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Aliases for ADIPOQ Gene

Aliases for ADIPOQ Gene

  • Adiponectin, C1Q And Collagen Domain Containing 2 3
  • GBP28 3 4 6
  • APM1 3 4 6
  • Adipose Most Abundant Gene Transcript 1 Protein 3 4
  • Adipocyte Complement-Related 30 KDa Protein 3 4
  • 30 KDa Adipocyte Complement-Related Protein 3 4
  • ADIPQTL1 3 6
  • ACRP30 3 4
  • APM-1 3 4
  • ACDC 3 4
  • Adipocyte, C1q And Collagen Domain-Containing Protein 4
  • Adipocyte, C1Q And Collagen Domain Containing 2
  • Adipose Most Abundant Gene Transcript 1 2
  • Adipose Specific Collagen-Like Factor 3
  • Gelatin-Binding Protein 28 3
  • Gelatin-Binding Protein 4
  • Adiponectin Precursor 2
  • Adiponectin 3
  • ADPN 3

External Ids for ADIPOQ Gene

Previous Symbols for ADIPOQ Gene

  • ACDC

Summaries for ADIPOQ Gene

Entrez Gene Summary for ADIPOQ Gene

  • This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

GeneCards Summary for ADIPOQ Gene

ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) is a Protein Coding gene. Diseases associated with ADIPOQ include adiponectin deficiency and chronic pulmonary heart disease. Among its related pathways are L1CAM interactions and Glucose / Energy Metabolism. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is COL8A1.

UniProtKB/Swiss-Prot for ADIPOQ Gene

  • Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Gene Wiki entry for ADIPOQ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADIPOQ Gene

Genomics for ADIPOQ Gene

Genomic Location for ADIPOQ Gene

Start:
186,842,674 bp from pter
End:
186,858,463 bp from pter
Size:
15,790 bases
Orientation:
Plus strand

Genomic View for ADIPOQ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADIPOQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADIPOQ Gene

Regulatory Elements for ADIPOQ Gene

Proteins for ADIPOQ Gene

  • Protein details for ADIPOQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15848-ADIPO_HUMAN
    Recommended name:
    Adiponectin
    Protein Accession:
    Q15848
    Secondary Accessions:
    • Q58EX9

    Protein attributes for ADIPOQ Gene

    Size:
    244 amino acids
    Molecular mass:
    26414 Da
    Quaternary structure:
    • Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely additionally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2. Interacts with CTRP9A via the C1q domain (heterotrimeric complex) (By similarity).
    Miscellaneous:
    • HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls.
    • Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164 show impaired secretion of adiponectin in any form

    Three dimensional structures from OCA and Proteopedia for ADIPOQ Gene

neXtProt entry for ADIPOQ Gene

Proteomics data for ADIPOQ Gene at MOPED

Post-translational modifications for ADIPOQ Gene

  • HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes (By similarity).
  • Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting.
  • O-glycosylated. Not N-glycosylated. O-linked glycans on hydroxylysines consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Sialylated to varying degrees depending on tissue. Thr-22 appears to be the major site of sialylation. Higher sialylation found in SGBS adipocytes than in HEK fibroblasts. Sialylation is not required neither for heterodimerization nor for secretion. Not sialylated on the glycosylated hydroxylysines. Desialylated forms are rapidly cleared from the circulation.
  • Glycosylation at Thr21, Thr22, Lys65, Lys68, Lys77, and Lys101

Other Protein References for ADIPOQ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADIPOQ Gene

Domains for ADIPOQ Gene

Gene Families for ADIPOQ Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

Q15848

UniProtKB/Swiss-Prot:

ADIPO_HUMAN
Domain:
  • The C1q domain is commonly called the globular domain:
    • Q15848
  • Contains 1 C1q domain.:
    • Q15848
  • Contains 1 collagen-like domain.:
    • Q15848
genes like me logo Genes that share domains with ADIPOQ: view

Function for ADIPOQ Gene

Molecular function for ADIPOQ Gene

UniProtKB/Swiss-Prot Function: Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Gene Ontology (GO) - Molecular Function for ADIPOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding ISS --
GO:0005125 cytokine activity NAS 12611609
GO:0005179 hormone activity IDA 11222466
GO:0005515 protein binding IPI 12070119
GO:0033691 sialic acid binding IDA 19855092
genes like me logo Genes that share ontologies with ADIPOQ: view
genes like me logo Genes that share phenotypes with ADIPOQ: view

Animal Models for ADIPOQ Gene

MGI Knock Outs for ADIPOQ:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADIPOQ Gene

Localization for ADIPOQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADIPOQ Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADIPOQ Gene COMPARTMENTS Subcellular localization image for ADIPOQ gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for ADIPOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IDA 10403784
GO:0005783 endoplasmic reticulum ISS --
GO:0009986 cell surface IDA 10982546
genes like me logo Genes that share ontologies with ADIPOQ: view

Pathways for ADIPOQ Gene

genes like me logo Genes that share pathways with ADIPOQ: view

Pathways by source for ADIPOQ Gene

1 R&D Systems pathway for ADIPOQ Gene
1 Qiagen pathway for ADIPOQ Gene
1 Cell Signaling Technology pathway for ADIPOQ Gene

Gene Ontology (GO) - Biological Process for ADIPOQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 18431508
GO:0006006 glucose metabolic process ISS --
GO:0006091 generation of precursor metabolites and energy TAS 10095105
GO:0006635 fatty acid beta-oxidation ISS --
genes like me logo Genes that share ontologies with ADIPOQ: view

Compounds for ADIPOQ Gene

UniProtKB/Swiss-Prot:

Q15848-ADIPO_HUMAN
Pharmaceutical: Adiponectin might be used in the treatment of diabetes type 2 and insulin resistance

