Aliases for KLF4 Gene
External Ids for KLF4 Gene
Previous GeneCards Identifiers for KLF4 Gene
GeneCards Summary for KLF4 Gene
KLF4 (Kruppel-Like Factor 4 (Gut)) is a Protein Coding gene. Diseases associated with KLF4 include secretory meningioma and skin squamous cell carcinoma. Among its related pathways are L1CAM interactions and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is KLF2.
UniProtKB/Swiss-Prot for KLF4 Gene
Transcription factor; can act both as activator and as repressor. Binds the 5-CACCC-3 core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.