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Aliases for COPB2 Gene

Aliases for COPB2 Gene

  • Coatomer Protein Complex, Subunit Beta 2 (Beta Prime) 2 3
  • Beta-Coat Protein 3 4
  • Beta-COP 3 4
  • P102 3 4
  • Coatomer Binding Complex, Beta Prime Subunit 3
  • Coatomer Subunit Beta 3
  • Betaprime-COP 3

External Ids for COPB2 Gene

Summaries for COPB2 Gene

Entrez Gene Summary for COPB2 Gene

  • The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM, Jul 2002]

GeneCards Summary for COPB2 Gene

COPB2 (Coatomer Protein Complex, Subunit Beta 2 (Beta Prime)) is a Protein Coding gene. Among its related pathways are COPI Mediated Transport and COPI Mediated Transport. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for COPB2 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

  • This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). Interacts with JAGN1.

Gene Wiki entry for COPB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPB2 Gene

Genomics for COPB2 Gene

Genomic Location for COPB2 Gene

Start:
139,355,600 bp from pter
End:
139,389,732 bp from pter
Size:
34,133 bases
Orientation:
Minus strand

Genomic View for COPB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for COPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPB2 Gene

Regulatory Elements for COPB2 Gene

Proteins for COPB2 Gene

  • Protein details for COPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35606-COPB2_HUMAN
    Recommended name:
    Coatomer subunit beta
    Protein Accession:
    P35606
    Secondary Accessions:
    • B4DZI8

    Protein attributes for COPB2 Gene

    Size:
    906 amino acids
    Molecular mass:
    102487 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1 (By similarity).

    Alternative splice isoforms for COPB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPB2 Gene

Proteomics data for COPB2 Gene at MOPED

Post-translational modifications for COPB2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys168, Lys318, Lys328, Lys346, Lys386, Lys608, Lys724, and Lys771

Other Protein References for COPB2 Gene

No data available for DME Specific Peptides for COPB2 Gene

Domains for COPB2 Gene

Gene Families for COPB2 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

COPB2_HUMAN
Family:
  • Belongs to the WD repeat COPB2 family.:
    • P35606
Similarity:
  • Contains 6 WD repeats.:
    • P35606
genes like me logo Genes that share domains with COPB2: view

Function for COPB2 Gene

Molecular function for COPB2 Gene

GENATLAS Biochemistry: Golgi coatomer complex,beta subunit,component of the coat of non clathrin coated vesicles,putatively involved in regulating membrane trafficking in the exocytic pathway
UniProtKB/Swiss-Prot Function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
UniProtKB/Swiss-Prot Function: This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). Interacts with JAGN1.

Gene Ontology (GO) - Molecular Function for COPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with COPB2: view
genes like me logo Genes that share phenotypes with COPB2: view

miRNA for COPB2 Gene

miRTarBase miRNAs that target COPB2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for COPB2 Gene

Localization for COPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPB2 Gene

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPB2 Gene COMPARTMENTS Subcellular localization image for COPB2 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 4
cytosol 4
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for COPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0030117 membrane coat --
GO:0030126 COPI vesicle coat IDA 14729954
genes like me logo Genes that share ontologies with COPB2: view

Pathways for COPB2 Gene

genes like me logo Genes that share pathways with COPB2: view

Gene Ontology (GO) - Biological Process for COPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS 11030615
GO:0006891 intra-Golgi vesicle-mediated transport IDA 8335000
GO:0016192 vesicle-mediated transport --
GO:0048205 COPI coating of Golgi vesicle TAS --
genes like me logo Genes that share ontologies with COPB2: view

Compounds for COPB2 Gene

(1) HMDB Compounds for COPB2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Novoseek inferred chemical compound relationships for COPB2 Gene

Compound -log(P) Hits PubMed IDs
propargyl alcohol 97.4 17
genes like me logo Genes that share compounds with COPB2: view

Transcripts for COPB2 Gene

Unigene Clusters for COPB2 Gene

Coatomer protein complex, subunit beta 2 (beta prime):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPB2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5:
SP6: - - -
SP7:
SP8: -
SP9:

ExUns: 22 ^ 23a · 23b ^ 24a · 24b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for COPB2 Gene

GeneLoc Exon Structure for
COPB2
ECgene alternative splicing isoforms for
COPB2

Expression for COPB2 Gene

mRNA expression in normal human tissues for COPB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPB2 Gene

