Aliases for CD19 Gene
Aliases for CD19 Gene
External Ids for CD19 Gene
- HGNC: 1633
- Entrez Gene: 930
- Ensembl: ENSG00000177455
- OMIM: 107265
- UniProtKB: P15391
Previous GeneCards Identifiers for CD19 Gene
- GC16U990011
- GC16P029266
- GC16P028941
- GC16P028980
- GC16P028850
- GC16P026811
Summaries for CD19 Gene
-
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
GeneCards Summary for CD19 Gene
CD19 (CD19 Molecule) is a Protein Coding gene. Diseases associated with CD19 include Immunodeficiency, Common Variable, 3 and Common Variable Immunodeficiency. Among its related pathways are RET signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include signal transducer activity, downstream of receptor.
UniProtKB/Swiss-Prot for CD19 Gene
-
Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Additional gene information for CD19 Gene
- Monarch Initiative
- Search for CD19 at DataMed
- Search for CD19 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD19 Gene
Genomics for CD19 Gene
GeneHancer (GH) Regulatory Elements for CD19 Gene
Regulatory Element Products
Genomic Locations for CD19 Gene
- chr16:28,931,916-28,939,347
- (GRCh38/hg38)
- Size:
- 7,432 bases
- Orientation:
- Plus strand
- chr16:28,943,260-28,950,668
- (GRCh37/hg19)
Genomic View for CD19 Gene
- Cytogenetic band:
-
- 16p11.2 by Ensembl
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC


RefSeq DNA sequence for CD19 Gene
Proteins for CD19 Gene
-
Protein details for CD19 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15391-CD19_HUMAN
- Recommended name:
- B-lymphocyte antigen CD19
- Protein Accession:
- P15391
- A0N0P9
- F5H635
- Q96S68
- Q9BRD6
Protein attributes for CD19 Gene
- Size:
- 556 amino acids
- Molecular mass:
- 61128 Da
- Quaternary structure:
-
- Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.
- SequenceCaution:
-
- Sequence=AAA35533.1; Type=Frameshift; Positions=396; Evidence={ECO:0000305};
Protein Expression for CD19 Gene
Post-translational modifications for CD19 Gene
- Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN.
- Glycosylation at Asn86, Asn125, Asn138, Asn181, and Asn265
Other Protein References for CD19 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CD19 (CD19)
- Cell Signaling Technology (CST) Antibodies for CD19 (CD19)
-
Custom Antibody ServicesOriGene Antibodies for CD19
- AM01058FC-N
- AM01058PU-N
- TA506236HM
- TA506236DM
- UM570071
- UM500071
- TA700295
- TA700286
- TA700285
- TA700284
- TA700283
- TA600286
- TA600285
- TA600284
- TA600283
- CF506285
- TA506285
- CF506280
- TA506280
- CF506279
- TA506279
- CF506273
- TA506273
- CF506241
- TA506241
- CF506240
- TA506240
- CF506239
- TA506239
- CF506236
- TA506236
- CF506234
- TA506234
- CF500363
- TA500363
- TA353666
- TA353665
- TA353029
- TA353028
- TA353027
- TA332563
- TA326211
- TA325321
- TA325320
- TA320241
- TA302072
- TA302071
- SM2119P
- SM2119F
- SM2119C
- SM1529RT
- SM1529R
- SM1529PS
- SM1529PP
- SM1529P
- SM1529LE
- SM1529FT
- SM1529F
- SM1529BT
- SM1529B
- SM1529APCT
- SM1529APC
- BM2368
- AP55866PU-S
- AP55866PU-N
- AP32823PU-N
- AP22796PU-N
- AP20344PU-N
- AM39014RP-N
- AM39014PU-N
- AM39014PP-N
- AM39014FC-N
- AM39014AC-N
- AM32397PU-N
- AM32270SU-N
- AM32071PU-N
- AM31229RP-N
- AM31228PU-N
- AM31228FC-N
- AM31228BT-N
- AM31228AF-N
- AM26049PU-N
- AM26006RP-N
- AM26006RD5-N
- AM26006PU-N
- AM26006PP-N
- AM26006FC-N
- AM26006BT-N
- AM26006AC-N
- AM06431SU-N
- AM06097PU-N
- AM05180RP-N
- AM05180PU-N
- AM05180PC-N
- AM05180FC-N
- AM01058PU-T
- Novus Biologicals Antibodies for CD19
-
Abcam antibodies for CD19
-
Cloud-Clone Corp. Antibodies for CD19
- Invitrogen Antibodies for CD19
- antibodies-online: Search results for 1372 available CD19 Antibodies ranked by validation data
- Compare Top CD19 Antibodies
-
Recommended
- 1 IF Antibody (anti-rat)
- 22 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 1 in vitro Antibody (anti-mouse)
- 2 in vivo Antibodies (anti-mouse)
- 2 ELISPOT (Detection) Antibodies (anti-mouse)
- 3 BCA Antibodies (anti-mouse)
- 5 IF Antibodies (anti-mouse)
- 13 ICFC Antibodies (anti-mouse)
- 14 IHC Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 51 WB Antibodies (anti-mouse)
- 80 IP Antibodies (anti-mouse)
- 170 FACS Antibodies (anti-mouse)
- 1 MA Antibody (anti-human)
- 1 in vitro Antibody (anti-human)
- 1 CC Antibody (anti-human)
- 4 ICFC Antibodies (anti-human)
- 5 Neut Antibodies (anti-human)
- 9 LMNX Antibodies (anti-human)
