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Aliases for GTF3C5 Gene

Aliases for GTF3C5 Gene

  • General Transcription Factor IIIC Subunit 5 2 3 5
  • General Transcription Factor IIIC, Polypeptide 5, 63kDa 2 3
  • Transcription Factor IIIC Subunit Epsilon 3 4
  • Transcription Factor IIIC 63 KDa Subunit 3 4
  • Transcription Factor IIIC, 63 KD 2 3
  • TFIIIC 63 KDa Subunit 3 4
  • TF3C-Epsilon 3 4
  • TFIIIC63 3 4
  • General Transcription Factor IIIC, Polypeptide 5 (63kD) 2
  • General Transcription Factor 3C Polypeptide 5 3
  • TFIIICepsilon 3
  • TFiiiC2-63 3

External Ids for GTF3C5 Gene

Previous GeneCards Identifiers for GTF3C5 Gene

  • GC09P126930
  • GC09P127462
  • GC09P129259
  • GC09P131182
  • GC09P132935
  • GC09P134895
  • GC09P135906
  • GC09P105399

Summaries for GTF3C5 Gene

GeneCards Summary for GTF3C5 Gene

GTF3C5 (General Transcription Factor IIIC Subunit 5) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation.

UniProtKB/Swiss-Prot for GTF3C5 Gene

  • Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Gene Wiki entry for GTF3C5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GTF3C5 Gene

Genomics for GTF3C5 Gene

Regulatory Elements for GTF3C5 Gene

Enhancers for GTF3C5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G133112 2.2 FANTOM5 Ensembl ENCODE dbSUPER 6.1 +98.3 98298 33.8 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 RALGDS TTF1 TSC1 GTF3C4 LINC00094 GBGT1 REXO4 EEF1A1P5 SLC2A6 SURF6
GH09G133080 1 Ensembl ENCODE 13.2 +50.9 50945 2.6 HDAC1 KLF1 ZNF175 RBBP5 RELA SCRT2 ZNF639 L3MBTL2 ZNF740 NR4A1 GTF3C5 CELP RALGDS GC09M133093
GH09G133886 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +858.0 858011 4.6 HDGF PKNOX1 FOXA2 ATF1 MLX ARNT ARID4B GLI4 DMAP1 ZNF2 COL5A1-AS1 CACFD1 GTF3C5 VAV2 GC09M133930 GC09P133784
GH09G133029 1.2 ENCODE 8 +0.0 32 2.5 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 TTF1 TSC1 SETX LINC00094 MED27 AK8 GTF3C4 SURF6 RALGDS GTF3C5
GH09G133008 0.7 ENCODE 11 -21.6 -21647 0.1 HDAC1 PKNOX1 FOXA2 TCF12 ZNF600 MAFK NFE2L2 SMARCE1 HLF FOXA3 RPL39P24 RNU7-21P GTF3C5 CEL GC09P133087 GC09P133086 GC09P133074 GC09P133055 GC09P132965
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GTF3C5 on UCSC Golden Path with GeneCards custom track

Promoters for GTF3C5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242528 -75 2001 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21

Genomic Location for GTF3C5 Gene

Chromosome:
9
Start:
133,030,675 bp from pter
End:
133,058,503 bp from pter
Size:
27,829 bases
Orientation:
Plus strand

Genomic View for GTF3C5 Gene

Genes around GTF3C5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GTF3C5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GTF3C5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GTF3C5 Gene

Proteins for GTF3C5 Gene

  • Protein details for GTF3C5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Q8-TF3C5_HUMAN
    Recommended name:
    General transcription factor 3C polypeptide 5
    Protein Accession:
    Q9Y5Q8
    Secondary Accessions:
    • A6NI44
    • A6NJB9
    • Q5T7U2
    • Q5T7U3
    • Q8N2U7
    • Q8N857
    • Q96GD9
    • Q9H4P2

    Protein attributes for GTF3C5 Gene

    Size:
    519 amino acids
    Molecular mass:
    59571 Da
    Quaternary structure:
    • Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP.

    Alternative splice isoforms for GTF3C5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GTF3C5 Gene

Post-translational modifications for GTF3C5 Gene

  • Ubiquitination at posLast=3838, posLast=256256, and posLast=367367
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GTF3C5 Gene

Domains & Families for GTF3C5 Gene

Gene Families for GTF3C5 Gene

Protein Domains for GTF3C5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y5Q8

UniProtKB/Swiss-Prot:

TF3C5_HUMAN :
  • Belongs to the TFIIIC subunit 5 family.
Family:
  • Belongs to the TFIIIC subunit 5 family.
genes like me logo Genes that share domains with GTF3C5: view

Function for GTF3C5 Gene

Molecular function for GTF3C5 Gene

UniProtKB/Swiss-Prot Function:
Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Gene Ontology (GO) - Molecular Function for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001002 contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IBA --
GO:0001003 contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IBA --
GO:0001005 contributes_to transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting IBA --
GO:0003677 contributes_to DNA binding IEA,IC 17409385
GO:0005515 protein binding IPI 17409385
genes like me logo Genes that share ontologies with GTF3C5: view
genes like me logo Genes that share phenotypes with GTF3C5: view

Animal Models for GTF3C5 Gene

MGI Knock Outs for GTF3C5:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GTF3C5 Gene

