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Aliases for MUC16 Gene

Aliases for MUC16 Gene

  • Mucin 16, Cell Surface Associated 2 3
  • CA125 3 4 6
  • Ovarian Cancer-Related Tumor Marker CA125 3 4
  • Ovarian Carcinoma Antigen CA125 3 4
  • CA125 Ovarian Cancer Antigen 3
  • Mucin-16 3
  • CA-125 4
  • MUC-16 4

External Ids for MUC16 Gene

Previous GeneCards Identifiers for MUC16 Gene

  • GC19M009087
  • GC19M009182
  • GC19M008805
  • GC19M008820
  • GC19U900441
  • GC19M008960
  • GC19M008584

Summaries for MUC16 Gene

GeneCards Summary for MUC16 Gene

MUC16 (Mucin 16, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC16 include mucinous ovarian cystadenoma and pleural cancer. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

UniProtKB/Swiss-Prot for MUC16 Gene

  • Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Gene Wiki entry for MUC16 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC16 Gene

Genomics for MUC16 Gene

Genomic Location for MUC16 Gene

Start:
8,848,840 bp from pter
End:
8,981,342 bp from pter
Size:
132,503 bases
Orientation:
Minus strand

Genomic View for MUC16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC16 Gene

No data available for Regulatory Elements for MUC16 Gene

Proteins for MUC16 Gene

  • Protein details for MUC16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXI7-MUC16_HUMAN
    Recommended name:
    Mucin-16
    Protein Accession:
    Q8WXI7
    Secondary Accessions:
    • Q6ZQW5
    • Q96RK2

    Protein attributes for MUC16 Gene

    Size:
    22152 amino acids
    Molecular mass:
    2353428 Da
    Quaternary structure:
    • Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN
    Miscellaneous:
    • Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening

neXtProt entry for MUC16 Gene

Proteomics data for MUC16 Gene at MOPED

Post-translational modifications for MUC16 Gene

  • Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.
  • Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.
  • May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.
  • May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts
  • Glycosylation at Asn139, Asn434, Ser472, Ser475, Ser477, Thr480, Ser620, Thr623, Thr624, Thr628, Ser708, Ser709, Thr718, Asn787, Ser908, Ser912, Ser913, Ser914, Ser918, Asn930, Asn957, Asn1375, Thr1512, Ser1514, Thr1515, Thr1516, Asn1633, Asn1840, Ser1864, Thr1867, Thr1870, Asn1877, Asn1890, Asn2345, Asn2375, Asn2737, Thr2983, Asn3086, Ser3147, Ser3148, Ser3150, Asn3179, Ser3211, Ser3212, Ser3216, Ser3218, Thr3391, Ser3396, Thr3397, Thr3398, Ser3402, Thr3403, Thr3416, Ser3417, Asn3502, Ser3796, Thr3800, Ser3802, Thr3807, Ser3808, Thr3814, Ser3815, Thr3816, Thr3820, Thr3821, Thr3822, Ser3823, Ser3832, Thr3835, Thr3836, Thr3843, Thr4009, Ser4013, Thr4016, Ser4060, Ser4061, Ser4067, Thr4132, Ser4134, Thr4137, Thr4138, Asn4222, Thr4252, Thr4257, Ser4258, Ser4262, Thr4268, Ser4271, Asn4500, Asn4608, Asn4615, Asn4626, Ser4662, Ser4665, Asn4863, Thr5082, Thr5093, Asn5098, Asn5133, Thr5187, Thr5191, Asn5230, Ser5236, Thr5237, Ser5243, Thr5244, Thr5249, Thr5251, Thr5259, Ser5260, Ser5261, Thr5264, Asn5322, Asn5396, Asn5472, Thr5555, Ser5556, Thr5560, Asn5691, Thr5776, Ser5778, Thr5779, Ser5780, Ser5781, Asn5865, Ser5902, Thr5905, Thr5906, Thr5907, Thr6073, Ser6074, Asn6090, Thr6265, Thr6275, Ser6360, Thr6362, Thr6363, Ser6365, Ser6383, Thr6385, Ser6386, Thr6387, Thr6394, Thr6397, Thr6398, Thr6431, Ser6434, Thr6435, Thr6440, Thr6446, Thr6449, Thr6451, Thr6577, Thr6578, Ser6579, Thr6585, Thr6684, Thr6685, Thr6688, Thr6690, Ser6691, Thr6693, Ser6697, Asn6734, Asn6861, Ser6947, Thr6948, Ser6950, Thr6952, Asn6963, Ser7071, Thr7074, Thr7075, Ser7078, Ser7242, Ser7244, Ser7245, Ser7367, Thr7370, Thr7371, Ser7374, Ser7536, Ser7540, Ser7541, Thr7543, Thr7544, Ser7610, Ser7612, Ser7613, Thr7616, Ser7618, Ser7676, Ser7679, Thr7825, Ser7829, Ser7830, Thr7832, Ser7960, Ser7963, Asn8031, Asn8057, Thr8115, Thr8118, Ser8119, Ser8120, Thr8122, Ser8239, Ser8241, Thr8244, Thr8245, Ser8248, Asn8326, Thr8413, Ser8414, Thr8417, Ser8418, Ser8536, Thr8539, Thr8540, Ser8543, Asn8620, Ser8644, Ser8645, Thr8647, Thr8654, Asn8686, Ser8716, Thr8717, Ser8718, Thr8721, Ser8722, Ser8723, Thr8725, Thr8793, Ser8799, Ser8800, Thr8805, Ser8809, Ser8810, Ser8813, Thr8817, Ser8819, Thr8822, Ser8842, Ser8845, Thr8886, Thr8890, Asn8915, Thr9009, Ser9010, Thr9011, Ser9012, Thr9019, Ser9022, Thr9023, Asn9204, Thr9365, Thr9370, Asn9495, Thr9553, Ser9554, Ser9716, Thr9718, Ser9719, Asn9787, Ser9811, Thr9814, Thr9871, Thr9874, Ser9876, Thr9878, Asn9920, Ser9996, Thr9999, Thr10000, Ser10003, Ser10005, Asn10077, Asn10175, Ser10301, Ser10303, Thr10426, Thr10428, Thr10436, Thr10447, Thr10456, Ser10457, Thr10458, Ser10459, Ser10462, Asn10512, Thr10681, Thr10683, Thr10684, Thr10687, Thr10692, Ser10693, Ser10694, Asn10702, Asn10751, Thr10796, Ser10797, Thr10800, Ser10801, Asn11055, Asn11226, Asn11265, Asn11369, Asn11596, Thr11610, Ser11611, Ser11838, Thr11840, Ser11842, Ser11846, Ser11965, Thr11967, Asn12081, Asn12102, Asn12118, Asn12170, Asn12237, Asn12274, Asn12395, Asn12416, Asn12432, Asn12551, Asn12572, Asn12588, Asn12706, Asn12727, Asn12743, Asn12826, Asn12862, Asn12883, Asn12982, Asn13018, Asn13039, Asn13055, Asn13174, Asn13195, Asn13211, Asn13330, Asn13351, Asn13367, Asn13423, Asn13486, Asn13507, Asn13523, Asn13579, Asn13642, Asn13663, Asn13679, Asn13798, Asn13819, Asn13835, Asn13954, Asn13975, Asn13991, Asn14110, Asn14131, Asn14147, Asn14266, Asn14287, Asn14303, Asn14359, Asn14422, Asn14459, Asn14580, Asn14601, Asn14617, Asn14736, Asn14757, Asn14773, Asn14825, Asn14892, Asn14913, Asn14929, Asn15048, Asn15069, Asn15204, Asn15241, Asn15360, Asn15381, Asn15397, Asn15516, Asn15537, Asn15672, Asn15693, Asn15709, Asn15827, Asn15848, Asn15864, Asn15947, Asn15983, Asn16004, Asn16020, Asn16138, Asn16159, Asn16175, Asn16258, Asn16294, Asn16315, Asn16331, Asn16450, Asn16471, Asn16487, Asn16539, Asn16606, Asn16627, Asn16643, Asn16762, Asn16783, Asn16799, Asn16918, Asn16939, Asn16955, Asn17074, Asn17095, Asn17111, Asn17230, Asn17251, Asn17386, Asn17407, Asn17423, Asn17542, Asn17563, Asn17579, Asn17698, Asn17719, Asn17854, Asn17875, Asn17891, Asn18010, Asn18031, Asn18047, Asn18166, Asn18187, Asn18203, Asn18322, Asn18343, Asn18359, Asn18478, Asn18499, Asn18515, Asn18634, Asn18655, Asn18790, Asn18811, Asn18827, Asn18946, Asn18967, Asn18983, Asn19039, Asn19102, Asn19123, Asn19139, Asn19258, Asn19279, Asn19295, Asn19414, Asn19435, Asn19451, Asn19570, Asn19591, Asn19607, Asn19726, Asn19747, Asn19763, Asn19881, Asn19902, Asn19918, Asn20037, Asn20058, Asn20074, Asn20157, Asn20193, Asn20214, Asn20230, Asn20349, Asn20370, Asn20505, Asn20526, Asn20661, Asn20682, Asn20698, Asn20817, Asn20838, Asn20973, Asn20994, Asn21010, Asn21129, Asn21150, Asn21166, Asn21285, Asn21306, Asn21378, Asn21389, Ser21419, Thr21421, Asn21441, Asn21461, Asn21477, Asn21574, Asn21595, Asn21725, Asn21745, Asn21840, Asn21857, Asn21899, Asn21932, Asn21971, Asn22008, Asn22062, and Asn22068
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MUC16 Gene