- 13 ICC Antibodies (anti-human)
- 14 IF/ICC Antibodies (anti-human)
- 24 IHC (fro) Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 43 IHC (p) Antibodies (anti-human)
- 60 IP Antibodies (anti-human)
- 78 IF Antibodies (anti-human)
- 96 IHC Antibodies (anti-human)
- 250 WB Antibodies (anti-human)
- 381 FACS Antibodies (anti-human)
- GeneTex CD19 antibody for CD19
-
Santa Cruz Biotechnology (SCBT) Antibodies for CD19
- Sino Biological Antibodies for CD19
Protein Products
- R&D Systems Proteins and Enzymes for CD19
-
OriGene Purified Proteins for CD19
- Search Origene for MassSpec and Protein Over-expression Lysates for CD19
- Origene Custom Protein Services for CD19
- Sino Biological Recombinant Proteins for CD19
- Sino Biological Cell Lysates for CD19
-
Cloud-Clone Corp. Proteins for CD19
- Search GeneTex for Proteins for CD19
-
ProSci Proteins for CD19
-
Abcam proteins for CD19
No data available for DME Specific Peptides for CD19 Gene
Domains & Families for CD19 Gene
Gene Families for CD19 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- FDA approved drug targets
- Predicted membrane proteins
Protein Domains for CD19 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CD19 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60916, highly similar to B-lymphocyte antigen CD19 (B4DW45_HUMAN)
- cDNA FLJ54955, highly similar to B-lymphocyte antigen CD19 (B4E2W1_HUMAN)
- T-cell surface antigen Leu-12 (CD19_HUMAN)
- cDNA FLJ27147 fis, clone SPL09574, highly similar to B-lymphocyte antigen CD19 (Q6ZNU2_HUMAN)
- CD19 (Q71UW0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CD19 Gene
Function for CD19 Gene
Molecular function for CD19 Gene
- GENATLAS Biochemistry:
- cell differentiation antigen CD19,95kDa,B cell surface membrane protein PAX5 (BSAP) dependent,identified by monoclonal antibodies B4,HD37 and others ,linked to the integrin associated CD9,CD81,KAI1
- UniProtKB/Swiss-Prot Function:
- Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Phenotypes From GWAS Catalog for CD19 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005057 | signal transducer activity, downstream of receptor | TAS | 1373518 |
GO:0005515 | protein binding | IPI | 19214191 |
GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | TAS | -- |
Phenotypes for CD19 Gene
- MGI mutant phenotypes for CD19:
-
inferred from 5 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- integument phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for CD19:
Animal Models for CD19 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD19
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CD19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD19 gene
- Search ViGene Biosciences for CD19
CRISPR Products
-
OriGene CRISPR knockouts for CD19
- genomics-online: gRNA clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
- Applied Biological Materials CRISPR for CD19
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD19
- GenScript: Design CRISPR guide RNA sequences for CD19
miRNA for CD19 Gene
- miRTarBase miRNAs that target CD19
miRNA Products
- Search ViGene Biosciences for CD19
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CD19
- Browse OriGene Inhibitory RNA Products For CD19
- genomics-online: shRNA clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CD19 gene
Clone Products
- Sino Biological Human cDNA Clone for CD19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD19
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CD19
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD19
Cell Line Products
-
Horizon Cell Lines for CD19
-
ViGene Biosciences adenoviral particle packaged cDNA for CD19 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CD19 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CD19 gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD19 Gene
Localization for CD19 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CD19 Gene
- Membrane; Single-pass type I membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 2472450 |
GO:0009897 | external side of plasma membrane | IEA,IDA | 17213291 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CD19 Gene
Pathways & Interactions for CD19 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | PI3K/AKT activation |
.89
|
|
3 | B cell receptor signaling pathway (KEGG) | ||
4 | HIV Life Cycle |
.45
|
|
5 | Downstream signaling events of B Cell Receptor (BCR) |
Pathways by source for CD19 Gene
