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Aliases for GPR55 Gene

Aliases for GPR55 Gene

  • G Protein-Coupled Receptor 55 2 3
  • G-Protein Coupled Receptor 55 3
  • LPIR1 3

External Ids for GPR55 Gene

Previous GeneCards Identifiers for GPR55 Gene

  • GC02M229835
  • GC02M230503
  • GC02M231736
  • GC02M231974
  • GC02M231597
  • GC02M231480
  • GC02M223614

Summaries for GPR55 Gene

Entrez Gene Summary for GPR55 Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPR55 Gene

GPR55 (G Protein-Coupled Receptor 55) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is GPR35.

UniProtKB/Swiss-Prot for GPR55 Gene

  • May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

Tocris Summary for GPR55 Gene

  • GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Originally designated an orphan receptor, GPR55 is now thought to be a functional receptor mediating the effects of ligands known to be inactive at CB1 and CB2, e.g. palmitoylethanolamide. GPR55 couples to Galpha13 and can mediate activation of the small G proteins rhoA, cdc42 and rac1. GPR55 mRNA is expressed in the brain, most abundantly in the caudate nucleus and putamen, with lesser levels in the hippocampus, thalamus, pons, cerebellum and frontal cortex. Peripherally, GPR55 mRNA is present in the spleen, adrenals and parts of the gastrointestinal tract. Putative physiological roles of GPR55 include pain signaling, control of vascular tone and inflammation. The human GPR55 receptor gene is localized to chromosome 2q36.3.

Gene Wiki entry for GPR55 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR55 Gene

Genomics for GPR55 Gene

Regulatory Elements for GPR55 Gene

Genomic Location for GPR55 Gene

230,907,318 bp from pter
230,961,066 bp from pter
53,749 bases
Minus strand

Genomic View for GPR55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR55 Gene

Proteins for GPR55 Gene

  • Protein details for GPR55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G-protein coupled receptor 55
    Protein Accession:
    Secondary Accessions:
    • Q8N580

    Protein attributes for GPR55 Gene

    319 amino acids
    Molecular mass:
    36637 Da
    Quaternary structure:
    No Data Available
    • The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results
    • Sequence=AAD22410.1; Type=Frameshift; Positions=132, 142; Evidence={ECO:0000305};

neXtProt entry for GPR55 Gene

Proteomics data for GPR55 Gene at MOPED

Post-translational modifications for GPR55 Gene

  • Glycosylation at Asn5 and Asn171
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR55 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR55 Gene

Domains for GPR55 Gene

Gene Families for GPR55 Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for GPR55 Gene

Suggested Antigen Peptide Sequences for GPR55 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2T6
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR55: view

Function for GPR55 Gene

Molecular function for GPR55 Gene

GENATLAS Biochemistry: G protein coupled receptor 55,highly expressed in the caudate nucleus and putamen with homology to P2RY5,GPR23,GPR35,CCR4
UniProtKB/Swiss-Prot Function: May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

Gene Ontology (GO) - Molecular Function for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9931487
GO:0004949 cannabinoid receptor activity IDA 19723626
genes like me logo Genes that share ontologies with GPR55: view
genes like me logo Genes that share phenotypes with GPR55: view

Animal Models for GPR55 Gene

MGI Knock Outs for GPR55:

miRNA for GPR55 Gene

miRTarBase miRNAs that target GPR55

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GPR55 Gene

Localization for GPR55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR55 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for GPR55 Gene COMPARTMENTS Subcellular localization image for GPR55 gene
Compartment Confidence
plasma membrane 5
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 18757503
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GPR55: view

Pathways for GPR55 Gene

genes like me logo Genes that share pathways with GPR55: view

Pathways by source for GPR55 Gene

Interacting Proteins for GPR55 Gene

Gene Ontology (GO) - Biological Process for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 9931487
GO:0007202 activation of phospholipase C activity IDA 18757503
GO:0035025 positive regulation of Rho protein signal transduction IDA 18757503
GO:0038171 cannabinoid signaling pathway IDA 19723626
GO:0045453 bone resorption IDA 19805329
genes like me logo Genes that share ontologies with GPR55: view

Compounds for GPR55 Gene

(4) Tocris Compounds for GPR55 Gene

Compound Action Cas Number
Abn-CBD Selective GPR55 agonist; neurobehaviorally inactive [22972-55-0]
CID 16020046 Selective GPR55 antagonist [834903-43-4]
O-1602 Potent GPR55 receptor agonist [317321-41-8]
Oleylethanolamide GPR55 agonist; also PPARalpha agonist [111-58-0]

