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Aliases for ACVRL1 Gene

Aliases for ACVRL1 Gene

  • Activin A Receptor Like Type 1 2 3 5
  • TGF-B Superfamily Receptor Type I 3 4
  • Activin A Receptor Type II-Like 1 2 3
  • Activin A Receptor Type IL 2 3
  • EC 2.7.11.30 4 61
  • ACVRLK1 3 4
  • TSR-I 3 4
  • ALK-1 3 4
  • ALK1 3 4
  • SKR3 3 4
  • Serine/Threonine-Protein Kinase Receptor R3 3
  • Activin A Receptor, Type II-Like Kinase 1 3
  • Activin Receptor-Like Kinase 1 4
  • EC 2.7.11 61
  • HHT2 3
  • ORW2 3
  • HHT 3

External Ids for ACVRL1 Gene

Previous HGNC Symbols for ACVRL1 Gene

  • ACVRLK1
  • ORW2

Previous GeneCards Identifiers for ACVRL1 Gene

  • GC12M052630
  • GC12P052332
  • GC12P052017
  • GC12P050587
  • GC12P049334
  • GC12P052300

Summaries for ACVRL1 Gene

Entrez Gene Summary for ACVRL1 Gene

  • This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACVRL1 Gene

ACVRL1 (Activin A Receptor Like Type 1) is a Protein Coding gene. Diseases associated with ACVRL1 include Telangiectasia, Hereditary Hemorrhagic, Type 2 and Acvrl1-Related Hereditary Hemorrhagic Telangiectasia. Among its related pathways are DREAM Repression and Dynorphin Expression and ERK Signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ACVR1.

UniProtKB/Swiss-Prot for ACVRL1 Gene

  • Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Gene Wiki entry for ACVRL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACVRL1 Gene

Genomics for ACVRL1 Gene

Regulatory Elements for ACVRL1 Gene

Enhancers for ACVRL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G051904 1.8 FANTOM5 Ensembl ENCODE dbSUPER 27.2 +2.1 2098 9.2 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF121 GLIS2 ELK1 GATA2 FOS ACVRL1 GC12P051921
GH12G051969 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +65.7 65685 5.2 PKNOX1 FOXA2 ARNT ZNF2 YY1 ZNF766 ZNF143 FOS JUNB REST NR4A1 HNRNPA3P10 GRASP ACVR1B ACVRL1 ANKRD33 GC12P051989
GH12G051975 1.4 Ensembl ENCODE dbSUPER 12.1 +70.1 70142 2.5 HDAC1 ELF3 HNRNPUL1 ATF1 ARID4B THRB RAD21 RARA GATA2 FOS ACVR1B GRASP NR4A1 ACVRL1 ANKRD33 ENSG00000260473 GC12P051989
GH12G051846 1.3 FANTOM5 ENCODE 12.6 -58.9 -58908 3.1 PKNOX1 SIN3A ZBTB40 GLIS2 EGR1 EGR2 SP3 ZEB2 SREBF1 ZNF148 SLC4A8 ACVRL1 ENSG00000261586 RNU6-574P GALNT6 ANKRD33 FIGNL2 SCN8A LOC105369971
GH12G051897 1 FANTOM5 Ensembl dbSUPER 15.2 -9.5 -9507 0.8 PKNOX1 ACVRL1 LOC102724178
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ACVRL1 on UCSC Golden Path with GeneCards custom track

Promoters for ACVRL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051957 592 1001 SUZ12 SALL2 ZNF791 ZFHX2 CTBP1 POLR2A ZNF169 HES1 EZH2 EGR2

Genomic Location for ACVRL1 Gene

Chromosome:
12
Start:
51,906,908 bp from pter
End:
51,923,361 bp from pter
Size:
16,454 bases
Orientation:
Plus strand

Genomic View for ACVRL1 Gene

Genes around ACVRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACVRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACVRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACVRL1 Gene

Proteins for ACVRL1 Gene

  • Protein details for ACVRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37023-ACVL1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase receptor R3
    Protein Accession:
    P37023
    Secondary Accessions:
    • A6NGA8

    Protein attributes for ACVRL1 Gene

    Size:
    503 amino acids
    Molecular mass:
    56124 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACVRL1 Gene

neXtProt entry for ACVRL1 Gene

Selected DME Specific Peptides for ACVRL1 Gene

P37023:
  • NILGFIASDMTSR
  • GSGSGLPFLVQRTVARQ
  • KVVCVDQQ
  • RVGTKRYM
  • KPAIAHRD
  • IADLGLA
  • VAVKIFSSR
  • EIFGTQGK
  • YNTVLLRH
  • VPNDPSFEDM
  • ECVGKGRYGEVWRG
  • SSTQLWLITHYHE
  • RYMAPEVL
  • YMAPEVL
  • CCIADLGLA

Post-translational modifications for ACVRL1 Gene

  • Glycosylation at posLast=9898
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for ACVRL1 Gene

Suggested Antigen Peptide Sequences for ACVRL1 Gene

Graphical View of Domain Structure for InterPro Entry

P37023

UniProtKB/Swiss-Prot:

ACVL1_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
genes like me logo Genes that share domains with ACVRL1: view

Function for ACVRL1 Gene

Molecular function for ACVRL1 Gene

GENATLAS Biochemistry:
activin A receptor,type II-like 1,homolog to ORW2
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
UniProtKB/Swiss-Prot Function:
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Enzyme Numbers (IUBMB) for ACVRL1 Gene

Gene Ontology (GO) - Molecular Function for ACVRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,IDA 12065756
GO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA,NAS 8242742
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IEA --
GO:0005024 transforming growth factor beta-activated receptor activity IDA 8242742
genes like me logo Genes that share ontologies with ACVRL1: view
genes like me logo Genes that share phenotypes with ACVRL1: view

Human Phenotype Ontology for ACVRL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ACVRL1 Gene

MGI Knock Outs for ACVRL1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ACVRL1 Gene

Localization for ACVRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACVRL1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACVRL1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ACVRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IDA 8242742
GO:0009986 cell surface IDA 8242742
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ACVRL1: view

Pathways & Interactions for ACVRL1 Gene

genes like me logo Genes that share pathways with ACVRL1: view

Pathways by source for ACVRL1 Gene

2 BioSystems pathways for ACVRL1 Gene
1 R&D Systems pathway for ACVRL1 Gene

SIGNOR curated interactions for ACVRL1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ACVRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IMP 16752392
GO:0001666 response to hypoxia IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001936 regulation of endothelial cell proliferation TAS 20406889
GO:0001937 negative regulation of endothelial cell proliferation IEA --
genes like me logo Genes that share ontologies with ACVRL1: view

Drugs & Compounds for ACVRL1 Gene

(6) Drugs for ACVRL1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra Target 0
Manganese Approved Nutra 34
Dalantercept Pharma inhibitor ALK1 inhibitor 0
Magnesium Nutra 0

(5) Additional Compounds for ACVRL1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ACVRL1: view

Transcripts for ACVRL1 Gene

Unigene Clusters for ACVRL1 Gene

Activin A receptor type II-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ACVRL1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2:
SP3: - - - - - - - -
SP4: - -

Relevant External Links for ACVRL1 Gene

GeneLoc Exon Structure for
ACVRL1
ECgene alternative splicing isoforms for
ACVRL1

Expression for ACVRL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACVRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACVRL1 Gene

This gene is overexpressed in Lung (x5.3).

Protein differential expression in normal tissues from HIPED for ACVRL1 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ACVRL1 Gene



Protein tissue co-expression partners for ACVRL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACVRL1 Gene:

ACVRL1

SOURCE GeneReport for Unigene cluster for ACVRL1 Gene:

Hs.591026

Evidence on tissue expression from TISSUES for ACVRL1 Gene

  • Nervous system(4.5)
  • Lung(3.2)
  • Heart(3.1)
  • Muscle(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ACVRL1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • head
  • lip
  • mouth
  • nose
  • salivary gland
  • tongue
Thorax:
  • breast
  • esophagus
  • heart
  • heart valve
  • lung
Abdomen:
  • duodenum
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • testicle
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with ACVRL1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ACVRL1 Gene

Orthologs for ACVRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACVRL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACVRL1 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia ACVRL1 34 35
  • 90.72 (n)
cow
(Bos Taurus)
Mammalia ACVRL1 34 35
  • 90.55 (n)
mouse
(Mus musculus)
Mammalia Acvrl1 34 16 35
  • 85.43 (n)
rat
(Rattus norvegicus)
Mammalia Acvrl1 34
  • 85.42 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACVRL1 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACVRL1 34 35
  • 69.78 (n)
lizard
(Anolis carolinensis)
Reptilia ACVRL1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493282 34
  • 60.29 (n)
zebrafish
(Danio rerio)
Actinopterygii acvrl1 34 35
  • 64.85 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3186 34
fruit fly
(Drosophila melanogaster)
Insecta sax 36 35
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea daf-1 36
  • 39 (a)
sma-6 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToMany
Species where no ortholog for ACVRL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACVRL1 Gene

ENSEMBL:
Gene Tree for ACVRL1 (if available)
TreeFam:
Gene Tree for ACVRL1 (if available)

Paralogs for ACVRL1 Gene

(8) SIMAP similar genes for ACVRL1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ACVRL1: view

Variants for ACVRL1 Gene

Sequence variations from dbSNP and Humsavar for ACVRL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs121909284 Pathogenic, Telangiectasia, hereditary hemorrhagic, 2 (HHT2) [MIM:600376] 51,916,219(+) CCGCC(A/C/G)GACCA reference, missense
rs121909285 Pathogenic, Telangiectasia, hereditary hemorrhagic, 2 (HHT2) [MIM:600376] 51,913,187(+) GCCTG(G/T)TGCAC reference, missense
rs121909287 Pathogenic, Telangiectasia, hereditary hemorrhagic, 2 (HHT2) [MIM:600376] 51,916,218(+) CCCGC(C/T)GGACC reference, missense
rs121909288 Pathogenic, Telangiectasia, hereditary hemorrhagic, 2 (HHT2) [MIM:600376] 51,920,831(+) CGCTG(C/T)GGATC reference, missense
rs139142865 Uncertain significance, Telangiectasia, hereditary hemorrhagic, 2 (HHT2) [MIM:600376] 51,920,826(+) CACCG(C/T)GCTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ACVRL1 Gene

Variant ID Type Subtype PubMed ID
nsv1069667 CNV deletion 25765185
nsv523741 CNV loss 19592680
nsv527286 CNV loss 19592680
nsv558895 CNV loss 21841781
nsv707 CNV insertion 18451855

Variation tolerance for ACVRL1 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACVRL1 Gene

Human Gene Mutation Database (HGMD)
ACVRL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACVRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACVRL1 Gene

Disorders for ACVRL1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for ACVRL1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
telangiectasia, hereditary hemorrhagic, type 2
  • hereditary hemorrhagic telangiectasia type 2
acvrl1-related hereditary hemorrhagic telangiectasia
  • hereditary hemorrhagic telangiectasia type 2
pulmonary hypertension
  • primary pulmonary hypertension
hereditary hemorrhagic telangiectasia
  • osler hemorrhagic telangiectasia syndrome
pulmonary hypertension, familial primary, 1, with or without hht
  • pulmonary hypertension, primary, fenfluramine or dexfenfluramine-associated
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ACVL1_HUMAN
  • Telangiectasia, hereditary hemorrhagic, 2 (HHT2) [MIM:600376]: A multisystemic vascular dysplasia leading to dilation of permanent blood vessels and arteriovenous malformations of skin, mucosa, and viscera. The disease is characterized by recurrent epistaxis and gastro-intestinal hemorrhage. Visceral involvement includes arteriovenous malformations of the lung, liver, and brain. {ECO:0000269 PubMed:10694922, ECO:0000269 PubMed:10767348, ECO:0000269 PubMed:11170071, ECO:0000269 PubMed:11484689, ECO:0000269 PubMed:14684682, ECO:0000269 PubMed:15024723, ECO:0000269 PubMed:15712270, ECO:0000269 PubMed:16525724, ECO:0000269 PubMed:16752392, ECO:0000269 PubMed:20414677, ECO:0000269 PubMed:26176610, ECO:0000269 PubMed:8640225, ECO:0000269 PubMed:9245985}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ACVRL1

Genetic Association Database (GAD)
ACVRL1
Human Genome Epidemiology (HuGE) Navigator
ACVRL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACVRL1
genes like me logo Genes that share disorders with ACVRL1: view

No data available for Genatlas for ACVRL1 Gene

Publications for ACVRL1 Gene

  1. Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. (PMID: 16752392) Bossler A.D. … Ganguly A. (Hum. Mutat. 2006) 3 4 22 46 64
  2. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. (PMID: 8640225) Johnson D.W. … Marchuk D.A. (Nat. Genet. 1996) 2 3 4 22 64
  3. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. (PMID: 8397373) ten Dijke P. … Miyazono K. (Oncogene 1993) 2 3 4 22 64
  4. Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex. (PMID: 22718755) Townson S.A. … Grinberg A.V. (J. Biol. Chem. 2012) 2 3 4 64
  5. Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation. (PMID: 20056902) Girerd B. … Humbert M. (Am. J. Respir. Crit. Care Med. 2010) 3 22 46 64

Products for ACVRL1 Gene

Sources for ACVRL1 Gene

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