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CD80 Gene(Protein Coding)

CD80 Molecule

GCID:
GC03M119524
GIFtS:
51
Genes Participants
UDN Logo

Aliases for CD80 Gene

Aliases for CD80 Gene

  • CD80 Molecule 2 3 5
  • CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen) 2 3
  • B-Lymphocyte Activation Antigen B7 2 3
  • CTLA-4 Counter-Receptor B7.1 3 4
  • Activation B7-1 Antigen 3 4
  • CD28LG1 3 4
  • CD28LG 3 4
  • LAB7 3 4
  • BB1 3 4
  • B7 3 4
  • Costimulatory Molecule Variant IgV-CD80 3
  • T-Lymphocyte Activation Antigen CD80 3
  • Costimulatory Factor CD80 3
  • CD80 Antigen 4
  • B7-1 3
  • B7.1 3

External Ids for CD80 Gene

Previous HGNC Symbols for CD80 Gene

  • CD28LG
  • CD28LG1

Previous GeneCards Identifiers for CD80 Gene

  • GC03M115885
  • GC03M118875
  • GC03M120524
  • GC03M120564
  • GC03M120725
  • GC03M119243
  • GC03M116618

Summaries for CD80 Gene

Entrez Gene Summary for CD80 Gene

  • The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD80 Gene

CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

UniProtKB/Swiss-Prot for CD80 Gene

  • Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

  • (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Wiki entry for CD80 Gene

Additional gene information for CD80 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD80 Gene

Genomics for CD80 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CD80 Gene

Promoters and enhancers for CD80 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH03I119557 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 575.9 -0.9 -899 5.8 HDGF HDAC1 PKNOX1 SMAD1 RB1 NFRKB BMI1 KLF5 IRF4 RAD21 CD80 ADPRH ARHGAP31 TMEM39A
GH03I119578 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 17.4 -20.2 -20212 2.4 HDGF RB1 SIN3A DMAP1 KLF5 YY1 ZNF207 ETV6 ATF7 IKZF2 ADPRH ENSG00000272967 CD80 MAATS1 PLA1A
GH03I119595 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 15.4 -37.2 -37196 3 FOXA2 PKNOX1 SMAD1 ZFP64 BATF RAD21 YY1 ATF7 IKZF2 RXRA PLA1A CD80 ADPRH COX17 ARHGAP31 TMEM39A POGLUT1 ENSG00000272967
GH03I119570 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 20 -11.4 -11366 2 PKNOX1 PAX8 EBF1 DPF2 NR2F2 IKZF1 STAT2 ZNF24 ATF7 RUNX3 CD80 PLA1A ARHGAP31 ADPRH POPDC2 TMEM39A POGLUT1 COX17
GH03I119675 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11 -117.3 -117270 2.6 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B COX17 MAATS1 POPDC2 CD80 LOC105374063
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CD80 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD80 gene promoter:

Genomic Locations for CD80 Gene

Genomic Locations for CD80 Gene
chr3:119,523,948-119,559,634
(GRCh38/hg38)
Size:
35,687 bases
Orientation:
Minus strand
chr3:119,243,140-119,278,481
(GRCh37/hg19)

Genomic View for CD80 Gene

Genes around CD80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD80 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CD80 Gene

Proteins for CD80 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CD80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33681-CD80_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD80
    Protein Accession:
    P33681
    Secondary Accessions:
    • Q5DTA9
    • Q5DTB0

    Protein attributes for CD80 Gene

    Size:
    288 amino acids
    Molecular mass:
    33048 Da
    Quaternary structure:
    • Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
    • (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.

    Three dimensional structures from OCA and Proteopedia for CD80 Gene

    Alternative splice isoforms for CD80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD80 Gene

Post-translational modifications for CD80 Gene

  • Glycosylation at Asn53, Asn89, Asn98, posLast=186186, posLast=207207, Asn211, Asn226, and Asn232

Other Protein References for CD80 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CD80
  • Santa Cruz Biotechnology (SCBT) Antibodies for CD80

Assay Products

  • Cloud-Clone Corp. Assay Kits for CD80
  • Abcam assays for CD80

No data available for DME Specific Peptides for CD80 Gene

Domains & Families for CD80 Gene

Gene Families for CD80 Gene

HGNC:
Human Protein Atlas (HPA):
  • CD markers
  • FDA approved drug targets
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for CD80 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CD80 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD80: view

No data available for UniProtKB/Swiss-Prot for CD80 Gene

Function for CD80 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CD80 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
UniProtKB/Swiss-Prot Function:
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus subgroup B.