1 Sino Biological pathway for CD19 Gene
1 Cell Signaling Technology pathway for CD19 Gene
2 BioSystems pathways for CD19 Gene
5 KEGG pathways for CD19 Gene
2 GeneGo (Thomson Reuters) pathways for CD19 Gene
3 R&D Systems pathways for CD19 Gene
3 Qiagen pathways for CD19 Gene
Interacting Proteins for CD19 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006968 | cellular defense response | TAS | 1373518 |
GO:0007166 | cell surface receptor signaling pathway | TAS | 1714482 |
GO:0030449 | regulation of complement activation | TAS | -- |
GO:0046854 | phosphatidylinositol phosphorylation | IEA | -- |
GO:0050776 | regulation of immune response | TAS | -- |
Drugs & Compounds for CD19 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1231,1231 | ||
Blinatumomab | Approved, Investigational | Pharma | Target, activator | 42 | ||
Tisagenlecleucel | Approved, Investigational | Pharma | Target, antibody | 0 | ||
Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3113 | ||
Idelalisib | Approved | Pharma | 51 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for CD19 Gene
mRNA/cDNA for CD19 Gene
- (5) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (58) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CD19
- genomics-online: gRNA clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
- Applied Biological Materials CRISPR for CD19
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CD19
- GenScript: Design CRISPR guide RNA sequences for CD19
miRNA Products
- Search ViGene Biosciences for CD19
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CD19
- Browse OriGene Inhibitory RNA Products For CD19
- genomics-online: shRNA clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CD19 gene
Clone Products
- Sino Biological Human cDNA Clone for CD19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CD19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD19
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CD19
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CD19
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP6: |
Expression for CD19 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Pro B-Cells Hematopoietic Bone Marrow
- Large Pre B-Cells Hematopoietic Bone Marrow
- Immature B-Cells Peripheral Blood
- Mature B-Cells Peripheral Blood
- Brain (Nervous System)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Adipose (Muscoskeletal System)
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CD19 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CD19 Gene
NURSA nuclear receptor signaling pathways regulating expression of CD19 Gene:
CD19SOURCE GeneReport for Unigene cluster for CD19 Gene:
Hs.652262Evidence on tissue expression from TISSUES for CD19 Gene
- Blood(4.8)
- Spleen(4.8)
- Bone marrow(3.5)
- Lymph node(3.5)
- Intestine(2.7)
- Lung(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for CD19 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- brain
- ear
- eye
- head
- hypothalamus
- meninges
- middle ear
- neck
- pituitary gland
- sinus
- skull
- thyroid
- bronchus
- heart
- lung
- adrenal gland
- intestine
- large intestine
- liver
- small intestine
- spleen
- stomach
- anus
- rectum
- uterus
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
- blood
- blood vessel
- bone marrow
- coagulation system
- lymph node
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for CD19
-
OriGene qPCR primer pairs and template standards for CD19
- genomics-online: primer clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
No data available for mRNA Expression by UniProt/SwissProt for CD19 Gene
Orthologs for CD19 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | CD19 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | CD19 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | CD19 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Cd19 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Cd19 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | CD19 34 |
|
OneToOne |
- Species where no ortholog for CD19 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for CD19 Gene
No data available for Paralogs for CD19 Gene
Variants for CD19 Gene
SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1037602719 | uncertain-significance, Common Variable Immune Deficiency, Recessive | 28,932,017(+) | T/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
