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Aliases for CD14 Gene

Aliases for CD14 Gene

  • CD14 Molecule 2 3 5
  • CD14 Antigen 2 4
  • Myeloid Cell-Specific Leucine-Rich Glycoprotein 4

External Ids for CD14 Gene

Previous GeneCards Identifiers for CD14 Gene

  • GC05M139827
  • GC05M139994
  • GC05M140039
  • GC05M139991
  • GC05M135156

Summaries for CD14 Gene

Entrez Gene Summary for CD14 Gene

  • The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

GeneCards Summary for CD14 Gene

CD14 (CD14 Molecule) is a Protein Coding gene. Diseases associated with CD14 include Mycobacterium Chelonae and Croup. Among its related pathways are Bacterial infections in CF airways and Activated TLR4 signalling. GO annotations related to this gene include lipopolysaccharide binding and lipoteichoic acid binding.

UniProtKB/Swiss-Prot for CD14 Gene

  • Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).

Gene Wiki entry for CD14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD14 Gene

Genomics for CD14 Gene

Regulatory Elements for CD14 Gene

Enhancers for CD14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G140609 1.7 FANTOM5 Ensembl ENCODE 45.2 +22.8 22801 3.8 PKNOX1 ATF1 FOXA2 ARNT TCF12 ZNF766 CBX5 GATA2 FOS NCOA1 CD14 APBB3 TMCO6 SLC35A4 IK EIF4EBP3 ANKHD1 NDUFA2 SRA1 HBEGF
GH05G140594 1.4 FANTOM5 Ensembl ENCODE 34.4 +37.7 37701 4.0 CREB3L1 TAF1 MAX CEBPG ZIC2 RAD21 YY1 ZNF766 CREM MIER1 CD14 APBB3 SRA1 TMCO6 PCDHA1 PCDHA2 HARS SLC35A4 PCDHA5 EIF4EBP3
GH05G140601 1.5 FANTOM5 Ensembl ENCODE 26.1 +31.1 31106 2.0 HDAC1 MLX NFIB SIN3A YY1 EGR2 THAP11 ZNF263 USF2 CEBPB APBB3 CD14 TMCO6 SRA1 SLC35A4 IK NDUFA2 EIF4EBP3 HBEGF ANKHD1
GH05G140588 1.6 FANTOM5 Ensembl ENCODE 24 +43.3 43346 4.1 HDGF CREB3L1 ARNT ZFP64 ARID4B SIN3A ZNF2 ZNF143 FOS DEK APBB3 PCDHB19P CD14 IGIP PCDHB17P PCDHAC2 ENSG00000272070 SLC35A4 PCDHA2 PCDHB18P
GH05G140250 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +381.2 381179 4.6 HDGF ATF1 FOXA2 PKNOX1 ARID4B SIN3A ZNF2 TCF12 GATA2 ZNF143 PFDN1 APBB3 CD14 HBEGF PURA SRA1 ANKHD1 SLC35A4 EIF4EBP3 IK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CD14 on UCSC Golden Path with GeneCards custom track

Promoters for CD14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187811 901 801 PKNOX1 FOXA2 THRB RAD21 RARA YY1 EGR1 ZNF143 FOS EGR2

Genomic Location for CD14 Gene

Chromosome:
5
Start:
140,631,728 bp from pter
End:
140,633,701 bp from pter
Size:
1,974 bases
Orientation:
Minus strand

Genomic View for CD14 Gene

Genes around CD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD14 Gene

Proteins for CD14 Gene

  • Protein details for CD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08571-CD14_HUMAN
    Recommended name:
    Monocyte differentiation antigen CD14
    Protein Accession:
    P08571
    Secondary Accessions:
    • Q53XT5
    • Q96FR6
    • Q96L99
    • Q9UNS3

    Protein attributes for CD14 Gene

    Size:
    375 amino acids
    Molecular mass:
    40076 Da
    Quaternary structure:
    • Interacts with LPS-bound LPB (PubMed:1698311, PubMed:23264655). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Interacts with LPAR1 (By similarity). Interacts with the TLR2:TLR6 or TLR2:TLR1 heterodimers; upon interaction with ligands such as diacylated lipopeptides and triacylated lipopeptides, respectively (PubMed:16880211). Interacts with MYO18A (PubMed:25965346).

