Aliases for ADIPOQ Gene
External Ids for ADIPOQ Gene
Previous HGNC Symbols for ADIPOQ Gene
Previous GeneCards Identifiers for ADIPOQ Gene
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
GeneCards Summary for ADIPOQ Gene
ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) is a Protein Coding gene. Diseases associated with ADIPOQ include adiponectin deficiency and chronic pulmonary heart disease. Among its related pathways are L1CAM interactions and Glucose / Energy Metabolism. GO annotations related to this gene include protein homodimerization activity and receptor binding. An important paralog of this gene is COL8A1.
UniProtKB/Swiss-Prot for ADIPOQ Gene
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.