Aliases for CD80 Gene
Aliases for CD80 Gene
External Ids for CD80 Gene
- HGNC: 1700
- Entrez Gene: 941
- Ensembl: ENSG00000121594
- OMIM: 112203
- UniProtKB: P33681
Previous HGNC Symbols for CD80 Gene
- CD28LG
- CD28LG1
Previous GeneCards Identifiers for CD80 Gene
- GC03M115885
- GC03M118875
- GC03M120524
- GC03M120564
- GC03M120725
- GC03M119243
- GC03M116618
Summaries for CD80 Gene
-
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
GeneCards Summary for CD80 Gene
CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Systemic Lupus Erythematosus and Rheumatoid Arthritis. Among its related pathways are CTLA4 Signaling and Th17 Differentiation Pathway. GO annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.
UniProtKB/Swiss-Prot for CD80 Gene
-
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
-
(Microbial infection) Acts as a receptor for adenovirus subgroup B.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD80 Gene
Genomics for CD80 Gene
Regulatory Elements for CD80 Gene
Enhancers for CD80 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around CD80 on UCSC Golden Path with GeneCards custom track
Promoters for CD80 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around CD80 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CD80 gene promoter:
Regulatory Element Products
Genomic Location for CD80 Gene
- Chromosome:
- 3
- Start:
- 119,523,948 bp from pter
- End:
- 119,559,634 bp from pter
- Size:
- 35,687 bases
- Orientation:
- Minus strand
Genomic View for CD80 Gene
Genes around CD80 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.33 by Ensembl
- 3q13.3-q21 by Entrez Gene
- 3q13.3-q21 by HGNC
CD80 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CD80 Gene
Proteins for CD80 Gene
-
Protein details for CD80 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33681-CD80_HUMAN
- Recommended name:
- T-lymphocyte activation antigen CD80
- Protein Accession:
- P33681
- Q5DTA9
- Q5DTB0
Protein attributes for CD80 Gene
- Size:
- 288 amino acids
- Molecular mass:
- 33048 Da
- Quaternary structure:
-
- Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
- (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.
Post-translational modifications for CD80 Gene
Other Protein References for CD80 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD80 (B7-1/CD80)
-
Custom Antibody ServicesOriGene Antibodies for CD80
- Novus Biologicals Antibodies for CD80
- Invitrogen Antibodies for CD80
- antibodies-online Antibodies for CD80: See all 669
- GeneTex CD80 antibody for CD80
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD80
Protein Products
- R&D Systems Proteins and Enzymes for CD80 (B7-1/CD80)
- Enzo Life Sciences proteins for CD80
- Search Origene for MassSpec and Protein Over-expression Lysates for CD80
- Origene Custom Protein Services for CD80
- Sino Biological Cell Lysates for CD80
- Sino Biological Recombinant Proteins for CD80
- antibodies-online Proteins for CD80: See all 32
- Search antibodies-online for peptides
- Search GeneTex for Proteins for CD80
Assay Products
- R&D Systems ELISAs and other biochemical assays for CD80 (B7-1/CD80)
- eBioscience Human sCD80 Instant ELISA 128 tests for CD80
- antibodies-online Kits for CD80: See all 28
- Abcam assays for CD80
No data available for DME Specific Peptides for CD80 Gene
Domains & Families for CD80 Gene
Gene Families for CD80 Gene
Protein Domains for CD80 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD80 Gene
Graphical View of Domain Structure for InterPro Entry
P33681- Domain:
-
- Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
- Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Function for CD80 Gene
Molecular function for CD80 Gene
- GENATLAS Biochemistry:
- cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
- UniProtKB/Swiss-Prot Function:
- Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
- UniProtKB/Swiss-Prot Function:
- (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Phenotypes for CD80 Gene
- MGI mutant phenotypes for CD80:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CD80:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased viability of wild-type and TP53 knockout cells
Animal Model Products
-
Taconic Biosciences Mouse Models for CD80
-
ViGene Biosciences lentiviral particle packaged cDNA for CD80 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
- Search ViGene Biosciences for CD80
CRISPR Products
-
OriGene CRISPR knockouts for CD80
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD80
- GenScript: Design CRISPR guide RNA sequences for CD80
miRNA Products
- Search ViGene Biosciences for CD80
Clone Products
- OriGene clones in human for CD80
- OriGene ORF clones in human,mouse,rat for CD80
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD80
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for CD80 (B7-1/CD80)
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CD80 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD80 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10270 ) for CD80
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD80 Gene
Localization for CD80 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytosol | 2 |
| nucleus | 2 |
| vacuole | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| lysosome | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
No data available for Gene Ontology (GO) - Cellular Components for CD80 Gene
Pathways & Interactions for CD80 Gene
More details on SuperPathways for CD80| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Interleukin-3, 5 and GM-CSF signaling |
.95
|
|
| 2 | PI3K events in ERBB4 signaling |
.82
|
|
| 3 | PEDF Induced Signaling |
.61
|
.47
|
| 4 | Allograft rejection | ||
| 5 | TGF-Beta Pathway |
.60
.57
|
.51
.40
|
Pathways by source for CD80 Gene
6 BioSystems pathways for CD80 Gene
45 Reactome pathways for CD80 Gene
3 GeneGo (Thomson Reuters) pathways for CD80 Gene
6 R&D Systems pathways for CD80 Gene
34 Qiagen pathways for CD80 Gene
Interacting Proteins for CD80 Gene
Selected Interacting proteins:
ENSP00000264246
P33681-CD80_HUMAN
for CD80 Gene via
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | -- |
| GO:0007267 | cell-cell signaling | IC | 9915850 |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | TAS | -- |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | TAS | -- |
| GO:0031295 | T cell costimulation | TAS | -- |
No data available for SIGNOR curated interactions for CD80 Gene
Drugs & Compounds for CD80 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CD80 Gene
mRNA/cDNA for CD80 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (15) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CD80
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD80
- GenScript: Design CRISPR guide RNA sequences for CD80
miRNA Products
- Search ViGene Biosciences for CD80
Clone Products
- OriGene clones in human for CD80
- OriGene ORF clones in human,mouse,rat for CD80
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CD80
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- R&D Systems cDNA Clones for CD80 (B7-1/CD80)
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10270 ) for CD80
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: |
Expression for CD80 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Bone Marrow Stromal Cells Pelvic Girdle
-
Mesenchymal Stem Cells
- Bone Marrow Stromal Cells Pelvic Girdle
- Blood (Hematopoietic System)
- Inner Cell Mass (Early Embryonic Tissues)
SOURCE GeneReport for Unigene cluster for CD80 Gene Hs.838
mRNA Expression by UniProt/SwissProt for CD80 Gene
P33681-CD80_HUMAN
Tissue specificity:
Expressed on activated B-cells, macrophages and dendritic cells.