    Three dimensional structures from OCA and Proteopedia for CD14 Gene

neXtProt entry for CD14 Gene

Post-translational modifications for CD14 Gene

  • N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at posLast=3737, posLast=151151, Asn282, posLast=323323, and posLast=336336
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CD14 Gene

Domains & Families for CD14 Gene

Gene Families for CD14 Gene

Protein Domains for CD14 Gene

Suggested Antigen Peptide Sequences for CD14 Gene

Graphical View of Domain Structure for InterPro Entry

P08571

UniProtKB/Swiss-Prot:

CD14_HUMAN :
  • The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.
Domain:
  • The C-terminal leucine-rich repeat (LRR) region is required for responses to smooth LPS.
genes like me logo Genes that share domains with CD14: view

Function for CD14 Gene

Molecular function for CD14 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD14,55kDa,expressed on macrophages and monocytes,involved in the clearance of apoptotic cells,also receptor for bacterial liposaccharides and recruiting LPS to TLR proteins and inducing a liposaccharide signaling pathway,regulator of IgE levels,identified by monoclonal antibodies My4,Mo2,UCHM1,VIM13,MoP15,risk factor for myocardial infarction
UniProtKB/Swiss-Prot Function:
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
UniProtKB/Swiss-Prot Induction:
The expression in monocytes is highly induced by 27-hydroxycholesterol, priming monocytes/macrophages such that LPS-mediated inflammatory reaction is accelerated. Secretion of soluble CD14 is also enhanced.

Gene Ontology (GO) - Molecular Function for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 12594207
GO:0001847 opsonin receptor activity TAS 2402637
GO:0005515 protein binding IPI 16880211
GO:0016019 peptidoglycan receptor activity TAS 8798531
GO:0070891 lipoteichoic acid binding IDA 12594207
genes like me logo Genes that share ontologies with CD14: view
genes like me logo Genes that share phenotypes with CD14: view

Animal Models for CD14 Gene

MGI Knock Outs for CD14:

Animal Model Products

CRISPR Products

miRNA for CD14 Gene

miRTarBase miRNAs that target CD14

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD14

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD14 Gene

Localization for CD14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD14 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269 PubMed:2462937, ECO:0000269 PubMed:2779588, ECO:0000269 PubMed:3385210}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD14 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
endosome 4
lysosome 1

Gene Ontology (GO) - Cellular Components for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005794 Golgi apparatus IDA,IEA 16880211
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CD14: view

Pathways & Interactions for CD14 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Diseases associated with the TLR signaling cascade
3 Toll-like Receptor Signaling Pathway
4 Toll Comparative Pathway
5 Innate Immune System
genes like me logo Genes that share pathways with CD14: view

Gene Ontology (GO) - Biological Process for CD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002237 response to molecule of bacterial origin IEA --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with CD14: view

No data available for SIGNOR curated interactions for CD14 Gene

Drugs & Compounds for CD14 Gene

(42) Drugs for CD14 Gene - From: PharmGKB, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
IC14 Pharma 0

(59) Additional Compounds for CD14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD14: view

Transcripts for CD14 Gene

Unigene Clusters for CD14 Gene

CD14 molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CD14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD14 Gene

No ASD Table

Relevant External Links for CD14 Gene

GeneLoc Exon Structure for
CD14
ECgene alternative splicing isoforms for
CD14

Expression for CD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD14 Gene

This gene is overexpressed in Whole Blood (x14.7) and Liver (x7.0).

