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Aliases for CD19 Gene

Aliases for CD19 Gene

  • CD19 Molecule 2 3
  • B-Lymphocyte Surface Antigen B4 3 4
  • T-Cell Surface Antigen Leu-12 3 4
  • Differentiation Antigen CD19 3 4
  • CD19 Antigen 2 4
  • CVID3 3
  • B4 3

External Ids for CD19 Gene

Previous GeneCards Identifiers for CD19 Gene

  • GC16U990011
  • GC16P029266
  • GC16P028941
  • GC16P028980
  • GC16P028850
  • GC16P026811

Summaries for CD19 Gene

Entrez Gene Summary for CD19 Gene

  • Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD19 Gene

CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include cd19-related common variable immune deficiency and immunodeficiency, common variable, 3. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include receptor signaling protein activity.

UniProtKB/Swiss-Prot for CD19 Gene

  • Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation

Gene Wiki entry for CD19 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD19 Gene

Genomics for CD19 Gene

Regulatory Elements for CD19 Gene

Genomic Location for CD19 Gene

Chromosome:
16
Start:
28,931,916 bp from pter
End:
28,939,347 bp from pter
Size:
7,432 bases
Orientation:
Plus strand

Genomic View for CD19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD19 Gene

Proteins for CD19 Gene

  • Protein details for CD19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15391-CD19_HUMAN
    Recommended name:
    B-lymphocyte antigen CD19
    Protein Accession:
    P15391
    Secondary Accessions:
    • A0N0P9
    • F5H635
    • Q96S68
    • Q9BRD6

    Protein attributes for CD19 Gene

    Size:
    556 amino acids
    Molecular mass:
    61128 Da
    Quaternary structure:
    • Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.
    SequenceCaution:
    • Sequence=AAA35533.1; Type=Frameshift; Positions=396; Evidence={ECO:0000305};

    Alternative splice isoforms for CD19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD19 Gene

Proteomics data for CD19 Gene at MOPED

Post-translational modifications for CD19 Gene

  • Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.
  • Glycosylation at Asn 86, Asn 125, Asn 138, Asn 181, and Asn 265
  • Modification sites at PhosphoSitePlus

Other Protein References for CD19 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD19 (CD19)

No data available for DME Specific Peptides for CD19 Gene

Domains & Families for CD19 Gene

Protein Domains for CD19 Gene

Graphical View of Domain Structure for InterPro Entry

P15391

UniProtKB/Swiss-Prot:

CD19_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with CD19: view

Function for CD19 Gene

Molecular function for CD19 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD19,95kDa,B cell surface membrane protein PAX5 (BSAP) dependent,identified by monoclonal antibodies B4,HD37 and others ,linked to the integrin associated CD9,CD81,KAI1
UniProtKB/Swiss-Prot Function:
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation

Gene Ontology (GO) - Molecular Function for CD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 1373518
GO:0005515 protein binding IPI 19214191
genes like me logo Genes that share ontologies with CD19: view
genes like me logo Genes that share phenotypes with CD19: view

Animal Models for CD19 Gene

MGI Knock Outs for CD19:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD19

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD19 Gene

Localization for CD19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD19 Gene COMPARTMENTS Subcellular localization image for CD19 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2472450
GO:0009897 external side of plasma membrane IDA 17213291
GO:0043234 protein complex IDA 23071339
genes like me logo Genes that share ontologies with CD19: view

Pathways & Interactions for CD19 Gene

SuperPathways for CD19 Gene

genes like me logo Genes that share pathways with CD19: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CD19 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CD19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006968 cellular defense response TAS 1373518
GO:0007166 cell surface receptor signaling pathway TAS 1714482
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0031052 chromosome breakage IEA --
genes like me logo Genes that share ontologies with CD19: view

Drugs & Compounds for CD19 Gene

(14) Drugs for CD19 Gene - From: ClinicalTrials, DGIdb, NovoSeek, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Blinatumomab Approved Pharma Target, activator 0
Aldesleukin Approved Pharma 372
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2525
Lenalidomide Approved Pharma Anti-angiogenic. 652
Pentostatin Approved, Investigational Pharma Inhibition, Inhibitor Adenosine deaminase inhibitor 51

(3) Additional Compounds for CD19 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LIPID
Phosphatidylinositol
Ricin
genes like me logo Genes that share compounds with CD19: view

Transcripts for CD19 Gene

Unigene Clusters for CD19 Gene

CD19 molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD19

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD19 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for CD19 Gene

GeneLoc Exon Structure for
CD19
ECgene alternative splicing isoforms for
CD19

Expression for CD19 Gene

mRNA expression in normal human tissues for CD19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD19 Gene

This gene is overexpressed in Spleen (x19.9) and Small Intestine - Terminal Ileum (x10.1).

