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Aliases for TRIP10 Gene

Aliases for TRIP10 Gene

  • Thyroid Hormone Receptor Interactor 10 2 3 5
  • Thyroid Receptor-Interacting Protein 10 3 4
  • TR-Interacting Protein 10 3 4
  • Salt Tolerant Protein 3 4
  • Salt Tolerator 2 3
  • Protein Felic 3 4
  • TRIP-10 3 4
  • HSTP 3 4
  • STOT 3 4
  • CIP4 3 4
  • STP 3 4
  • Cdc42-Interacting Protein 2

External Ids for TRIP10 Gene

Previous HGNC Symbols for TRIP10 Gene

  • STOT

Previous GeneCards Identifiers for TRIP10 Gene

  • GC19P006834
  • GC19P006679
  • GC19P006690
  • GC19P006502

Summaries for TRIP10 Gene

GeneCards Summary for TRIP10 Gene

TRIP10 (Thyroid Hormone Receptor Interactor 10) is a Protein Coding gene. Diseases associated with TRIP10 include Wiskott-Aldrich Syndrome. Among its related pathways are Signaling by Rho GTPases and Translation Insulin regulation of translation. GO annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is FNBP1L.

UniProtKB/Swiss-Prot for TRIP10 Gene

  • Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Gene Wiki entry for TRIP10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP10 Gene

Genomics for TRIP10 Gene

Regulatory Elements for TRIP10 Gene

Enhancers for TRIP10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIP10 on UCSC Golden Path with GeneCards custom track

Promoters for TRIP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIP10 Gene

Chromosome:
19
Start:
6,737,925 bp from pter
End:
6,751,526 bp from pter
Size:
13,602 bases
Orientation:
Plus strand

Genomic View for TRIP10 Gene

Genes around TRIP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP10 Gene

Proteins for TRIP10 Gene

  • Protein details for TRIP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15642-CIP4_HUMAN
    Recommended name:
    Cdc42-interacting protein 4
    Protein Accession:
    Q15642
    Secondary Accessions:
    • B2R8A6
    • B7WP22
    • D6W645
    • O15184
    • Q53G22
    • Q5TZN1
    • Q6FI24
    • Q8NFL1
    • Q8TCY1
    • Q8TDX3
    • Q96RJ1

    Protein attributes for TRIP10 Gene

    Size:
    601 amino acids
    Molecular mass:
    68352 Da
    Quaternary structure:
    • Interacts specifically with GTP-bound RHOQ. Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound CDC42. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and WASL/N-WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT.

    Three dimensional structures from OCA and Proteopedia for TRIP10 Gene

    Alternative splice isoforms for TRIP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIP10 Gene

Proteomics data for TRIP10 Gene at MOPED

Post-translational modifications for TRIP10 Gene

Other Protein References for TRIP10 Gene

No data available for DME Specific Peptides for TRIP10 Gene

Domains & Families for TRIP10 Gene

Gene Families for TRIP10 Gene

Protein Domains for TRIP10 Gene

Suggested Antigen Peptide Sequences for TRIP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15642

UniProtKB/Swiss-Prot:

CIP4_HUMAN :
  • The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation.
  • Belongs to the FNBP1 family.
  • Contains 1 REM (Hr1) repeat.
Domain:
  • The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation.
  • Contains 1 F-BAR domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the FNBP1 family.
Similarity:
  • Contains 1 REM (Hr1) repeat.
genes like me logo Genes that share domains with TRIP10: view

Function for TRIP10 Gene

Molecular function for TRIP10 Gene

UniProtKB/Swiss-Prot Function:
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
UniProtKB/Swiss-Prot Induction:
Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during differentiation.

Gene Ontology (GO) - Molecular Function for TRIP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005086 ARF guanyl-nucleotide exchange factor activity IBA --
genes like me logo Genes that share ontologies with TRIP10: view
genes like me logo Genes that share phenotypes with TRIP10: view

Animal Models for TRIP10 Gene

MGI Knock Outs for TRIP10:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIP10 Gene

Localization for TRIP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP10 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.
Isoform 5: Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIP10 Gene COMPARTMENTS Subcellular localization image for TRIP10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
golgi apparatus 5
lysosome 5
nucleus 5
plasma membrane 5
vacuole 5
endosome 1

Gene Ontology (GO) - Cellular Components for TRIP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 9210375
GO:0005764 lysosome IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TRIP10: view

Pathways & Interactions for TRIP10 Gene

genes like me logo Genes that share pathways with TRIP10: view

Pathways by source for TRIP10 Gene

2 BioSystems pathways for TRIP10 Gene
3 Reactome pathways for TRIP10 Gene
1 KEGG pathway for TRIP10 Gene

SIGNOR curated interactions for TRIP10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRIP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9210375
GO:0043547 positive regulation of GTPase activity IBA,TAS --
genes like me logo Genes that share ontologies with TRIP10: view

