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Aliases for COPB2 Gene

Aliases for COPB2 Gene

  • Coatomer Protein Complex Subunit Beta 2 2 3
  • Coatomer Protein Complex Subunit Beta 2 (Beta Prime) 2 3 5
  • Coatomer Protein Complex, Subunit Beta 2 (Beta Prime) 2 3
  • Coatomer Protein Complex Subunit Beta Prime 2 3
  • Beta-Coat Protein 3 4
  • Beta-Cop 3 4
  • P102 3 4
  • Coatomer Binding Complex, Beta Prime Subunit 3
  • Betaprime-COP 3

External Ids for COPB2 Gene

Previous GeneCards Identifiers for COPB2 Gene

  • GC03U990100
  • GC03M140357
  • GC03M140397
  • GC03M140559
  • GC03M139076
  • GC03M136451

Summaries for COPB2 Gene

Entrez Gene Summary for COPB2 Gene

  • The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM, Jul 2002]

GeneCards Summary for COPB2 Gene

COPB2 (Coatomer Protein Complex Subunit Beta 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Golgi-to-ER retrograde transport. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for COPB2 Gene

  • The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).

  • This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). Interacts with JAGN1.

Gene Wiki entry for COPB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for COPB2 Gene

Genomics for COPB2 Gene

Regulatory Elements for COPB2 Gene

Enhancers for COPB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around COPB2 on UCSC Golden Path with GeneCards custom track

Promoters for COPB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around COPB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for COPB2 Gene

Chromosome:
3
Start:
139,355,600 bp from pter
End:
139,389,732 bp from pter
Size:
34,133 bases
Orientation:
Minus strand

Genomic View for COPB2 Gene

Genes around COPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
COPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for COPB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for COPB2 Gene

Proteins for COPB2 Gene

  • Protein details for COPB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35606-COPB2_HUMAN
    Recommended name:
    Coatomer subunit beta
    Protein Accession:
    P35606
    Secondary Accessions:
    • B4DZI8

    Protein attributes for COPB2 Gene

    Size:
    906 amino acids
    Molecular mass:
    102487 Da
    Quaternary structure:
    • Oligomeric complex that consists of at least the alpha, beta, beta, gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A. Interacts with SCYL1 (By similarity).

    Alternative splice isoforms for COPB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for COPB2 Gene

Proteomics data for COPB2 Gene at MOPED

Post-translational modifications for COPB2 Gene

  • Ubiquitination at Lys 168, Lys 318, Lys 328, Lys 346, Lys 386, Lys 608, and Lys 724
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for COPB2 Gene

Domains & Families for COPB2 Gene

Gene Families for COPB2 Gene

Suggested Antigen Peptide Sequences for COPB2 Gene

Graphical View of Domain Structure for InterPro Entry

P35606

UniProtKB/Swiss-Prot:

COPB2_HUMAN :
  • Belongs to the WD repeat COPB2 family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat COPB2 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with COPB2: view

Function for COPB2 Gene

Molecular function for COPB2 Gene

GENATLAS Biochemistry:
Golgi coatomer complex,beta subunit,component of the coat of non clathrin coated vesicles,putatively involved in regulating membrane trafficking in the exocytic pathway
UniProtKB/Swiss-Prot Function:
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
UniProtKB/Swiss-Prot Function:
This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner (By similarity). Interacts with JAGN1.

Gene Ontology (GO) - Molecular Function for COPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with COPB2: view

Phenotypes for COPB2 Gene

GenomeRNAi human phenotypes for COPB2:
genes like me logo Genes that share phenotypes with COPB2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for COPB2 Gene

Localization for COPB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for COPB2 Gene

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for COPB2 Gene COMPARTMENTS Subcellular localization image for COPB2 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for COPB2 Gene

Pathways & Interactions for COPB2 Gene

genes like me logo Genes that share pathways with COPB2: view

Gene Ontology (GO) - Biological Process for COPB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048205 COPI coating of Golgi vesicle TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with COPB2: view

No data available for SIGNOR curated interactions for COPB2 Gene

Drugs & Compounds for COPB2 Gene

(1) Drugs for COPB2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for COPB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with COPB2: view

Transcripts for COPB2 Gene

Unigene Clusters for COPB2 Gene

Coatomer protein complex, subunit beta 2 (beta prime):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for COPB2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5:
SP6: - - -
SP7:
SP8: -
SP9:

ExUns: 22 ^ 23a · 23b ^ 24a · 24b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for COPB2 Gene

