Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CD9 Gene

Aliases for CD9 Gene

  • CD9 Molecule 2 3
  • MIC3 3 4 6
  • Cell Growth-Inhibiting Gene 2 Protein 3 4
  • Motility Related Protein-1 2 3
  • Leukocyte Antigen MIC3 3 4
  • CD9 Antigen (P24) 2 3
  • Tetraspanin-29 3 4
  • 5H9 Antigen 3 4
  • CD9 Antigen 3 4
  • TSPAN-29 3 4
  • TSPAN29 3 4
  • MRP-1 3 4
  • Motility-Related Protein 4
  • BA-2/P24 Antigen 3
  • DRAP-27 3
  • BTCC-1 3
  • P24 4

External Ids for CD9 Gene

Previous HGNC Symbols for CD9 Gene

  • MIC3

Previous GeneCards Identifiers for CD9 Gene

  • GC12P006164
  • GC12P006284
  • GC12P006308

Summaries for CD9 Gene

Entrez Gene Summary for CD9 Gene

  • This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]

GeneCards Summary for CD9 Gene

CD9 (CD9 Molecule) is a Protein Coding gene. Diseases associated with CD9 include acquired immunodeficiency syndrome and oral candidiasis. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include integrin binding. An important paralog of this gene is TSPAN9.

UniProtKB/Swiss-Prot for CD9 Gene

  • Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.

Gene Wiki entry for CD9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD9 Gene

Genomics for CD9 Gene

Regulatory Elements for CD9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD9 Gene

Start:
6,199,715 bp from pter
End:
6,238,271 bp from pter
Size:
38,557 bases
Orientation:
Plus strand

Genomic View for CD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD9 Gene

Proteins for CD9 Gene

  • Protein details for CD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21926-CD9_HUMAN
    Recommended name:
    CD9 antigen
    Protein Accession:
    P21926
    Secondary Accessions:
    • D3DUQ9
    • Q5J7W6
    • Q96ES4

    Protein attributes for CD9 Gene

    Size:
    228 amino acids
    Molecular mass:
    25416 Da
    Quaternary structure:
    • Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Interacts with CD63. Identified in a complex with CD63 and ITGB3. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.

neXtProt entry for CD9 Gene

Proteomics data for CD9 Gene at MOPED

Post-translational modifications for CD9 Gene

  • Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.
  • Glycosylation at Asn52 and Asn53
  • Modification sites at PhosphoSitePlus

Other Protein References for CD9 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CD9 (CD9)

No data available for DME Specific Peptides for CD9 Gene

Domains for CD9 Gene

Gene Families for CD9 Gene

HGNC:
  • CD :CD molecules
  • TSPAN :Tetraspanins

Suggested Antigen Peptide Sequences for CD9 Gene

Graphical View of Domain Structure for InterPro Entry

P21926

UniProtKB/Swiss-Prot:

CD9_HUMAN :
  • P21926
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD9: view

Function for CD9 Gene

Molecular function for CD9 Gene

GENATLAS Biochemistry: cell differentiation antigen CD9 (p34),24kDa,membrane glycoprotein,single chain,identified by monoclonal antibodies ALB6,BLI16,FMC56
UniProtKB/Swiss-Prot Function: Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.

Gene Ontology (GO) - Molecular Function for CD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 11278880
genes like me logo Genes that share ontologies with CD9: view
genes like me logo Genes that share phenotypes with CD9: view

Animal Models for CD9 Gene

MGI Knock Outs for CD9:

Animal Model Products

CRISPR Products

miRNA for CD9 Gene

miRTarBase miRNAs that target CD9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CD9 Gene

Localization for CD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD9 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD9 Gene COMPARTMENTS Subcellular localization image for CD9 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
endosome 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 2037603
GO:0005925 focal adhesion IDA 21423176
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CD9: view

Pathways for CD9 Gene

genes like me logo Genes that share pathways with CD9: view

Pathways by source for CD9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006928 movement of cell or subcellular component IDA 8478605
GO:0007155 cell adhesion IDA 7511626
GO:0007338 single fertilization TAS --
GO:0007342 fusion of sperm to egg plasma membrane TAS --
genes like me logo Genes that share ontologies with CD9: view

Compounds for CD9 Gene

(67) Novoseek inferred chemical compound relationships for CD9 Gene

Compound -log(P) Hits PubMed IDs
zidovudine 82.9 39
didanosine 75.4 10
neopterin 67.6 29
curdlan sulfate 66.6 1
3-fluoro-3-deoxythymidine 51.3 1
genes like me logo Genes that share compounds with CD9: view

