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Aliases for CD28 Gene

Aliases for CD28 Gene

  • CD28 Molecule 2 3
  • CD28 Antigen 3 4
  • Tp44 3 4
  • T-Cell-Specific Surface Glycoprotein CD28 3
  • T-Cell-Specific Surface Glycoprotein 2
  • CD28 Antigen (Tp44) 2

External Ids for CD28 Gene

Previous GeneCards Identifiers for CD28 Gene

  • GC02P202788
  • GC02P203295
  • GC02P204535
  • GC02P204773
  • GC02P204396
  • GC02P204279
  • GC02P196418

Summaries for CD28 Gene

Entrez Gene Summary for CD28 Gene

  • The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

GeneCards Summary for CD28 Gene

CD28 (CD28 Molecule) is a Protein Coding gene. Diseases associated with CD28 include sialadenitis and common variable immunodeficiency. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include identical protein binding and SH3/SH2 adaptor activity. An important paralog of this gene is CTLA4.

UniProtKB/Swiss-Prot for CD28 Gene

  • Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival

Gene Wiki entry for CD28 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD28 Gene

Genomics for CD28 Gene

Genomic Location for CD28 Gene

203,706,475 bp from pter
203,738,912 bp from pter
32,438 bases
Plus strand

Genomic View for CD28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD28 Gene

Proteins for CD28 Gene

  • Protein details for CD28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell-specific surface glycoprotein CD28
    Protein Accession:
    Secondary Accessions:
    • A8KAC1
    • Q13964
    • Q52M23
    • Q70WG0
    • Q8NI54
    • Q8NI55
    • Q8NI56
    • Q8WXJ2
    • Q9BYV0

    Protein attributes for CD28 Gene

    220 amino acids
    Molecular mass:
    25066 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2.

    Three dimensional structures from OCA and Proteopedia for CD28 Gene

    Alternative splice isoforms for CD28 Gene

neXtProt entry for CD28 Gene

Proteomics data for CD28 Gene at MOPED

Post-translational modifications for CD28 Gene

  • Glycosylation at Asn37, Asn71, Asn92, Asn105, and Asn129
  • Modification sites at PhosphoSitePlus

Other Protein References for CD28 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CD28 Gene

Domains for CD28 Gene

Gene Families for CD28 Gene

  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CD28 Gene

Suggested Antigen Peptide Sequences for CD28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P10747
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with CD28: view

Function for CD28 Gene

Molecular function for CD28 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD28 (Tp44),44kDa,identified by monoclonal antibody 9.3,KOLT2,expressed in T lymphocyte,CD80,CD86 ligand,stimulating PDE7 for T cell activation,regulated by CBLB
UniProtKB/Swiss-Prot Function:
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival

Gene Ontology (GO) - Molecular Function for CD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12777399
GO:0005070 SH3/SH2 adaptor activity IDA 19641626
GO:0005515 protein binding IPI 10820259
GO:0015026 coreceptor activity TAS 9784967
GO:0042802 identical protein binding NAS 3159820
genes like me logo Genes that share ontologies with CD28: view
genes like me logo Genes that share phenotypes with CD28: view

Animal Models for CD28 Gene

MGI Knock Outs for CD28:

Animal Model Products

miRNA for CD28 Gene

miRTarBase miRNAs that target CD28

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD28

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD28 Gene

Localization for CD28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD28 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CD28 Gene COMPARTMENTS Subcellular localization image for CD28 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 1

Gene Ontology (GO) - Cellular Components for CD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9784967
GO:0009897 external side of plasma membrane IDA 11390434
genes like me logo Genes that share ontologies with CD28: view

Pathways for CD28 Gene

genes like me logo Genes that share pathways with CD28: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CD28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002863 positive regulation of inflammatory response to antigenic stimulus IEA --
GO:0006959 humoral immune response TAS 8717514
GO:0007166 cell surface receptor signaling pathway TAS 9784967
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CD28: view

Compounds for CD28 Gene

(32) Novoseek inferred chemical compound relationships for CD28 Gene

Compound -log(P) Hits PubMed IDs
ctla4-ig 75.5 3
pp 100 66.4 6
phosphatidylinositol 56.4 47
tyrosine 54.5 109
ionomycin 52.3 7
genes like me logo Genes that share compounds with CD28: view

Transcripts for CD28 Gene

Unigene Clusters for CD28 Gene

CD28 molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD28

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD28 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2: -
SP3: - -

Relevant External Links for CD28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD28 Gene

mRNA expression in normal human tissues for CD28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD28 Gene

This gene is overexpressed in Whole Blood (11.4).

