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Aliases for CD9 Gene

Aliases for CD9 Gene

  • CD9 Molecule 2 3
  • Cell Growth-Inhibiting Gene 2 Protein 3 4
  • Motility Related Protein-1 2 3
  • Leukocyte Antigen MIC3 3 4
  • CD9 Antigen (P24) 2 3
  • Tetraspanin-29 3 4
  • 5H9 Antigen 3 4
  • TSPAN-29 3 4
  • TSPAN29 3 4
  • MRP-1 3 4
  • MIC3 3 4
  • Motility-Related Protein 4
  • BA-2/P24 Antigen 3
  • CD9 Antigen 4
  • DRAP-27 3
  • BTCC-1 3
  • P24 4

External Ids for CD9 Gene

Previous HGNC Symbols for CD9 Gene

  • MIC3

Previous GeneCards Identifiers for CD9 Gene

  • GC12P006164
  • GC12P006284
  • GC12P006308

Summaries for CD9 Gene

Entrez Gene Summary for CD9 Gene

  • This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]

GeneCards Summary for CD9 Gene

CD9 (CD9 Molecule) is a Protein Coding gene. Diseases associated with CD9 include cytomegalovirus retinitis and prolapse of female genital organ. Among its related pathways are Infectious disease and Hemostasis. GO annotations related to this gene include integrin binding. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for CD9 Gene

  • Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.

Gene Wiki entry for CD9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD9 Gene

Genomics for CD9 Gene

Regulatory Elements for CD9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD9 Gene

Chromosome:
12
Start:
6,199,715 bp from pter
End:
6,238,271 bp from pter
Size:
38,557 bases
Orientation:
Plus strand

Genomic View for CD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD9 Gene

Proteins for CD9 Gene

  • Protein details for CD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21926-CD9_HUMAN
    Recommended name:
    CD9 antigen
    Protein Accession:
    P21926
    Secondary Accessions:
    • D3DUQ9
    • Q5J7W6
    • Q96ES4

    Protein attributes for CD9 Gene

    Size:
    228 amino acids
    Molecular mass:
    25416 Da
    Quaternary structure:
    • Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts with CD63. Identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.

neXtProt entry for CD9 Gene

Proteomics data for CD9 Gene at MOPED

Post-translational modifications for CD9 Gene

  • Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.
  • Glycosylation at Asn 52 and Asn 53
  • Modification sites at PhosphoSitePlus

Other Protein References for CD9 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD9 (CD9)

No data available for DME Specific Peptides for CD9 Gene

Domains & Families for CD9 Gene

Gene Families for CD9 Gene

Suggested Antigen Peptide Sequences for CD9 Gene

Graphical View of Domain Structure for InterPro Entry

P21926

UniProtKB/Swiss-Prot:

CD9_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD9: view

Function for CD9 Gene

Molecular function for CD9 Gene

GENATLAS Biochemistry:
cell differentiation antigen CD9 (p34),24kDa,membrane glycoprotein,single chain,identified by monoclonal antibodies ALB6,BLI16,FMC56
UniProtKB/Swiss-Prot Function:
Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.

Gene Ontology (GO) - Molecular Function for CD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 11278880
genes like me logo Genes that share ontologies with CD9: view
genes like me logo Genes that share phenotypes with CD9: view

Animal Models for CD9 Gene

MGI Knock Outs for CD9:

Animal Model Products

miRNA for CD9 Gene

miRTarBase miRNAs that target CD9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD9 Gene

Localization for CD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD9 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD9 Gene COMPARTMENTS Subcellular localization image for CD9 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
endosome 2
cytosol 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 2037603
GO:0005925 focal adhesion IDA 21423176
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CD9: view

Pathways & Interactions for CD9 Gene

genes like me logo Genes that share pathways with CD9: view

Pathways by source for CD9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006928 movement of cell or subcellular component IDA 8478605
GO:0007155 cell adhesion IDA 7511626
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007338 single fertilization TAS --
genes like me logo Genes that share ontologies with CD9: view

No data available for SIGNOR curated interactions for CD9 Gene

Drugs & Compounds for CD9 Gene

(35) Drugs for CD9 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 971
Cimetidine Approved Pharma Inhibition, Inhibitor H2 receptor antagonist, H2 antagonist, I1 agonist 66
Cocaine Approved, Illicit Pharma 441
Deferiprone Approved Pharma 49
Didanosine Approved Pharma 150

(33) Additional Compounds for CD9 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
3-fluoro-3-deoxythymidine
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
deoxyribonucleic acid
dextran sulfate
genes like me logo Genes that share compounds with CD9: view