rs10633752 | uncertain-significance, Common Variable Immune Deficiency, Recessive | 28,939,254(+) | GTGTGTGTGTGTGTGTGTGTGTGT/GTGTGTGTGTGTGTGTGTGT/GTGTGTGTGTGTGTGTGTGTGT/GTGTGTGTGTGTGTGTGTGTGTGTGT/GTGTGTGTGTGTGTGTGTGTGTGTGTGT/GTGTGTGTGTGTGTGTGTGTGTGTGTGTGT/GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT/GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs117769220 | likely-benign, Common Variable Immune Deficiency, Recessive | 28,932,961(+) | C/T | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
rs142342927 | likely-benign, Common Variable Immune Deficiency, Recessive | 28,932,936(+) | G/A | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
rs142818579 | uncertain-significance, Common Variable Immune Deficiency, Recessive | 28,937,346(+) | C/T | coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2830n100 | CNV | gain | 25217958 |
dgv2831n100 | CNV | gain | 25217958 |
dgv4987n54 | CNV | gain | 21841781 |
esv2758640 | CNV | gain+loss | 17122850 |
esv3570454 | CNV | gain | 25503493 |
esv3892826 | CNV | gain+loss | 25118596 |
nsv1059555 | CNV | gain | 25217958 |
nsv518648 | CNV | loss | 19592680 |
nsv519100 | CNV | gain | 19592680 |
nsv571805 | CNV | loss | 21841781 |
Additional Variant Information for CD19 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD19 Gene
Disorders for CD19 Gene

(44) MalaCards diseases for CD19 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
immunodeficiency, common variable, 3 |
|
|
common variable immunodeficiency |
|
|
immunodeficiency, common variable, 2 |
|
|
transient hypogammaglobulinemia of infancy |
|
|
transient hypogammaglobulinemia |
|
|
UniProtKB/Swiss-Prot
CD19_HUMAN- Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:16672701}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for CD19
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for CD19 Gene
Publications for CD19 Gene
- Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese. (PMID: 12215898) Kuroki K … Tokunaga K (Genes and immunity 2002) 3 4 44 58
- Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes. (PMID: 1370948) Zhou LJ … Tedder TF (Immunogenetics 1992) 3 4 22 58
- Individual and epistatic effects of genetic polymorphisms of B-cell co-stimulatory molecules on susceptibility to pemphigus foliaceus. (PMID: 19421221) Malheiros D … Petzl-Erler ML (Genes and immunity 2009) 3 44 58
- Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H … Horiuchi T (Rheumatology (Oxford, England) 2008) 3 44 58
- Association of CD22 gene polymorphism with susceptibility to limited cutaneous systemic sclerosis. (PMID: 17493148) Hitomi Y … Sato S (Tissue antigens 2007) 3 44 58
Products for CD19 Gene
- R&D Systems Antibodies for CD19 (CD19)
- R&D Systems Proteins and Enzymes for CD19
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for CD19
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- Custom Antibody ServicesOriGene Antibodies for CD19
- AM01058FC-N
- AM01058PU-N
- AM01058PU-T
- AM05180FC-N
- AM05180PC-N
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- AM26006RP-N
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- AM31228AF-N
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- AM31228FC-N
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- AM31229RP-N
- AM32071PU-N
- AM32270SU-N
- AM32397PU-N
- AM39014AC-N
- AM39014FC-N
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- AP20344PU-N
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- AP55866PU-N
- AP55866PU-S
- BM2368
- SM1529APC
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- SM1529B
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- SM1529F
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- SM1529LE
- SM1529P
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- SM1529R
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- SM2119C
- SM2119F
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- TA302071
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- TA500363
- CF500363
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- CF506234
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- CF506236
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- CF506239
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- CF506240
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- TA506273
- CF506273
- TA506279
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- TA506280
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- TA506285
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- TA600283
