External Ids for GPR55 Gene
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
GeneCards Summary for GPR55 Gene
GPR55 (G Protein-Coupled Receptor 55) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is GPR35.
UniProtKB/Swiss-Prot for GPR55 Gene
May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.
GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Originally designated an orphan receptor, GPR55 is now thought to be a functional receptor mediating the effects of ligands known to be inactive at CB1 and CB2, e.g. palmitoylethanolamide. GPR55 couples to Galpha13 and can mediate activation of the small G proteins rhoA, cdc42 and rac1. GPR55 mRNA is expressed in the brain, most abundantly in the caudate nucleus and putamen, with lesser levels in the hippocampus, thalamus, pons, cerebellum and frontal cortex. Peripherally, GPR55 mRNA is present in the spleen, adrenals and parts of the gastrointestinal tract. Putative physiological roles of GPR55 include pain signaling, control of vascular tone and inflammation. The human GPR55 receptor gene is localized to chromosome 2q36.3.