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Aliases for VAMP3 Gene

Aliases for VAMP3 Gene

  • Vesicle Associated Membrane Protein 3 2 3 5
  • Cellubrevin 2 3 4
  • Synaptobrevin-3 3 4
  • VAMP-3 3 4
  • CEB 3 4
  • SYB3 4

External Ids for VAMP3 Gene

Previous GeneCards Identifiers for VAMP3 Gene

  • GC01P007413
  • GC01P007640
  • GC01P007540
  • GC01P006979

Summaries for VAMP3 Gene

Entrez Gene Summary for VAMP3 Gene

  • Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for VAMP3 Gene

VAMP3 (Vesicle Associated Membrane Protein 3) is a Protein Coding gene. Diseases associated with VAMP3 include tetanus and primary bacterial infectious disease. Among its related pathways are Arf6 trafficking events and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include SNARE binding and syntaxin-1 binding. An important paralog of this gene is VAMP1.

UniProtKB/Swiss-Prot for VAMP3 Gene

  • SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Wiki entry for VAMP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for VAMP3 Gene

Genomics for VAMP3 Gene

Regulatory Elements for VAMP3 Gene

Promoters for VAMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around VAMP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for VAMP3 Gene

Chromosome:
1
Start:
7,771,269 bp from pter
End:
7,781,432 bp from pter
Size:
10,164 bases
Orientation:
Plus strand

Genomic View for VAMP3 Gene

Genes around VAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
VAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for VAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for VAMP3 Gene

Proteins for VAMP3 Gene

  • Protein details for VAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15836-VAMP3_HUMAN
    Recommended name:
    Vesicle-associated membrane protein 3
    Protein Accession:
    Q15836
    Secondary Accessions:
    • Q9BRV4

    Protein attributes for VAMP3 Gene

    Size:
    100 amino acids
    Molecular mass:
    11309 Da
    Quaternary structure:
    • Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with BCAP31; involved in VAMP3 export from the endoplasmic reticulum.

neXtProt entry for VAMP3 Gene

Proteomics data for VAMP3 Gene at MOPED

Post-translational modifications for VAMP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for VAMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for VAMP3 (VAMP3)

No data available for DME Specific Peptides for VAMP3 Gene

Domains & Families for VAMP3 Gene

Gene Families for VAMP3 Gene

Protein Domains for VAMP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q15836

UniProtKB/Swiss-Prot:

VAMP3_HUMAN :
  • Contains 1 v-SNARE coiled-coil homology domain.
  • Belongs to the synaptobrevin family.
Domain:
  • Contains 1 v-SNARE coiled-coil homology domain.
Family:
  • Belongs to the synaptobrevin family.
genes like me logo Genes that share domains with VAMP3: view

Function for VAMP3 Gene

Molecular function for VAMP3 Gene

UniProtKB/Swiss-Prot Function:
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
genes like me logo Genes that share phenotypes with VAMP3: view

Animal Models for VAMP3 Gene

MGI Knock Outs for VAMP3:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for VAMP3 Gene

Localization for VAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for VAMP3 Gene

Membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for VAMP3 Gene COMPARTMENTS Subcellular localization image for VAMP3 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 5
extracellular 2
golgi apparatus 2
lysosome 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for VAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 24055037
GO:0005829 cytosol IEA,IDA 22589474
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0030136 clathrin-coated vesicle IDA 19478182
genes like me logo Genes that share ontologies with VAMP3: view

Pathways & Interactions for VAMP3 Gene

genes like me logo Genes that share pathways with VAMP3: view

Pathways by source for VAMP3 Gene

Gene Ontology (GO) - Biological Process for VAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly IEA,TAS 9885218
GO:0006904 vesicle docking involved in exocytosis TAS 9885218
GO:0035493 SNARE complex assembly IEA --
GO:0042147 retrograde transport, endosome to Golgi IDA 18195106
GO:0070254 NOT mucus secretion IMP 22144578
genes like me logo Genes that share ontologies with VAMP3: view

No data available for SIGNOR curated interactions for VAMP3 Gene

Drugs & Compounds for VAMP3 Gene

(2) Drugs for VAMP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for VAMP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with VAMP3: view