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- TA700283
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- TA700286
- TA700295
- UM500071
- UM570071
- TA506236DM
- TA506236HM
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CD19
- Search Origene for MassSpec and Protein Over-expression Lysates for CD19
- Origene Custom Protein Services for CD19
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CD19
- Browse OriGene Inhibitory RNA Products For CD19
- OriGene qPCR primer pairs and template standards for CD19
- OriGene qPCR primer pairs for CD19
- OriGene CRISPR knockouts for CD19
- OriGene ORF clones in human for CD19
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CD19
- GenScript: Next-day shipping of latest version cDNA ORF clones for CD19 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CD19
- GenScript Custom Assay Services for CD19
- GenScript Custom overexpressing Cell Line Services for CD19
- GenScript: Design CRISPR guide RNA sequences for CD19
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- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CD19
- Cell Signaling Technology (CST) Antibodies for CD19 (CD19)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for CD19
- Sino Biological Recombinant Proteins for CD19
- Sino Biological Cell Lysates for CD19
- Sino Biological Antibodies for CD19
- Sino Biological Assays for CD19
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CD19
- Novus Biologicals lysates and proteins for CD19
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CD19
- Abcam proteins for CD19
- Find your target
- Browse Primary Antibodies
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- Cloud-Clone Corp. Antibodies for CD19
- Cloud-Clone Corp. Proteins for CD19
- Cloud-Clone Corp. Assay Kits for CD19
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CD19
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CD19
- VectorBuilder custom plasmid, inducible vectors for CD19
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CD19
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 1372 available CD19 Antibodies ranked by validation data
- Compare Top CD19 Antibodies
- Recommended
- 381 FACS Antibodies (anti-human)
- 250 WB Antibodies (anti-human)
- 96 IHC Antibodies (anti-human)
- 78 IF Antibodies (anti-human)
- 60 IP Antibodies (anti-human)
- 43 IHC (p) Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 24 IHC (fro) Antibodies (anti-human)
- 14 IF/ICC Antibodies (anti-human)
- 13 ICC Antibodies (anti-human)
- 9 LMNX Antibodies (anti-human)
- 5 Neut Antibodies (anti-human)
- 4 ICFC Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 in vitro Antibody (anti-human)
- 1 MA Antibody (anti-human)
- 170 FACS Antibodies (anti-mouse)
- 80 IP Antibodies (anti-mouse)
- 51 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 14 IHC Antibodies (anti-mouse)
- 13 ICFC Antibodies (anti-mouse)
- 5 IF Antibodies (anti-mouse)
- 3 BCA Antibodies (anti-mouse)
- 2 ELISPOT (Detection) Antibodies (anti-mouse)
- 2 in vivo Antibodies (anti-mouse)
- 1 in vitro Antibody (anti-mouse)
- 24 IF (p) Antibodies (anti-rat)
- 22 WB Antibodies (anti-rat)
- 1 IF Antibody (anti-rat)
- antibodies-online: Search results for 41 available CD19 Elisa Kits ranked by validation data
- Compare Top CD19 Elisa Kits
- antibodies-online: Search results for 32 available CD19 Proteins ranked by validation data
- Compare Top CD19 Proteins
- GeneTex CD19 antibody for CD19
- Search GeneTex for Proteins for CD19
- ViGene Biosciences adenoviral particle packaged cDNA for CD19 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CD19 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CD19 gene
- Search ViGene Biosciences for CD19
- Santa Cruz Biotechnology (SCBT) Antibodies for CD19
- Search Santa Cruz Biotechnology (SCBT) for CD19 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CD19
- Horizon Cell Lines for CD19
- genomics-online: cdna clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
- orf clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
- genomics-online: gRNA clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
- genomics-online: primer clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
- genomics-online: shRNA clones - Search results for 120 available CD19 gene related products
- Overview of 120 available CD19 gene related products
Sources for CD19 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard