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Aliases for MRFAP1 Gene

Aliases for MRFAP1 Gene

  • Morf4 Family Associated Protein 1 2 3 5
  • Protein Associated With MRG Of 14 KDa 3 4
  • PAM14 3 4
  • PGR1 3 4
  • Mof4 Family Associated Protein 1 3
  • T-Cell Activation Protein 3
  • Protein PGR1 4

External Ids for MRFAP1 Gene

Previous GeneCards Identifiers for MRFAP1 Gene

  • GC04P006761
  • GC04P006692
  • GC04P006643
  • GC04P006573

Summaries for MRFAP1 Gene

Entrez Gene Summary for MRFAP1 Gene

  • This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for MRFAP1 Gene

MRFAP1 (Morf4 Family Associated Protein 1) is a Protein Coding gene. Diseases associated with MRFAP1 include Cervix Uteri Carcinoma In Situ. An important paralog of this gene is MRFAP1L1.

Gene Wiki entry for MRFAP1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRFAP1 Gene

Genomics for MRFAP1 Gene

Regulatory Elements for MRFAP1 Gene

Enhancers for MRFAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRFAP1 on UCSC Golden Path with GeneCards custom track

Promoters for MRFAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRFAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRFAP1 Gene

6,640,091 bp from pter
6,642,745 bp from pter
2,655 bases
Plus strand

Genomic View for MRFAP1 Gene

Genes around MRFAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRFAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRFAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRFAP1 Gene

Proteins for MRFAP1 Gene

  • Protein details for MRFAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MORF4 family-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KVT2
    • D3DVT3

    Protein attributes for MRFAP1 Gene

    127 amino acids
    Molecular mass:
    14650 Da
    Quaternary structure:
    • Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.

neXtProt entry for MRFAP1 Gene

Proteomics data for MRFAP1 Gene at MOPED

Post-translational modifications for MRFAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRFAP1 Gene

No data available for DME Specific Peptides for MRFAP1 Gene

Domains & Families for MRFAP1 Gene

Protein Domains for MRFAP1 Gene


Suggested Antigen Peptide Sequences for MRFAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MORF4 family-associated protein family.
  • Belongs to the MORF4 family-associated protein family.
genes like me logo Genes that share domains with MRFAP1: view

No data available for Gene Families for MRFAP1 Gene

Function for MRFAP1 Gene

genes like me logo Genes that share phenotypes with MRFAP1: view

Animal Models for MRFAP1 Gene

MGI Knock Outs for MRFAP1:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRFAP1 Gene

Localization for MRFAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRFAP1 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Colocalizes with MORF4L1 to cell nuclei. {ECO:0000269 PubMed:11500496, ECO:0000269 PubMed:12397079}.

Subcellular locations from

Jensen Localization Image for MRFAP1 Gene COMPARTMENTS Subcellular localization image for MRFAP1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for MRFAP1 Gene

Pathways & Interactions for MRFAP1 Gene

SuperPathways for MRFAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRFAP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for MRFAP1 Gene

Drugs & Compounds for MRFAP1 Gene

No Compound Related Data Available

Transcripts for MRFAP1 Gene

Unigene Clusters for MRFAP1 Gene

Morf4 family associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRFAP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP4: - -

Relevant External Links for MRFAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRFAP1 Gene

mRNA expression in normal human tissues for MRFAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRFAP1 Gene

This gene is overexpressed in Fetal ovary (13.8), Bone (12.2), Ovary (9.8), and Prostate (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRFAP1 Gene

SOURCE GeneReport for Unigene cluster for MRFAP1 Gene Hs.406590

genes like me logo Genes that share expression patterns with MRFAP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MRFAP1 Gene

Orthologs for MRFAP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MRFAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRFAP1 35
  • 91.34 (n)
  • 95.28 (a)
  • 95 (a)
(Canis familiaris)
Mammalia MRFAP1 35
  • 90.03 (n)
  • 94.49 (a)
  • 94 (a)
(Mus musculus)
Mammalia Mrfap1 35
  • 86.4 (n)
  • 86.4 (a)
Mrfap1 16
Gm5814 36
  • 83 (a)
Mrfap1 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Mrfap1 35
  • 86.93 (n)
  • 86.4 (a)
Species with no ortholog for MRFAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRFAP1 Gene

Gene Tree for MRFAP1 (if available)
Gene Tree for MRFAP1 (if available)

Paralogs for MRFAP1 Gene

Paralogs for MRFAP1 Gene

(1) SIMAP similar genes for MRFAP1 Gene using alignment to 1 proteins: Pseudogenes for MRFAP1 Gene

genes like me logo Genes that share paralogs with MRFAP1: view

Variants for MRFAP1 Gene

Sequence variations from dbSNP and Humsavar for MRFAP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs12695 -- 6,642,546(+) GATGA(C/G)AGTAT utr-variant-3-prime
rs1059220 -- 6,642,664(+) GGTCA(A/G)AACCC utr-variant-3-prime
rs3207078 -- 6,641,207(+) CTGGT(A/C/G)GAGCT intron-variant, reference, synonymous-codon
rs3207079 -- 6,641,213(+) GAGCT(C/G)GTCTG intron-variant, reference, synonymous-codon
rs3207097 -- 6,641,054(+) ATGCT(C/T)ATCCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MRFAP1 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv829849 CNV Loss 17160897
nsv4215 CNV Loss 18451855

Variation tolerance for MRFAP1 Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRFAP1 Gene

Disorders for MRFAP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRFAP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervix uteri carcinoma in situ
  • carcinoma in situ of cervix
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MRFAP1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MRFAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRFAP1 Gene

Publications for MRFAP1 Gene

  1. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. (PMID: 17008723) Zhang P. … Ding J. (Protein Sci. 2006) 3 4 67
  2. PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. (PMID: 15367658) Tominaga K. … Pereira-Smith O.M. (Mol. Cell. Biol. 2004) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for MRFAP1 Gene

Sources for MRFAP1 Gene