Aliases for HMGN3 Gene
External Ids for HMGN3 Gene
Previous HGNC Symbols for HMGN3 Gene
Previous GeneCards Identifiers for HMGN3 Gene
Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for HMGN3 Gene
HMGN3 (High Mobility Group Nucleosomal Binding Domain 3) is a Protein Coding gene. GO annotations related to this gene include thyroid hormone receptor binding and nucleosomal DNA binding.
UniProtKB/Swiss-Prot for HMGN3 Gene
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).