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Aliases for FTMT Gene

Aliases for FTMT Gene

  • Ferritin Mitochondrial 2 3
  • EC 1.16.3.1 4 64
  • Ferritin, Mitochondrial 3
  • Mitochondrial Ferritin 3
  • Ferritin H Subunit 3
  • MTF 3

External Ids for FTMT Gene

Summaries for FTMT Gene

GeneCards Summary for FTMT Gene

FTMT (Ferritin Mitochondrial) is a Protein Coding gene. Diseases associated with FTMT include spontaneous pneumothorax and pneumothorax. Among its related pathways are Mineral absorption and Metabolism of porphyrins. GO annotations related to this gene include ferric iron binding and ferroxidase activity. An important paralog of this gene is FTL.

UniProtKB/Swiss-Prot for FTMT Gene

  • Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Gene Wiki entry for FTMT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTMT Gene

Genomics for FTMT Gene

Genomic Location for FTMT Gene

Start:
121,851,955 bp from pter
End:
121,852,833 bp from pter
Size:
879 bases
Orientation:
Plus strand

Genomic View for FTMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FTMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTMT Gene

Regulatory Elements for FTMT Gene

Proteins for FTMT Gene

  • Protein details for FTMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4E7-FTMT_HUMAN
    Recommended name:
    Ferritin, mitochondrial
    Protein Accession:
    Q8N4E7
    Secondary Accessions:

    Protein attributes for FTMT Gene

    Size:
    242 amino acids
    Molecular mass:
    27538 Da
    Quaternary structure:
    • Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited

    Three dimensional structures from OCA and Proteopedia for FTMT Gene

neXtProt entry for FTMT Gene

Proteomics data for FTMT Gene at MOPED

Selected DME Specific Peptides for FTMT Gene

Post-translational modifications for FTMT Gene

No Post-translational modifications

Other Protein References for FTMT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FTMT Gene

UniProtKB/Swiss-Prot:

FTMT_HUMAN
Domain:
  • Contains 1 ferritin-like diiron domain.:
    • Q8N4E7
Family:
  • Belongs to the ferritin family.:
    • Q8N4E7
genes like me logo Genes that share domains with FTMT: view

No data available for Gene Families for FTMT Gene

Function for FTMT Gene

Molecular function for FTMT Gene

UniProtKB/Swiss-Prot CatalyticActivity: 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
UniProtKB/Swiss-Prot Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Enzyme Numbers (IUBMB) for FTMT Gene

Gene Ontology (GO) - Molecular Function for FTMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004322 ferroxidase activity IEA --
GO:0008199 ferric iron binding IEA --
genes like me logo Genes that share ontologies with FTMT: view

Phenotypes for FTMT Gene

MGI mutant phenotypes for FTMT:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FTMT: view

Animal Models for FTMT Gene

MGI Knock Outs for FTMT:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for FTMT Gene

Localization for FTMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for FTMT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FTMT Gene COMPARTMENTS Subcellular localization image for FTMT gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for FTMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with FTMT: view

Pathways for FTMT Gene

genes like me logo Genes that share pathways with FTMT: view

Pathways by source for FTMT Gene

Interacting Proteins for FTMT Gene

Gene Ontology (GO) - Biological Process for FTMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006826 iron ion transport IEA --
GO:0006879 cellular iron ion homeostasis IDA 18160053
GO:0008284 positive regulation of cell proliferation IDA 18160053
GO:0051347 positive regulation of transferase activity IDA 18160053
GO:0051349 positive regulation of lyase activity IDA 18160053
genes like me logo Genes that share ontologies with FTMT: view

Compounds for FTMT Gene

(4) HMDB Compounds for FTMT Gene

Compound Synonyms Cas Number PubMed IDs
Copper
  • Cu
7440-50-8
Iron
  • Armco iron
7439-89-6
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5

(7) Novoseek inferred chemical compound relationships for FTMT Gene

Compound -log(P) Hits PubMed IDs
iron 70.5 67
ferric ammonium citrate 70.3 4
deferoxamine 50.7 4
iron-sulfur 38.5 1
endotoxin 31.8 4
genes like me logo Genes that share compounds with FTMT: view

Transcripts for FTMT Gene

mRNA/cDNA for FTMT Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FTMT Gene

Ferritin mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FTMT Gene

No ASD Table

Relevant External Links for FTMT Gene

GeneLoc Exon Structure for
FTMT
ECgene alternative splicing isoforms for
FTMT

Expression for FTMT Gene

mRNA expression in normal human tissues for FTMT Gene

mRNA differential expression in normal tissues according to GTEx for FTMT Gene

This gene is overexpressed in Testis (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FTMT Gene

SOURCE GeneReport for Unigene cluster for FTMT Gene Hs.105324

mRNA Expression by UniProt/SwissProt for FTMT Gene

Q8N4E7-FTMT_HUMAN
Tissue specificity: Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine.
genes like me logo Genes that share expressions with FTMT: view

Orthologs for FTMT Gene

This gene was present in the common ancestor of animals.

