Aliases for CD80 Gene
Aliases for CD80 Gene
External Ids for CD80 Gene
- HGNC: 1700
- Entrez Gene: 941
- Ensembl: ENSG00000121594
- OMIM: 112203
- UniProtKB: P33681
Previous HGNC Symbols for CD80 Gene
- CD28LG
- CD28LG1
Previous GeneCards Identifiers for CD80 Gene
- GC03M115885
- GC03M118875
- GC03M120524
- GC03M120564
- GC03M120725
- GC03M119243
- GC03M116618
Summaries for CD80 Gene
-
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD80 Gene
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Focal Segmental Glomerulosclerosis and Vaccinia. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
UniProtKB/Swiss-Prot for CD80 Gene
-
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
-
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
Additional gene information for CD80 Gene
- Monarch Initiative
- Search for CD80 at DataMed
- Search for CD80 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD80 Gene
Genomics for CD80 Gene
GeneHancer (GH) Regulatory Elements for CD80 Gene
- Top Transcription factor binding sites by QIAGEN in the CD80 gene promoter:
Regulatory Element Products
Genomic Locations for CD80 Gene
- chr3:119,523,948-119,559,634
- (GRCh38/hg38)
- Size:
- 35,687 bases
- Orientation:
- Minus strand
- chr3:119,243,140-119,278,481
- (GRCh37/hg19)
Genomic View for CD80 Gene
- Cytogenetic band:
-
- 3q13.33 by Ensembl
- 3q13.33 by Entrez Gene
- 3q13.33 by HGNC


RefSeq DNA sequence for CD80 Gene
Proteins for CD80 Gene
-
Protein details for CD80 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33681-CD80_HUMAN
- Recommended name:
- T-lymphocyte activation antigen CD80
- Protein Accession:
- P33681
- Q5DTA9
- Q5DTB0
Protein attributes for CD80 Gene
- Size:
- 288 amino acids
- Molecular mass:
- 33048 Da
- Quaternary structure:
-
- Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
- (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.
Post-translational modifications for CD80 Gene
- Glycosylation at Asn53, Asn89, Asn98, posLast=186186, posLast=207207, Asn211, Asn226, and Asn232
Other Protein References for CD80 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
Abcam antibodies for CD80
- Invitrogen Antibodies for CD80
- antibodies-online: Search results for 772 available CD80 Antibodies ranked by validation data
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Recommended
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- 16 IHC Antibodies (anti-mouse)
- 25 IHC (fro) Antibodies (anti-mouse)
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- 2 IHC Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
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- 28 IF Antibodies (anti-human)
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- GeneTex CD80 antibody for CD80
-
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- CD80 molecule [8679]
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- CD80 molecule [RF16046]
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- CD80 molecule [RF16045]
- CD80 molecule [RF16044-HRP]
- CD80 molecule [RF16044]
- CD80 molecule [RF16043-HRP]
- CD80 molecule [RF16043]
- CD80 molecule [RF16042-HRP]
- CD80 molecule [RF16042]
- CD80 molecule [RF16041-HRP]
- CD80 molecule [RF16041]
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD80
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Protein Products
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-
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-
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-
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- antibodies-online: Search results for available CD80 related products ranked by validation data
-
Abcam assays for CD80
No data available for DME Specific Peptides for CD80 Gene
Domains & Families for CD80 Gene
Gene Families for CD80 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- FDA approved drug targets
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for CD80 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD80 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD80 Gene
Function for CD80 Gene
Molecular function for CD80 Gene
- GENATLAS Biochemistry:
- cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
- UniProtKB/Swiss-Prot Function:
- Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Phenotypes From GWAS Catalog for CD80 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001618 | virus receptor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 9915850 |
GO:0015026 | coreceptor activity | NAS | 9915850 |
GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | TAS | -- |
Phenotypes for CD80 Gene
- MGI mutant phenotypes for CD80:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD80:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased viability of wild-type and TP53 knockout cells
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miRNA for CD80 Gene
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CD80 gene related products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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Horizon Cell Lines for CD80
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD80 Gene
Localization for CD80 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene
- Membrane; Single-pass type I membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IEA | -- |
GO:0005886 | plasma membrane | NAS,TAS | -- |
GO:0009986 | cell surface | IDA,HDA | 23981064 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD80 Gene
Pathways & Interactions for CD80 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
.61
|
.47
|
2 | RET signaling |
.92
|
|
3 | PI3K/AKT activation |
.89
|
|
4 | Allograft rejection | ||
5 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
Pathways by source for CD80 Gene
6 BioSystems pathways for CD80 Gene
33 Reactome pathways for CD80 Gene
3 GeneGo (Thomson Reuters) pathways for CD80 Gene
6 R&D Systems pathways for CD80 Gene
34 Qiagen pathways for CD80 Gene
Interacting Proteins for CD80 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007267 | cell-cell signaling | IC | -- |
GO:0009967 | positive regulation of signal transduction | NAS | 9915850 |
GO:0016032 | viral process | IEA | -- |
GO:0031295 | T cell costimulation | TAS | -- |
GO:0035556 | intracellular signal transduction | NAS | 9915850 |
No data available for SIGNOR curated interactions for CD80 Gene
Drugs & Compounds for CD80 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Abatacept | Approved | Pharma | Target, antagonist, binder | 210 | ||
Belatacept | Approved, Investigational | Pharma | Target, inhibitor | 0 | ||