Domains for MUC16 Gene

Gene Families for MUC16 Gene

HGNC:

Protein Domains for MUC16 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MUC16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WXI7

UniProtKB/Swiss-Prot:

MUC16_HUMAN :
  • Q8WXI7
Domain:
  • Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail
  • Contains 56 SEA domains.
Similarity:
  • Contains 2 ANK repeats.
genes like me logo Genes that share domains with MUC16: view

Function for MUC16 Gene

Molecular function for MUC16 Gene

UniProtKB/Swiss-Prot Function: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
UniProtKB/Swiss-Prot Induction: Up-regulated in ovarian cancer cells.

Gene Ontology (GO) - Molecular Function for MUC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14676194
genes like me logo Genes that share ontologies with MUC16: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MUC16 Gene

Localization for MUC16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC16 Gene

Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC16 Gene COMPARTMENTS Subcellular localization image for MUC16 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MUC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MUC16: view

Pathways for MUC16 Gene

genes like me logo Genes that share pathways with MUC16: view

Gene Ontology (GO) - Biological Process for MUC16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0007155 cell adhesion NAS 14676194
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC16: view

Compounds for MUC16 Gene

(36) Novoseek inferred chemical compound relationships for MUC16 Gene

Compound -log(P) Hits PubMed IDs
b 723 49.2 3
paclitaxel 45.3 2
icodextrin 45.1 9
progesterone 37.8 26
carboplatin 37.1 2
genes like me logo Genes that share compounds with MUC16: view

Transcripts for MUC16 Gene

mRNA/cDNA for MUC16 Gene

(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MUC16 Gene

Mucin 16, cell surface associated:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MUC16

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MUC16
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MUC16 Gene

No ASD Table

Relevant External Links for MUC16 Gene

GeneLoc Exon Structure for
MUC16
ECgene alternative splicing isoforms for
MUC16

Expression for MUC16 Gene

mRNA expression in normal human tissues for MUC16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC16 Gene

This gene is overexpressed in Cervix - Endocervix (24.2), Minor Salivary Gland (8.7), and Adipose - Visceral (Omentum) (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MUC16 Gene

