene promoter:

Genomic Locations for MED21 Gene

Genomic Locations for MED21 Gene
chr12:27,022,522-27,066,343
(GRCh38/hg38)
Size:
43,822 bases
Orientation:
Plus strand
chr12:27,175,479-27,219,276
(GRCh37/hg19)

Genomic View for MED21 Gene

Genes around MED21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MED21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MED21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MED21 Gene

Proteins for MED21 Gene

  • Protein details for MED21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13503-MED21_HUMAN
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 21
    Protein Accession:
    Q13503
    Secondary Accessions:
    • B2R4I3
    • Q6IB05
    • Q92811

    Protein attributes for MED21 Gene

    Size:
    144 amino acids
    Molecular mass:
    15564 Da
    Quaternary structure:
    • Interacts with PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with THRA in a ligand-dependent fashion.

neXtProt entry for MED21 Gene

Post-translational modifications for MED21 Gene

Other Protein References for MED21 Gene

No data available for DME Specific Peptides for MED21 Gene

Domains & Families for MED21 Gene

Gene Families for MED21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MED21 Gene

Suggested Antigen Peptide Sequences for MED21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13503

UniProtKB/Swiss-Prot:

MED21_HUMAN :
  • Belongs to the Mediator complex subunit 21 family.
Family:
  • Belongs to the Mediator complex subunit 21 family.
genes like me logo Genes that share domains with MED21: view

Function for MED21 Gene

Molecular function for MED21 Gene

UniProtKB/Swiss-Prot Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Gene Ontology (GO) - Molecular Function for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001104 RNA polymerase II transcription cofactor activity IBA --
GO:0003713 transcription coactivator activity IDA 12037571
GO:0003899 DNA-directed 5-3 RNA polymerase activity TAS 8598913
GO:0005515 protein binding IPI 14638676
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with MED21: view
genes like me logo Genes that share phenotypes with MED21: view

Animal Models for MED21 Gene

MGI Knock Outs for MED21:

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MED21 Gene

Localization for MED21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MED21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MED21 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005634 nucleus IEA --
GO:0016592 mediator complex IDA 12037571
genes like me logo Genes that share ontologies with MED21: view

Pathways & Interactions for MED21 Gene

genes like me logo Genes that share pathways with MED21: view

Gene Ontology (GO) - Biological Process for MED21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8598913
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with MED21: view

No data available for SIGNOR curated interactions for MED21 Gene

Drugs & Compounds for MED21 Gene

No Compound Related Data Available

Transcripts for MED21 Gene

Unigene Clusters for MED21 Gene

Mediator complex subunit 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MED21 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5
SP1: - - -
SP2: -
SP3:
SP4: - -

Relevant External Links for MED21 Gene

GeneLoc Exon Structure for
MED21
ECgene alternative splicing isoforms for
MED21

Expression for MED21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MED21 Gene

Protein differential expression in normal tissues from HIPED for MED21 Gene

This gene is overexpressed in Pancreas (35.7), Bone (14.0), and Placenta (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MED21 Gene



NURSA nuclear receptor signaling pathways regulating expression of MED21 Gene:

MED21

SOURCE GeneReport for Unigene cluster for MED21 Gene:

Hs.286145

Evidence on tissue expression from TISSUES for MED21 Gene

  • Nervous system(4.7)
  • Kidney(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MED21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MED21 Gene

Orthologs for MED21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MED21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MED21 33 34
  • 99.77 (n)
oppossum
(Monodelphis domestica)
Mammalia MED21 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MED21 33 34
  • 94.68 (n)
-- 34
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MED21 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MED21 33 34
  • 92.82 (n)
mouse
(Mus musculus)
Mammalia Med21 33 16 34
  • 92.82 (n)
rat
(Rattus norvegicus)
Mammalia Med21 33
  • 92.13 (n)
chicken
(Gallus gallus)
Aves MED21 33 34
  • 81.25 (n)
lizard
(Anolis carolinensis)
Reptilia MED21 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia med21 33
  • 71.53 (n)
Str.17613 33
zebrafish
(Danio rerio)
Actinopterygii med21 33 34
  • 74.88 (n)
wufk48d02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1468 33
fruit fly
(Drosophila melanogaster)
Insecta MED21 33 34
  • 60.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta MED21_ANOGA 33
  • 56.07 (n)
worm
(Caenorhabditis elegans)
Secernentea mdt-21 34
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToOne
Species where no ortholog for MED21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MED21 Gene

ENSEMBL:
Gene Tree for MED21 (if available)
TreeFam:
Gene Tree for MED21 (if available)

Paralogs for MED21 Gene

Pseudogenes.org Pseudogenes for MED21 Gene

genes like me logo Genes that share paralogs with MED21: view

No data available for Paralogs for MED21 Gene

Variants for MED21 Gene

Sequence variations from dbSNP and Humsavar for MED21 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005200 -- 27,023,303(+) T/A intron_variant
rs1000065298 -- 27,024,679(+) G/C intron_variant
rs1000108541 -- 27,030,141(+) G/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000377855 -- 27,031,009(+) G/C downstream_transcript_variant
rs1000654685 -- 27,024,321(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MED21 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV deletion 23290073

Variation tolerance for MED21 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MED21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MED21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MED21 Gene

Disorders for MED21 Gene

Additional Disease Information for MED21

No disorders were found for MED21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MED21 Gene

Publications for MED21 Gene

  1. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. (PMID: 9734358) Sun X … Reinberg D (Molecular cell 1998) 3 4 22 58
  2. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. (PMID: 8598913) Chao DM … Young RA (Nature 1996) 2 3 4 58
  3. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. (PMID: 15989967) Zhang X … Roeder RG (Molecular cell 2005) 3 4 58
  4. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. (PMID: 15175163) Sato S … Conaway RC (Molecular cell 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MED21 Gene

  • Addgene plasmids for MED21

Sources for MED21 Gene

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