Phenotypes From GWAS Catalog for CD80 Gene

Gene Ontology (GO) - Molecular Function for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 9915850
GO:0015026 coreceptor activity NAS 9915850
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS --
genes like me logo Genes that share ontologies with CD80: view
genes like me logo Genes that share phenotypes with CD80: view

Animal Models for CD80 Gene

MGI Knock Outs for CD80:

Animal Model Products

CRISPR Products

miRNA for CD80 Gene

miRTarBase miRNAs that target CD80

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD80 Gene

Localization for CD80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD80 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane NAS,TAS --
GO:0009986 cell surface IDA,HDA 23981064
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD80: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD80 Gene

Pathways & Interactions for CD80 Gene

genes like me logo Genes that share pathways with CD80: view

Gene Ontology (GO) - Biological Process for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IC --
GO:0009967 positive regulation of signal transduction NAS 9915850
GO:0016032 viral process IEA --
GO:0031295 T cell costimulation TAS --
GO:0035556 intracellular signal transduction NAS 9915850
genes like me logo Genes that share ontologies with CD80: view

No data available for SIGNOR curated interactions for CD80 Gene

Drugs & Compounds for CD80 Gene

Products:

  1. Drug

(26) Drugs for CD80 Gene - From: DrugBank, ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma Target, antagonist, binder 210
Belatacept Approved, Investigational Pharma Target, inhibitor 0
Durvalumab Approved, Investigational Pharma Target, binder 0
Galiximab Investigational Pharma Target 0
Pharmaceutical Solutions Pharma 9000

(10) Additional Compounds for CD80 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD80: view

Transcripts for CD80 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CD80 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD80 Gene

CD80 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD80 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CD80 Gene

GeneLoc Exon Structure for
CD80
ECgene alternative splicing isoforms for
CD80

Expression for CD80 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD80 Gene

mRNA expression in normal human tissues for CD80 Gene
mRNA expression by GTEx for CD80 GenemRNA expression by BioGPS for CD80 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CD80 Gene:

CD80

SOURCE GeneReport for Unigene cluster for CD80 Gene:

Hs.838

mRNA Expression by UniProt/SwissProt for CD80 Gene:

P33681-CD80_HUMAN
Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells.

Evidence on tissue expression from TISSUES for CD80 Gene

  • Nervous system(4.3)
  • Spleen(3.8)
  • Lymph node(3.6)
  • Blood(3.5)
  • Bone marrow(2.6)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CD80: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD80 Gene

Orthologs for CD80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CD80 33 34
  • 99.54 (n)
cow
(Bos Taurus)
 Mammalia CD80 33 34
  • 74.85 (n)
dog
(Canis familiaris)
 Mammalia CD80 33 34
  • 71.53 (n)
rat
(Rattus norvegicus)
 Mammalia Cd80 33
  • 70.81 (n)
mouse
(Mus musculus)
 Mammalia Cd80 33 16 34
  • 65.87 (n)
oppossum
(Monodelphis domestica)
 Mammalia CD80 34
  • 26 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CD80 34
  • 23 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia CD80 34
  • 23 (a)
 OneToOne
Species where no ortholog for CD80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD80 Gene

ENSEMBL:
Gene Tree for CD80 (if available)
TreeFam:
Gene Tree for CD80 (if available)

Paralogs for CD80 Gene

Paralogs for CD80 Gene

genes like me logo Genes that share paralogs with CD80: view

Variants for CD80 Gene

Sequence variations from dbSNP and Humsavar for CD80 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000213010 -- 119,545,406(-) T/G intron_variant
rs1000244113 -- 119,543,558(-) G/A intron_variant
rs1000533706 -- 119,529,740(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000679202 -- 119,539,635(-) G/C intron_variant
rs1000881304 -- 119,556,523(-) A/C 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD80 Gene

Variant ID Type Subtype PubMed ID
esv3353419 CNV insertion 20981092
nsv829695 CNV loss 17160897

Variation tolerance for CD80 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD80 Gene

Disorders for CD80 Gene

MalaCards: The human disease database

(21) MalaCards diseases for CD80 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CD80 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD80

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene

Publications for CD80 Gene

  1. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T … Mishima M (Respiration; international review of thoracic diseases 2005) 3 22 44 58
  2. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M … Tokunaga K (Genes and immunity 2000) 3 22 44 58
  3. Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PMID: 1377173) Selvakumar A … Dupont B (Immunogenetics 1992) 3 4 22 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PMID: 20066438) Ishizaki Y … Hara T (Human genetics 2010) 3 44 58

Products for CD80 Gene

Sources for CD80 Gene

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