Aliases for PRDM6 Gene
External Ids for PRDM6 Gene
GeneCards Summary for PRDM6 Gene
PRDM6 (PR Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and histone-lysine N-methyltransferase activity. An important paralog of this gene is PRDM11.
UniProtKB/Swiss-Prot for PRDM6 Gene
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates Lys-20 of histone H4 in vitro. Lys-20 methylation represents a specific tag for epigenetic transcriptional repression (By similarity).