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Aliases for GPR55 Gene

Aliases for GPR55 Gene

  • G Protein-Coupled Receptor 55 2 3 5
  • G-Protein Coupled Receptor 55 3
  • LPIR1 3

External Ids for GPR55 Gene

Previous GeneCards Identifiers for GPR55 Gene

  • GC02M229835
  • GC02M230503
  • GC02M231736
  • GC02M231974
  • GC02M231597
  • GC02M231480
  • GC02M223614

Summaries for GPR55 Gene

Entrez Gene Summary for GPR55 Gene

  • This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]

GeneCards Summary for GPR55 Gene

GPR55 (G Protein-Coupled Receptor 55) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is GPR35.

UniProtKB/Swiss-Prot for GPR55 Gene

  • May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

Tocris Summary for GPR55 Gene

  • GPR55 is a non-CB1/CB2 receptor that exhibits affinity for endogenous, plant and synthetic cannabinoids. Originally designated an orphan receptor, GPR55 is now thought to be a functional receptor mediating the effects of ligands known to be inactive at CB1 and CB2.

Gene Wiki entry for GPR55 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR55 Gene

Genomics for GPR55 Gene

Regulatory Elements for GPR55 Gene

Enhancers for GPR55 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G230943 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.1 +17.1 17114 1.4 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A BMI1 SCRT2 ZNF143 ZNF207 GPR55 GC02M230912 COX20P2
GH02G230956 1.5 FANTOM5 ENCODE dbSUPER 8.4 +4.0 3967 1.6 PKNOX1 WRNIP1 SP3 JUNB TSHZ1 TBX21 CBX8 GLIS1 NBN KDM1A GPR55 COX20P2 GC02M230912
GH02G230908 1.2 ENCODE dbSUPER 9.5 +52.5 52525 1.1 PKNOX1 FOS NCOA1 REST ZNF592 SMARCA4 MYNN NBN KDM1A WT1 GPR55 ENSG00000230385 LOC151484
GH02G230947 1 FANTOM5 dbSUPER 8.8 +13.1 13054 0.4 HDGF TBP PKNOX1 RELA EGR1 POLR2A EED ETV6 RELB IKZF2 GPR55 COX20P2 GC02M230912
GH02G230656 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.4 +300.4 300382 8.4 HDGF PKNOX1 ARNT YBX1 ZNF766 ZNF143 ZNF207 ZNF263 JUNB REST CAB39 LOC101928816 RNU6-451P ZBTB8OSP2 LINC00471 SP110 SP140 GPR55 ARMC9 SP140L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GPR55 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR55 Gene

Chromosome:
2
Start:
230,907,318 bp from pter
End:
230,961,227 bp from pter
Size:
53,910 bases
Orientation:
Minus strand

Genomic View for GPR55 Gene

Genes around GPR55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR55 Gene

Proteins for GPR55 Gene

  • Protein details for GPR55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2T6-GPR55_HUMAN
    Recommended name:
    G-protein coupled receptor 55
    Protein Accession:
    Q9Y2T6
    Secondary Accessions:
    • Q8N580

    Protein attributes for GPR55 Gene

    Size:
    319 amino acids
    Molecular mass:
    36637 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.
    SequenceCaution:
    • Sequence=AAD22410.1; Type=Frameshift; Positions=132, 142; Evidence={ECO:0000305};

neXtProt entry for GPR55 Gene

Post-translational modifications for GPR55 Gene

  • Glycosylation at isoforms=5 and posLast=171171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR55 Gene

Domains & Families for GPR55 Gene

Protein Domains for GPR55 Gene

Suggested Antigen Peptide Sequences for GPR55 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2T6

UniProtKB/Swiss-Prot:

GPR55_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR55: view

Function for GPR55 Gene

Molecular function for GPR55 Gene

GENATLAS Biochemistry:
G protein coupled receptor 55,highly expressed in the caudate nucleus and putamen with homology to P2RY5,GPR23,GPR35,CCR4
UniProtKB/Swiss-Prot Function:
May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.

Gene Ontology (GO) - Molecular Function for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9931487
GO:0004949 cannabinoid receptor activity IDA 19723626
genes like me logo Genes that share ontologies with GPR55: view
genes like me logo Genes that share phenotypes with GPR55: view

Animal Models for GPR55 Gene

MGI Knock Outs for GPR55:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR55

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR55 Gene

Localization for GPR55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR55 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR55 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IDA 18757503
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR55: view

Pathways & Interactions for GPR55 Gene

genes like me logo Genes that share pathways with GPR55: view

Pathways by source for GPR55 Gene

Gene Ontology (GO) - Biological Process for GPR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9931487
GO:0007202 activation of phospholipase C activity IDA 18757503
GO:0035025 positive regulation of Rho protein signal transduction IDA 18757503
GO:0038171 cannabinoid signaling pathway IEA --
genes like me logo Genes that share ontologies with GPR55: view

