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Aliases for CD80 Gene

Aliases for CD80 Gene

  • CD80 Molecule 2 3
  • CD28LG 3 4 6
  • LAB7 3 4 6
  • CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen) 2 3
  • B-Lymphocyte Activation Antigen B7 2 3
  • CTLA-4 Counter-Receptor B7.1 3 4
  • Activation B7-1 Antigen 3 4
  • CD28LG1 3 4
  • BB1 3 4
  • B7 3 4
  • Costimulatory Molecule Variant IgV-CD80 3
  • T-Lymphocyte Activation Antigen CD80 3
  • Costimulatory Factor CD80 3
  • CD80 Antigen 4
  • B7-1 3
  • B7.1 3

External Ids for CD80 Gene

Previous Symbols for CD80 Gene

  • CD28LG
  • CD28LG1

Summaries for CD80 Gene

Entrez Gene Summary for CD80 Gene

  • The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD80 Gene

CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include sialadenitis and lymphocytic choriomeningitis. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

UniProtKB/Swiss-Prot for CD80 Gene

  • Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

Gene Wiki entry for CD80 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD80 Gene

Genomics for CD80 Gene

Genomic Location for CD80 Gene

Start:
119,524,293 bp from pter
End:
119,559,634 bp from pter
Size:
35,342 bases
Orientation:
Minus strand

Genomic View for CD80 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD80 Gene

Regulatory Elements for CD80 Gene

Proteins for CD80 Gene

  • Protein details for CD80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33681-CD80_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD80
    Protein Accession:
    P33681
    Secondary Accessions:
    • Q5DTA9
    • Q5DTB0

    Protein attributes for CD80 Gene

    Size:
    288 amino acids
    Molecular mass:
    33048 Da
    Quaternary structure:
    • Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.

    Three dimensional structures from OCA and Proteopedia for CD80 Gene

    Alternative splice isoforms for CD80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD80 Gene

Proteomics data for CD80 Gene at MOPED

Post-translational modifications for CD80 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn53, Asn89, Asn98, Asn186, Asn207, Asn211, Asn226, and Asn232

Other Protein References for CD80 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CD80 Gene

Domains for CD80 Gene

Gene Families for CD80 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

Protein Domains for CD80 Gene

UniProtKB/Swiss-Prot:

CD80_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • P33681
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P33681
genes like me logo Genes that share domains with CD80: view

Function for CD80 Gene

Molecular function for CD80 Gene

GENATLAS Biochemistry: cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
UniProtKB/Swiss-Prot Function: Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

Gene Ontology (GO) - Molecular Function for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11279502
GO:0015026 coreceptor activity NAS 9915850
genes like me logo Genes that share ontologies with CD80: view
genes like me logo Genes that share phenotypes with CD80: view

Animal Models for CD80 Gene

MGI Knock Outs for CD80:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CD80 Gene

Localization for CD80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD80 Gene COMPARTMENTS Subcellular localization image for CD80 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 23981064
GO:0016021 integral component of membrane IC 9915850
genes like me logo Genes that share ontologies with CD80: view

Pathways for CD80 Gene

SuperPathways for CD80 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 PEDF Induced Signaling
4 Allograft rejection
5 TGF-Beta Pathway
genes like me logo Genes that share pathways with CD80: view

Gene Ontology (GO) - Biological Process for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007267 cell-cell signaling IC 9915850
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0009967 positive regulation of signal transduction NAS 9915850
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CD80: view

Compounds for CD80 Gene

(2) Drugbank Compounds for CD80 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abatacept
  • BMS-188667
332348-12-6 target antagonist
Belatacept
  • BMS-224818
706808-37-9 target

(27) Novoseek inferred chemical compound relationships for CD80 Gene

Compound -log(P) Hits PubMed IDs
ctla4-ig 76.9 15
tn 1000 53 1
ct-26 25.9 2
ionomycin 24.2 2
cyclosporin a 20.8 3
genes like me logo Genes that share compounds with CD80: view

Transcripts for CD80 Gene

mRNA/cDNA for CD80 Gene

Unigene Clusters for CD80 Gene

CD80 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD80 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CD80 Gene

GeneLoc Exon Structure for
CD80
ECgene alternative splicing isoforms for
CD80

Expression for CD80 Gene

mRNA expression in normal human tissues for CD80 Gene

SOURCE GeneReport for Unigene cluster for CD80 Gene Hs.838

mRNA Expression by UniProt/SwissProt for CD80 Gene

P33681-CD80_HUMAN
Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells
genes like me logo Genes that share expressions with CD80: view

Orthologs for CD80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD80 36
  • 99.54 (n)
  • 99.31 (a)
CD80 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD80 36
  • 74.85 (n)
  • 59.93 (a)
CD80 37
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD80 36
  • 71.53 (n)
  • 55.21 (a)
CD80 37
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd80 36
  • 65.87 (n)
  • 47.41 (a)
Cd80 16
Cd80 37
  • 39 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD80 37
  • 26 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd80 36
  • 70.81 (n)
  • 54.84 (a)
chicken
(Gallus gallus)
Aves CD80 37
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD80 37
  • 23 (a)
OneToOne
Species with no ortholog for CD80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD80 Gene

ENSEMBL:
Gene Tree for CD80 (if available)
TreeFam:
Gene Tree for CD80 (if available)

Paralogs for CD80 Gene

Paralogs for CD80 Gene

genes like me logo Genes that share paralogs with CD80: view

Variants for CD80 Gene

Sequence variations from dbSNP and Humsavar for CD80 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs491407 -- 119,538,341(+) AGTAC(A/G)CAAGT intron-variant
rs503083 -- 119,530,635(-) CCATA(C/T)CCACC intron-variant
rs527004 -- 119,550,265(-) GGGAA(C/T)GAATA intron-variant
rs527172 -- 119,539,955(+) ACTTA(A/G)CACAG intron-variant
rs544721 -- 119,535,235(+) CTAGA(A/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD80 Gene

Variant ID Type Subtype PubMed ID
nsv829695 CNV Loss 17160897
esv269361 CNV Insertion 20981092

Relevant External Links for CD80 Gene

HapMap Linkage Disequilibrium report
CD80

Disorders for CD80 Gene

(94) Novoseek inferred disease relationships for CD80 Gene

Disease -log(P) Hits PubMed IDs
necrosis 49.9 26
tumors 47.7 115
tetanus 43.9 1
autoimmune diseases 39 9
lymphocytic leukemia chronic b-cell 29.3 4

Relevant External Links for CD80

Genetic Association Database (GAD)
CD80
Human Genome Epidemiology (HuGE) Navigator
CD80
genes like me logo Genes that share disorders with CD80: view

No data available for UniProtKB/Swiss-Prot for CD80 Gene

Publications for CD80 Gene

  1. Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PMID: 1377173) Selvakumar A. … Dupont B. (Immunogenetics 1992) 3 4 23
  2. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M. … Tokunaga K. (Genes Immun. 2000) 3 23 49
  3. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T. … Mishima M. (Respiration 2005) 3 23 49
  4. Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma. (PMID: 17524139) Chang C.S. … Chung C.Y. (BMC Cancer 2007) 3 23
  5. Role of CD80 in stimulating T lymphocyte activation. (PMID: 16521215) Li D.C. … Fu J.X. (World J. Gastroenterol. 2006) 3 23

Products for CD80 Gene

Sources for CD80 Gene

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