(28) IUPHAR Ligand for GPR55 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]CP55940 Agonist Full agonist 9.7
CP55940 Agonist Full agonist 9.2
AM281 Antagonist Antagonist 8.52
JWH015 Agonist Agonist 8.4
palmitoylethanolamide Agonist Agonist 8.4
CP55,244 Agonist Inverse agonist 8.3
rimonabant Antagonist Antagonist 8.2
GSK494581A Agonist Agonist 8.19
GSK575594A Agonist Agonist 8.17
2-arachidonyl glyceryl ether Agonist Agonist 8
O-arachidonoyl ethanolamine Agonist Agonist 7.92
lysophosphatidylinositol Agonist Agonist 7.31
O-1602 Agonist Agonist 7.19
HU-210 Antagonist Antagonist 7
CID1792197 Agonist Agonist 6.96
2-arachidonoylglycerol Agonist Partial agonist 6.8
CID1172084 Agonist Agonist 6.8
CP55,667 Antagonist Inverse agonist 6.8
CID2440433 Agonist Agonist 6.6
oleoylethanolamide Agonist Agonist 6.5
abnormal cannabidiol Agonist Agonist 6.08
AM251 Agonist Partial agonist 4.02
Delta9-tetrahydrocannabinol Channel blocker None
anandamide Channel blocker None
cannabidiol Channel blocker None
2-arachidonoylglycerolphosphoinositol Agonist Full agonist
T1117 Agonist Agonist
[3H]rimonabant Agonist Partial agonist
genes like me logo Genes that share compounds with GPR55: view

Transcripts for GPR55 Gene

Unigene Clusters for GPR55 Gene

G protein-coupled receptor 55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR55 Gene

No ASD Table

Relevant External Links for GPR55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR55 Gene

mRNA expression in normal human tissues for GPR55 Gene

mRNA differential expression in normal tissues according to GTEx for GPR55 Gene

This gene is overexpressed in Testis (5.5) and Spleen (4.2).

SOURCE GeneReport for Unigene cluster for GPR55 Gene Hs.114545

mRNA Expression by UniProt/SwissProt for GPR55 Gene

Tissue specificity: Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts.
genes like me logo Genes that share expressions with GPR55: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for GPR55 Gene

Orthologs for GPR55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR55 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR55 35
  • 98.64 (n)
  • 99.37 (a)
GPR55 36
  • 99 (a)
(Bos Taurus)
Mammalia GPR55 35
  • 83.07 (n)
  • 79.94 (a)
GPR55 36
  • 79 (a)
(Canis familiaris)
Mammalia GPR55 35
  • 85.16 (n)
  • 84.95 (a)
GPR55 36
  • 83 (a)
(Mus musculus)
Mammalia Gpr55 35
  • 81.22 (n)
  • 77.53 (a)
Gpr55 16
Gpr55 36
  • 74 (a)
(Monodelphis domestica)
Mammalia GPR55 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia GPR55 36
  • 51 (a)
(Rattus norvegicus)
Mammalia Gpr55 35
  • 79.96 (n)
  • 75 (a)
(Gallus gallus)
Aves GPR55 35
  • 59.72 (n)
  • 47.7 (a)
GPR55 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490418 35
  • 54.22 (n)
  • 47 (a)
(Danio rerio)
Actinopterygii gpr55a 36
  • 28 (a)
LOC793909 35
  • 54.33 (n)
  • 44.13 (a)
Species with no ortholog for GPR55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR55 Gene

Gene Tree for GPR55 (if available)
Gene Tree for GPR55 (if available)

Paralogs for GPR55 Gene

Paralogs for GPR55 Gene

Selected SIMAP similar genes for GPR55 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPR55: view

Variants for GPR55 Gene

Sequence variations from dbSNP and Humsavar for GPR55 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1079869 -- 230,921,924(-) TATGG(G/T)GGAAC intron-variant
rs1344926 -- 230,920,490(+) ttttt(A/T)aaaaa intron-variant
rs1344927 -- 230,920,598(+) CAAAA(C/T)GCCAG intron-variant
rs1347746 -- 230,917,490(+) TGACC(A/T)CATAC intron-variant
rs1561326 -- 230,924,166(+) TTGTC(A/C/G)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR55 Gene

Variant ID Type Subtype PubMed ID
nsv834565 CNV Gain 17160897
nsv470522 CNV Loss 18288195
nsv875956 CNV Gain 21882294

Relevant External Links for GPR55 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR55 Gene

Disorders for GPR55 Gene

Relevant External Links for GPR55

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GPR55: view

No data available for UniProtKB/Swiss-Prot for GPR55 Gene

Publications for GPR55 Gene

  1. The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA- dependent Ca2+ signaling and NFAT activation. (PMID: 18757503) Henstridge C.M. … Irving A.J. (FASEB J. 2009) 3 4 23
  2. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. (PMID: 9931487) Sawzdargo M. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. (PMID: 19723626) Kapur A. … Abood M.E. (J. Biol. Chem. 2009) 3 4
  5. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. (PMID: 19805329) Whyte L.S. … Rogers M.J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4

Products for GPR55 Gene

Sources for GPR55 Gene

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