(1) HMDB Compounds for ADIPOQ Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(140) Novoseek inferred chemical compound relationships for ADIPOQ Gene

Compound -log(P) Hits PubMed IDs
glucose 86.9 305
pioglitazone 83 131
cholesterol 78.8 168
lipid 77.9 185
rosiglitazone 77.9 110
genes like me logo Genes that share compounds with ADIPOQ: view

Transcripts for ADIPOQ Gene

mRNA/cDNA for ADIPOQ Gene

Unigene Clusters for ADIPOQ Gene

Adiponectin, C1Q and collagen domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADIPOQ Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for ADIPOQ Gene

GeneLoc Exon Structure for
ADIPOQ
ECgene alternative splicing isoforms for
ADIPOQ

Expression for ADIPOQ Gene

mRNA expression in normal human tissues for ADIPOQ Gene

mRNA differential expression in normal tissues according to GTEx for ADIPOQ Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (19.9), Adipose - Subcutaneous (18.8), and Breast - Mammary Tissue (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADIPOQ Gene

SOURCE GeneReport for Unigene cluster for ADIPOQ Gene Hs.80485

mRNA Expression by UniProt/SwissProt for ADIPOQ Gene

Q15848-ADIPO_HUMAN
Tissue specificity: Synthesized exclusively by adipocytes and secreted into plasma
genes like me logo Genes that share expressions with ADIPOQ: view

Orthologs for ADIPOQ Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADIPOQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADIPOQ 35
  • 99.59 (n)
  • 99.18 (a)
ADIPOQ 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADIPOQ 35
  • 87.17 (n)
  • 83.57 (a)
ADIPOQ 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADIPOQ 35
  • 87.3 (n)
  • 84.42 (a)
APM1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adipoq 35
  • 80.56 (n)
  • 84.65 (a)
Adipoq 16
Adipoq 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADIPOQ 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADIPOQ 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adipoq 35
  • 81.1 (n)
  • 83.98 (a)
chicken
(Gallus gallus)
Aves ADIPOQ 35
  • 70.11 (n)
  • 74.18 (a)
ADIPOQ 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADIPOQ 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adipoq 35
  • 64.9 (n)
  • 64.73 (a)
zebrafish
(Danio rerio)
Actinopterygii adipoqa 36
  • 34 (a)
OneToMany
adipoqb 35
  • 65.62 (n)
  • 61.88 (a)
adipoqb 36
  • 48 (a)
OneToMany
Species with no ortholog for ADIPOQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADIPOQ Gene

ENSEMBL:
Gene Tree for ADIPOQ (if available)
TreeFam:
Gene Tree for ADIPOQ (if available)

Paralogs for ADIPOQ Gene

Selected SIMAP similar genes for ADIPOQ Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADIPOQ: view

Variants for ADIPOQ Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ADIPOQ Gene

Q15848-ADIPO_HUMAN
Genetic variations in ADIPOQ influence the variance in adiponectin serum levels and define the adiponectin serum levels quantitative trait locus 1 (ADIPQTL1) [MIM:612556]

Sequence variations from dbSNP and Humsavar for ADIPOQ Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs182052 -- 186,842,993(+) ATTTT(A/G)CCCAG intron-variant
rs266729 -- 186,841,685(+) CCTGC(C/G)CTTCA upstream-variant-2KB
rs266730 -- 186,840,922(+) aggct(A/G)gagcg upstream-variant-2KB
rs710445 -- 186,843,729(+) GGCAT(A/G)TAGTG intron-variant
rs822388 -- 186,844,495(+) AAAAA(A/G)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADIPOQ Gene

Variant ID Type Subtype PubMed ID
dgv1541e1 CNV Complex 17122850
esv34136 CNV Loss 18971310
nsv508263 CNV Loss 20534489
nsv878071 CNV Gain 21882294
nsv4155 CNV Loss 18451855
nsv246 CNV Loss 15895083

Relevant External Links for ADIPOQ Gene

HapMap Linkage Disequilibrium report
ADIPOQ
Human Gene Mutation Database (HGMD)
ADIPOQ

Disorders for ADIPOQ Gene

(1) OMIM Diseases for ADIPOQ Gene (605441)

UniProtKB/Swiss-Prot

ADIPO_HUMAN
  • Adiponectin deficiency (ADPND) [MIM:612556]: A condition that results in very low concentrations of plasma adiponectin. {ECO:0000269 PubMed:10918532}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(97) Novoseek inferred disease relationships for ADIPOQ Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 95.2 310
insulin sensitivity 93.9 293
obesity 90.8 241
cardiovascular diseases 80.5 137
fatty liver 80.1 71

Relevant External Links for ADIPOQ

Genetic Association Database (GAD)
ADIPOQ
Human Genome Epidemiology (HuGE) Navigator
ADIPOQ
genes like me logo Genes that share disorders with ADIPOQ: view

Publications for ADIPOQ Gene

  1. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. (PMID: 10982546) Ouchi N. … Matsuzawa Y. (Circulation 2000) 3 4 23
  2. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. (PMID: 11756320) Stumvoll M. … HAoring H. (Diabetes 2002) 3 23 48
  3. Association between adiponectin and mediators of inflammation in obese women. (PMID: 12663465) Engeli S. … Sharma A.M. (Diabetes 2003) 3 23 48
  4. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. (PMID: 12878598) Waki H. … Kadowaki T. (J. Biol. Chem. 2003) 3 4 23
  5. Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin. (PMID: 14675060) Stenvinkel P. … Nordfors L. (Kidney Int. 2004) 3 23 48

Products for ADIPOQ Gene

Sources for ADIPOQ Gene

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