Localization for GTF3C5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GTF3C5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GTF3C5 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000127 transcription factor TFIIIC complex IDA 17409385
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS,IDA --
genes like me logo Genes that share ontologies with GTF3C5: view

Pathways & Interactions for GTF3C5 Gene

genes like me logo Genes that share pathways with GTF3C5: view

Gene Ontology (GO) - Biological Process for GTF3C5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000999 RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly IEA --
GO:0001009 transcription from RNA polymerase III type 2 promoter IBA --
GO:0006351 transcription, DNA-templated IC 17409385
GO:0006383 transcription from RNA polymerase III promoter IC 17409385
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with GTF3C5: view

No data available for SIGNOR curated interactions for GTF3C5 Gene

Drugs & Compounds for GTF3C5 Gene

No Compound Related Data Available

Transcripts for GTF3C5 Gene

Unigene Clusters for GTF3C5 Gene

General transcription factor IIIC, polypeptide 5, 63kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GTF3C5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c · 9d ^ 10a ·
SP1: - -
SP2: - - - - - - - -
SP3:
SP4: - - - - -
SP5: - - -
SP6: - - - - - - - - - - - -
SP7:
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - - - - - -
SP11:
SP12: - - - - - - - - - - - - - - - -
SP13: -
SP14: - - - - - - - - - - -
SP15: - - - - - - - - -
SP16: - - -

ExUns: 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16
SP1: - - -
SP2:
SP3: - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for GTF3C5 Gene

GeneLoc Exon Structure for
GTF3C5
ECgene alternative splicing isoforms for
GTF3C5

Expression for GTF3C5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GTF3C5 Gene

Protein differential expression in normal tissues from HIPED for GTF3C5 Gene

This gene is overexpressed in Lung (28.2), Peripheral blood mononuclear cells (7.7), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GTF3C5 Gene



Protein tissue co-expression partners for GTF3C5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GTF3C5 Gene:

GTF3C5

SOURCE GeneReport for Unigene cluster for GTF3C5 Gene:

Hs.495417

Evidence on tissue expression from TISSUES for GTF3C5 Gene

  • Nervous system(5)
  • Kidney(4.6)
  • Skin(4.4)
  • Spleen(4.3)
  • Intestine(3.2)
  • Eye(3.1)
  • Lung(3.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with GTF3C5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GTF3C5 Gene

Orthologs for GTF3C5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GTF3C5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GTF3C5 34 35
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia GTF3C5 34 35
  • 86.88 (n)
cow
(Bos Taurus)
Mammalia GTF3C5 34 35
  • 85.32 (n)
mouse
(Mus musculus)
Mammalia Gtf3c5 34 16 35
  • 83.69 (n)
rat
(Rattus norvegicus)
Mammalia Gtf3c5 34
  • 83.5 (n)
oppossum
(Monodelphis domestica)
Mammalia GTF3C5 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GTF3C5 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves GTF3C5 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GTF3C5 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gtf3c5 34
  • 70.31 (n)
Str.13723 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4179 34
zebrafish
(Danio rerio)
Actinopterygii gtf3c5 34 35
  • 59.69 (n)
Dr.17162 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009321 34
  • 45.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cd 35 34
  • 44.53 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T02C12.3 34
  • 40.78 (n)
tftc-5 35
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFC1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToOne
Species where no ortholog for GTF3C5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GTF3C5 Gene

ENSEMBL:
Gene Tree for GTF3C5 (if available)
TreeFam:
Gene Tree for GTF3C5 (if available)

Paralogs for GTF3C5 Gene

No data available for Paralogs for GTF3C5 Gene

Variants for GTF3C5 Gene

Sequence variations from dbSNP and Humsavar for GTF3C5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000082477 -- 133,047,802(+) CAGGC(A/G)TAAGC intron-variant
rs1000115125 -- 133,047,574(+) TGGAA(G/T)GCAGT intron-variant
rs1000258627 -- 133,042,805(+) GAGAC(A/G)GGTGA intron-variant
rs1000282782 -- 133,047,694(+) CTTTT(A/G)TATTT intron-variant
rs1000362483 -- 133,031,535(+) TTAGT(A/G)GAGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for GTF3C5 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
esv2761264 CNV loss 21179565
esv3621930 CNV loss 21293372
nsv466606 CNV loss 19166990
nsv508564 CNV deletion 20534489
nsv520759 CNV loss 19592680
nsv615596 CNV loss 21841781
nsv6746 CNV insertion 18451855
nsv819112 CNV gain 19587683
nsv831744 CNV gain+loss 17160897

Variation tolerance for GTF3C5 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GTF3C5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GTF3C5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GTF3C5 Gene

Disorders for GTF3C5 Gene

Relevant External Links for GTF3C5

Genetic Association Database (GAD)
GTF3C5
Human Genome Epidemiology (HuGE) Navigator
GTF3C5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GTF3C5

No disorders were found for GTF3C5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GTF3C5 Gene

Publications for GTF3C5 Gene

  1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. (PMID: 17409385) Dumay-Odelot H. … Teichmann M. (J. Biol. Chem. 2007) 3 4 22 64
  2. Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III. (PMID: 10373544) Hsieh Y.-J. … Roeder R.G. (Mol. Cell. Biol. 1999) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for GTF3C5 Gene

Sources for GTF3C5 Gene

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