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Aliases for MRFAP1 Gene

Aliases for MRFAP1 Gene

  • Morf4 Family Associated Protein 1 2 3
  • Protein Associated With MRG Of 14 KDa 3 4
  • PAM14 3 4
  • PGR1 3 4
  • MORF4 Family-Associated Protein 1 3
  • Mof4 Family Associated Protein 1 3
  • T-Cell Activation Protein 3
  • Protein PGR1 4

External Ids for MRFAP1 Gene

Previous GeneCards Identifiers for MRFAP1 Gene

  • GC04P006761
  • GC04P006692
  • GC04P006643
  • GC04P006573

Summaries for MRFAP1 Gene

Entrez Gene Summary for MRFAP1 Gene

  • This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for MRFAP1 Gene

MRFAP1 (Morf4 Family Associated Protein 1) is a Protein Coding gene. An important paralog of this gene is MRFAP1L1.

Gene Wiki entry for MRFAP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRFAP1 Gene

Genomics for MRFAP1 Gene

Regulatory Elements for MRFAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRFAP1 Gene

Start:
6,640,091 bp from pter
End:
6,642,745 bp from pter
Size:
2,655 bases
Orientation:
Plus strand

Genomic View for MRFAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRFAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRFAP1 Gene

Proteins for MRFAP1 Gene

  • Protein details for MRFAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y605-MOFA1_HUMAN
    Recommended name:
    MORF4 family-associated protein 1
    Protein Accession:
    Q9Y605
    Secondary Accessions:
    • B3KVT2
    • D3DVT3

    Protein attributes for MRFAP1 Gene

    Size:
    127 amino acids
    Molecular mass:
    14650 Da
    Quaternary structure:
    • Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.

neXtProt entry for MRFAP1 Gene

Proteomics data for MRFAP1 Gene at MOPED

Post-translational modifications for MRFAP1 Gene

  • Ubiquitination at Lys56
  • Modification sites at PhosphoSitePlus

Other Protein References for MRFAP1 Gene

No data available for DME Specific Peptides for MRFAP1 Gene

Domains for MRFAP1 Gene

Protein Domains for MRFAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRFAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y605

UniProtKB/Swiss-Prot:

MOFA1_HUMAN :
  • Q9Y605
Family:
  • Belongs to the MORF4 family-associated protein family.
genes like me logo Genes that share domains with MRFAP1: view

No data available for Gene Families for MRFAP1 Gene

Function for MRFAP1 Gene

Gene Ontology (GO) - Molecular Function for MRFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11500496
genes like me logo Genes that share ontologies with MRFAP1: view

Phenotypes for MRFAP1 Gene

genes like me logo Genes that share phenotypes with MRFAP1: view

Animal Models for MRFAP1 Gene

MGI Knock Outs for MRFAP1:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MRFAP1 Gene

Localization for MRFAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRFAP1 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with MORF4L1 to cell nuclei. {ECO:0000269 PubMed:11500496, ECO:0000269 PubMed:12397079}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRFAP1 Gene COMPARTMENTS Subcellular localization image for MRFAP1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MRFAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MRFAP1: view

Pathways for MRFAP1 Gene

SuperPathways for MRFAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRFAP1 Gene

None

No data available for Pathways by source for MRFAP1 Gene

Transcripts for MRFAP1 Gene

Unigene Clusters for MRFAP1 Gene

Morf4 family associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRFAP1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRFAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2:
SP3:
SP4: - -
SP5:
SP6:

Relevant External Links for MRFAP1 Gene

GeneLoc Exon Structure for
MRFAP1
ECgene alternative splicing isoforms for
MRFAP1

Expression for MRFAP1 Gene

mRNA expression in normal human tissues for MRFAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRFAP1 Gene

SOURCE GeneReport for Unigene cluster for MRFAP1 Gene Hs.406590

genes like me logo Genes that share expressions with MRFAP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRFAP1 Gene

Orthologs for MRFAP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MRFAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRFAP1 35
  • 91.34 (n)
  • 95.28 (a)
MRFAP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRFAP1 35
  • 90.03 (n)
  • 94.49 (a)
MRFAP1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5814 36
  • 83 (a)
OneToMany
Mrfap1 35
  • 86.4 (n)
  • 86.4 (a)
Mrfap1 16
Mrfap1 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mrfap1 35
  • 86.93 (n)
  • 86.4 (a)
Species with no ortholog for MRFAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRFAP1 Gene

ENSEMBL:
Gene Tree for MRFAP1 (if available)
TreeFam:
Gene Tree for MRFAP1 (if available)

Paralogs for MRFAP1 Gene

Paralogs for MRFAP1 Gene

Selected SIMAP similar genes for MRFAP1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MRFAP1 Gene

genes like me logo Genes that share paralogs with MRFAP1: view

Variants for MRFAP1 Gene

Sequence variations from dbSNP and Humsavar for MRFAP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12695 -- 6,642,546(+) GATGA(C/G)AGTAT utr-variant-3-prime
rs1059220 -- 6,642,664(+) GGTCA(A/G)AACCC utr-variant-3-prime
rs3207078 -- 6,641,207(+) CTGGT(C/G)GAGCT synonymous-codon, reference, intron-variant
rs3207079 -- 6,641,213(+) GAGCT(C/G)GTCTG synonymous-codon, reference, intron-variant
rs3806818 -- 6,640,604(-) GGGGG(C/T)GAGCT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRFAP1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv829849 CNV Loss 17160897
nsv4215 CNV Loss 18451855

Relevant External Links for MRFAP1 Gene

HapMap Linkage Disequilibrium report
MRFAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRFAP1 Gene

Disorders for MRFAP1 Gene

Relevant External Links for MRFAP1

Genetic Association Database (GAD)
MRFAP1
genes like me logo Genes that share disorders with MRFAP1: view

No data available for UniProtKB/Swiss-Prot for MRFAP1 Gene

Publications for MRFAP1 Gene

  1. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. (PMID: 17008723) Zhang P. … Ding J. (Protein Sci. 2006) 3 4
  2. MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. (PMID: 11500496) Leung J.K. … Pereira-Smith O.M. (J. Biol. Chem. 2001) 3 4
  3. MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. (PMID: 12397079) Pardo P.S. … Pereira-Smith O.M. (J. Biol. Chem. 2002) 3 4
  4. MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner. (PMID: 14506250) Tominaga K. … Pereira-Smith O.M. (J. Biol. Chem. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MRFAP1 Gene

Sources for MRFAP1 Gene

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