Orthologs for FTMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTMT 36
  • 99.04 (n)
  • 97.93 (a)
FTMT 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FTMT 36
  • 84.16 (n)
  • 78.93 (a)
FTMT 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 78 (a)
OneToMany
-- 37
  • 78 (a)
OneToMany
LOC608550 36
  • 83.68 (n)
  • 79.67 (a)
mouse
(Mus musculus)
Mammalia Ftmt 36
  • 78.76 (n)
  • 77.64 (a)
Ftmt 16
Ftmt 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 40 (a)
ManyToMany
-- 37
  • 71 (a)
ManyToMany
-- 37
  • 78 (a)
ManyToMany
-- 37
  • 48 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ftmt 36
  • 79.61 (n)
  • 77.22 (a)
chicken
(Gallus gallus)
Aves FTH 37
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 78 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fth1a 37
  • 71 (a)
ManyToMany
fth1b 37
  • 70 (a)
ManyToMany
zgc:92066 36
  • 67.84 (n)
  • 67.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fer3HCH 36
  • 54.12 (n)
  • 46.3 (a)
Species with no ortholog for FTMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FTMT Gene

ENSEMBL:
Gene Tree for FTMT (if available)
TreeFam:
Gene Tree for FTMT (if available)

Paralogs for FTMT Gene

Paralogs for FTMT Gene

Selected SIMAP similar genes for FTMT Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FTMT Gene

genes like me logo Genes that share paralogs with FTMT: view

Variants for FTMT Gene

Sequence variations from dbSNP and Humsavar for FTMT Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7720502 -- 121,851,802(+) TCCCC(A/G)GCGCC upstream-variant-2KB
rs12517730 -- 121,851,217(+) tagta(A/G)agacg upstream-variant-2KB
rs13358715 -- 121,852,914(+) GGTAA(C/T)TATGG downstream-variant-500B
rs28620434 -- 121,850,768(+) AATAG(C/T)AATCT upstream-variant-2KB
rs34576128 -- 121,852,863(+) CTTTT(-/T)ACTAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FTMT Gene

Variant ID Type Subtype PubMed ID
nsv830469 CNV Gain 17160897

Relevant External Links for FTMT Gene

HapMap Linkage Disequilibrium report
FTMT
Human Gene Mutation Database (HGMD)
FTMT

Disorders for FTMT Gene

(1) University of Copenhagen DISEASES for FTMT Gene

(9) Novoseek inferred disease relationships for FTMT Gene

Disease -log(P) Hits PubMed IDs
anemia sideroblastic 87.8 6
friedreich ataxia 80.2 2
anemia refractory 48.3 1
cerebral vasospasm 43.2 1
iron overload 42.8 3

Relevant External Links for FTMT

Genetic Association Database (GAD)
FTMT
Human Genome Epidemiology (HuGE) Navigator
FTMT
genes like me logo Genes that share disorders with FTMT: view

No data available for UniProtKB/Swiss-Prot for FTMT Gene

Publications for FTMT Gene

  1. A human mitochondrial ferritin encoded by an intronless gene. (PMID: 11323407) Levi S. … Drysdale J. (J. Biol. Chem. 2001) 2 3 4 23
  2. Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala. (PMID: 15201052) Langlois d'Estaintot B. … Arosio P. (J. Mol. Biol. 2004) 3 4 23
  3. The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin. (PMID: 18160053) Zanella I. … Arosio P. (Biochim. Biophys. Acta 2008) 3 23
  4. Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin. (PMID: 15755449) Bou-Abdallah F. … Chasteen N.D. (J. Mol. Biol. 2005) 3 23
  5. Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia. (PMID: 12406866) Cazzola M. … Arosio P. (Blood 2003) 3 23

Products for FTMT Gene

Sources for FTMT Gene

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