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Aliases for GPR37L1 Gene

Aliases for GPR37L1 Gene

  • G Protein-Coupled Receptor 37 Like 1 2 3
  • Endothelin B Receptor-Like Protein 2 3 4
  • G-Protein Coupled Receptor 37-Like 1 3 4
  • ETBR-LP-2 3 4
  • Endothelin Type B Receptor-Like Protein 2 3
  • G-Protein Coupled Receptor 37 Like 1 3
  • Prosaposin Receptor GPR37L1 3
  • ET(B)R-LP-2 3
  • ETBRLP2 4

External Ids for GPR37L1 Gene

Summaries for GPR37L1 Gene

GeneCards Summary for GPR37L1 Gene

GPR37L1 (G Protein-Coupled Receptor 37 Like 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is EDNRB.

UniProtKB/Swiss-Prot for GPR37L1 Gene

  • Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Wiki entry for GPR37L1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR37L1 Gene

Genomics for GPR37L1 Gene

Genomic Location for GPR37L1 Gene

Start:
202,122,858 bp from pter
End:
202,133,592 bp from pter
Size:
10,735 bases
Orientation:
Plus strand

Genomic View for GPR37L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GPR37L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR37L1 Gene

Regulatory Elements for GPR37L1 Gene

Proteins for GPR37L1 Gene

  • Protein details for GPR37L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60883-ETBR2_HUMAN
    Recommended name:
    Prosaposin receptor GPR37L1
    Protein Accession:
    O60883
    Secondary Accessions:
    • B2R7M9
    • Q5SXP7
    • Q86VP7

    Protein attributes for GPR37L1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR37L1 Gene

Proteomics data for GPR37L1 Gene at MOPED

Post-translational modifications for GPR37L1 Gene

Other Protein References for GPR37L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR37L1 Gene

Domains for GPR37L1 Gene

Gene Families for GPR37L1 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for GPR37L1 Gene

UniProtKB/Swiss-Prot:

ETBR2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • O60883
genes like me logo Genes that share domains with GPR37L1: view

Function for GPR37L1 Gene

Molecular function for GPR37L1 Gene

UniProtKB/Swiss-Prot Function: Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade.

Gene Ontology (GO) - Molecular Function for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding IPI 20517885
GO:0008528 G-protein coupled peptide receptor activity IDA 23690594
GO:0042277 peptide binding IPI 23690594
genes like me logo Genes that share ontologies with GPR37L1: view

Phenotypes for GPR37L1 Gene

genes like me logo Genes that share phenotypes with GPR37L1: view

Animal Models for GPR37L1 Gene

MGI Knock Outs for GPR37L1:

miRNA for GPR37L1 Gene

miRTarBase miRNAs that target GPR37L1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for GPR37L1 Gene

Localization for GPR37L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR37L1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GPR37L1 Gene COMPARTMENTS Subcellular localization image for GPR37L1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 9539149
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR37L1: view

Pathways for GPR37L1 Gene

SuperPathways for GPR37L1 Gene

genes like me logo Genes that share pathways with GPR37L1: view

Pathways by source for GPR37L1 Gene

1 BioSystems pathway for GPR37L1 Gene

Interacting Proteins for GPR37L1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356251%0d%0a9606.ENSP00000377055%0d%0a9606.ENSP00000349238%0d%0a
Selected Interacting proteins: ENSP00000356251 O60883-ETBR2_HUMAN for GPR37L1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for GPR37L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA 23690594
GO:0008150 biological_process --
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation IEA --
GO:0043410 positive regulation of MAPK cascade IDA 23690594
genes like me logo Genes that share ontologies with GPR37L1: view

Compounds for GPR37L1 Gene

(1) IUPHAR Ligand for GPR37L1 Gene

Ligand Type Action Affinity Pubmed IDs
prosaptide Agonist Agonist 8.15
genes like me logo Genes that share compounds with GPR37L1: view

Transcripts for GPR37L1 Gene

mRNA/cDNA for GPR37L1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR37L1 Gene

