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Aliases for VAMP3 Gene

Aliases for VAMP3 Gene

  • Vesicle-Associated Membrane Protein 3 2 3
  • Cellubrevin 2 3 4
  • Synaptobrevin-3 3 4
  • VAMP-3 3 4
  • CEB 3 4
  • SYB3 4

External Ids for VAMP3 Gene

Summaries for VAMP3 Gene

Entrez Gene Summary for VAMP3 Gene

  • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP3 Gene

VAMP3 (Vesicle-Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with VAMP3 include tetanus. Among its related pathways are Arf6 trafficking events and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include syntaxin-1 binding. An important paralog of this gene is VAMP4.

UniProtKB/Swiss-Prot for VAMP3 Gene

  • SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Wiki entry for VAMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP3 Gene

Genomics for VAMP3 Gene

Genomic Location for VAMP3 Gene

Start:
7,771,269 bp from pter
End:
7,781,432 bp from pter
Size:
10,164 bases
Orientation:
Plus strand

Genomic View for VAMP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for VAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP3 Gene

Proteins for VAMP3 Gene

  • Protein details for VAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15836-VAMP3_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 3
    Protein Accession:
    Q15836
    Secondary Accessions:
    • Q9BRV4

    Protein attributes for VAMP3 Gene

    Size:
    100 amino acids
    Molecular mass:
    11309 Da
    Quaternary structure:
    • Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum.

neXtProt entry for VAMP3 Gene

Proteomics data for VAMP3 Gene at MOPED

Post-translational modifications for VAMP3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys35, Lys66, and Lys68

Other Protein References for VAMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for VAMP3 Gene

Domains for VAMP3 Gene

Gene Families for VAMP3 Gene

HGNC:
  • VAMP :Vesicle-associated membrane proteins

Protein Domains for VAMP3 Gene

UniProtKB/Swiss-Prot:

VAMP3_HUMAN
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.:
    • Q15836
Family:
  • Belongs to the synaptobrevin family.:
    • Q15836
genes like me logo Genes that share domains with VAMP3: view

Function for VAMP3 Gene

Molecular function for VAMP3 Gene

UniProtKB/Swiss-Prot Function: SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Ontology (GO) - Molecular Function for VAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IBA --
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12130530
GO:0017075 syntaxin-1 binding IEA --
genes like me logo Genes that share ontologies with VAMP3: view
genes like me logo Genes that share phenotypes with VAMP3: view

Animal Models for VAMP3 Gene

MGI Knock Outs for VAMP3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for VAMP3 Gene

Localization for VAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP3 Gene

Membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP3 Gene COMPARTMENTS Subcellular localization image for VAMP3 gene
Compartment Confidence
endosome 5
plasma membrane 4
cytosol 3
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for VAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 24055037
GO:0005829 cytosol IDA 22589474
GO:0005886 plasma membrane ISS --
GO:0008021 synaptic vesicle IBA --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with VAMP3: view

Pathways for VAMP3 Gene

genes like me logo Genes that share pathways with VAMP3: view

Pathways by source for VAMP3 Gene

1 Qiagen pathway for VAMP3 Gene
1 BioSystems pathway for VAMP3 Gene

Gene Ontology (GO) - Biological Process for VAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling ISS --
GO:0006461 protein complex assembly TAS 9885218
GO:0006887 exocytosis TAS 9885218
GO:0006904 vesicle docking involved in exocytosis TAS 9885218
GO:0006906 vesicle fusion IBA --
genes like me logo Genes that share ontologies with VAMP3: view

Compounds for VAMP3 Gene

(5) Novoseek inferred chemical compound relationships for VAMP3 Gene

Compound -log(P) Hits PubMed IDs
n-ethylmaleimide 28.9 1
glucose 25.2 3
phosphatidylinositol 3.93 1
atp 0 1
hydrogen 0 2
genes like me logo Genes that share compounds with VAMP3: view

Transcripts for VAMP3 Gene

mRNA/cDNA for VAMP3 Gene

Unigene Clusters for VAMP3 Gene

Vesicle-associated membrane protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: -

