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Aliases for KLF4 Gene

Aliases for KLF4 Gene

  • Kruppel-Like Factor 4 (Gut) 2 3 5
  • Epithelial Zinc Finger Protein EZF 3 4
  • Gut-Enriched Krueppel-Like Factor 3 4
  • GKLF 3 4
  • EZF 3 4
  • Endothelial Kruppel-Like Zinc Finger Protein 3

External Ids for KLF4 Gene

Previous GeneCards Identifiers for KLF4 Gene

  • GC09M101042
  • GC09M101979
  • GC09M103704
  • GC09M105626
  • GC09M107326
  • GC09M109286
  • GC09M110247
  • GC09M079848

Summaries for KLF4 Gene

Entrez Gene Summary for KLF4 Gene

  • This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

GeneCards Summary for KLF4 Gene

KLF4 (Kruppel-Like Factor 4 (Gut)) is a Protein Coding gene. Diseases associated with KLF4 include esophageal cancer and skin squamous cell carcinoma. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and Wnt / Hedgehog / Notch. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is KLF8.

UniProtKB/Swiss-Prot for KLF4 Gene

  • Transcription factor; can act both as activator and as repressor. Binds the 5-CACCC-3 core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Gene Wiki entry for KLF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF4 Gene

Genomics for KLF4 Gene

Regulatory Elements for KLF4 Gene

Enhancers for KLF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLF4 on UCSC Golden Path with GeneCards custom track

Promoters for KLF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF4 Gene

Chromosome:
9
Start:
107,484,852 bp from pter
End:
107,490,482 bp from pter
Size:
5,631 bases
Orientation:
Minus strand

Genomic View for KLF4 Gene

Genes around KLF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF4 Gene

Proteins for KLF4 Gene

  • Protein details for KLF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43474-KLF4_HUMAN
    Recommended name:
    Krueppel-like factor 4
    Protein Accession:
    O43474
    Secondary Accessions:
    • B2R8S4
    • B3KT79
    • L0R3I6
    • L0R4N5
    • P78338
    • Q5T3J8
    • Q5T3J9
    • Q8N717
    • Q9UNP3

    Protein attributes for KLF4 Gene

    Size:
    513 amino acids
    Molecular mass:
    54671 Da
    Quaternary structure:
    • Interacts with POU5F1/OCT4 and SOX2 (By similarity). Interacts with MUC1 (via the C-terminal domain). Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a.
    SequenceCaution:
    • Sequence=AAB48399.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC03462.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD42165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH29923.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH30811.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABG25917.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG36271.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59020.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW59021.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KLF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF4 Gene

Proteomics data for KLF4 Gene at MOPED

Post-translational modifications for KLF4 Gene

  • Ubiquitination at Lys 32
  • Modification sites at PhosphoSitePlus

Other Protein References for KLF4 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KLF4 (KLF4)

No data available for DME Specific Peptides for KLF4 Gene

Domains & Families for KLF4 Gene

Protein Domains for KLF4 Gene

Suggested Antigen Peptide Sequences for KLF4 Gene

Graphical View of Domain Structure for InterPro Entry

O43474

UniProtKB/Swiss-Prot:

KLF4_HUMAN :
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF4: view

Function for KLF4 Gene

Molecular function for KLF4 Gene

GENATLAS Biochemistry:
Kruppel-like factor 4 (gut),zinc finger protein,mouse EZF and GKLF homolog,nuclear,expressed in select tissues,colon,testis,lung and small intestine,binding DNA fragments,containing the CACCC motif of the beta globin promoter,acting both as a transcriptional activator and repressor
UniProtKB/Swiss-Prot Function:
Transcription factor; can act both as activator and as repressor. Binds the 5-CACCC-3 core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Gene Ontology (GO) - Molecular Function for KLF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IDA 21539536
GO:0005515 protein binding IEA,IPI 19751731
GO:0008134 transcription factor binding IEA --
GO:0042826 histone deacetylase binding IEA --
GO:0044212 transcription regulatory region DNA binding IEA,ISS --
genes like me logo Genes that share ontologies with KLF4: view
genes like me logo Genes that share phenotypes with KLF4: view

Animal Models for KLF4 Gene

MGI Knock Outs for KLF4:

Animal Model Products

Targeted motifs for KLF4 Gene
HOMER Transcription Factor Regulatory Elements motif KLF4
  • Consensus sequence: GCCACACCCA Submotif: canonical Cell Type: mES GEO ID: GSE11431

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF4 Gene

Localization for KLF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF4 Gene COMPARTMENTS Subcellular localization image for KLF4 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 2
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for KLF4 Gene

