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Aliases for HMGN3 Gene

Aliases for HMGN3 Gene

  • High Mobility Group Nucleosomal Binding Domain 3 2 3
  • TRIP7 3 4 6
  • TR-Interacting Protein 7 3 4
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 3 3
  • Thyroid Hormone Receptor Interacting Protein 7 3
  • Thyroid Receptor-Interacting Protein 7 4
  • Thyroid Hormone Receptor Interactor 7 2
  • PNAS-24 3
  • PNAS-25 3
  • TRIP-7 4

External Ids for HMGN3 Gene

Previous HGNC Symbols for HMGN3 Gene

  • TRIP7

Previous GeneCards Identifiers for HMGN3 Gene

  • GC06M079853
  • GC06M079906
  • GC06M079967
  • GC06M077104

Summaries for HMGN3 Gene

Entrez Gene Summary for HMGN3 Gene

  • Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. The protein encoded by this gene binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for HMGN3 Gene

HMGN3 (High Mobility Group Nucleosomal Binding Domain 3) is a Protein Coding gene. GO annotations related to this gene include thyroid hormone receptor binding and nucleosomal DNA binding.

UniProtKB/Swiss-Prot for HMGN3 Gene

  • Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).

Gene Wiki entry for HMGN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN3 Gene

Genomics for HMGN3 Gene

Regulatory Elements for HMGN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HMGN3 Gene

Start:
79,201,245 bp from pter
End:
79,235,470 bp from pter
Size:
34,226 bases
Orientation:
Minus strand

Genomic View for HMGN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGN3 Gene

Proteins for HMGN3 Gene

  • Protein details for HMGN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15651-HMGN3_HUMAN
    Recommended name:
    High mobility group nucleosome-binding domain-containing protein 3
    Protein Accession:
    Q15651
    Secondary Accessions:
    • B2RD37
    • Q5HYD3
    • Q7RTT0
    • Q969M5
    • Q9BZT7

    Protein attributes for HMGN3 Gene

    Size:
    99 amino acids
    Molecular mass:
    10666 Da
    Quaternary structure:
    • Interacts with the ligand binding domain of the thyroid receptor (TR) (in vitro). Requires the presence of thyroid hormone for its interaction. Interacts with nucleosomes.
    SequenceCaution:
    • Sequence=AAA73877.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HMGN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMGN3 Gene

Proteomics data for HMGN3 Gene at MOPED

Post-translational modifications for HMGN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGN3 Gene

No data available for DME Specific Peptides for HMGN3 Gene

Domains for HMGN3 Gene

Gene Families for HMGN3 Gene

HGNC:
  • HMG :High-mobility group / Canonical

Protein Domains for HMGN3 Gene

Suggested Antigen Peptide Sequences for HMGN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15651

UniProtKB/Swiss-Prot:

HMGN3_HUMAN :
  • Q15651
Family:
  • Belongs to the HMGN family.
genes like me logo Genes that share domains with HMGN3: view

Function for HMGN3 Gene

Molecular function for HMGN3 Gene

UniProtKB/Swiss-Prot Function: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
UniProtKB/Swiss-Prot Induction: By estrogen

Gene Ontology (GO) - Molecular Function for HMGN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding --
GO:0031492 nucleosomal DNA binding IEA --
GO:0046966 thyroid hormone receptor binding NAS 7776974
genes like me logo Genes that share ontologies with HMGN3: view

Phenotypes for HMGN3 Gene

genes like me logo Genes that share phenotypes with HMGN3: view

Animal Models for HMGN3 Gene

MGI Knock Outs for HMGN3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HMGN3 Gene

Localization for HMGN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGN3 Gene COMPARTMENTS Subcellular localization image for HMGN3 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for HMGN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HMGN3: view

Pathways for HMGN3 Gene

SuperPathways for HMGN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HMGN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0008150 biological_process ND --
GO:0016568 chromatin modification IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter --
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with HMGN3: view

No data available for Pathways by source for HMGN3 Gene

Transcripts for HMGN3 Gene

Unigene Clusters for HMGN3 Gene

High mobility group nucleosomal binding domain 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMGN3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7:
SP8: -

Relevant External Links for HMGN3 Gene

GeneLoc Exon Structure for
HMGN3
ECgene alternative splicing isoforms for
HMGN3

Expression for HMGN3 Gene

mRNA expression in normal human tissues for HMGN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGN3 Gene

SOURCE GeneReport for Unigene cluster for HMGN3 Gene Hs.77558

mRNA Expression by UniProt/SwissProt for HMGN3 Gene

Q15651-HMGN3_HUMAN
Tissue specificity: Expressed in kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate and uterus. Low expression in liver, spleen, placenta and ovaries.
genes like me logo Genes that share expressions with HMGN3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HMGN3 Gene

Orthologs for HMGN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGN3 35
  • 100 (n)
  • 100 (a)
HMGN3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HMGN3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMGN3 36
  • 64 (a)
OneToOne
LOC611307 35
  • 96.61 (n)
  • 96.87 (a)
mouse
(Mus musculus)
Mammalia Hmgn3 16
Hmgn3 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMGN3 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmgn3 35
  • 89.25 (n)
  • 85.48 (a)
chicken
(Gallus gallus)
Aves HMGN3 35
  • 84.78 (n)
  • 80.43 (a)
HMGN3 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMGN3 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64252 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
hmgn3 35
  • 65.79 (n)
  • 64.04 (a)
hmgn3 36
  • 48 (a)
OneToOne
Species with no ortholog for HMGN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMGN3 Gene

ENSEMBL:
Gene Tree for HMGN3 (if available)
TreeFam:
Gene Tree for HMGN3 (if available)

Paralogs for HMGN3 Gene

Selected SIMAP similar genes for HMGN3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HMGN3 Gene

genes like me logo Genes that share paralogs with HMGN3: view

No data available for Paralogs for HMGN3 Gene

Variants for HMGN3 Gene

Sequence variations from dbSNP and Humsavar for HMGN3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs989191 -- 79,204,239(-) ATAAA(A/C)ACCTT intron-variant
rs1414280 -- 79,219,013(+) ACTAT(A/C)taata intron-variant
rs1414281 -- 79,227,270(+) TTTTC(C/T)ATTAG intron-variant
rs1414282 -- 79,227,271(+) TTTCC(A/G)TTAGA intron-variant
rs2095633 -- 79,207,156(-) cttaa(C/T)tcatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGN3 Gene

Variant ID Type Subtype PubMed ID
nsv830706 CNV Gain 17160897

Relevant External Links for HMGN3 Gene

HapMap Linkage Disequilibrium report
HMGN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN3 Gene

Disorders for HMGN3 Gene

No disorders were found for HMGN3 Gene.

No data available for UniProtKB/Swiss-Prot for HMGN3 Gene

Publications for HMGN3 Gene

  1. HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome- binding proteins. (PMID: 11356838) West K.L. … Bustin M. (J. Biol. Chem. 2001) 2 3 4 23
  2. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4
  3. Differential display RT-PCR analysis of enterovirus-71-infected rhabdomyosarcoma cells reveals mRNA expression responses of multiple human genes with known and novel functions. (PMID: 12033773) Leong P.W. … Chow V.T.K. (Virology 2002) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for HMGN3 Gene

Sources for HMGN3 Gene

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