Transcripts for CD9 Gene

mRNA/cDNA for CD9 Gene

(12) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CD9 Gene

CD9 molecule:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CD9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CD9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - - -

Relevant External Links for CD9 Gene

GeneLoc Exon Structure for
CD9
ECgene alternative splicing isoforms for
CD9

Expression for CD9 Gene

mRNA expression in normal human tissues for CD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CD9 Gene

This gene is overexpressed in Esophagus - Mucosa (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD9 Gene

SOURCE GeneReport for Unigene cluster for CD9 Gene Hs.114286

mRNA Expression by UniProt/SwissProt for CD9 Gene

P21926-CD9_HUMAN
Tissue specificity: Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells.
genes like me logo Genes that share expressions with CD9: view

In Situ Assay Products

Orthologs for CD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CD9 35
  • 99.56 (n)
  • 99.56 (a)
CD9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CD9 35
  • 87.32 (n)
  • 84.51 (a)
CD9 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD9 35
  • 88.41 (n)
  • 90.82 (a)
CD9 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cd9 35
  • 85.99 (n)
  • 89.82 (a)
Cd9 16
Cd9 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CD9 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cd9 35
  • 86.43 (n)
  • 92.48 (a)
chicken
(Gallus gallus)
Aves CD9 35
  • 72.2 (n)
  • 73.99 (a)
CD9 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD9 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24740 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cd9 35
  • 70.06 (n)
  • 71.24 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9244 35
zebrafish
(Danio rerio)
Actinopterygii cd9a 35
  • 67.11 (n)
  • 60.18 (a)
cd9a 36
  • 60 (a)
OneToMany
cd9b 36
  • 55 (a)
OneToMany
Dr.27131 35
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tsp-9 36
  • 26 (a)
OneToMany
Species with no ortholog for CD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD9 Gene

ENSEMBL:
Gene Tree for CD9 (if available)
TreeFam:
Gene Tree for CD9 (if available)

Paralogs for CD9 Gene

Paralogs for CD9 Gene

Selected SIMAP similar genes for CD9 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CD9: view

Variants for CD9 Gene

Sequence variations from dbSNP and Humsavar for CD9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs25606 -- 6,198,319(-) GAGAT(-/CAGAGG)CAGAG upstream-variant-2KB
rs709852 -- 6,203,001(-) CTCCA(C/T)AGGGA intron-variant
rs735885 -- 6,203,497(-) CCTCT(C/T)TCTGG intron-variant
rs758730 -- 6,205,077(-) AGACC(A/G)TGGGG intron-variant
rs758731 -- 6,204,879(-) GGAAG(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CD9 Gene

Variant ID Type Subtype PubMed ID
nsv832320 CNV Loss 17160897
dgv1351n71 CNV Loss 21882294
nsv832321 CNV Gain+Loss 17160897
nsv470263 CNV Gain 18288195

Relevant External Links for CD9 Gene

HapMap Linkage Disequilibrium report
CD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD9 Gene

Disorders for CD9 Gene

(2) University of Copenhagen DISEASES for CD9 Gene

(72) Novoseek inferred disease relationships for CD9 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 87.2 116
hiv infections 82.2 76
aids-related complex 81.9 4
aids 73.7 67
viremia 63.2 13

Relevant External Links for CD9

Genetic Association Database (GAD)
CD9
Human Genome Epidemiology (HuGE) Navigator
CD9
genes like me logo Genes that share disorders with CD9: view

No data available for UniProtKB/Swiss-Prot for CD9 Gene

Publications for CD9 Gene

  1. Molecular cloning of the CD9 antigen. A new family of cell surface proteins. (PMID: 1840589) Boucheix C. … Uzan G. (J. Biol. Chem. 1991) 3 4 23
  2. Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. (PMID: 8478605) Ikeyama S. … Miyake M. (J. Exp. Med. 1993) 3 4 23
  3. Organization of the human CD9 gene. (PMID: 8486348) Rubinstein E. … Boucheix C. (Genomics 1993) 3 4 23
  4. Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility. (PMID: 1720807) Miyake M. … Ikeyama S. (J. Exp. Med. 1991) 3 4 23
  5. Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking. (PMID: 14556650) Kovalenko O.V. … Hemler M.E. (Biochem. J. 2004) 3 4 23

Products for CD9 Gene

Sources for CD9 Gene

Back to Top

Content