Transcripts for CD9 Gene

mRNA/cDNA for CD9 Gene

(3) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD9 Gene

CD9 molecule:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - - -

Relevant External Links for CD9 Gene

GeneLoc Exon Structure for
CD9
ECgene alternative splicing isoforms for
CD9

Expression for CD9 Gene

mRNA expression in normal human tissues for CD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD9 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for CD9 Gene

This gene is overexpressed in Nasal epithelium (12.9), Spinal cord (8.1), and Urine (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD9 Gene



SOURCE GeneReport for Unigene cluster for CD9 Gene Hs.114286

mRNA Expression by UniProt/SwissProt for CD9 Gene

P21926-CD9_HUMAN
Tissue specificity: Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells.
genes like me logo Genes that share expression patterns with CD9: view

Protein tissue co-expression partners for CD9 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD9 35
  • 87.32 (n)
  • 84.51 (a)
CD9 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD9 35
  • 88.41 (n)
  • 90.82 (a)
CD9 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd9 35
  • 85.99 (n)
  • 89.82 (a)
Cd9 16
Cd9 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CD9 35
  • 99.56 (n)
  • 99.56 (a)
CD9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd9 35
  • 86.43 (n)
  • 92.48 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CD9 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD9 35
  • 72.2 (n)
  • 73.99 (a)
CD9 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD9 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cd9 35
  • 70.06 (n)
  • 71.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24740 35
zebrafish
(Danio rerio)
Actinopterygii cd9a 35
  • 67.11 (n)
  • 60.18 (a)
Dr.27131 35
cd9a 36
  • 60 (a)
OneToMany
cd9b 36
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9244 35
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-9 36
  • 26 (a)
OneToMany
Species with no ortholog for CD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD9 Gene

ENSEMBL:
Gene Tree for CD9 (if available)
TreeFam:
Gene Tree for CD9 (if available)

Paralogs for CD9 Gene

Paralogs for CD9 Gene

(14) SIMAP similar genes for CD9 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD9: view

Variants for CD9 Gene

Sequence variations from dbSNP and Humsavar for CD9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs25606 -- 6,198,319(-) GAGAT(-/CAGAGG)CAGAG upstream-variant-2KB
rs709852 -- 6,203,001(-) CTCCA(C/T)AGGGA intron-variant
rs733700 -- 6,228,808(-) ACTAT(C/T)CCTTG intron-variant
rs735885 -- 6,203,497(-) CCTCT(C/T)TCTGG intron-variant
rs740839 -- 6,229,471(+) TACAG(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD9 Gene

Variant ID Type Subtype PubMed ID
nsv832320 CNV Loss 17160897
dgv1351n71 CNV Loss 21882294
nsv832321 CNV Gain+Loss 17160897
nsv470263 CNV Gain 18288195

Variation tolerance for CD9 Gene

Residual Variation Intolerance Score: 47.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD9 Gene

HapMap Linkage Disequilibrium report
CD9
Human Gene Mutation Database (HGMD)
CD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD9 Gene

Disorders for CD9 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CD9 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
cytomegalovirus retinitis
prolapse of female genital organ
enterocele
  • vaginal enterocele, congenital
testicular leukemia
hemangioma of spleen
  • splenic hemangioma
- elite association
Search CD9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD9

Genetic Association Database (GAD)
CD9
Human Genome Epidemiology (HuGE) Navigator
CD9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD9
genes like me logo Genes that share disorders with CD9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD9 Gene

Publications for CD9 Gene

  1. Expression and function of CD9 in melanoma cells. (PMID: 19777564) Fan J. … Niles R.M. (Mol. Carcinog. 2010) 23 67
  2. Expression of the tetraspanins CD9, CD37, CD63, and CD151 in Merkel cell carcinoma: strong evidence for a posttranscriptional fine-tuning of CD9 gene expression. (PMID: 20118909) Woegerbauer M. … Erovic B.M. (Mod. Pathol. 2010) 23 67
  3. Downregulation of CD9 protein expression is associated with aggressive behavior of oral squamous cell carcinoma. (PMID: 20060356) Buim M.E. … Soares F.A. (Oral Oncol. 2010) 23 67
  4. Identification of new target molecules PTK2, TGFBR2 and CD9 overexpressed during advanced bone marrow remodelling in primary myelofibrosis. (PMID: 19604240) Bock O. … Kreipe H. (Br. J. Haematol. 2009) 23 67
  5. The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells. (PMID: 18247373) Murayama Y. … Hayashi N. (J. Cell. Physiol. 2008) 23 67

Products for CD9 Gene

Sources for CD9 Gene

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