No data available for SIGNOR curated interactions for GPR55 Gene

Drugs & Compounds for GPR55 Gene

(32) Drugs for GPR55 Gene - From: ApexBio, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cannabidiol Approved, Investigational Pharma Partial agonist, Agonist 0
Rimonabant Approved, Investigational Pharma Antagonist, antagonist CB1 receptor antagonist 45
O-1602 Pharma Agonist Potent GPR55 receptor agonist 0
Abn-CBD Pharma Selective GPR55 agonist; neurobehaviorally inactive 0
CID 16020046 Pharma Selective GPR55 antagonist 0

(3) Additional Compounds for GPR55 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Delta<sup>9</sup>-tetrahydrocannabinol
Partial agonist, Agonist
oleoylethanolamide
Agonist
ML 193
713121-80-3

(5) Tocris Compounds for GPR55 Gene

Compound Action Cas Number
Abn-CBD Selective GPR55 agonist; neurobehaviorally inactive 22972-55-0
CID 16020046 Selective GPR55 antagonist 834903-43-4
ML 193 Potent, selective GPR55 antagonist 713121-80-3
O-1602 Potent GPR55 receptor agonist 317321-41-8
Oleylethanolamide Lipid mediator, anorexic actions; also GPR55 and PPARalpha agonist 111-58-0

(5) ApexBio Compounds for GPR55 Gene

Compound Action Cas Number
Abn-CBD 22972-55-0
CID 16020046 834903-43-4
O-1602 317321-41-8
Oleylethanolamide 111-58-0
Palmitoylethanolamide 544-31-0
genes like me logo Genes that share compounds with GPR55: view

Transcripts for GPR55 Gene

Unigene Clusters for GPR55 Gene

G protein-coupled receptor 55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR55 Gene

No ASD Table

Relevant External Links for GPR55 Gene

GeneLoc Exon Structure for
GPR55
ECgene alternative splicing isoforms for
GPR55

Expression for GPR55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR55 Gene

mRNA differential expression in normal tissues according to GTEx for GPR55 Gene

This gene is overexpressed in Testis (x5.5) and Spleen (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of GPR55 Gene:

GPR55

SOURCE GeneReport for Unigene cluster for GPR55 Gene:

Hs.114545

mRNA Expression by UniProt/SwissProt for GPR55 Gene:

Q9Y2T6-GPR55_HUMAN
Tissue specificity: Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts.

Evidence on tissue expression from TISSUES for GPR55 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with GPR55: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR55 Gene

Orthologs for GPR55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR55 34 35
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia GPR55 34 35
  • 85.16 (n)
cow
(Bos Taurus)
Mammalia GPR55 34 35
  • 83.07 (n)
mouse
(Mus musculus)
Mammalia Gpr55 34 16 35
  • 81.22 (n)
rat
(Rattus norvegicus)
Mammalia Gpr55 34
  • 79.96 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR55 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR55 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR55 34 35
  • 59.72 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490418 34
  • 54.22 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC793909 34
  • 54.33 (n)
gpr55a 35
  • 28 (a)
OneToOne
Species where no ortholog for GPR55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR55 Gene

ENSEMBL:
Gene Tree for GPR55 (if available)
TreeFam:
Gene Tree for GPR55 (if available)

Paralogs for GPR55 Gene

Paralogs for GPR55 Gene

(6) SIMAP similar genes for GPR55 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPR55: view

Variants for GPR55 Gene

Sequence variations from dbSNP and Humsavar for GPR55 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs193920808 Uncertain significance 230,910,022(-) GGACA(C/T)CACGA reference, missense
rs1000068457 -- 230,906,943(+) TGTAT(G/T)CAGAG downstream-variant-500B
rs1000097878 -- 230,958,403(+) AATTA(C/T)ACTCT intron-variant
rs1000297241 -- 230,909,140(+) TCCCC(A/G)CTCCC utr-variant-3-prime
rs1000310941 -- 230,933,246(+) CCTGT(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GPR55 Gene

Variant ID Type Subtype PubMed ID
nsv470522 CNV loss 18288195
nsv834565 CNV gain 17160897

Variation tolerance for GPR55 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.32; 81.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR55 Gene

Human Gene Mutation Database (HGMD)
GPR55
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR55 Gene

Disorders for GPR55 Gene

Relevant External Links for GPR55

Genetic Association Database (GAD)
GPR55
Human Genome Epidemiology (HuGE) Navigator
GPR55
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR55

No disorders were found for GPR55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR55 Gene

Publications for GPR55 Gene

  1. The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA- dependent Ca2+ signaling and NFAT activation. (PMID: 18757503) Henstridge C.M. … Irving A.J. (FASEB J. 2009) 3 4 22 64
  2. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. (PMID: 9931487) Sawzdargo M. … O'Dowd B.F. (Brain Res. Mol. Brain Res. 1999) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. (PMID: 19723626) Kapur A. … Abood M.E. (J. Biol. Chem. 2009) 3 4 64
  5. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. (PMID: 19805329) Whyte L.S. … Rogers M.J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 64

Products for GPR55 Gene

Sources for GPR55 Gene

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