Transcripts for VAMP3 Gene

mRNA/cDNA for VAMP3 Gene

Unigene Clusters for VAMP3 Gene

Vesicle-associated membrane protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for VAMP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - - -
SP8: -

Relevant External Links for VAMP3 Gene

GeneLoc Exon Structure for
VAMP3
ECgene alternative splicing isoforms for
VAMP3

Expression for VAMP3 Gene

mRNA expression in normal human tissues for VAMP3 Gene

Protein differential expression in normal tissues from HIPED for VAMP3 Gene

This gene is overexpressed in Brain (25.6) and Nasal epithelium (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for VAMP3 Gene



SOURCE GeneReport for Unigene cluster for VAMP3 Gene Hs.66708

genes like me logo Genes that share expression patterns with VAMP3: view

Protein tissue co-expression partners for VAMP3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for VAMP3 Gene

Orthologs for VAMP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for VAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia VAMP3 35
  • 87.75 (n)
  • 100 (a)
VAMP3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia VAMP3 35
  • 85.71 (n)
  • 90.82 (a)
VAMP3 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Vamp3 35
  • 86.18 (n)
  • 93.9 (a)
Vamp3 16
Vamp3 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia VAMP3 35
  • 99.67 (n)
  • 100 (a)
VAMP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Vamp3 35
  • 86.99 (n)
  • 93.9 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves VAMP3 35
  • 82.41 (n)
  • 98.61 (a)
VAMP3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia VAMP3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia vamp3 35
  • 74.07 (n)
  • 90.12 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16507 35
zebrafish
(Danio rerio)
Actinopterygii vamp3 35
  • 76.32 (n)
  • 90.79 (a)
vamp3 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta n-syb 36
  • 28 (a)
ManyToMany
Syb 36
  • 36 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea snb-1 36
  • 61 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNC1 36
  • 26 (a)
ManyToMany
SNC2 36
  • 26 (a)
ManyToMany
NYV1 38
Species with no ortholog for VAMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for VAMP3 Gene

ENSEMBL:
Gene Tree for VAMP3 (if available)
TreeFam:
Gene Tree for VAMP3 (if available)

Paralogs for VAMP3 Gene

Paralogs for VAMP3 Gene

(6) SIMAP similar genes for VAMP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with VAMP3: view

Variants for VAMP3 Gene

Sequence variations from dbSNP and Humsavar for VAMP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs707457 -- 7,771,004(-) CACTG(G/T)CGAGG upstream-variant-2KB
rs707458 -- 7,772,152(-) TTAGA(A/G)AGTCA intron-variant
rs707459 -- 7,772,229(-) CATGC(A/T)TTTCC intron-variant
rs2239846 -- 7,773,242(+) GGTGG(A/G)ACAGT intron-variant
rs11582799 -- 7,771,966(+) CTCTT(C/T)CACCT intron-variant

Variation tolerance for VAMP3 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for VAMP3 Gene

HapMap Linkage Disequilibrium report
VAMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for VAMP3 Gene

Disorders for VAMP3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for VAMP3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tetanus
  • clostridial tetanus
primary bacterial infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search VAMP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for VAMP3

Genetic Association Database (GAD)
VAMP3
Human Genome Epidemiology (HuGE) Navigator
VAMP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
VAMP3
genes like me logo Genes that share disorders with VAMP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for VAMP3 Gene

Publications for VAMP3 Gene

  1. Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. (PMID: 9885218) Bernstein A.M. … Whiteheart S.W. (Blood 1999) 2 3 4 23 67
  2. TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. (PMID: 19781582) Fader C.M. … Colombo M.I. (Biochim. Biophys. Acta 2009) 3 23
  3. VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. (PMID: 19910495) Kean M.J. … Coppolino M.G. (J. Cell. Sci. 2009) 3 23
  4. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. (PMID: 18253931) Sander L.E. … Lorentz A. (Eur. J. Immunol. 2008) 3 23
  5. Hyperacidification of cellubrevin endocytic compartments and defective endosomal recycling in cystic fibrosis respiratory epithelial cells. (PMID: 11809765) Poschet J.F. … Deretic V. (J. Biol. Chem. 2002) 3 23

Products for VAMP3 Gene

Sources for VAMP3 Gene

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