SOURCE GeneReport for Unigene cluster for COPB2 Gene Hs.681616

genes like me logo Genes that share expressions with COPB2: view

Orthologs for COPB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia COPB2 36
  • 99.71 (n)
  • 99.67 (a)
COPB2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia COPB2 36
  • 93.34 (n)
  • 98.68 (a)
COPB2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPB2 36
  • 94.04 (n)
  • 99.01 (a)
COPB2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copb2 36
  • 91.97 (n)
  • 98.34 (a)
Copb2 16
Copb2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COPB2 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Copb2 36
  • 90.5 (n)
  • 97.35 (a)
chicken
(Gallus gallus)
Aves COPB2 36
  • 82.82 (n)
  • 93.93 (a)
COPB2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPB2 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia wufc55e05-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia copb2 36
  • 76.42 (n)
  • 90.73 (a)
Str.1132 36
zebrafish
(Danio rerio)
Actinopterygii copb2 36
  • 77.1 (n)
  • 90.68 (a)
copb2 37
  • 87 (a)
OneToOne
wufc55e05 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004798 36
  • 62.95 (n)
  • 68.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta betaCop 36
  • 64.12 (n)
  • 69.21 (a)
betaCop 37
  • 68 (a)
OneToOne
bgrCop 38
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_F38E11.5 36
  • 63.42 (n)
  • 66.59 (a)
copb-2 37
  • 57 (a)
OneToMany
E03H4.8 37
  • 51 (a)
OneToMany
Y41C4A.11 37
  • 34 (a)
OneToMany
Y41C4A.11 38
  • 47 (a)
F38E11.5 38
  • 65 (a)
E03H4.8 38
  • 50 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL118W 36
  • 52.81 (n)
  • 47.49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC27 36
  • 54.24 (n)
  • 48.13 (a)
SEC27 37
  • 42 (a)
OneToOne
SEC27 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01958g 36
  • 54.88 (n)
  • 48.65 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9587 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79990 36
  • 62.13 (n)
  • 62.09 (a)
rice
(Oryza sativa)
Liliopsida Os.46583 36
Os06g0143900 36
  • 60.41 (n)
  • 58.82 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07319 36
  • 56.4 (n)
  • 53.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec27 36
  • 55.02 (n)
  • 47.78 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4264 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3776 37
  • 72 (a)
OneToOne
Species with no ortholog for COPB2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPB2 Gene

ENSEMBL:
Gene Tree for COPB2 (if available)
TreeFam:
Gene Tree for COPB2 (if available)

Paralogs for COPB2 Gene

Selected SIMAP similar genes for COPB2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with COPB2: view

No data available for Paralogs for COPB2 Gene

Variants for COPB2 Gene

Sequence variations from dbSNP and Humsavar for COPB2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1586862 -- 139,383,599(+) ACACA(C/T)CAAAA intron-variant
rs1602626 -- 139,364,928(-) CTATA(C/T)GGTAT intron-variant
rs1844977 -- 139,358,573(+) CTACT(C/T)GGGAG intron-variant
rs2307031 -- 139,357,978(+) AAGAG(G/T)GTAAT intron-variant
rs6766875 -- 139,378,561(+) CAAGA(C/T)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPB2 Gene

Variant ID Type Subtype PubMed ID
nsv877543 CNV Gain 21882294
nsv4034 CNV Loss 18451855

Relevant External Links for COPB2 Gene

HapMap Linkage Disequilibrium report
COPB2

Disorders for COPB2 Gene

(1) University of Copenhagen DISEASES for COPB2 Gene

(1) Novoseek inferred disease relationships for COPB2 Gene

Disease -log(P) Hits PubMed IDs
sarcoma 41.7 3

Relevant External Links for COPB2

Human Genome Epidemiology (HuGE) Navigator
COPB2
genes like me logo Genes that share disorders with COPB2: view

No data available for UniProtKB/Swiss-Prot for COPB2 Gene

Publications for COPB2 Gene

  1. A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins. (PMID: 8335000) Harrison-Lavoie K.J. … Willison K.R. (EMBO J. 1993) 3 4 23
  2. Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. (PMID: 9858824) De Baere E. … Messiaen L. (Cytogenet. Cell Genet. 1998) 2 3
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for COPB2 Gene

Sources for COPB2 Gene

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