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Aliases for MS4A3 Gene

Aliases for MS4A3 Gene

  • Membrane Spanning 4-Domains A3 2 3
  • Membrane-Spanning 4-Domains, Subfamily A, Member 3 (Hematopoietic Cell-Specific) 2 3 5
  • Hematopoietic-Specific Transmembrane Protein 4 3 4
  • CD20 Antigen-Like Protein 3 4
  • CD20L 3 4
  • HTM4 3 4
  • Hematopoietic Cell 4 Transmembrane Protein 3
  • IgE Receptor Beta Subunit 3
  • IgE Receptor Beta Chain 3
  • CD20 Antigen Homolog 3

External Ids for MS4A3 Gene

Previous HGNC Symbols for MS4A3 Gene

  • CD20L

Previous GeneCards Identifiers for MS4A3 Gene

  • GC11P062218
  • GC11P061337
  • GC11P059599
  • GC11P059580
  • GC11P059824
  • GC11P056172

Summaries for MS4A3 Gene

Entrez Gene Summary for MS4A3 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A3 Gene

MS4A3 (Membrane Spanning 4-Domains A3) is a Protein Coding gene. An important paralog of this gene is MS4A2.

UniProtKB/Swiss-Prot for MS4A3 Gene

  • Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).

Gene Wiki entry for MS4A3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A3 Gene

Genomics for MS4A3 Gene

Regulatory Elements for MS4A3 Gene

Enhancers for MS4A3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MS4A3 on UCSC Golden Path with GeneCards custom track

Promoters for MS4A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MS4A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A3 Gene

Chromosome:
11
Start:
60,056,587 bp from pter
End:
60,071,128 bp from pter
Size:
14,542 bases
Orientation:
Plus strand

Genomic View for MS4A3 Gene

Genes around MS4A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A3 Gene

Proteins for MS4A3 Gene

  • Protein details for MS4A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HJ5-MS4A3_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 3
    Protein Accession:
    Q96HJ5
    Secondary Accessions:
    • A8MTP8
    • Q8NHW2

    Protein attributes for MS4A3 Gene

    Size:
    214 amino acids
    Molecular mass:
    22933 Da
    Quaternary structure:
    • Interacts with CDKN3. Interacts with CDKN3-CDK2 complexes through its binding to CDKN3; this interaction facilitates dissociation of cyclin A from CDKN3-CDK2 complexes.

    Alternative splice isoforms for MS4A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MS4A3 Gene

Proteomics data for MS4A3 Gene at MOPED

Post-translational modifications for MS4A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A3 Gene

No data available for DME Specific Peptides for MS4A3 Gene

Domains & Families for MS4A3 Gene

Gene Families for MS4A3 Gene

Protein Domains for MS4A3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MS4A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HJ5

UniProtKB/Swiss-Prot:

MS4A3_HUMAN :
  • The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.
  • Belongs to the MS4A family.
Domain:
  • The C-terminal region is required for binding to CDKN3-CDK2 complexes and the modulation of CDKN3 activity.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A3: view

Function for MS4A3 Gene

Molecular function for MS4A3 Gene

GENATLAS Biochemistry:
membrane-spanning 4-domains,subfamily A,member 3,hematopoietic cell-specific
UniProtKB/Swiss-Prot Function:
Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
genes like me logo Genes that share phenotypes with MS4A3: view

Animal Model Products

miRNA for MS4A3 Gene

miRTarBase miRNAs that target MS4A3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A3 Gene

Localization for MS4A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A3 Gene

Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear area.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A3 Gene COMPARTMENTS Subcellular localization image for MS4A3 gene
Compartment Confidence
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MS4A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MS4A3: view

Pathways & Interactions for MS4A3 Gene

SuperPathways for MS4A3 Gene

No Data Available

Interacting Proteins for MS4A3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000278865%0d%0a9606.ENSP00000266970%0d%0a9606.ENSP00000335357%0d%0a
Selected Interacting proteins: Q96HJ5-MS4A3_HUMAN ENSP00000278865 for MS4A3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for MS4A3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MS4A3 Gene

Drugs & Compounds for MS4A3 Gene

No Compound Related Data Available

Transcripts for MS4A3 Gene

Unigene Clusters for MS4A3 Gene

Membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: -

Relevant External Links for MS4A3 Gene

GeneLoc Exon Structure for
MS4A3
ECgene alternative splicing isoforms for
MS4A3

Expression for MS4A3 Gene

mRNA expression in normal human tissues for MS4A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A3 Gene

This gene is overexpressed in Whole Blood (x45.8).

SOURCE GeneReport for Unigene cluster for MS4A3 Gene Hs.99960

mRNA Expression by UniProt/SwissProt for MS4A3 Gene

Q96HJ5-MS4A3_HUMAN
Tissue specificity: Expressed specifically in hematopoietic cells and tissues.
genes like me logo Genes that share expression patterns with MS4A3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MS4A3 Gene

Orthologs for MS4A3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MS4A3 35
  • 63.48 (n)
  • 47.83 (a)
MS4A3 36
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ms4a3 35
  • 73.94 (n)
  • 64.36 (a)
Ms4a3 16
Ms4a3 36
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MS4A3 35
  • 95.17 (n)
  • 90.34 (a)
MS4A3 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ms4a3 35
  • 72.12 (n)
  • 61.54 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 23 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia MS4A3 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
OneToMany
Species with no ortholog for MS4A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A3 Gene

ENSEMBL:
Gene Tree for MS4A3 (if available)
TreeFam:
Gene Tree for MS4A3 (if available)

Paralogs for MS4A3 Gene

Paralogs for MS4A3 Gene

(1) SIMAP similar genes for MS4A3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MS4A3: view

Variants for MS4A3 Gene

Sequence variations from dbSNP and Humsavar for MS4A3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs526453 -- 60,065,214(-) aaaaa(A/G)aaaaa intron-variant
rs528823 -- 60,069,624(+) GTAAC(C/T)ATCTC reference, synonymous-codon
rs533855 -- 60,062,725(+) TGATT(C/T)GCAAT intron-variant
rs571760 -- 60,057,053(+) CTGAT(A/G)ATGAG intron-variant
rs573612 -- 60,071,492(+) CTTGT(A/T)TCCTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MS4A3 Gene

Variant ID Type Subtype PubMed ID
nsv832173 CNV Gain 17160897
nsv509411 CNV Insertion 20534489
nsv336 CNV Insertion 18451855
nsv468579 CNV Gain 19166990

Variation tolerance for MS4A3 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A3 Gene

HapMap Linkage Disequilibrium report
MS4A3
Human Gene Mutation Database (HGMD)
MS4A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A3 Gene

Disorders for MS4A3 Gene

Relevant External Links for MS4A3

Genetic Association Database (GAD)
MS4A3
Human Genome Epidemiology (HuGE) Navigator
MS4A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MS4A3

No disorders were found for MS4A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A3 Gene

Publications for MS4A3 Gene

  1. Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions. (PMID: 7524084) Adra C.N. … Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23 67
  2. Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. (PMID: 15671017) Chinami M. … Adra C.N. (J. Biol. Chem. 2005) 3 23
  3. Human HTm4 is a hematopoietic cell cycle regulator. (PMID: 11781350) Donato J.-L. … Adra C.N. (J. Clin. Invest. 2002) 3 23
  4. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 3 23
  5. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 3 23

Products for MS4A3 Gene

Sources for MS4A3 Gene

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