Protein differential expression in normal tissues for CD28 Gene

This gene is overexpressed in CD8 Tcells (48.9) and CD4 Tcells (17.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD28 Gene

SOURCE GeneReport for Unigene cluster for CD28 Gene Hs.443123

mRNA Expression by UniProt/SwissProt for CD28 Gene

Tissue specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells
genes like me logo Genes that share expressions with CD28: view

Expression partners for CD28 Gene

In Situ Assay Products

Orthologs for CD28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CD28 35
  • 81.43 (n)
  • 78.08 (a)
CD28 36
  • 76 (a)
(Canis familiaris)
Mammalia CD28 35
  • 84.55 (n)
  • 79.55 (a)
CD28 36
  • 80 (a)
(Mus musculus)
Mammalia Cd28 35
  • 77.02 (n)
  • 69.9 (a)
Cd28 16
Cd28 36
  • 67 (a)
(Pan troglodytes)
Mammalia CD28 35
  • 99.7 (n)
  • 100 (a)
CD28 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cd28 35
  • 77.67 (n)
  • 71.36 (a)
(Monodelphis domestica)
Mammalia CD28 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia CD28 36
  • 56 (a)
(Gallus gallus)
Aves CD28 35
  • 62.32 (n)
  • 51.69 (a)
CD28 36
  • 50 (a)
(Anolis carolinensis)
Reptilia CD28 36
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd28 35
  • 49.78 (n)
  • 43.51 (a)
Species with no ortholog for CD28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD28 Gene

Gene Tree for CD28 (if available)
Gene Tree for CD28 (if available)

Paralogs for CD28 Gene

Paralogs for CD28 Gene

genes like me logo Genes that share paralogs with CD28: view

Variants for CD28 Gene

Sequence variations from dbSNP and Humsavar for CD28 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1181388 -- 203,711,228(-) CACCT(C/T)TCTGT intron-variant
rs1181389 -- 203,710,167(-) AAGTC(A/G)TGTAA intron-variant
rs1181390 -- 203,707,954(-) GAACA(A/C/G)GTTGA intron-variant
rs1879877 -- 203,705,277(-) CTTTG(A/C)AGAGA upstream-variant-2KB
rs2013278 -- 203,725,935(-) CACCA(A/T)GCCCA intron-variant

Relevant External Links for CD28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CD28 Gene

Disorders for CD28 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CD28 Gene in MalaCards »

(2) Diseases for CD28 Gene including...

(64) Novoseek inferred disease relationships for CD28 Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 46.1 8
common variable immunodeficiency 44.3 1
infection chronic 39.1 2
hiv infections 38.3 14
autoimmunity 35.9 3

Relevant External Links for CD28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CD28: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CD28 Gene

Publications for CD28 Gene

  1. A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28. (PMID: 11877290) Hanawa H. … Ochi A. (Blood 2002) 3 4 23
  2. CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. (PMID: 11884439) Appleman L.J. … Boussiotis V.A. (J. Immunol. 2002) 3 23
  3. Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule. (PMID: 11714771) Hombach A. … Abken H. (J. Immunol. 2001) 3 23
  4. The phosphatidylinositol phosphatase PTEN is under control of costimulation and regulates proliferation in human T cells. (PMID: 11932928) Schmidt-Weber C.B. … Blaser K. (Eur. J. Immunol. 2002) 3 23
  5. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. (PMID: 12195015) Riley J.L. … Linsley P.S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 23

Products for CD28 Gene

Sources for CD28 Gene

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