Primer Products
-
OriGene qPCR primer pairs for CD80
-
OriGene qPCR primer pairs and template standards for CD80
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CD80 Gene
Orthologs for CD80 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | CD80 35 |
|
||
| CD80 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | CD80 35 |
|
||
| CD80 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Cd80 35 |
|
||
| Cd80 16 |
|
||||
| Cd80 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | CD80 35 |
|
||
| CD80 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Cd80 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CD80 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CD80 36 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CD80 36 |
|
OneToOne |
- Species with no ortholog for CD80:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CD80 Gene
Variants for CD80 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs715890 | -- | 119,556,546(+) | TGAAA(C/T)GTAGG | intron-variant, upstream-variant-2KB | |
| rs722045 | -- | 119,545,747(+) | ccccc(C/T)acatt | intron-variant | |
| rs1852211 | -- | 119,555,902(-) | AACAG(C/T)CTGGA | intron-variant, utr-variant-5-prime | |
| rs1852212 | -- | 119,560,388(-) | CTGGT(A/G)TGGGA | upstream-variant-2KB | |
| rs1880661 | -- | 119,560,001(-) | TGGTC(C/T)TGTGA | upstream-variant-2KB |
Residual Variation Intolerance Score:
60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.87;
34.96% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CD80 Gene
Disorders for CD80 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| systemic lupus erythematosus |
|
|
| rheumatoid arthritis |
|
|
| chronic lymphocytic leukemia |
|
|
| ross river fever |
|
|
| fungal esophagitis |
|
|
Search CD80 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CD80
No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene
Publications for CD80 Gene
- Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T. … Mishima M. (Respiration 2005) 3 23 48 67
- Types I and II interferons upregulate the costimulatory CD80 molecule in monocytes via interferon regulatory factor-1. (PMID: 19433065) Bauvois B. … Kolb J.P. (Biochem. Pharmacol. 2009) 3 23
- Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma. (PMID: 17524139) Chang C.S. … Chung C.Y. (BMC Cancer 2007) 3 23
- Role of CD80 in stimulating T lymphocyte activation. (PMID: 16521215) Li D.C. … Fu J.X. (World J. Gastroenterol. 2006) 3 23
- CD80 transfected human hepatocellular carcinoma cells activate cytotoxic T lymphocytes to target HCC cells with shared tumor antigens. (PMID: 15254713) Chan R.C. … Xie Y. (Oncol. Rep. 2004) 3 23
Products for CD80 Gene
- R&D Systems Antibodies for CD80 (B7-1/CD80)
- R&D Systems Proteins and Enzymes for CD80 (B7-1/CD80)
- R&D Systems ELISAs and other biochemical assays for CD80 (B7-1/CD80)
- R&D Systems cDNA Clones for CD80 (B7-1/CD80)
- Browse Primary Antibodies
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- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CD80
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for CD80
- Origene Custom Protein Services for CD80
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for CD80
- Browse OriGene Inhibitory RNA Products For CD80
- OriGene qPCR primer pairs for CD80
- OriGene qPCR primer pairs and template standards for CD80
- OriGene CRISPR knockouts for CD80
- OriGene clones in human for CD80
- OriGene ORF clones in human,mouse,rat for CD80
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for CD80
- GenScript Custom Assay Services for CD80
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- GenScript: Design CRISPR guide RNA sequences for CD80
- Design optimal peptide antigens
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- Plasmid Preparation
- GenScript Custom Peptide Services for CD80
- Sino Biological Human cDNA Clone for CD80
- Sino Biological Cell Lysates for CD80
- Sino Biological Recombinant Proteins for CD80
- 4000+ Proteins
- Search Sino Biological for antibodies, proteins & pathways
- Protein Production Services
- Transfection Reagents
- Protein A/G/L resins
- Isotyping reagents
- Novus Biologicals Antibodies for CD80
- Novus Biologicals proteins and lysates for CD80
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for CD80
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Search eBioscience for CD80 related proteins
- eBioscience Human sCD80 Instant ELISA 128 tests for CD80
- eBioscience FlowRNA Probe Sets (VA1-10270 ) for CD80
- antibodies-online Antibodies for CD80: See all 669
- antibodies-online Kits for CD80: See all 28
- antibodies-online Proteins for CD80: See all 32
- Search antibodies-online for peptides
- GeneTex CD80 antibody for CD80
- Search GeneTex for Proteins for CD80
- ViGene Biosciences adenoviral particle packaged cDNA for CD80 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD80 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD80 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD80 gene
- Search ViGene Biosciences for CD80
- Search ViGene Biosciences for CD80
- Santa Cruz Biotechnology (SCBT) Antibodies for CD80
- Search Santa Cruz Biotechnology (SCBT) for CD80 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD80
Sources for CD80 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon