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Aliases for GPR37L1 Gene

Aliases for GPR37L1 Gene

  • G Protein-Coupled Receptor 37 Like 1 2 3 5
  • Endothelin B Receptor-Like Protein 2 3 4
  • G-Protein Coupled Receptor 37-Like 1 3 4
  • ETBR-LP-2 3 4
  • Endothelin Type B Receptor-Like Protein 2 3
  • G-Protein Coupled Receptor 37 Like 1 3
  • ET(B)R-LP-2 3
  • ETBRLP2 4

External Ids for GPR37L1 Gene

Previous GeneCards Identifiers for GPR37L1 Gene

  • GC01U990381
  • GC01P199381
  • GC01P198823
  • GC01P200358
  • GC01P202091
  • GC01P173257

Summaries for GPR37L1 Gene

GeneCards Summary for GPR37L1 Gene

GPR37L1 (G Protein-Coupled Receptor 37 Like 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled peptide receptor activity. An important paralog of this gene is EDNRB.

UniProtKB/Swiss-Prot for GPR37L1 Gene

  • Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Wiki entry for GPR37L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR37L1 Gene

Genomics for GPR37L1 Gene

Regulatory Elements for GPR37L1 Gene

Enhancers for GPR37L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around GPR37L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for GPR37L1 Gene

Chromosome:
1
Start:
202,118,705 bp from pter
End:
202,133,592 bp from pter
Size:
14,888 bases
Orientation:
Plus strand

Genomic View for GPR37L1 Gene

Genes around GPR37L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR37L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR37L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR37L1 Gene

Proteins for GPR37L1 Gene

  • Protein details for GPR37L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60883-ETBR2_HUMAN
    Recommended name:
    Prosaposin receptor GPR37L1
    Protein Accession:
    O60883
    Secondary Accessions:
    • B2R7M9
    • Q5SXP7
    • Q86VP7

    Protein attributes for GPR37L1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR37L1 Gene

Proteomics data for GPR37L1 Gene at MOPED

Post-translational modifications for GPR37L1 Gene

Other Protein References for GPR37L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPR37L1 Gene

Domains & Families for GPR37L1 Gene

Gene Families for GPR37L1 Gene

Protein Domains for GPR37L1 Gene

Suggested Antigen Peptide Sequences for GPR37L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60883

UniProtKB/Swiss-Prot:

ETBR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR37L1: view

Function for GPR37L1 Gene

Molecular function for GPR37L1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Ontology (GO) - Molecular Function for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 20517885
genes like me logo Genes that share ontologies with GPR37L1: view
genes like me logo Genes that share phenotypes with GPR37L1: view

Animal Models for GPR37L1 Gene

MGI Knock Outs for GPR37L1:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR37L1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR37L1 Gene

Localization for GPR37L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR37L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR37L1 Gene COMPARTMENTS Subcellular localization image for GPR37L1 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for GPR37L1 Gene

Pathways & Interactions for GPR37L1 Gene

genes like me logo Genes that share pathways with GPR37L1: view

Pathways by source for GPR37L1 Gene

Interacting Proteins for GPR37L1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356251%0d%0a9606.ENSP00000377055%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: O60883-ETBR2_HUMAN ENSP00000356251 for GPR37L1 Gene via UniProtKB I2D STRING

Gene Ontology (GO) - Biological Process for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:1903206 negative regulation of hydrogen peroxide-induced cell death IEA,ISS 23690594
genes like me logo Genes that share ontologies with GPR37L1: view

No data available for SIGNOR curated interactions for GPR37L1 Gene

Drugs & Compounds for GPR37L1 Gene

(1) Drugs for GPR37L1 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
prosaptide Pharma Agonist 0
genes like me logo Genes that share compounds with GPR37L1: view

Transcripts for GPR37L1 Gene

mRNA/cDNA for GPR37L1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR37L1 Gene

G protein-coupled receptor 37 like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR37L1 Gene

No ASD Table

Relevant External Links for GPR37L1 Gene

GeneLoc Exon Structure for
GPR37L1
ECgene alternative splicing isoforms for
GPR37L1

Expression for GPR37L1 Gene

mRNA expression in normal human tissues for GPR37L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR37L1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.9), Brain - Putamen (basal ganglia) (x5.4), Brain - Nucleus accumbens (basal ganglia) (x5.3), Brain - Amygdala (x5.1), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for GPR37L1 Gene

This gene is overexpressed in Spinal cord (46.8) and Frontal cortex (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR37L1 Gene



SOURCE GeneReport for Unigene cluster for GPR37L1 Gene Hs.132049

mRNA Expression by UniProt/SwissProt for GPR37L1 Gene

O60883-ETBR2_HUMAN
Tissue specificity: Expressed in the central nervous system.
genes like me logo Genes that share expression patterns with GPR37L1: view

Protein tissue co-expression partners for GPR37L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for GPR37L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR37L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR37L1 35
  • 78.93 (n)
  • 74.22 (a)
GPR37L1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR37L1 35
  • 86.93 (n)
  • 87.39 (a)
GPR37L1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr37l1 35
  • 86.07 (n)
  • 90.85 (a)
Gpr37l1 16
Gpr37l1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR37L1 35
  • 99.1 (n)
  • 99.79 (a)
GPR37L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr37l1 35
  • 86.97 (n)
  • 91.68 (a)
oppossum
(Monodelphis domestica)
Mammalia GPR37L1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR37L1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR37L1 35
  • 76.09 (n)
  • 70.36 (a)
GPR37L1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR37L1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr37l1 35
  • 57.51 (n)
  • 56.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18103 35
zebrafish
(Danio rerio)
Actinopterygii gpr37l1b 35
  • 59.46 (n)
  • 53.06 (a)
gpr37l1a 36
  • 48 (a)
OneToMany
gpr37l1b 36
  • 49 (a)
OneToMany
Species with no ortholog for GPR37L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR37L1 Gene

ENSEMBL:
Gene Tree for GPR37L1 (if available)
TreeFam:
Gene Tree for GPR37L1 (if available)

Paralogs for GPR37L1 Gene

Paralogs for GPR37L1 Gene

(1) SIMAP similar genes for GPR37L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR37L1: view

Variants for GPR37L1 Gene

Sequence variations from dbSNP and Humsavar for GPR37L1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_047455 -
VAR_047456 -
VAR_047457 -
rs3795593 -- 202,122,918(+) CCCTG(C/T)ACTCA intron-variant, utr-variant-5-prime
rs3820380 -- 202,127,687(+) TCCTT(A/G)TCCCC intron-variant

Variation tolerance for GPR37L1 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.26; 70.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GPR37L1 Gene

HapMap Linkage Disequilibrium report
GPR37L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR37L1 Gene

Disorders for GPR37L1 Gene

Relevant External Links for GPR37L1

Genetic Association Database (GAD)
GPR37L1
Human Genome Epidemiology (HuGE) Navigator
GPR37L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GPR37L1

No disorders were found for GPR37L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR37L1 Gene

Publications for GPR37L1 Gene

  1. A new family of orphan G protein-coupled receptors predominantly expressed in the brain. (PMID: 9539149) Valdenaire O. … Richards J.G. (FEBS Lett. 1998) 2 3 4 23 67
  2. The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death. (PMID: 24749734) Dutta P. … Dev K.K. (J. Neurochem. 2014) 3
  3. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. (PMID: 23690594) Meyer R.C. … Hall R.A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3

Products for GPR37L1 Gene

Sources for GPR37L1 Gene

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