Drugs & Compounds for TRIP10 Gene

(2) Drugs for TRIP10 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(124) Additional Compounds for TRIP10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PS(14:0/14:0)
  • 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:0)
  • Phosphatidylserine(28:0)
  • PS(14:0/14:0)
  • PS(28:0)
PS(14:0/14:1(9Z))
  • 1-Myristoyl-2-myristoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/14:1)
  • Phosphatidylserine(14:0/14:1n5)
  • Phosphatidylserine(14:0/14:1w5)
  • Phosphatidylserine(28:1)
PS(14:0/16:0)
  • 1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:0)
  • Phosphatidylserine(30:0)
  • PS(14:0/16:0)
  • PS(30:0)
PS(14:0/16:1(9Z))
  • 1-Myristoyl-2-palmitoleoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/16:1)
  • Phosphatidylserine(14:0/16:1n7)
  • Phosphatidylserine(14:0/16:1w7)
  • Phosphatidylserine(30:1)
PS(14:0/18:0)
  • 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphoserine
  • Phosphatidylserine(14:0/18:0)
  • Phosphatidylserine(32:0)
  • PS(14:0/18:0)
  • PS(32:0)
genes like me logo Genes that share compounds with TRIP10: view

Transcripts for TRIP10 Gene

Unigene Clusters for TRIP10 Gene

Thyroid hormone receptor interactor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - -
SP7:
SP8: - - - - -
SP9:
SP10: - -
SP11: - - -
SP12:

ExUns: 15 ^ 16 ^ 17a · 17b · 17c · 17d · 17e · 17f
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TRIP10 Gene

GeneLoc Exon Structure for
TRIP10
ECgene alternative splicing isoforms for
TRIP10

Expression for TRIP10 Gene

mRNA expression in normal human tissues for TRIP10 Gene

mRNA differential expression in normal tissues according to GTEx for TRIP10 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for TRIP10 Gene

This gene is overexpressed in Lymph node (16.4) and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIP10 Gene



SOURCE GeneReport for Unigene cluster for TRIP10 Gene Hs.515094

mRNA Expression by UniProt/SwissProt for TRIP10 Gene

Q15642-CIP4_HUMAN
Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
genes like me logo Genes that share expression patterns with TRIP10: view

Protein tissue co-expression partners for TRIP10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIP10 Gene

Orthologs for TRIP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIP10 35
  • 87.91 (n)
  • 92.68 (a)
TRIP10 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP10 35
  • 89.24 (n)
  • 94.12 (a)
TRIP10 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trip10 35
  • 82.11 (n)
  • 88.29 (a)
Trip10 16
Trip10 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trip10 35
  • 78.86 (n)
  • 85.85 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIP10 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIP10 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIP10 36
  • 97 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii zgc56292 35
zgc:101777 35
  • 62.37 (n)
  • 62.43 (a)
TRIP10 (1 of 2) 36
  • 55 (a)
OneToMany
TRIP10 (2 of 2) 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cip4 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea toca-1 36
  • 24 (a)
ManyToMany
toca-2 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for TRIP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIP10 Gene

ENSEMBL:
Gene Tree for TRIP10 (if available)
TreeFam:
Gene Tree for TRIP10 (if available)

Paralogs for TRIP10 Gene

Paralogs for TRIP10 Gene

(3) SIMAP similar genes for TRIP10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRIP10: view

Variants for TRIP10 Gene

Sequence variations from dbSNP and Humsavar for TRIP10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs71177116 -- 6,742,095(+) AAAAA(-/A)TAGGG intron-variant
rs1049229 -- 6,751,268(+) CGGGG(A/G)GCCCC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1049230 -- 6,751,270(+) GGGAG(C/T)CCCAG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1049232 -- 6,751,282(+) ACCTA(G/T)GCACT nc-transcript-variant, reference, missense, utr-variant-3-prime
rs71309647 -- 6,745,146(+) AAGGC(-/GGGCA)GGCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIP10 Gene

Variant ID Type Subtype PubMed ID
nsv470120 CNV Loss 18288195
dgv3703n71 CNV Loss 21882294
dgv14e196 CNV Duplication 17116639
nsv910940 CNV Loss 21882294
nsv519827 CNV Loss 19592680
nsv910941 CNV Loss 21882294
nsv910942 CNV Loss 21882294
nsv519561 CNV Loss 19592680

Variation tolerance for TRIP10 Gene

Residual Variation Intolerance Score: 19.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIP10 Gene

Disorders for TRIP10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIP10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
wiskott-aldrich syndrome
  • wiskott syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIP10
genes like me logo Genes that share disorders with TRIP10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIP10 Gene

Publications for TRIP10 Gene

  1. Molecular cloning and chromosomal localization of human salt-tolerant protein. (PMID: 11294612) Tsuji E. … Tsuji Y. (Genetica 2000) 2 3 4 23 67
  2. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton. (PMID: 9210375) Aspenstroem P. (Curr. Biol. 1997) 2 3 23
  3. F-BAR-containing adaptor CIP4 localizes to early endosomes and regulates Epidermal Growth Factor Receptor trafficking and downregulation. (PMID: 19632321) Hu J. … Craig A.W. (Cell. Signal. 2009) 3 23
  4. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. (PMID: 17512409) Shimada A. … Yokoyama S. (Cell 2007) 3 23
  5. Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. (PMID: 17785506) Banerjee P.P. … Orange J.S. (J. Exp. Med. 2007) 3 23

Products for TRIP10 Gene

Sources for TRIP10 Gene

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