Pathways & Interactions for KLF4 Gene

genes like me logo Genes that share pathways with KLF4: view

SIGNOR curated interactions for KLF4 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20551324
GO:0007500 mesodermal cell fate determination TAS 8940147
GO:0008285 negative regulation of cell proliferation IEA,TAS 8702718
GO:0010628 positive regulation of gene expression IGI 22267480
GO:0010629 negative regulation of gene expression IGI 22267480
genes like me logo Genes that share ontologies with KLF4: view

Drugs & Compounds for KLF4 Gene

(5) Drugs for KLF4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for KLF4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KLF4: view

Transcripts for KLF4 Gene

Unigene Clusters for KLF4 Gene

Kruppel-like factor 4 (gut):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF4 Gene

No ASD Table

Relevant External Links for KLF4 Gene

GeneLoc Exon Structure for
KLF4
ECgene alternative splicing isoforms for
KLF4

Expression for KLF4 Gene

mRNA expression in normal human tissues for KLF4 Gene

mRNA differential expression in normal tissues according to GTEx for KLF4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.2) and Skin - Sun Exposed (Lower leg) (x6.2).

Protein differential expression in normal tissues from HIPED for KLF4 Gene

This gene is overexpressed in Monocytes (48.3) and Placenta (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLF4 Gene



SOURCE GeneReport for Unigene cluster for KLF4 Gene Hs.376206

genes like me logo Genes that share expression patterns with KLF4: view

Protein tissue co-expression partners for KLF4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for KLF4 Gene

Orthologs for KLF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF4 35
  • 91.54 (n)
  • 95.74 (a)
KLF4 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF4 35
  • 80.43 (n)
  • 81.65 (a)
KLF4 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf4 35
  • 88.52 (n)
  • 92.02 (a)
Klf4 16
Klf4 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF4 35
  • 99.72 (n)
  • 100 (a)
KLF4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf4 35
  • 88.35 (n)
  • 92.42 (a)
oppossum
(Monodelphis domestica)
Mammalia KLF4 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF4 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF4 35
  • 70.35 (n)
  • 67.57 (a)
KLF4 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF4 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf4 35
  • 61.13 (n)
  • 61.04 (a)
zebrafish
(Danio rerio)
Actinopterygii klf4a 35
  • 57.35 (n)
  • 57.96 (a)
klf4a 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9895 37
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 56 (a)
F56F11.3 37
  • 79 (a)
mua-1 37
  • 65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.290 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for KLF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF4 Gene

ENSEMBL:
Gene Tree for KLF4 (if available)
TreeFam:
Gene Tree for KLF4 (if available)

Paralogs for KLF4 Gene

Paralogs for KLF4 Gene

Pseudogenes.org Pseudogenes for KLF4 Gene

genes like me logo Genes that share paralogs with KLF4: view

Variants for KLF4 Gene

Sequence variations from dbSNP and Humsavar for KLF4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1059913 - 107,487,450(-) CAGGA(C/G/T)TACCC reference, missense
rs1059914 - 107,487,433(-) TGGGT(C/T)TTGAG reference, missense
rs1059912 -- 107,487,484(-) CACAC(A/G)ACTTC reference, missense
rs1059915 -- 107,487,407(-) AGGGA(A/C/T)TGTCA reference, synonymous-codon, missense
rs113390016 -- 107,490,353(+) GCGCT(C/T)GGCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLF4 Gene

Variant ID Type Subtype PubMed ID
nsv825028 CNV Gain 20364138

Variation tolerance for KLF4 Gene

Residual Variation Intolerance Score: 43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF4 Gene

HapMap Linkage Disequilibrium report
KLF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF4 Gene

Disorders for KLF4 Gene

MalaCards: The human disease database

(7) MalaCards diseases for KLF4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
esophageal cancer
  • esophageal cancer, somatic
skin squamous cell carcinoma
  • epidermoid skin carcinoma
colorectal cancer
  • colorectal cancer, somatic
venous hemangioma
germ cell and embryonal cancer
  • germ cell and embryonal neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search KLF4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF4

Genetic Association Database (GAD)
KLF4
Human Genome Epidemiology (HuGE) Navigator
KLF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF4
genes like me logo Genes that share disorders with KLF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF4 Gene

Publications for KLF4 Gene

  1. Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. (PMID: 9422764) Yet S.-F. … Lee M.-E. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. KLF4, p21 and context-dependent opposing forces in cancer. (PMID: 16372018) Rowland B.D. … Peeper D.S. (Nat. Rev. Cancer 2006) 2 3 23
  3. Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells. (PMID: 19968965) Villarreal G. … GarcA-a-CardeA+a G. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. (PMID: 20072650) Nakahara Y. … Taylor M.D. (Neoplasia 2010) 3 23
  5. MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal cancer cell lines. (PMID: 20075075) Tian Y. … Liu Z. (J. Biol. Chem. 2010) 3 23

Products for KLF4 Gene

Sources for KLF4 Gene

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