SOURCE GeneReport for Unigene cluster for MUC16 Gene Hs.432676

mRNA Expression by UniProt/SwissProt for MUC16 Gene

Q8WXI7-MUC16_HUMAN
Tissue specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
genes like me logo Genes that share expressions with MUC16: view

In Situ Assay Products

Orthologs for MUC16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC16 35
  • 94.14 (n)
  • 90.21 (a)
cow
(Bos Taurus)
Mammalia MUC16 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MUC16 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Muc16 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MUC16 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUC16 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves MUC16 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MUC16 36
  • 40 (a)
OneToOne
Species with no ortholog for MUC16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC16 Gene

ENSEMBL:
Gene Tree for MUC16 (if available)
TreeFam:
Gene Tree for MUC16 (if available)

Paralogs for MUC16 Gene

No data available for Paralogs for MUC16 Gene

Variants for MUC16 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC16 Gene

Q8WXI7-MUC16_HUMAN
The number of repeats is highly polymorphic

Sequence variations from dbSNP and Humsavar for MUC16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs744246 -- 8,882,913(+) TGCCT(A/G)TGGGG intron-variant
rs752410 -- 8,883,609(-) ATTAC(A/T)GCCCC intron-variant
rs873869 -- 8,883,697(-) TGTCT(C/T)GTTCC intron-variant
rs881877 -- 8,908,753(-) TGCCC(A/G)TATGC intron-variant
rs918535 -- 8,946,254(+) ATGTT(G/T)GTCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MUC16 Gene

Variant ID Type Subtype PubMed ID
nsv469648 CNV Complex 16826518
nsv428362 CNV Gain+Loss 18775914
nsv483078 CNV Complex 15286789
nsv911019 CNV Gain 21882294
dgv48n68 CNV Gain 17160897
dgv1056e1 CNV Complex 17122850
nsv2406 CNV Insertion 18451855
esv2718141 CNV Deletion 23290073
esv2221846 CNV Deletion 18987734
esv2664410 CNV Deletion 23128226
esv2718142 CNV Deletion 23290073
esv2718143 CNV Deletion 23290073
esv2718144 CNV Deletion 23290073
esv2117991 CNV Deletion 18987734
esv2718145 CNV Deletion 23290073
esv2718146 CNV Deletion 23290073
nsv2407 CNV Insertion 18451855
dgv621e199 CNV Deletion 23128226
esv2718147 CNV Deletion 23290073
nsv523652 CNV Loss 19592680
nsv470123 CNV Loss 18288195

Relevant External Links for MUC16 Gene

HapMap Linkage Disequilibrium report
MUC16

Disorders for MUC16 Gene

(1) University of Copenhagen DISEASES for MUC16 Gene

(97) Novoseek inferred disease relationships for MUC16 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 88.9 218
ovarian carcinoma 85.3 83
ovarian tumor benign 84.1 12
recurrent ovarian cancer 79.7 16
stage ovarian cancer 75.1 13

Relevant External Links for MUC16

Genetic Association Database (GAD)
MUC16
Human Genome Epidemiology (HuGE) Navigator
MUC16
genes like me logo Genes that share disorders with MUC16: view

No data available for UniProtKB/Swiss-Prot for MUC16 Gene

Publications for MUC16 Gene

  1. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. (PMID: 11369781) Yin B.W.T. … Lloyd K.O. (J. Biol. Chem. 2001) 2 3 4 23
  2. Characterization of the oligosaccharides associated with the human ovarian tumor marker CA125. (PMID: 12734200) Kui Wong N. … Patankar M.S. (J. Biol. Chem. 2003) 3 4 23
  3. Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. (PMID: 15788735) McLemore M.R. … Aouizerat B. (Biol. Res. Nurs. 2005) 3 4 23
  4. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. (PMID: 14676194) Rump A. … Miyajima A. (J. Biol. Chem. 2004) 3 4 23
  5. Production of CA125 by human lung cancer cell lines. (PMID: 15599662) Homma S. … Sekizawa K. (Clin. Exp. Med. 2004) 3 23

Products for MUC16 Gene

Sources for MUC16 Gene

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