GeneLoc Exon Structure for
COPB2
ECgene alternative splicing isoforms for
COPB2

Expression for COPB2 Gene

mRNA expression in normal human tissues for COPB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for COPB2 Gene

This gene is overexpressed in Lymph node (7.7) and Salivary gland (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for COPB2 Gene



SOURCE GeneReport for Unigene cluster for COPB2 Gene Hs.681616

genes like me logo Genes that share expression patterns with COPB2: view

Protein tissue co-expression partners for COPB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for COPB2 Gene

Orthologs for COPB2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for COPB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COPB2 35
  • 93.34 (n)
  • 98.68 (a)
COPB2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COPB2 35
  • 94.04 (n)
  • 99.01 (a)
COPB2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Copb2 35
  • 91.97 (n)
  • 98.34 (a)
Copb2 16
Copb2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COPB2 35
  • 99.71 (n)
  • 99.67 (a)
COPB2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Copb2 35
  • 90.5 (n)
  • 97.35 (a)
oppossum
(Monodelphis domestica)
Mammalia COPB2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves COPB2 35
  • 82.82 (n)
  • 93.93 (a)
COPB2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia COPB2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia copb2 35
  • 76.42 (n)
  • 90.73 (a)
Str.1132 35
African clawed frog
(Xenopus laevis)
Amphibia wufc55e05-prov 35
zebrafish
(Danio rerio)
Actinopterygii copb2 35
  • 77.1 (n)
  • 90.68 (a)
wufc55e05 35
copb2 36
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bgrCop 37
  • 70 (a)
betaCop 35
  • 64.12 (n)
  • 69.21 (a)
betaCop 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004798 35
  • 62.95 (n)
  • 68.98 (a)
worm
(Caenorhabditis elegans)
Secernentea E03H4.8 37
  • 50 (a)
F38E11.5 37
  • 65 (a)
Y41C4A.11 37
  • 47 (a)
CELE_F38E11.5 35
  • 63.42 (n)
  • 66.59 (a)
copb-2 36
  • 57 (a)
OneToMany
E03H4.8 36
  • 51 (a)
OneToMany
Y41C4A.11 36
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL118W 35
  • 52.81 (n)
  • 47.49 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01958g 35
  • 54.88 (n)
  • 48.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC27 35
  • 54.24 (n)
  • 48.13 (a)
SEC27 36
  • 42 (a)
OneToOne
SEC27 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79990 35
  • 62.13 (n)
  • 62.09 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9587 35
rice
(Oryza sativa)
Liliopsida Os.46583 35
Os06g0143900 35
  • 60.41 (n)
  • 58.82 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4264 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07319 35
  • 56.4 (n)
  • 53.17 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec27 35
  • 55.02 (n)
  • 47.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3776 36
  • 72 (a)
OneToOne
Species with no ortholog for COPB2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for COPB2 Gene

ENSEMBL:
Gene Tree for COPB2 (if available)
TreeFam:
Gene Tree for COPB2 (if available)

Paralogs for COPB2 Gene

genes like me logo Genes that share paralogs with COPB2: view

No data available for Paralogs for COPB2 Gene

Variants for COPB2 Gene

Sequence variations from dbSNP and Humsavar for COPB2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2307031 -- 139,357,978(+) AAGAG(G/T)GTAAT intron-variant
rs9819368 -- 139,359,768(+) ACCAT(A/G)GTGTC intron-variant
rs7616756 -- 139,358,132(+) CCTAC(A/G)TATCC intron-variant
rs9821891 -- 139,372,480(+) CAAGA(A/G)TGTTT intron-variant
rs6766875 -- 139,378,561(+) CAAGA(C/T)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for COPB2 Gene

Variant ID Type Subtype PubMed ID
nsv877543 CNV Gain 21882294
nsv4034 CNV Loss 18451855

Variation tolerance for COPB2 Gene

Residual Variation Intolerance Score: 8.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for COPB2 Gene

HapMap Linkage Disequilibrium report
COPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for COPB2 Gene

Disorders for COPB2 Gene

Relevant External Links for COPB2

Human Genome Epidemiology (HuGE) Navigator
COPB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
COPB2

No disorders were found for COPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for COPB2 Gene

Publications for COPB2 Gene

  1. A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins. (PMID: 8335000) Harrison-Lavoie K.J. … Willison K.R. (EMBO J. 1993) 3 4 23 67
  2. Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. (PMID: 9858824) De Baere E. … Messiaen L. (Cytogenet. Cell Genet. 1998) 2 3
  3. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3

Products for COPB2 Gene

Sources for COPB2 Gene

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