Relevant External Links for VAMP3 Gene

GeneLoc Exon Structure for
VAMP3
ECgene alternative splicing isoforms for
VAMP3

Expression for VAMP3 Gene

mRNA expression in normal human tissues for VAMP3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP3 Gene

SOURCE GeneReport for Unigene cluster for VAMP3 Gene Hs.66708

genes like me logo Genes that share expressions with VAMP3: view

Orthologs for VAMP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia VAMP3 36
  • 99.67 (n)
  • 100 (a)
VAMP3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia VAMP3 36
  • 87.75 (n)
  • 100 (a)
VAMP3 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAMP3 36
  • 85.71 (n)
  • 90.82 (a)
VAMP3 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp3 36
  • 86.18 (n)
  • 93.9 (a)
Vamp3 16
Vamp3 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 83 (a)
OneToMany
-- 37
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Vamp3 36
  • 86.99 (n)
  • 93.9 (a)
chicken
(Gallus gallus)
Aves VAMP3 36
  • 82.41 (n)
  • 98.61 (a)
VAMP3 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP3 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16507 36
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp3 36
  • 74.07 (n)
  • 90.12 (a)
zebrafish
(Danio rerio)
Actinopterygii vamp3 36
  • 76.32 (n)
  • 90.79 (a)
vamp3 37
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta n-syb 37
  • 28 (a)
ManyToMany
Syb 37
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea snb-1 37
  • 61 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NYV1 39
SNC1 37
  • 26 (a)
ManyToMany
SNC2 37
  • 26 (a)
ManyToMany
Species with no ortholog for VAMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP3 Gene

ENSEMBL:
Gene Tree for VAMP3 (if available)
TreeFam:
Gene Tree for VAMP3 (if available)

Paralogs for VAMP3 Gene

Paralogs for VAMP3 Gene

Selected SIMAP similar genes for VAMP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VAMP3: view

Variants for VAMP3 Gene

Sequence variations from dbSNP and Humsavar for VAMP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs228733 -- 7,781,765(-) AGACG(A/G)GGTCG downstream-variant-500B
rs228734 -- 7,776,148(-) gttca(C/T)acact intron-variant
rs697673 -- 7,777,782(-) ATCTG(A/G)TTGCA intron-variant
rs697674 -- 7,777,818(-) CACTT(C/G)TAAAC intron-variant
rs697675 -- 7,778,053(-) GAGTA(G/T)TATAT intron-variant

Relevant External Links for VAMP3 Gene

HapMap Linkage Disequilibrium report
VAMP3

No data available for Structural Variations from Database of Genomic Variants (DGV) for VAMP3 Gene

Disorders for VAMP3 Gene

(1) MalaCards Diseases for VAMP3 Gene

Search for VAMP3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for VAMP3 Gene

(2) Novoseek inferred disease relationships for VAMP3 Gene

Disease -log(P) Hits PubMed IDs
tetanus 79.7 29
tuberculosis 0 1

Relevant External Links for VAMP3

Genetic Association Database (GAD)
VAMP3
Human Genome Epidemiology (HuGE) Navigator
VAMP3
genes like me logo Genes that share disorders with VAMP3: view

No data available for UniProtKB/Swiss-Prot for VAMP3 Gene

Publications for VAMP3 Gene

  1. Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. (PMID: 9885218) Bernstein A.M. … Whiteheart S.W. (Blood 1999) 2 3 4 23
  2. Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. (PMID: 9396746) Annaert W.G. … Jahn R. (J. Cell Biol. 1997) 3 23
  3. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. (PMID: 9614185) Galli T. … Louvard D. (Mol. Biol. Cell 1998) 3 23
  4. Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. (PMID: 9701566) Riento K. … Olkkonen V.M. (J. Cell. Sci. 1998) 3 23
  5. Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. (PMID: 11839770) Mallard F. … Johannes L. (J. Cell Biol. 2002) 3 23

Products for VAMP3 Gene

  • Addgene plasmids for VAMP3

Sources for VAMP3 Gene

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