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Aliases for CD80 Gene

Aliases for CD80 Gene

  • CD80 Molecule 2 3 5
  • CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen) 2 3
  • B-Lymphocyte Activation Antigen B7 2 3
  • CTLA-4 Counter-Receptor B7.1 3 4
  • Activation B7-1 Antigen 3 4
  • CD28LG1 3 4
  • CD28LG 3 4
  • LAB7 3 4
  • BB1 3 4
  • B7 3 4
  • Costimulatory Molecule Variant IgV-CD80 3
  • T-Lymphocyte Activation Antigen CD80 3
  • Costimulatory Factor CD80 3
  • CD80 Antigen 4
  • B7-1 3
  • B7.1 3

External Ids for CD80 Gene

Previous HGNC Symbols for CD80 Gene

  • CD28LG
  • CD28LG1

Previous GeneCards Identifiers for CD80 Gene

  • GC03M115885
  • GC03M118875
  • GC03M120524
  • GC03M120564
  • GC03M120725
  • GC03M119243
  • GC03M116618

Summaries for CD80 Gene

Entrez Gene Summary for CD80 Gene

  • The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

GeneCards Summary for CD80 Gene

CD80 (CD80 Molecule) is a Protein Coding gene. Diseases associated with CD80 include Vaccinia and Systemic Lupus Erythematosus. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include coreceptor activity. An important paralog of this gene is CD86.

UniProtKB/Swiss-Prot for CD80 Gene

  • Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

  • (Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Wiki entry for CD80 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD80 Gene

Genomics for CD80 Gene

Regulatory Elements for CD80 Gene

Enhancers for CD80 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G119557 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25.9 -0.9 -900 5.8 HDGF PKNOX1 WRNIP1 SIN3A YY1 TCF12 ZNF766 ZNF143 ZNF207 FOS CD80 ADPRH ARHGAP31 TMEM39A
GH03G119570 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20 -11.4 -11367 2.0 PKNOX1 MTA2 EBF1 DPF2 NR2F2 IKZF1 STAT2 EED PBX2 RELB CD80 PLA1A ARHGAP31 ADPRH POPDC2 TMEM39A POGLUT1 COX17
GH03G119626 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -69.8 -69760 5.2 PKNOX1 KLF17 RAD21 YY1 ZNF766 GATA2 SCRT2 FOS RELB IKZF2 ADPRH MAATS1 RPL10P7 COX17 CD80 POPDC2 ARHGAP31 PLA1A GPR156 GSK3B
GH03G119595 1.4 FANTOM5 Ensembl ENCODE 15.4 -37.2 -37197 3.0 PKNOX1 TBL1XR1 ZFP64 WRNIP1 RAD21 YY1 RELB SMAD5 USF2 JUNB CD80 ADPRH COX17 ARHGAP31 TMEM39A POGLUT1 PLA1A ENSG00000272967
GH03G119578 1.2 ENCODE dbSUPER 17.4 -20.2 -20212 2.4 HDGF WRNIP1 SIN3A DMAP1 YY1 ZNF207 REST ZNF579 NBN STAT3 ADPRH CD80 MAATS1 ENSG00000272967 PLA1A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD80 on UCSC Golden Path with GeneCards custom track

Genomic Location for CD80 Gene

Chromosome:
3
Start:
119,523,948 bp from pter
End:
119,559,634 bp from pter
Size:
35,687 bases
Orientation:
Minus strand

Genomic View for CD80 Gene

Genes around CD80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD80 Gene

Proteins for CD80 Gene

  • Protein details for CD80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33681-CD80_HUMAN
    Recommended name:
    T-lymphocyte activation antigen CD80
    Protein Accession:
    P33681
    Secondary Accessions:
    • Q5DTA9
    • Q5DTB0

    Protein attributes for CD80 Gene

    Size:
    288 amino acids
    Molecular mass:
    33048 Da
    Quaternary structure:
    • Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper-like arrangement.
    • (Microbial infection) Interacts with adenovirus subgroup B fiber proteins.

    Three dimensional structures from OCA and Proteopedia for CD80 Gene

    Alternative splice isoforms for CD80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD80 Gene

Post-translational modifications for CD80 Gene

  • Glycosylation at posLast=5353, posLast=8989, Asn98, posLast=186186, posLast=207207, Asn211, Asn226, and posLast=232232
  • Modification sites at PhosphoSitePlus

Other Protein References for CD80 Gene

No data available for DME Specific Peptides for CD80 Gene

Domains & Families for CD80 Gene

Protein Domains for CD80 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CD80: view

No data available for UniProtKB/Swiss-Prot for CD80 Gene

Function for CD80 Gene

Molecular function for CD80 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD80,identified by monoclonal antibody BB1,B7.1,expressed in T lymphocyte,CD28,CD86 ligand
UniProtKB/Swiss-Prot Function:
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for adenovirus subgroup B.