Durvalumab | Approved, Investigational | Pharma | Target, binder | 0 | ||
Galiximab | Investigational | Pharma | Target | 0 | ||
Pharmaceutical Solutions | Pharma | 9000 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for CD80 Gene
mRNA/cDNA for CD80 Gene
- (3) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (15) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CD80
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CD80 gene related products
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-
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ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||
SP5: |
Expression for CD80 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Blood (Hematopoietic System)
- Inner Cell Mass (Early Embryonic Tissues)
NURSA nuclear receptor signaling pathways regulating expression of CD80 Gene:
CD80SOURCE GeneReport for Unigene cluster for CD80 Gene:
Hs.838mRNA Expression by UniProt/SwissProt for CD80 Gene:
P33681-CD80_HUMANEvidence on tissue expression from TISSUES for CD80 Gene
- Nervous system(4.3)
- Spleen(3.8)
- Lymph node(3.6)
- Blood(3.5)
- Bone marrow(2.6)
- Skin(2.1)
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No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD80 Gene
Orthologs for CD80 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CD80 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | CD80 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | CD80 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cd80 33 |
|
||
mouse (Mus musculus) |
Mammalia | Cd80 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | CD80 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | CD80 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | CD80 34 |
|
OneToOne |
- Species where no ortholog for CD80 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CD80 Gene
Variants for CD80 Gene
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000213010 | -- | 119,545,406(-) | T/G | intron_variant | |
rs1000244113 | -- | 119,543,558(-) | G/A | intron_variant | |
rs1000533706 | -- | 119,529,740(-) | A/G | genic_downstream_transcript_variant, intron_variant | |
rs1000679202 | -- | 119,539,635(-) | G/C | intron_variant | |
rs1000881304 | -- | 119,556,523(-) | A/C | 5_prime_UTR_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3353419 | CNV | insertion | 20981092 |
nsv829695 | CNV | loss | 17160897 |
Additional Variant Information for CD80 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CD80
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD80 Gene
Disorders for CD80 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
focal segmental glomerulosclerosis |
|
|
vaccinia |
|
|
systemic lupus erythematosus |
|
|
follicular lymphoma |
|
|
rheumatoid arthritis |
|
Additional Disease Information for CD80
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene
Publications for CD80 Gene
- Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T … Mishima M (Respiration; international review of thoracic diseases 2005) 3 22 44 58
- New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M … Tokunaga K (Genes and immunity 2000) 3 22 44 58
- Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PMID: 1377173) Selvakumar A … Dupont B (Immunogenetics 1992) 3 4 22 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
- PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PMID: 20066438) Ishizaki Y … Hara T (Human genetics 2010) 3 44 58
Products for CD80 Gene
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for CD80
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp. Assay Kits for CD80
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CD80
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD80
- VectorBuilder custom plasmid, inducible vectors for CD80
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD80
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 772 available CD80 Antibodies ranked by validation data
- Compare Top CD80 Antibodies
- Recommended
- 171 WB Antibodies (anti-human)
- 129 FACS Antibodies (anti-human)
- 31 IP Antibodies (anti-human)
- 28 IF Antibodies (anti-human)
- 20 IHC (p) Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 5 LMNX Antibodies (anti-human)
- 3 IF/ICC Antibodies (anti-human)
- 3 ICFC Antibodies (anti-human)
- 3 Neut Antibodies (anti-human)
- 2 Func Antibodies (anti-human)
- 15 FACS Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 12 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 98 FACS Antibodies (anti-mouse)
- 48 IP Antibodies (anti-mouse)
- 32 WB Antibodies (anti-mouse)
- 28 IHC (p) Antibodies (anti-mouse)
- 25 IHC (fro) Antibodies (anti-mouse)
- 16 IHC Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 3 Neut Antibodies (anti-mouse)
- 2 EIA Antibodies (anti-mouse)
- 2 ICC Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IC Antibody (anti-mouse)
- 1 ISt Antibody (anti-mouse)
- antibodies-online: Search results for available CD80 related products ranked by validation data
- antibodies-online: Search results for 49 available CD80 Proteins ranked by validation data
- Compare Top CD80 Proteins
- GeneTex CD80 antibody for CD80
- Search GeneTex for Proteins for CD80
- ViGene Biosciences adenoviral particle packaged cDNA for CD80 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD80 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
- Search ViGene Biosciences for CD80
- Santa Cruz Biotechnology (SCBT) Antibodies for CD80
- Search Santa Cruz Biotechnology (SCBT) for CD80 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD80
- Custom Antibody ServicesProSci Antibodies for CD80
- CD80 molecule [8679]
- CD80 molecule [RF16041]
- CD80 molecule [RF16041-HRP]
- CD80 molecule [RF16042]
- CD80 molecule [RF16042-HRP]
- CD80 molecule [RF16043]
- CD80 molecule [RF16043-HRP]
- CD80 molecule [RF16044]
- CD80 molecule [RF16044-HRP]
- CD80 molecule [RF16045]
- CD80 molecule [RF16045-HRP]
- CD80 molecule [RF16046]
- CD80 molecule [RF16046-HRP]
- ProSci Proteins for CD80
- Horizon Cell Lines for CD80
- genomics-online: cdna clones - Search results for available CD80 gene related products
- orf clones - Search results for available CD80 gene related products
- genomics-online: gRNA clones - Search results for available CD80 gene related products
- genomics-online: primer clones - Search results for available CD80 gene related products
- genomics-online: shRNA clones - Search results for available CD80 gene related products
Sources for CD80 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew