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Aliases for TSIX Gene

Subcategory (RNA class) for TSIX Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for TSIX Gene

  • TSIX Transcript, XIST Antisense RNA 2 3
  • TSIX Transcript, XIST Antisense RNA (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 13 2 3
  • XIST Antisense RNA (Non-Protein Coding) 2 3
  • X (Inactive)-Specific Transcript, Antisense (Non-Protein Coding) 3
  • X-Inactivation-Specific Transcript-Antisense 3
  • X (Inactive)-Specific Transcript, Antisense 2
  • NCRNA00013 3
  • LINC00013 3
  • XIST-AS1 3
  • XIST-AS 3
  • XISTAS 3

External Ids for TSIX Gene

ORGUL Members for TSIX Gene

Summaries for TSIX Gene

Entrez Gene Summary for TSIX Gene

  • In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSIX Gene

TSIX (TSIX Transcript, XIST Antisense RNA) is a RNA Gene, and belongs to lncRNA RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSIX Gene

Genomics for TSIX Gene

Genomic Location for TSIX Gene

Start:
73,792,205 bp from pter
End:
73,829,231 bp from pter
Size:
37,027 bases
Orientation:
Plus strand

Genomic View for TSIX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TSIX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSIX Gene

Regulatory Elements for TSIX Gene

Proteins for TSIX Gene

Post-translational modifications for TSIX Gene

No Post-translational modifications

No data available for DME Specific Peptides for TSIX Gene

Domains for TSIX Gene

Gene Families for TSIX Gene

HGNC:
  • LNCRNA :Long non-coding RNAs
genes like me logo Genes that share domains with TSIX: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for TSIX Gene

Function for TSIX Gene

Molecular function for TSIX Gene

GENATLAS Biochemistry: gene antisense to XIST,involved in the early steps of X-inactivation

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TSIX Gene

Localization for TSIX Gene

No data available for Gene Ontology (GO) - Cellular Components for TSIX Gene

Pathways for TSIX Gene

SuperPathways for TSIX Gene

No Data Available

Interacting Proteins for TSIX Gene

Gene Ontology (GO) - Biological Process for TSIX Gene

None

No data available for Pathways by source for TSIX Gene

Transcripts for TSIX Gene

mRNA/cDNA for TSIX Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TSIX Gene

No ASD Table

Relevant External Links for TSIX Gene

GeneLoc Exon Structure for
TSIX
ECgene alternative splicing isoforms for
TSIX

Expression for TSIX Gene

No Expression Related Data Available

Orthologs for TSIX Gene

Evolution for TSIX Gene

ENSEMBL:
Gene Tree for TSIX (if available)
TreeFam:
Gene Tree for TSIX (if available)

No data available for Orthologs for TSIX Gene

Paralogs for TSIX Gene

No data available for Paralogs for TSIX Gene

Variants for TSIX Gene

Sequence variations from dbSNP and Humsavar for TSIX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs798615 -- 73,793,812(+) ATATA(A/T)AAGGT nc-transcript-variant
rs798616 -- 73,792,898(+) gacgg(A/G)gtttc nc-transcript-variant
rs798617 -- 73,792,420(+) cactt(A/G)aaccc nc-transcript-variant
rs798618 -- 73,792,050(+) tacaa(C/T)tcttc upstream-variant-2KB
rs798619 -- 73,791,903(+) gctgt(C/T)ttttt upstream-variant-2KB

Relevant External Links for TSIX Gene

HapMap Linkage Disequilibrium report
TSIX

No data available for Structural Variations from Database of Genomic Variants (DGV) for TSIX Gene

Disorders for TSIX Gene

No disorders were found for TSIX Gene.

No data available for UniProtKB/Swiss-Prot for TSIX Gene

Publications for TSIX Gene

  1. Tsix, a gene antisense to Xist at the X-inactivation centre. (PMID: 10192391) Lee J.T. … Warshawsky D. (Nat. Genet. 1999) 2 3 23
  2. CTCF, a candidate trans-acting factor for X-inactivation choice. (PMID: 11743158) Chao W. … Lee J.T. (Science 2002) 3 23
  3. Characterization and quantitation of differential Tsix transcripts: implications for Tsix function. (PMID: 12499393) Shibata S. … Lee J.T. (Hum. Mol. Genet. 2003) 23
  4. Characterization of expression at the human XIST locus in somatic, embryonal carcinoma, and transgenic cell lines. (PMID: 12906856) Chow J.C. … Brown C.J. (Genomics 2003) 23
  5. Tsix transcription- versus RNA-based mechanisms in Xist repression and epigenetic choice. (PMID: 15458646) Shibata S. … Lee J.T. (Curr. Biol. 2004) 23

Products for TSIX Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TSIX
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TSIX
    • Block miRNA regulation of TSIX using miScript Target Protectors

    Sources for TSIX Gene

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