Gene Ontology (GO) - Molecular Function for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005515 protein binding IPI 9915850
GO:0015026 coreceptor activity NAS 9915850
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS --
genes like me logo Genes that share ontologies with CD80: view
genes like me logo Genes that share phenotypes with CD80: view

Animal Models for CD80 Gene

MGI Knock Outs for CD80:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD80

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CD80 Gene

Localization for CD80 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD80 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD80 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 23981064
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CD80: view

Pathways & Interactions for CD80 Gene

genes like me logo Genes that share pathways with CD80: view

Gene Ontology (GO) - Biological Process for CD80 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IC 9915850
GO:0009967 positive regulation of signal transduction NAS 9915850
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS --
GO:0016032 viral process IEA --
GO:0031295 T cell costimulation TAS --
genes like me logo Genes that share ontologies with CD80: view

No data available for SIGNOR curated interactions for CD80 Gene

Drugs & Compounds for CD80 Gene

(25) Drugs for CD80 Gene - From: DrugBank, ClinicalTrials, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Abatacept Approved Pharma binder, Target, antagonist 197
Belatacept Approved Pharma inhibitor, Target 0
Durvalumab Approved Pharma Target, binder 0
Galiximab Investigational Pharma Target 0
Pharmaceutical Solutions Pharma 8192

(11) Additional Compounds for CD80 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD80: view

Transcripts for CD80 Gene

mRNA/cDNA for CD80 Gene

Unigene Clusters for CD80 Gene

CD80 molecule:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD80 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: -
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CD80 Gene

GeneLoc Exon Structure for
CD80
ECgene alternative splicing isoforms for
CD80

Expression for CD80 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD80 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CD80 Gene:

CD80

SOURCE GeneReport for Unigene cluster for CD80 Gene:

Hs.838

mRNA Expression by UniProt/SwissProt for CD80 Gene:

P33681-CD80_HUMAN
Tissue specificity: Expressed on activated B-cells, macrophages and dendritic cells.

Evidence on tissue expression from TISSUES for CD80 Gene

  • Nervous system(4.3)
  • Spleen(3.8)
  • Lymph node(3.6)
  • Blood(3.5)
  • Bone marrow(2.6)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with CD80: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD80 Gene

Orthologs for CD80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD80 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia CD80 34 35
  • 74.85 (n)
dog
(Canis familiaris)
Mammalia CD80 34 35
  • 71.53 (n)
rat
(Rattus norvegicus)
Mammalia Cd80 34
  • 70.81 (n)
mouse
(Mus musculus)
Mammalia Cd80 34 16 35
  • 65.87 (n)
oppossum
(Monodelphis domestica)
Mammalia CD80 35
  • 26 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD80 35
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD80 35
  • 23 (a)
OneToOne
Species where no ortholog for CD80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD80 Gene

ENSEMBL:
Gene Tree for CD80 (if available)
TreeFam:
Gene Tree for CD80 (if available)

Paralogs for CD80 Gene

Paralogs for CD80 Gene

genes like me logo Genes that share paralogs with CD80: view

Variants for CD80 Gene

Sequence variations from dbSNP and Humsavar for CD80 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000213010 -- 119,545,406(+) TACAG(G/T)TCAGT intron-variant
rs1000244113 -- 119,543,558(+) TTCAA(A/G)TGATT intron-variant
rs1000533706 -- 119,529,740(+) TAAAC(A/G)TGAGA intron-variant
rs1000679202 -- 119,539,635(+) GTACA(C/G)GAAAA intron-variant
rs1000881304 -- 119,556,523(+) TAAAA(A/C)ACCTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CD80 Gene

Variant ID Type Subtype PubMed ID
esv3353419 CNV insertion 20981092
nsv829695 CNV loss 17160897

Variation tolerance for CD80 Gene

Residual Variation Intolerance Score: 60.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD80 Gene

Disorders for CD80 Gene

MalaCards: The human disease database

(16) MalaCards diseases for CD80 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
vaccinia
systemic lupus erythematosus
  • lupus nephritis
follicular lymphoma
  • lymphoma, follicular
fungal esophagitis
wegener granulomatosis
  • wegener's granulomatosis
- elite association - COSMIC cancer census association via MalaCards
Search CD80 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD80

Genetic Association Database (GAD)
CD80
Human Genome Epidemiology (HuGE) Navigator
CD80
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD80
genes like me logo Genes that share disorders with CD80: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD80 Gene

Publications for CD80 Gene

  1. Polymorphisms of B7 (CD80 and CD86) genes do not affect disease susceptibility to sarcoidosis. (PMID: 15942292) Handa T. … Mishima M. (Respiration 2005) 3 22 46 64
  2. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PMID: 11196673) Matsushita M. … Tokunaga K. (Genes Immun. 2000) 3 22 46 64
  3. Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7. (PMID: 1377173) Selvakumar A. … Dupont B. (Immunogenetics 1992) 3 4 22 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis. (PMID: 20066438) Ishizaki Y. … Hara T. (Hum. Genet. 2010) 3 46 64

Products for CD80 Gene

Sources for CD80 Gene

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