G protein-coupled receptor 37 like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GPR37L1 Gene

No ASD Table

Relevant External Links for GPR37L1 Gene

GeneLoc Exon Structure for
GPR37L1
ECgene alternative splicing isoforms for
GPR37L1

Expression for GPR37L1 Gene

mRNA expression in normal human tissues for GPR37L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR37L1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (5.9), Brain - Putamen (basal ganglia) (5.4), Brain - Nucleus accumbens (basal ganglia) (5.3), Brain - Amygdala (5.1), and Brain - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for GPR37L1 Gene

SOURCE GeneReport for Unigene cluster for GPR37L1 Gene Hs.132049

mRNA Expression by UniProt/SwissProt for GPR37L1 Gene

O60883-ETBR2_HUMAN
Tissue specificity: Expressed in the central nervous system
genes like me logo Genes that share expressions with GPR37L1: view

Orthologs for GPR37L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR37L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR37L1 36
  • 99.1 (n)
  • 99.79 (a)
GPR37L1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR37L1 36
  • 78.93 (n)
  • 74.22 (a)
GPR37L1 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR37L1 36
  • 86.93 (n)
  • 87.39 (a)
GPR37L1 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr37l1 36
  • 86.07 (n)
  • 90.85 (a)
Gpr37l1 16
Gpr37l1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR37L1 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR37L1 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr37l1 36
  • 86.97 (n)
  • 91.68 (a)
chicken
(Gallus gallus)
Aves GPR37L1 36
  • 76.09 (n)
  • 70.36 (a)
GPR37L1 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR37L1 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18103 36
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr37l1 36
  • 57.51 (n)
  • 56.52 (a)
zebrafish
(Danio rerio)
Actinopterygii gpr37l1a 37
  • 48 (a)
OneToMany
gpr37l1b 36
  • 59.46 (n)
  • 53.06 (a)
gpr37l1b 37
  • 49 (a)
OneToMany
Species with no ortholog for GPR37L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR37L1 Gene

ENSEMBL:
Gene Tree for GPR37L1 (if available)
TreeFam:
Gene Tree for GPR37L1 (if available)

Paralogs for GPR37L1 Gene

Paralogs for GPR37L1 Gene

Selected SIMAP similar genes for GPR37L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPR37L1: view

Variants for GPR37L1 Gene

Sequence variations from dbSNP and Humsavar for GPR37L1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3795593 -- 202,122,918(+) CCCTG(C/T)ACTCA utr-variant-5-prime
rs3795594 - 202,123,204(+) CCAAG(C/G)CCTTG reference, missense
rs3795595 - 202,123,232(+) CCCCG(A/G)CAAGG missense, reference
rs3795596 -- 202,123,287(+) ACAGG(A/G)GCACC reference, synonymous-codon
rs3820380 -- 202,127,687(+) TCCTT(A/G)TCCCC intron-variant

Relevant External Links for GPR37L1 Gene

HapMap Linkage Disequilibrium report
GPR37L1

No data available for Structural Variations from Database of Genomic Variants (DGV) for GPR37L1 Gene

Disorders for GPR37L1 Gene

Relevant External Links for GPR37L1

Genetic Association Database (GAD)
GPR37L1
Human Genome Epidemiology (HuGE) Navigator
GPR37L1
genes like me logo Genes that share disorders with GPR37L1: view

No data available for UniProtKB/Swiss-Prot for GPR37L1 Gene

Publications for GPR37L1 Gene

  1. A new family of orphan G protein-coupled receptors predominantly expressed in the brain. (PMID: 9539149) Valdenaire O. … Richards J.G. (FEBS Lett. 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. (PMID: 23690594) Meyer R.C. … Hall R.A. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4
  4. Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. (PMID: 20360844) Arking D.E. … Chugh S.S. (PLoS ONE 2010) 3 49
  5. Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase. (PMID: 20517885) Zhao X. … Hendrickon R.C. (Proteomics 2010) 3

Products for GPR37L1 Gene

Sources for GPR37L1 Gene

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