Protein differential expression in normal tissues from HIPED for CD14 Gene

This gene is overexpressed in Milk (24.2), Urine (18.9), and Vitreous humor (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CD14 Gene



Protein tissue co-expression partners for CD14 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD14 Gene:

CD14

SOURCE GeneReport for Unigene cluster for CD14 Gene:

Hs.163867

mRNA Expression by UniProt/SwissProt for CD14 Gene:

P08571-CD14_HUMAN
Tissue specificity: Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Evidence on tissue expression from TISSUES for CD14 Gene

  • Liver(4.7)
  • Nervous system(4.7)
  • Blood(4.6)
  • Bone marrow(4.4)
  • Lung(3)
  • Muscle(2.7)
  • Lymph node(2.1)
  • Stomach(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CD14: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CD14 Gene

Orthologs for CD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD14 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia CD14 34 35
  • 79.4 (n)
dog
(Canis familiaris)
Mammalia CD14 34
  • 77.75 (n)
mouse
(Mus musculus)
Mammalia Cd14 34 16 35
  • 72.99 (n)
rat
(Rattus norvegicus)
Mammalia Cd14 34
  • 72.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CD14 35
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CD14 35
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD14 35
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 22 (a)
OneToMany
-- 35
  • 20 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10497 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13785 34
Species where no ortholog for CD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD14 Gene

ENSEMBL:
Gene Tree for CD14 (if available)
TreeFam:
Gene Tree for CD14 (if available)

Paralogs for CD14 Gene

No data available for Paralogs for CD14 Gene

Variants for CD14 Gene

Sequence variations from dbSNP and Humsavar for CD14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1002825640 -- 140,631,601(+) TTCTT(-/GAG)GAGGA intron-variant, downstream-variant-500B
rs1003752066 -- 140,634,734(+) GGCCT(C/G)TCAAA intron-variant, upstream-variant-2KB
rs1003922204 -- 140,634,314(+) CACCA(A/G)TTTCG intron-variant, upstream-variant-2KB
rs1006243753 -- 140,631,697(+) AGACA(C/T)CCAAT intron-variant, downstream-variant-500B
rs1006335701 -- 140,631,323(+) GGAGA(A/G)GGAGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CD14 Gene

Variant ID Type Subtype PubMed ID
esv3606953 CNV loss 21293372

Variation tolerance for CD14 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD14 Gene

Human Gene Mutation Database (HGMD)
CD14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD14 Gene

Disorders for CD14 Gene

MalaCards: The human disease database

(13) MalaCards diseases for CD14 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mycobacterium chelonae
  • m. chelonae
croup
  • acute laryngotracheobronchitis
mycobacterium kansasii
  • m. kansasii
paroxysmal nocturnal hemoglobinuria
  • marchiafava-micheli disease
monocytic leukemia
  • schilling's leukemia
- elite association - COSMIC cancer census association via MalaCards
Search CD14 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD14

Genetic Association Database (GAD)
CD14
Human Genome Epidemiology (HuGE) Navigator
CD14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD14
genes like me logo Genes that share disorders with CD14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD14 Gene

Publications for CD14 Gene

  1. CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation? (PMID: 20398919) Munthe-Kaas M.C. … Lyle R. (J. Allergy Clin. Immunol. 2010) 3 22 46 64
  2. Influence of C-159T SNP of the CD14 gene promoter on lung function in smokers. (PMID: 19361972) Zhou H. … Peden D.B. (Respir Med 2009) 3 22 46 64
  3. Influence of CD14 polymorphism on CD14 expression in patients with extensive burns. (PMID: 18951711) Lin J. … Sheng Z.Y. (Burns 2009) 3 22 46 64
  4. Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation. (PMID: 17949800) Levan T.D. … Martinez F.D. (J. Allergy Clin. Immunol. 2008) 3 22 46 64
  5. [Association of CD14 gene polymorphism with atopic diseases in Chinese Han ethnic group children]. (PMID: 17456337) Zhang H.L. … Li C.C. (Zhonghua Er Ke Za Zhi 2007) 3 22 46 64

Products for CD14 Gene

  • Addgene plasmids for CD14

Sources for CD14 Gene

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