Protein differential expression in normal tissues from HIPED for CD19 Gene

This gene is overexpressed in Blymphocyte (29.0), Lymph node (26.7), and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD19 Gene



SOURCE GeneReport for Unigene cluster for CD19 Gene Hs.652262

genes like me logo Genes that share expression patterns with CD19: view

Protein tissue co-expression partners for CD19 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CD19 Gene

Orthologs for CD19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD19 35
  • 78.37 (n)
  • 68.76 (a)
CD19 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD19 35
  • 81.45 (n)
  • 72.36 (a)
CD19 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd19 35
  • 76.29 (n)
  • 67.46 (a)
Cd19 16
Cd19 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD19 35
  • 98.7 (n)
  • 98.51 (a)
CD19 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd19 35
  • 75.46 (n)
  • 66.61 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 41 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CD19 36
  • 23 (a)
OneToOne
Species with no ortholog for CD19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD19 Gene

ENSEMBL:
Gene Tree for CD19 (if available)
TreeFam:
Gene Tree for CD19 (if available)

Paralogs for CD19 Gene

No data available for Paralogs for CD19 Gene

Variants for CD19 Gene

Sequence variations from dbSNP and Humsavar for CD19 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2032907 -- 28,937,975(-) CAGGA(G/T)GGGGG intron-variant
rs2070961 -- 28,938,152(+) GACTC(C/T)GACTC intron-variant
rs2070962 -- 28,939,111(+) CTGGA(C/T)CCCTC intron-variant
rs2904880 - 28,933,075(+) CGTGT(C/G)TCCCA reference, missense, nc-transcript-variant
rs2904881 -- 28,937,448(+) CTTCT(A/C)CACCA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CD19 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
nsv905700 CNV Loss 21882294
nsv905701 CNV Loss 21882294
nsv905702 CNV Gain+Loss 21882294
nsv518648 CNV Loss 19592680
nsv519100 CNV Gain 19592680

Variation tolerance for CD19 Gene

Residual Variation Intolerance Score: 18.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD19 Gene

HapMap Linkage Disequilibrium report
CD19
Human Gene Mutation Database (HGMD)
CD19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD19 Gene

Disorders for CD19 Gene

MalaCards: The human disease database

(42) MalaCards diseases for CD19 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
cd19-related common variable immune deficiency
  • immunodeficiency, common variable, 3
immunodeficiency, common variable, 3
  • cvid3
invasive malignant thymoma
  • infiltrating thymoma
transient hypogammaglobulinemia of infancy
b cell prolymphocytic leukemia
  • leukemia, b cell prolymphocytic
- elite association
Search CD19 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD19_HUMAN
  • Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:16672701}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CD19

Genetic Association Database (GAD)
CD19
Human Genome Epidemiology (HuGE) Navigator
CD19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD19
genes like me logo Genes that share disorders with CD19: view

No data available for Genatlas for CD19 Gene

Publications for CD19 Gene

  1. Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles. (PMID: 20042272) Nguyen C.T. … Walker G.C. (Cancer Lett. 2010) 23 67
  2. Manufacturing validation of biologically functional T cells targeted to CD19 antigen for autologous adoptive cell therapy. (PMID: 19238016) Hollyman D. … RiviA"re I. (J. Immunother. 2009) 23 67
  3. [Relationship between immunological characteristics and prognosis in children with acute myeloid leukemia]. (PMID: 19374802) Gu L.J. … Ye H. (Zhongguo Dang Dai Er Ke Za Zhi 2009) 23 67
  4. The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes. (PMID: 18641017) Tabera S. … San Miguel J.F. (Haematologica 2008) 23 67
  5. [Preparation of the immunotoxin 2E8-norcantharidin and its targeting killing effect in vitro]. (PMID: 19099803) Li L.X. … Luo C.F. (Zhonghua Er Ke Za Zhi 2008) 23 67

Products for CD19 Gene

Sources for CD19 Gene

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